KR840005076A - A-21978c 사이클릭펩티드 유도체의 제조방법 - Google Patents

A-21978c 사이클릭펩티드 유도체의 제조방법 Download PDF

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KR840005076A
KR840005076A KR1019830002222A KR830002222A KR840005076A KR 840005076 A KR840005076 A KR 840005076A KR 1019830002222 A KR1019830002222 A KR 1019830002222A KR 830002222 A KR830002222 A KR 830002222A KR 840005076 A KR840005076 A KR 840005076A
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Prior art keywords
hydrogen
amino
protecting group
alkyl
cyclic peptide
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KR1019830002222A
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KR860002185B1 (ko
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데보노 마누엘
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아더 알. 웨일
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045—Actinoplanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/62—Streptosporangium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

A-21978C 사이클릭 펩티드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(3)의 A-21978C핵 또는 그의 적당히 보호된 유도체, 또는 그의 약제학적으로 허용할수 있는 염을 일반식(5)의 아실화제 또는 그의 활성화된 유도체와 반응시킴을 특징으로 하여 일반식(1)의 A-21978C 사이클릭 펩티드 유도체 또는 그의 약제학적으로 허용할수 있는 염을 제조하는 방법.
    상기식에서, R은 일반식의 치환된 벤조일 그룹이고,
    R2는 C8-C15알킬이며, X는 수소, 클로로, 브로모, 요도, 니트로, C1-C3알킬, 히드록시, C1-C3알콕시 또는 C1-C3알킬티오이고,
    R1은 수소 또는 아미노-보호그룹이며,
    R' 및 R0는 독립적으로 수소 또는 아미노-보호그룹이다.
  2. 제1항에 있어서, R2가 C10-C13알킬임이 특징인 방법.
  3. 제2항에 있어서, R2-O-가 도데실옥시임이 특징인 방법.
  4. 제1 내지 제3항중의 어느 하나에 있어서, X가 수소임이 특징인 방법.
  5. 제2항에 있어서, R2-O-가 p-(n-도데실옥시)이고 X가 수소임이 특징인 방법.
  6. 제1항 내지 제3항중의 어느 하나에 있어서, X가 클로로, 브로모 또는 요도 중에서 선택됨이 특징인 방법.
  7. 제1항 내지 제3항 및 제5항 중의 어느 하나에 있어서, R1이 아미노-보호그룹임이 특징인 방법.
  8. 제7항에 있어서, 아미노-보호그룹이 3급-부톡시카보닐임이 특징인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002222A 1982-05-21 1983-05-19 A-21978c 사이클릭 펩티드 유도체의 제조방법 KR860002185B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US380498 1982-05-21
US06/380,498 US4399067A (en) 1982-05-21 1982-05-21 Derivatives of A-21978C cyclic peptides
US380.498 1982-05-21

Publications (2)

Publication Number Publication Date
KR840005076A true KR840005076A (ko) 1984-11-03
KR860002185B1 KR860002185B1 (ko) 1986-12-24

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KR1019830002222A KR860002185B1 (ko) 1982-05-21 1983-05-19 A-21978c 사이클릭 펩티드 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4399067A (ko)
KR (1) KR860002185B1 (ko)
AT (1) AT380022B (ko)
CA (1) CA1215043A (ko)
DD (1) DD209810A5 (ko)
DK (1) DK220983A (ko)
EG (1) EG16042A (ko)
ES (1) ES8407012A1 (ko)
FI (1) FI831746L (ko)
GR (1) GR79259B (ko)
HU (1) HU192955B (ko)
PH (1) PH21382A (ko)
PL (1) PL242096A1 (ko)
PT (1) PT76701B (ko)
RO (1) RO86721B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1315229C (en) * 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
US5256548A (en) * 1990-11-21 1993-10-26 Bristol-Myers Squibb Company Antiviral antibiotic BU-4344V
US5140101A (en) * 1990-11-21 1992-08-18 Bristol-Myers Squibb Company Antiviral antibiotic BU-4344V
EP2295444A3 (en) 1999-12-15 2011-03-23 Cubist Pharmaceutical Inc. Lipopeptides as antibacterial agents
MXPA02006030A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos como agentes antibacterianos.
MXPA02006028A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
DE60232158D1 (de) * 2001-08-06 2009-06-10 Cubist Pharm Inc Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
EP1932853A1 (en) 2001-08-06 2008-06-18 Cubist Pharmaceutical Inc. Novel depsipeptides and process for preparing same
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
EP2674437A1 (en) * 2008-12-22 2013-12-18 Cubist Pharmaceuticals, Inc. Novel antibacterial agents for the treatment of GRAM positive infections
AR074874A1 (es) * 2008-12-23 2011-02-16 Biosource Pharm Inc Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto.
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150059A (en) * 1962-12-26 1964-09-22 Lilly Co Eli Penicillin deacylation via actinoplanaceae fermentation
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
US4293482A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4289692A (en) * 1979-12-13 1981-09-15 Eli Lilly And Company Derivatives of A-30912D nucleus
US4293486A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4297277A (en) * 1979-12-13 1981-10-27 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293484A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912H nucleus

Also Published As

Publication number Publication date
RO86721B (ro) 1985-05-01
DK220983D0 (da) 1983-05-18
ES522561A0 (es) 1984-09-01
ATA178383A (de) 1985-08-15
PH21382A (en) 1987-10-15
HU192955B (en) 1987-08-28
PT76701A (en) 1983-06-01
PT76701B (en) 1986-03-27
GR79259B (ko) 1984-10-22
PL242096A1 (en) 1984-07-02
FI831746L (fi) 1983-11-22
ES8407012A1 (es) 1984-09-01
US4399067A (en) 1983-08-16
RO86721A (ro) 1985-04-17
DK220983A (da) 1983-11-22
FI831746A0 (fi) 1983-05-18
DD209810A5 (de) 1984-05-23
AT380022B (de) 1986-03-25
EG16042A (en) 1986-12-30
KR860002185B1 (ko) 1986-12-24
CA1215043A (en) 1986-12-09

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