JPS55131000A - Production of 24,25-dihydroxycholesterol derivative - Google Patents

Production of 24,25-dihydroxycholesterol derivative

Info

Publication number
JPS55131000A
JPS55131000A JP3831779A JP3831779A JPS55131000A JP S55131000 A JPS55131000 A JP S55131000A JP 3831779 A JP3831779 A JP 3831779A JP 3831779 A JP3831779 A JP 3831779A JP S55131000 A JPS55131000 A JP S55131000A
Authority
JP
Japan
Prior art keywords
hydroxyl
derivative
protected
protecting
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3831779A
Other languages
Japanese (ja)
Other versions
JPS6215079B2 (en
Inventor
Osamu Nishikawa
Kenji Ishimaru
Toru Takeshita
Hideki Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP3831779A priority Critical patent/JPS55131000A/en
Publication of JPS55131000A publication Critical patent/JPS55131000A/en
Publication of JPS6215079B2 publication Critical patent/JPS6215079B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: After reduced, a specific 25-hydroxy-24-oxocholesterol is removed the protecting groups from the hydroxyl groups of protected on the hydroxyl groups to give title compound useful as a starting material of activation type vitamin D3 with industrial advantage.
CONSTITUTION: A 25-hydroxy-24-oxocholesterol derivative of formula I (R1 and R5 are H, group protecting hydroxyl; R2 is H, hydroxyl, protected hydroxyl; R3 and R4 is H, or combines together to form C-C bond) is reduced in methanol with a reducing agent that has selectivity to olefin, such as sodium borohydride, at 20°C. Subsequently, when necessary, the protecting group on hydroxyl is removed or hydroxyl is protected to give the objective derivative of formula II (R6 is H, hydroxyl-protecting group).
COPYRIGHT: (C)1980,JPO&Japio
JP3831779A 1979-04-02 1979-04-02 Production of 24,25-dihydroxycholesterol derivative Granted JPS55131000A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3831779A JPS55131000A (en) 1979-04-02 1979-04-02 Production of 24,25-dihydroxycholesterol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3831779A JPS55131000A (en) 1979-04-02 1979-04-02 Production of 24,25-dihydroxycholesterol derivative

Publications (2)

Publication Number Publication Date
JPS55131000A true JPS55131000A (en) 1980-10-11
JPS6215079B2 JPS6215079B2 (en) 1987-04-06

Family

ID=12521899

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3831779A Granted JPS55131000A (en) 1979-04-02 1979-04-02 Production of 24,25-dihydroxycholesterol derivative

Country Status (1)

Country Link
JP (1) JPS55131000A (en)

Also Published As

Publication number Publication date
JPS6215079B2 (en) 1987-04-06

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