PT3107899T - Amidas policíclicas de ligação ao aldeído desidrogenase 2 mitocondrial (aldh2) e seu uso para o tratamento do cancro - Google Patents

Amidas policíclicas de ligação ao aldeído desidrogenase 2 mitocondrial (aldh2) e seu uso para o tratamento do cancro

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Publication number
PT3107899T
PT3107899T PT157113366T PT15711336T PT3107899T PT 3107899 T PT3107899 T PT 3107899T PT 157113366 T PT157113366 T PT 157113366T PT 15711336 T PT15711336 T PT 15711336T PT 3107899 T PT3107899 T PT 3107899T
Authority
PT
Portugal
Prior art keywords
aldh2
cancer
treatment
aldehyde dehydrogenase
mitochondrial aldehyde
Prior art date
Application number
PT157113366T
Other languages
English (en)
Original Assignee
Aviv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviv Therapeutics Inc filed Critical Aviv Therapeutics Inc
Publication of PT3107899T publication Critical patent/PT3107899T/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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