JPS55131000A - Production of 24,25-dihydroxycholesterol derivative - Google Patents
Production of 24,25-dihydroxycholesterol derivativeInfo
- Publication number
- JPS55131000A JPS55131000A JP3831779A JP3831779A JPS55131000A JP S55131000 A JPS55131000 A JP S55131000A JP 3831779 A JP3831779 A JP 3831779A JP 3831779 A JP3831779 A JP 3831779A JP S55131000 A JPS55131000 A JP S55131000A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyl
- derivative
- protected
- protecting
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: After reduced, a specific 25-hydroxy-24-oxocholesterol is removed the protecting groups from the hydroxyl groups of protected on the hydroxyl groups to give title compound useful as a starting material of activation type vitamin D3 with industrial advantage.
CONSTITUTION: A 25-hydroxy-24-oxocholesterol derivative of formula I (R1 and R5 are H, group protecting hydroxyl; R2 is H, hydroxyl, protected hydroxyl; R3 and R4 is H, or combines together to form C-C bond) is reduced in methanol with a reducing agent that has selectivity to olefin, such as sodium borohydride, at 20°C. Subsequently, when necessary, the protecting group on hydroxyl is removed or hydroxyl is protected to give the objective derivative of formula II (R6 is H, hydroxyl-protecting group).
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3831779A JPS55131000A (en) | 1979-04-02 | 1979-04-02 | Production of 24,25-dihydroxycholesterol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3831779A JPS55131000A (en) | 1979-04-02 | 1979-04-02 | Production of 24,25-dihydroxycholesterol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55131000A true JPS55131000A (en) | 1980-10-11 |
JPS6215079B2 JPS6215079B2 (en) | 1987-04-06 |
Family
ID=12521899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3831779A Granted JPS55131000A (en) | 1979-04-02 | 1979-04-02 | Production of 24,25-dihydroxycholesterol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55131000A (en) |
-
1979
- 1979-04-02 JP JP3831779A patent/JPS55131000A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6215079B2 (en) | 1987-04-06 |
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