IT1319682B1 - Procedimento di sintesi del paclitaxel. - Google Patents

Procedimento di sintesi del paclitaxel.

Info

Publication number
IT1319682B1
IT1319682B1 IT2000MI002654A ITMI20002654A IT1319682B1 IT 1319682 B1 IT1319682 B1 IT 1319682B1 IT 2000MI002654 A IT2000MI002654 A IT 2000MI002654A IT MI20002654 A ITMI20002654 A IT MI20002654A IT 1319682 B1 IT1319682 B1 IT 1319682B1
Authority
IT
Italy
Prior art keywords
paclitaxel
summary procedure
procedure
preparation
deacetylbaccatine iii
Prior art date
Application number
IT2000MI002654A
Other languages
English (en)
Inventor
Arturo Battaglia
Paolo Dambruoso
Andrea Guerrini
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT2000MI002654A priority Critical patent/IT1319682B1/it
Application filed by Indena Spa filed Critical Indena Spa
Priority to CA002430814A priority patent/CA2430814C/en
Priority to AU3453502A priority patent/AU3453502A/xx
Priority to JP2002547916A priority patent/JP2004515497A/ja
Priority to AU2002234535A priority patent/AU2002234535B2/en
Priority to US10/433,601 priority patent/US6768012B2/en
Priority to RU2003116901/04A priority patent/RU2276147C2/ru
Priority to CNB018200745A priority patent/CN1286828C/zh
Priority to ES01985349T priority patent/ES2221656T3/es
Priority to DK01985349T priority patent/DK1339703T3/da
Priority to KR1020037007262A priority patent/KR100846891B1/ko
Priority to PL01366120A priority patent/PL195121B1/pl
Priority to CZ20031534A priority patent/CZ300024B6/cs
Priority to PCT/EP2001/014084 priority patent/WO2002046177A1/en
Priority to AT01985349T priority patent/ATE267820T1/de
Priority to EP01985349A priority patent/EP1339703B1/en
Priority to DE60103560T priority patent/DE60103560T2/de
Priority to HU0500615A priority patent/HU229373B1/hu
Priority to SK697-2003A priority patent/SK286616B6/sk
Priority to TR2004/01435T priority patent/TR200401435T4/xx
Priority to SI200130104T priority patent/SI1339703T1/xx
Priority to IL15633101A priority patent/IL156331A0/xx
Priority to PT01985349T priority patent/PT1339703E/pt
Publication of ITMI20002654A1 publication Critical patent/ITMI20002654A1/it
Priority to NO20032558A priority patent/NO328505B1/no
Priority to IL156331A priority patent/IL156331A/en
Publication of IT1319682B1 publication Critical patent/IT1319682B1/it
Application granted granted Critical
Priority to HK04105846A priority patent/HK1063052A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
IT2000MI002654A 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel. IT1319682B1 (it)

Priority Applications (26)

Application Number Priority Date Filing Date Title
IT2000MI002654A IT1319682B1 (it) 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel.
SI200130104T SI1339703T1 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
JP2002547916A JP2004515497A (ja) 2000-12-06 2001-12-03 パクリタキセルの調製方法
AU2002234535A AU2002234535B2 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
US10/433,601 US6768012B2 (en) 2000-12-06 2001-12-03 Process for the preparation of paclitaxel
RU2003116901/04A RU2276147C2 (ru) 2000-12-06 2001-12-03 Способ получения паклитаксела
CNB018200745A CN1286828C (zh) 2000-12-06 2001-12-03 制备紫杉醇的方法
ES01985349T ES2221656T3 (es) 2000-12-06 2001-12-03 Procedimiento de fabricacion de paclitaxel.
DK01985349T DK1339703T3 (da) 2000-12-06 2001-12-03 Fremgangsmåde til fremstilling af paclitaxel
KR1020037007262A KR100846891B1 (ko) 2000-12-06 2001-12-03 파클리탁셀의 제조방법
PL01366120A PL195121B1 (pl) 2000-12-06 2001-12-03 Sposób wytwarzania paklitakselu oraz związek pośredni
CZ20031534A CZ300024B6 (cs) 2000-12-06 2001-12-03 Zpusob výroby paclitaxelu
CA002430814A CA2430814C (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
PCT/EP2001/014084 WO2002046177A1 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
TR2004/01435T TR200401435T4 (tr) 2000-12-06 2001-12-03 Paklitaksel hazırlamak için işlem
DE60103560T DE60103560T2 (de) 2000-12-06 2001-12-03 Prozess zur herstellung von paclitaxel
HU0500615A HU229373B1 (hu) 2000-12-06 2001-12-03 Eljárás paclitaxel elõállítására
SK697-2003A SK286616B6 (sk) 2000-12-06 2001-12-03 Spôsob výroby paklitaxelu a medziprodukty
EP01985349A EP1339703B1 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
AU3453502A AU3453502A (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
IL15633101A IL156331A0 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel
PT01985349T PT1339703E (pt) 2000-12-06 2001-12-03 Processo para a preparacao de paclitaxel
AT01985349T ATE267820T1 (de) 2000-12-06 2001-12-03 Prozess zur herstellung von paclitaxel
NO20032558A NO328505B1 (no) 2000-12-06 2003-06-05 Fremgangsmate for fremstilling av paklitaxel
IL156331A IL156331A (en) 2000-12-06 2003-06-05 Process for the preparation of paclitaxel and intermediate material for this process
HK04105846A HK1063052A1 (en) 2000-12-06 2004-08-06 A process for the preparation of paclitaxel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002654A IT1319682B1 (it) 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel.

Publications (2)

Publication Number Publication Date
ITMI20002654A1 ITMI20002654A1 (it) 2002-06-06
IT1319682B1 true IT1319682B1 (it) 2003-10-23

Family

ID=11446197

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI002654A IT1319682B1 (it) 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel.

Country Status (23)

Country Link
US (1) US6768012B2 (it)
EP (1) EP1339703B1 (it)
JP (1) JP2004515497A (it)
KR (1) KR100846891B1 (it)
CN (1) CN1286828C (it)
AT (1) ATE267820T1 (it)
AU (2) AU3453502A (it)
CA (1) CA2430814C (it)
CZ (1) CZ300024B6 (it)
DE (1) DE60103560T2 (it)
DK (1) DK1339703T3 (it)
ES (1) ES2221656T3 (it)
HK (1) HK1063052A1 (it)
HU (1) HU229373B1 (it)
IL (2) IL156331A0 (it)
IT (1) IT1319682B1 (it)
NO (1) NO328505B1 (it)
PL (1) PL195121B1 (it)
PT (1) PT1339703E (it)
RU (1) RU2276147C2 (it)
SK (1) SK286616B6 (it)
TR (1) TR200401435T4 (it)
WO (1) WO2002046177A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
EP1599457A4 (en) * 2003-02-04 2008-05-07 Natural Pharmaceuticals Inc METHOD AND COMPOSITION FOR PREPARING A COMPOUND WITH AN ACTIVE BENZOYLATING ACTIVE INCLUDING RING CHLORINE-FREE ACTIVE
CN1303077C (zh) 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
ES2363524T3 (es) * 2006-05-12 2011-08-08 Indena S.P.A. Proceso de preparación de un derivado de taxano.
CN103254187B (zh) * 2012-02-15 2016-05-25 浙江大学宁波理工学院 一种紫杉烷衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5917062A (en) 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6020507A (en) 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.

Also Published As

Publication number Publication date
PL366120A1 (en) 2005-01-24
NO20032558D0 (no) 2003-06-05
ES2221656T3 (es) 2005-01-01
RU2276147C2 (ru) 2006-05-10
IL156331A0 (en) 2004-01-04
DE60103560T2 (de) 2004-09-16
CN1509277A (zh) 2004-06-30
HU229373B1 (hu) 2013-11-28
SK286616B6 (sk) 2009-02-05
KR100846891B1 (ko) 2008-07-17
AU2002234535B2 (en) 2006-02-02
EP1339703A1 (en) 2003-09-03
HK1063052A1 (en) 2004-12-10
CZ20031534A3 (cs) 2003-08-13
TR200401435T4 (tr) 2004-08-23
US20040049060A1 (en) 2004-03-11
CA2430814A1 (en) 2002-06-13
IL156331A (en) 2006-10-31
JP2004515497A (ja) 2004-05-27
KR20030055332A (ko) 2003-07-02
AU3453502A (en) 2002-06-18
HUP0500615A2 (hu) 2005-11-28
CA2430814C (en) 2009-04-07
ATE267820T1 (de) 2004-06-15
WO2002046177A1 (en) 2002-06-13
ITMI20002654A1 (it) 2002-06-06
US6768012B2 (en) 2004-07-27
CZ300024B6 (cs) 2009-01-14
DK1339703T3 (da) 2004-09-27
DE60103560D1 (de) 2004-07-01
PL195121B1 (pl) 2007-08-31
PT1339703E (pt) 2004-08-31
NO328505B1 (no) 2010-03-08
NO20032558L (no) 2003-06-05
EP1339703B1 (en) 2004-05-26
SK6972003A3 (en) 2003-11-04
CN1286828C (zh) 2006-11-29

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