KR840004509A - 옥시캄 유도체를 함유하는 제약조성물과 그 제조방법 - Google Patents

옥시캄 유도체를 함유하는 제약조성물과 그 제조방법 Download PDF

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KR840004509A
KR840004509A KR1019830001935A KR830001935A KR840004509A KR 840004509 A KR840004509 A KR 840004509A KR 1019830001935 A KR1019830001935 A KR 1019830001935A KR 830001935 A KR830001935 A KR 830001935A KR 840004509 A KR840004509 A KR 840004509A
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pharmaceutical composition
oxycam
derivative
composition according
organic solvent
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KR1019830001935A
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KR900008441B1 (ko
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게브하르트 우베
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테하슈베르트, 이만스만
괴데케 악티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

옥시캄 유도체를 함유하는 제약조성물과 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 일반식(Ⅰ)으로 표시되는 옥시캄 유도체를 하나이상 포함하는 제약조성물.
    상기식에서, R은 헤테로싸이클릭링이며, X와 Y는 다음의 구조식을 갖는 유기염기동일 몰량 이상과 축합된 방향족 링으로서
    R´-NH-CH2-(CHOH)n-CH2OH
    여기서 R´은 수소원자 또는 탄소수 6개까지를 포함하는 알킬 래디칼이며, n은 3 또는 4이다.
  2. 생리학적으로 적합하고 물과 혼화되기 쉬운 유기용매가 5-70용량%로 들어있는 수용액에서, 옥시캄유도체 1몰당 제1항의 일반식(Ⅱ)의 염기를 1.2-2몰 함유하고 제1항의 일반식(Ⅰ)의 옥시캄 유도체를 하나이상 함유하는 제약조성물.
  3. 옥시캄 유도체가 이속시캄인 상기 모든항에 의한 제약조성물.
  4. 염기가 메틸-글루카민인 상기 모든항에 의한 제약조성물.
  5. 물과 혼화하기 쉬운 유기용매가 폴리에틸렌 글라이콜 또는 디메틸아세트아마드인 제2항에서 제4항 까지의 모든항에 의한 제약조성물.
  6. 상기 일반식(Ⅰ)의 옥시캄 유도체의 농도가 10-20%인, 제2항에서 제5항까지의 모든항에 의한 제약조성물.
  7. 유기용매의 비율이 10-30중량%인, 제2항에서 제6항까지의 모든 항에 의한 제약조성물.
  8. 유기용매가 함유되어 있지않고, 동결건조물로 존재하는 제1항에 의한 제약조성물.
  9. 대략 40-80℃의 온도에서 생리학적으로 적합하고 물과 혼화하기 쉬운 유기용매의 비율이 5-70%인 수용액에서, 옥시캄 유도체가 일반식(Ⅱ)의 유기염기 동일 몰량이상과 함께 용해되어 있는 상기 일반식(Ⅰ)의 옥시캄 유도체를 하나이상 함유하는 주사용액의 제조방법.
  10. 완전용해에 충분한 양의 물에 40-80℃에서 옥시캄 유도체가 상기 일반식(Ⅱ)의 유기 염기 1.5-2몰의 양과 함께 용해되어 있고, 이렇게 얻어진 용액을 공지된 방법으로 냉각시키고 동결건조시켜, 상기일반식(Ⅰ)의 옥시캄 유도체를 적어도 하나이상 함유하는 동결건조 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001935A 1982-05-08 1983-05-06 옥시캄 유도체를 함유하는 제약조성물의 제조방법 KR900008441B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3217315A DE3217315C2 (de) 1982-05-08 1982-05-08 Arzneimittelzubereitungen mit einem Gehalt an Oxicam-Derivaten
DEP3217315 1982-05-08

Publications (2)

Publication Number Publication Date
KR840004509A true KR840004509A (ko) 1984-10-22
KR900008441B1 KR900008441B1 (ko) 1990-11-22

Family

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KR1019830001935A KR900008441B1 (ko) 1982-05-08 1983-05-06 옥시캄 유도체를 함유하는 제약조성물의 제조방법

Country Status (23)

Country Link
US (1) US4482554A (ko)
EP (1) EP0093999B1 (ko)
JP (1) JPS5931713A (ko)
KR (1) KR900008441B1 (ko)
AR (1) AR230634A1 (ko)
AT (1) ATE29383T1 (ko)
AU (1) AU551337B2 (ko)
CA (1) CA1204668A (ko)
DD (1) DD211484A5 (ko)
DE (2) DE3217315C2 (ko)
DK (1) DK157731C (ko)
ES (1) ES522107A0 (ko)
FI (1) FI79944C (ko)
GR (1) GR77503B (ko)
HU (1) HU197208B (ko)
IE (1) IE54729B1 (ko)
IL (1) IL68421A (ko)
NO (1) NO163314C (ko)
NZ (1) NZ204086A (ko)
PH (2) PH22726A (ko)
SU (1) SU1295993A3 (ko)
YU (1) YU90383A (ko)
ZA (1) ZA832816B (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
DE3435843A1 (de) * 1984-09-29 1986-04-03 Gödecke AG, 1000 Berlin Antirheumatisch wirksame suppositorien
DE3437232A1 (de) * 1984-10-10 1986-04-17 Mack Chem Pharm Stabilisierte injektionsloesungen von piroxicam
JPH0430634Y2 (ko) * 1985-06-10 1992-07-23
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
ES2038733T3 (es) * 1987-12-04 1993-08-01 Asta Medica Ag Procedimiento para preparar una solucion inyectable de la sal de acido tioctico con trometanol y/o aminoacidos basicos.
HU205550B (en) * 1990-11-27 1992-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pyroxycam solution of increased stability, free from effects damaging tussues
JPH06507882A (ja) * 1990-12-03 1994-09-08 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 滑膜癒着の防止
IT1283252B1 (it) * 1996-03-15 1998-04-16 Pulitzer Italiana Soluzioni di piroxicam iniettabili per via parenterale
AU1885999A (en) * 1998-02-17 1999-08-30 Miciopharma Chemical Aktiengesellschaft A watersoluble nimesulide adduct also for injectable use
WO1999048182A1 (fr) 1998-03-14 1999-09-23 The Furukawa Electric Co., Ltd. Dissipateur de chaleur destine a une ligne de transmission, ligne de transmission comprenant le dissipateur de chaleur et procede d'installation du dissipateur de chaleur sur la ligne de transmission
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
DE10030345A1 (de) * 2000-06-20 2002-01-10 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen
DE10161077A1 (de) * 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US8992980B2 (en) * 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004021281A1 (de) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin
DE102004030409A1 (de) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh Neue Verwendung von Meloxicam in der Veterinärmedizin
EP1942902A1 (en) * 2005-09-30 2008-07-16 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical preparation containing meloxicam
IN2012DN03157A (ko) 2009-10-12 2015-09-18 Boehringer Ingelheim Vetmed
US20110218191A1 (en) * 2010-03-03 2011-09-08 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long term-treatment of kidney disorders in cats
AU2010347598B2 (en) 2010-03-03 2014-11-27 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629650A (ko) * 1967-05-18 1900-01-01
JPS4931815A (ko) * 1972-07-27 1974-03-22
SE421792B (sv) * 1976-01-12 1982-02-01 Pfizer Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
FI831534L (fi) 1983-11-09
DE3373414D1 (en) 1987-10-15
EP0093999A2 (de) 1983-11-16
EP0093999B1 (de) 1987-09-09
CA1204668A (en) 1986-05-20
ES8405274A1 (es) 1984-06-01
US4482554A (en) 1984-11-13
IE830785L (en) 1983-11-08
FI79944B (fi) 1989-12-29
NO163314C (no) 1990-05-09
PH22726A (en) 1988-11-28
YU90383A (en) 1988-02-29
GR77503B (ko) 1984-09-24
DE3217315C2 (de) 1986-05-22
NO163314B (no) 1990-01-29
ES522107A0 (es) 1984-06-01
DK204683D0 (da) 1983-05-06
SU1295993A3 (ru) 1987-03-07
AR230634A1 (es) 1984-05-31
FI831534A0 (fi) 1983-05-04
EP0093999A3 (en) 1985-05-15
NZ204086A (en) 1986-02-21
IE54729B1 (en) 1990-01-17
AU1366483A (en) 1983-11-10
IL68421A (en) 1986-04-29
NO831610L (no) 1983-11-09
AU551337B2 (en) 1986-04-24
ATE29383T1 (de) 1987-09-15
FI79944C (fi) 1990-04-10
DD211484A5 (de) 1984-07-18
KR900008441B1 (ko) 1990-11-22
DK157731C (da) 1990-07-16
JPS5931713A (ja) 1984-02-20
ZA832816B (en) 1983-12-28
DE3217315A1 (de) 1983-11-10
DK157731B (da) 1990-02-12
JPH0257049B2 (ko) 1990-12-03
HU197208B (en) 1989-03-28
IL68421A0 (en) 1983-07-31
PH24334A (en) 1990-05-29
DK204683A (da) 1983-11-09

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