KR910009720A - 알콕시메틸리덴 에피포도필로톡신 배당체 - Google Patents

알콕시메틸리덴 에피포도필로톡신 배당체 Download PDF

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Publication number
KR910009720A
KR910009720A KR1019900018740A KR900018740A KR910009720A KR 910009720 A KR910009720 A KR 910009720A KR 1019900018740 A KR1019900018740 A KR 1019900018740A KR 900018740 A KR900018740 A KR 900018740A KR 910009720 A KR910009720 A KR 910009720A
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South Korea
Prior art keywords
compound
tumor
alkoxy
hydrogen
ethoxy
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KR1019900018740A
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English (en)
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KR930007382B1 (ko
Inventor
오오누마 다께시
나이또 다까유끼
가메이 히데오
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도미니크 앰. 매짜펠
브리스톨-마이어즈 스퀴브 컴페니
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Publication of KR910009720A publication Critical patent/KR910009720A/ko
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Publication of KR930007382B1 publication Critical patent/KR930007382B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

알콕시메틸리덴 에피포도필로톡신 배당체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음 일반식을 갖는 화합물
    상기식중, R1과 R2중 하나는 C1-5알킬C1-5및 알콕시이고 다른 하나는 수소, C1-5알콕시중에서 선택되는 기이고; R3는 수소 또는 -P(O)(OM)2이다(여기서 M은 수소 또는 알칼리 금속 양이온임).
  2. 제1항에 있어서, R1과 R2중 하나는 C1-5알콕시이고 다른 하나는 H인 것이 특징인 화합물.
  3. 제1항에 있어서, R1과 R2가 각각 C1-5알콕시인 것이 특징인 화합물.
  4. 제1항에 있어서, R3은 H이고; R1과 R2중 하나는 메톡시와 에톡시에서 선택되고, 다른 하나는 수소, 메톡시 및 에톡시 중에서 선택되는 것이 특징인 화합물.
  5. 제1항에 있어서, R3은 H이고; R1과 R2가 동일하고 메톡시와 에톡시에서 선택되는 것이 특징인 화합물.
  6. 제1항의 화합물의 항종양 유효량과 약리적으로 허용되는 담체로 됨을 특징으로 하는 항종양 약리적 조성물,
  7. 종양이 있는 비인간 포유를 숙주에게 제1항의 화합물의 항종양 유효량을 투여하는 것으로 되는, 비인간 포유류 숙주에 있어서의 종양 억제방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018740A 1989-11-20 1990-11-19 알콕시메틸리덴 에피포도필로톡신 배당체 KR930007382B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/438,829 US5034380A (en) 1989-11-20 1989-11-20 Alkoxymethylidene epipodophyllotoxin glucosides
US438.829 1989-11-20
US438,829 1989-11-20

Publications (2)

Publication Number Publication Date
KR910009720A true KR910009720A (ko) 1991-06-28
KR930007382B1 KR930007382B1 (ko) 1993-08-09

Family

ID=23742200

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900018740A KR930007382B1 (ko) 1989-11-20 1990-11-19 알콕시메틸리덴 에피포도필로톡신 배당체

Country Status (15)

Country Link
US (1) US5034380A (ko)
EP (1) EP0433678A1 (ko)
JP (1) JPH0686476B2 (ko)
KR (1) KR930007382B1 (ko)
AU (1) AU614698B2 (ko)
CA (1) CA2029748A1 (ko)
FI (1) FI905685A (ko)
HU (1) HU208019B (ko)
IE (1) IE904162A1 (ko)
IL (1) IL95884A (ko)
NO (1) NO174204C (ko)
NZ (1) NZ236106A (ko)
PT (1) PT95931A (ko)
YU (1) YU220790A (ko)
ZA (1) ZA909252B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW260671B (ko) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
US5458299A (en) * 1993-11-17 1995-10-17 Collins; Kenneth Aircraft deicing apparatus
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
JPH087254B2 (ja) * 1989-08-07 1996-01-29 富士通株式会社 半導体集積回路装置

Also Published As

Publication number Publication date
PT95931A (pt) 1991-09-13
KR930007382B1 (ko) 1993-08-09
AU6671190A (en) 1991-05-23
AU614698B2 (en) 1991-09-05
JPH0686476B2 (ja) 1994-11-02
IE904162A1 (en) 1991-05-22
YU220790A (sh) 1992-09-07
NZ236106A (en) 1991-11-26
CA2029748A1 (en) 1991-05-21
NO174204B (no) 1993-12-20
ZA909252B (en) 1991-09-25
NO174204C (no) 1994-04-06
NO904967D0 (no) 1990-11-16
IL95884A0 (en) 1991-07-18
HU208019B (en) 1993-07-28
HUT55406A (en) 1991-05-28
NO904967L (no) 1991-05-21
EP0433678A1 (en) 1991-06-26
FI905685A0 (fi) 1990-11-16
FI905685A (fi) 1991-05-21
JPH03170494A (ja) 1991-07-24
US5034380A (en) 1991-07-23
IL95884A (en) 1994-10-21

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