ATE180488T1 - Synthese von 4-alkoxy-n-acetylneuraminsäure - Google Patents

Synthese von 4-alkoxy-n-acetylneuraminsäure

Info

Publication number
ATE180488T1
ATE180488T1 AT95926764T AT95926764T ATE180488T1 AT E180488 T1 ATE180488 T1 AT E180488T1 AT 95926764 T AT95926764 T AT 95926764T AT 95926764 T AT95926764 T AT 95926764T AT E180488 T1 ATE180488 T1 AT E180488T1
Authority
AT
Austria
Prior art keywords
alkoxy
synthesis
group
alkyl
alkylated
Prior art date
Application number
AT95926764T
Other languages
English (en)
Inventor
Avraham Liav
Ragen F Hardgrave
Sheri Blystone
Gregory A Turner
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE180488T1 publication Critical patent/ATE180488T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95926764T 1994-08-05 1995-07-21 Synthese von 4-alkoxy-n-acetylneuraminsäure ATE180488T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/286,573 US5556963A (en) 1994-08-05 1994-08-05 Synthesis of 4-alkoxy-N-acetylneuraminic acid

Publications (1)

Publication Number Publication Date
ATE180488T1 true ATE180488T1 (de) 1999-06-15

Family

ID=23099220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95926764T ATE180488T1 (de) 1994-08-05 1995-07-21 Synthese von 4-alkoxy-n-acetylneuraminsäure

Country Status (12)

Country Link
US (1) US5556963A (de)
EP (1) EP0775152B1 (de)
JP (1) JP3947218B2 (de)
AT (1) ATE180488T1 (de)
AU (1) AU685312B2 (de)
CA (1) CA2195872A1 (de)
DE (1) DE69509903T2 (de)
DK (1) DK0775152T3 (de)
ES (1) ES2131841T3 (de)
GR (1) GR3030713T3 (de)
NO (1) NO305757B1 (de)
WO (1) WO1996004291A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663055A (en) * 1989-12-29 1997-09-02 Oklahoma Medical Research Foundation Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
US5958973A (en) * 1993-09-03 1999-09-28 Gilead Sciences, Inc. Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
JP3300365B2 (ja) 1995-02-27 2002-07-08 ギリアード サイエンシーズ，インコーポレイテッド ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US5891855A (en) 1996-02-12 1999-04-06 The Scripps Research Institute Inhibitors of leaderless protein export
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5719020A (en) * 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US20040053999A1 (en) * 1997-09-17 2004-03-18 Bischofberger Norbert W. Novel compounds and methods for synthesis and therapy
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
EP1185710A2 (de) * 1999-04-16 2002-03-13 Zymetx, Inc. Verfahren zum nachweis von viren, das viralisch-codierte enzymen und chemilumineszentsubstraten verwendet
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US9119866B2 (en) 2008-04-08 2015-09-01 Huiru Wang Glycan-based drugs, therapies and biomarkers
WO2023062386A1 (en) * 2021-10-14 2023-04-20 Owlstone Medical Limited Method for the synthesis of evoc probes

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950322A (en) * 1973-08-27 1976-04-13 Research Corporation Fluorogenic substrate glycosides
US5239091A (en) * 1988-08-30 1993-08-24 G. D. Searle & Co. 2-deoxy derivatives of N-acetyl neuraminic acid and their preparation
US5191073A (en) * 1989-02-13 1993-03-02 Miles Inc. Chromogenic merocyanine enzyme substrates
WO1991009972A1 (en) * 1989-12-29 1991-07-11 Symex Corp. Methods for diagnosting human influenza and 4-position modified chromogenic n-acetylneuraminic acid substrates for use therein
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
US5138044A (en) * 1990-08-13 1992-08-11 Glycomed, Inc. Synthesis of sialosides
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
US5252458A (en) * 1990-12-31 1993-10-12 Symex Corp. Method for visually detecting the presence of a virus in a clinical specimen
JPH04300890A (ja) * 1991-03-29 1992-10-23 Nisshin Oil Mills Ltd:The シアル酸部分を変換したガングリオシドｇｍ３類縁体

Also Published As

Publication number Publication date
AU3103395A (en) 1996-03-04
DK0775152T3 (da) 1999-11-29
CA2195872A1 (en) 1996-02-15
JP3947218B2 (ja) 2007-07-18
DE69509903T2 (de) 1999-10-28
NO305757B1 (no) 1999-07-19
NO970462L (no) 1997-04-07
NO970462D0 (no) 1997-02-03
EP0775152B1 (de) 1999-05-26
EP0775152A1 (de) 1997-05-28
GR3030713T3 (en) 1999-11-30
US5556963A (en) 1996-09-17
AU685312B2 (en) 1998-01-15
WO1996004291A1 (en) 1996-02-15
DE69509903D1 (de) 1999-07-01
JPH10506103A (ja) 1998-06-16
ES2131841T3 (es) 1999-08-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee