JPS54154753A - Tetrahydroesterastin and its preparation - Google Patents

Tetrahydroesterastin and its preparation

Info

Publication number
JPS54154753A
JPS54154753A JP6172578A JP6172578A JPS54154753A JP S54154753 A JPS54154753 A JP S54154753A JP 6172578 A JP6172578 A JP 6172578A JP 6172578 A JP6172578 A JP 6172578A JP S54154753 A JPS54154753 A JP S54154753A
Authority
JP
Japan
Prior art keywords
formula
esterastin
compound
catalyst
tetrahydroesterastin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6172578A
Other languages
Japanese (ja)
Other versions
JPS6145620B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tomio Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP6172578A priority Critical patent/JPS54154753A/en
Priority to GB7909606A priority patent/GB2023604B/en
Priority to US06/033,359 priority patent/US4202824A/en
Priority to CA327,981A priority patent/CA1133921A/en
Priority to DE2920890A priority patent/DE2920890C2/en
Priority to FR7913929A priority patent/FR2426679B1/fr
Publication of JPS54154753A publication Critical patent/JPS54154753A/en
Priority to CA000407406A priority patent/CA1155862A/en
Publication of JPS6145620B2 publication Critical patent/JPS6145620B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I.
USE: Antiesterase active substances having enlarged inhibitory enzyme groups compared with esterastin, a particularly powerful anticholesterol esterase activity, and expected possibility of application as a remedy for thrombosis and arteriosclerosis in addition to arthritis and rheumatic fever.
PROCESS: Esterastin of formula II dissolved in methanol is reduced with a hydrogenation catalyst, e.g. platinum oxide or Pd, in a hydrogen atmosphere or Paal's reduction apparatus for 2 hr to overnight. The catalyst is removed by filtration, and the filtrate is concentrated to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP6172578A 1978-05-25 1978-05-25 Tetrahydroesterastin and its preparation Granted JPS54154753A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP6172578A JPS54154753A (en) 1978-05-25 1978-05-25 Tetrahydroesterastin and its preparation
GB7909606A GB2023604B (en) 1978-05-25 1979-03-19 Physiologically active derivatives of esterastin and production thereof
US06/033,359 US4202824A (en) 1978-05-25 1979-04-26 Physiologically active derivatives of esterastin
CA327,981A CA1133921A (en) 1978-05-25 1979-05-22 Physiologically active derivatives of esterastin and production thereof
DE2920890A DE2920890C2 (en) 1978-05-25 1979-05-23 Esterastine derivatives and processes for their preparation
FR7913929A FR2426679B1 (en) 1978-05-25 1979-05-23
CA000407406A CA1155862A (en) 1978-05-25 1982-07-15 Physiologically active derivatives of esterastin and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6172578A JPS54154753A (en) 1978-05-25 1978-05-25 Tetrahydroesterastin and its preparation

Publications (2)

Publication Number Publication Date
JPS54154753A true JPS54154753A (en) 1979-12-06
JPS6145620B2 JPS6145620B2 (en) 1986-10-08

Family

ID=13179472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6172578A Granted JPS54154753A (en) 1978-05-25 1978-05-25 Tetrahydroesterastin and its preparation

Country Status (1)

Country Link
JP (1) JPS54154753A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04145213A (en) * 1990-10-08 1992-05-19 Fuji Photo Film Co Ltd Bearing for carrier roller

Also Published As

Publication number Publication date
JPS6145620B2 (en) 1986-10-08

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