CH659474A5 - Optisch aktive trans-apovincaminsaeureester, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel. - Google Patents
Optisch aktive trans-apovincaminsaeureester, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel. Download PDFInfo
- Publication number
- CH659474A5 CH659474A5 CH5868/84A CH586884A CH659474A5 CH 659474 A5 CH659474 A5 CH 659474A5 CH 5868/84 A CH5868/84 A CH 5868/84A CH 586884 A CH586884 A CH 586884A CH 659474 A5 CH659474 A5 CH 659474A5
- Authority
- CH
- Switzerland
- Prior art keywords
- ethyl
- quinolizine
- octahydroindolo
- methoxycarbonyl
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU811753A HU186891B (en) | 1981-06-12 | 1981-06-12 | Process for producing esters of apovincaminic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH659474A5 true CH659474A5 (de) | 1987-01-30 |
Family
ID=10956018
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH5868/84A CH659474A5 (de) | 1981-06-12 | 1982-06-10 | Optisch aktive trans-apovincaminsaeureester, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel. |
| CH3597/82A CH656128A5 (de) | 1981-06-12 | 1982-06-10 | Optisch aktive und racemische 1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH3597/82A CH656128A5 (de) | 1981-06-12 | 1982-06-10 | Optisch aktive und racemische 1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
Country Status (24)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
| HU191454B (en) * | 1984-10-05 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt.,Hu | Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof |
| HU198207B (en) * | 1985-04-19 | 1989-08-28 | Richter Gedeon Vegyeszet | Process for production of derivatives of eburnamenin and medical compositions containing them |
| JPH0438474Y2 (US07943777-20110517-C00090.png) * | 1986-04-30 | 1992-09-09 | ||
| JPS63164190U (US07943777-20110517-C00090.png) * | 1987-02-18 | 1988-10-26 | ||
| JP2851133B2 (ja) * | 1989-06-21 | 1999-01-27 | リヒター ゲデオン ベジェセティ ジャール アール．テー． | 新規ラセミ及び光学的活性オクタヒドロ―インド―ロ〔２，３―ａ〕テトラヒドロピラニル〔２，３―ｃ〕キノリジンジエステル誘導体及びその調製方法 |
| HU214600B (hu) * | 1995-12-22 | 1998-04-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására |
| WO2003020702A2 (en) | 2001-08-31 | 2003-03-13 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain |
| WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
| WO2018069312A1 (en) * | 2016-10-11 | 2018-04-19 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Treatment of synucleinopathies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3770724A (en) * | 1970-03-31 | 1973-11-06 | Roussel Uclaf | Process for preparing pentacyclic alkaloids |
| HU163143B (US07943777-20110517-C00090.png) * | 1971-05-07 | 1973-06-28 | ||
| US4033969A (en) * | 1972-06-19 | 1977-07-05 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vincamine derivatives |
| US4033960A (en) * | 1973-07-31 | 1977-07-05 | Bayer Aktiengesellschaft | 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation |
| AU499923B2 (en) * | 1975-06-27 | 1979-05-03 | Richter Gedeon Vegyeszeti Gyar N | Indoloquinolizine derivatives & their production |
| FR2389625B1 (US07943777-20110517-C00090.png) * | 1977-05-06 | 1980-04-18 | Roussel Uclaf | |
| FR2459799A1 (fr) * | 1979-06-22 | 1981-01-16 | Synthelabo | Synthese de la ()-vincamine |
| JPS55100383A (en) * | 1979-01-25 | 1980-07-31 | Sumitomo Chem Co Ltd | Preparation of novel nitrogen-containing polycyclic compound |
| AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
| HU181495B (en) * | 1979-05-31 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for producing hydroxy-imino-eburnane derivatives |
| HU180927B (en) * | 1979-07-13 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing 1k-hydroximino-e-homoe-eburane de rivatives |
| FR2468605A1 (fr) * | 1979-10-30 | 1981-05-08 | Richter Gedeon Vegyeszet | Procede de preparation d'ester de l'acide apovincaminique |
| HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
-
1981
- 1981-06-12 HU HU811753A patent/HU186891B/hu not_active IP Right Cessation
-
1982
- 1982-05-31 IL IL65922A patent/IL65922A/xx not_active IP Right Cessation
- 1982-06-02 ZA ZA823873A patent/ZA823873B/xx unknown
- 1982-06-02 FI FI821963A patent/FI71142C/fi not_active IP Right Cessation
- 1982-06-08 GR GR68366A patent/GR76494B/el unknown
- 1982-06-09 PT PT75042A patent/PT75042B/pt not_active IP Right Cessation
- 1982-06-09 SE SE8203580A patent/SE450383B/sv not_active IP Right Cessation
- 1982-06-10 CH CH5868/84A patent/CH659474A5/de not_active IP Right Cessation
- 1982-06-10 CH CH3597/82A patent/CH656128A5/de not_active IP Right Cessation
- 1982-06-10 FR FR8210103A patent/FR2507605B1/fr not_active Expired
- 1982-06-11 IT IT67752/82A patent/IT1200961B/it active
- 1982-06-11 AU AU84798/82A patent/AU551445B2/en not_active Ceased
- 1982-06-11 DK DK262982A patent/DK152651C/da not_active IP Right Cessation
- 1982-06-11 GB GB08217030A patent/GB2102415B/en not_active Expired
- 1982-06-11 BE BE0/208331A patent/BE893492A/fr not_active IP Right Cessation
- 1982-06-11 AT AT0227182A patent/AT382619B/de not_active IP Right Cessation
- 1982-06-11 NL NL8202396A patent/NL192452C/nl not_active IP Right Cessation
- 1982-06-11 US US06/387,676 patent/US4474960A/en not_active Expired - Lifetime
- 1982-06-11 SU SU3452054A patent/SU1258326A3/ru active
- 1982-06-11 NO NO821954A patent/NO821954L/no unknown
- 1982-06-11 ES ES513016A patent/ES513016A0/es active Granted
- 1982-06-11 DE DE19823222096 patent/DE3222096A1/de not_active Withdrawn
- 1982-06-12 JP JP57099997A patent/JPS5843971A/ja active Pending
- 1982-12-14 FR FR8220957A patent/FR2515653B1/fr not_active Expired
-
1983
- 1983-02-22 SU SU833557652A patent/SU1376947A3/ru active
- 1983-06-11 CA CA000405030A patent/CA1258071A/en not_active Expired
- 1983-06-16 ES ES523345A patent/ES523345A0/es active Granted
-
1984
- 1984-11-30 ES ES538125A patent/ES8604581A1/es not_active Expired
-
1985
- 1985-01-07 GB GB08500325A patent/GB2151629B/en not_active Expired
-
1986
- 1986-03-13 AU AU54712/86A patent/AU568790B2/en not_active Ceased
-
1987
- 1987-01-02 SE SE8700015A patent/SE461654B/sv not_active IP Right Cessation
-
1991
- 1991-09-26 JP JP3317577A patent/JPH0714932B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-07 GE GEAP1993974A patent/GEP19970819B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |