JPS54154753A - Tetrahydroesterastin and its preparation - Google Patents
Tetrahydroesterastin and its preparationInfo
- Publication number
- JPS54154753A JPS54154753A JP6172578A JP6172578A JPS54154753A JP S54154753 A JPS54154753 A JP S54154753A JP 6172578 A JP6172578 A JP 6172578A JP 6172578 A JP6172578 A JP 6172578A JP S54154753 A JPS54154753 A JP S54154753A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- esterastin
- compound
- catalyst
- tetrahydroesterastin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound of formula I.
USE: Antiesterase active substances having enlarged inhibitory enzyme groups compared with esterastin, a particularly powerful anticholesterol esterase activity, and expected possibility of application as a remedy for thrombosis and arteriosclerosis in addition to arthritis and rheumatic fever.
PROCESS: Esterastin of formula II dissolved in methanol is reduced with a hydrogenation catalyst, e.g. platinum oxide or Pd, in a hydrogen atmosphere or Paal's reduction apparatus for 2 hr to overnight. The catalyst is removed by filtration, and the filtrate is concentrated to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6172578A JPS54154753A (en) | 1978-05-25 | 1978-05-25 | Tetrahydroesterastin and its preparation |
GB7909606A GB2023604B (en) | 1978-05-25 | 1979-03-19 | Physiologically active derivatives of esterastin and production thereof |
US06/033,359 US4202824A (en) | 1978-05-25 | 1979-04-26 | Physiologically active derivatives of esterastin |
CA327,981A CA1133921A (en) | 1978-05-25 | 1979-05-22 | Physiologically active derivatives of esterastin and production thereof |
DE2920890A DE2920890C2 (en) | 1978-05-25 | 1979-05-23 | Esterastine derivatives and processes for their preparation |
FR7913929A FR2426679B1 (en) | 1978-05-25 | 1979-05-23 | |
CA000407406A CA1155862A (en) | 1978-05-25 | 1982-07-15 | Physiologically active derivatives of esterastin and production thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6172578A JPS54154753A (en) | 1978-05-25 | 1978-05-25 | Tetrahydroesterastin and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54154753A true JPS54154753A (en) | 1979-12-06 |
JPS6145620B2 JPS6145620B2 (en) | 1986-10-08 |
Family
ID=13179472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6172578A Granted JPS54154753A (en) | 1978-05-25 | 1978-05-25 | Tetrahydroesterastin and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54154753A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04145213A (en) * | 1990-10-08 | 1992-05-19 | Fuji Photo Film Co Ltd | Bearing for carrier roller |
-
1978
- 1978-05-25 JP JP6172578A patent/JPS54154753A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6145620B2 (en) | 1986-10-08 |
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