AT382619B - Verfahren zur herstellung von neuen optisch aktiven und racemischen trans- und/oder cis-1-(2'-(alkoxycarbonyl)-2'-(hydroxyimino) -aethyl)-1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizinen - Google Patents

Verfahren zur herstellung von neuen optisch aktiven und racemischen trans- und/oder cis-1-(2'-(alkoxycarbonyl)-2'-(hydroxyimino) -aethyl)-1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizinen

Info

Publication number
AT382619B
AT382619B AT0227182A AT227182A AT382619B AT 382619 B AT382619 B AT 382619B AT 0227182 A AT0227182 A AT 0227182A AT 227182 A AT227182 A AT 227182A AT 382619 B AT382619 B AT 382619B
Authority
AT
Austria
Prior art keywords
chinolizines
octahydroindolo
aethyl
hydroxyimino
alkoxycarbonyl
Prior art date
Application number
AT0227182A
Other languages
English (en)
Other versions
ATA227182A (de
Inventor
Csaba Ing Chem Dr Szantay
Lajos Dr Szabo
Gyoergy Ing Chem Dr Kalaus
Janos Dr Kreidl
Laszlo Ing Chem Dr Czibula
Gyoergy Ing Chem Visky
Andras Dr Nemes
Maria Ing Chem Dr Farkas
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to AT321085A priority Critical patent/AT389697B/de
Publication of ATA227182A publication Critical patent/ATA227182A/de
Application granted granted Critical
Publication of AT382619B publication Critical patent/AT382619B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
AT0227182A 1981-06-12 1982-06-11 Verfahren zur herstellung von neuen optisch aktiven und racemischen trans- und/oder cis-1-(2'-(alkoxycarbonyl)-2'-(hydroxyimino) -aethyl)-1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizinen AT382619B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT321085A AT389697B (de) 1981-06-12 1985-11-07 Verfahren zur herstellung von optisch aktiven und von racemischen trans- und/oder cis-apovincaminsaeureestern

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU811753A HU186891B (en) 1981-06-12 1981-06-12 Process for producing esters of apovincaminic acid

Publications (2)

Publication Number Publication Date
ATA227182A ATA227182A (de) 1986-08-15
AT382619B true AT382619B (de) 1987-03-25

Family

ID=10956018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0227182A AT382619B (de) 1981-06-12 1982-06-11 Verfahren zur herstellung von neuen optisch aktiven und racemischen trans- und/oder cis-1-(2'-(alkoxycarbonyl)-2'-(hydroxyimino) -aethyl)-1-alkyl-1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)chinolizinen

Country Status (24)

Country Link
US (1) US4474960A (de)
JP (2) JPS5843971A (de)
AT (1) AT382619B (de)
AU (2) AU551445B2 (de)
BE (1) BE893492A (de)
CA (1) CA1258071A (de)
CH (2) CH656128A5 (de)
DE (1) DE3222096A1 (de)
DK (1) DK152651C (de)
ES (3) ES513016A0 (de)
FI (1) FI71142C (de)
FR (2) FR2507605B1 (de)
GB (2) GB2102415B (de)
GE (1) GEP19970819B (de)
GR (1) GR76494B (de)
HU (1) HU186891B (de)
IL (1) IL65922A (de)
IT (1) IT1200961B (de)
NL (1) NL192452C (de)
NO (1) NO821954L (de)
PT (1) PT75042B (de)
SE (2) SE450383B (de)
SU (2) SU1258326A3 (de)
ZA (1) ZA823873B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182411B (en) * 1981-11-03 1984-01-30 Richter Gedeon Vegyeszet Process for preparing eburnamonine derivatives
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU198207B (en) * 1985-04-19 1989-08-28 Richter Gedeon Vegyeszet Process for production of derivatives of eburnamenin and medical compositions containing them
JPH0438474Y2 (de) * 1986-04-30 1992-09-09
JPS63164190U (de) * 1987-02-18 1988-10-26
BE1004471A3 (fr) * 1989-06-21 1992-12-01 Richter Gedeon Vegyeszet Nouveaux derives diester d'octahydro-indolo-[2,3-a]-tetrahydropyranyl [2,3-c] quinolizine racemiques et optiquement actifs et procede pour les preparer.
HU214600B (hu) * 1995-12-22 1998-04-28 Richter Gedeon Vegyészeti Gyár Rt. Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
ES2429132T3 (es) 2001-08-31 2013-11-13 The Rockefeller University Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro
SG10201507362TA (en) 2009-08-05 2015-10-29 Intra Cellular Therapies Inc Novel Regulatory Proteins And Inhibitors
EP3525788B1 (de) * 2016-10-11 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Behandlung von synukleinopathien

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT351541B (de) * 1975-06-27 1979-07-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von indolo(2,3-a) chinolizinen und ihren salzen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
HU163143B (de) * 1971-05-07 1973-06-28
US4033969A (en) * 1972-06-19 1977-07-05 Agence Nationale De Valorisation De La Recherche (Anvar) Vincamine derivatives
US4033960A (en) * 1973-07-31 1977-07-05 Bayer Aktiengesellschaft 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
FR2389625B1 (de) * 1977-05-06 1980-04-18 Roussel Uclaf
FR2459799A1 (fr) * 1979-06-22 1981-01-16 Synthelabo Synthese de la ()-vincamine
JPS55100383A (en) * 1979-01-25 1980-07-31 Sumitomo Chem Co Ltd Preparation of novel nitrogen-containing polycyclic compound
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
HU181495B (en) * 1979-05-31 1983-07-28 Richter Gedeon Vegyeszet Process for producing hydroxy-imino-eburnane derivatives
HU180927B (en) * 1979-07-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
FR2468605A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede de preparation d'ester de l'acide apovincaminique
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT351541B (de) * 1975-06-27 1979-07-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von indolo(2,3-a) chinolizinen und ihren salzen

Also Published As

Publication number Publication date
IT1200961B (it) 1989-01-27
FR2507605B1 (fr) 1985-12-13
ES8400433A1 (es) 1983-10-16
SU1258326A3 (ru) 1986-09-15
PT75042A (en) 1982-07-01
SE450383B (sv) 1987-06-22
GR76494B (de) 1984-08-10
ES523345A0 (es) 1985-04-01
IL65922A (en) 1985-07-31
DK152651B (da) 1988-04-05
IT8267752A0 (it) 1982-06-11
IL65922A0 (en) 1982-08-31
FR2507605A1 (fr) 1982-12-17
FR2515653A1 (fr) 1983-05-06
AU568790B2 (en) 1988-01-07
CA1258071A (en) 1989-08-01
AU551445B2 (en) 1986-05-01
HU186891B (en) 1985-10-28
PT75042B (en) 1984-10-09
GB2151629A (en) 1985-07-24
ES513016A0 (es) 1983-10-16
JPH0517474A (ja) 1993-01-26
ES8604581A1 (es) 1986-02-01
AU8479882A (en) 1982-12-16
FR2515653B1 (fr) 1985-12-06
NL8202396A (nl) 1983-01-03
GB2151629B (en) 1986-01-02
GB2102415A (en) 1983-02-02
ATA227182A (de) 1986-08-15
ES8504192A1 (es) 1985-04-01
FI821963A0 (fi) 1982-06-02
SE461654B (sv) 1990-03-12
BE893492A (fr) 1982-12-13
DE3222096A1 (de) 1983-01-05
JPS5843971A (ja) 1983-03-14
GEP19970819B (en) 1997-01-30
NL192452C (nl) 1997-08-04
FI71142B (fi) 1986-08-14
SE8700015D0 (sv) 1987-01-02
GB2102415B (en) 1986-01-02
JPH0714932B2 (ja) 1995-02-22
GB8500325D0 (en) 1985-02-13
ES538125A0 (es) 1986-02-01
CH656128A5 (de) 1986-06-13
DK262982A (da) 1982-12-13
FI71142C (fi) 1986-11-24
AU5471286A (en) 1986-07-31
SU1376947A3 (ru) 1988-02-23
US4474960A (en) 1984-10-02
ZA823873B (en) 1983-05-25
NL192452B (nl) 1997-04-01
SE8700015L (sv) 1987-01-02
SE8203580L (sv) 1982-12-13
DK152651C (da) 1988-08-22
CH659474A5 (de) 1987-01-30
NO821954L (no) 1982-12-13

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