NL192452B - Werkwijze voor de bereiding van optisch actieve apovincaminezuuresters, en van optisch actieve cis- en trans-isomeren van octahydroindolo-£2,3-a| chinolizinederivaten en farmaceutische preparaten. - Google Patents

Werkwijze voor de bereiding van optisch actieve apovincaminezuuresters, en van optisch actieve cis- en trans-isomeren van octahydroindolo-£2,3-a| chinolizinederivaten en farmaceutische preparaten.

Info

Publication number
NL192452B
NL192452B NL8202396A NL8202396A NL192452B NL 192452 B NL192452 B NL 192452B NL 8202396 A NL8202396 A NL 8202396A NL 8202396 A NL8202396 A NL 8202396A NL 192452 B NL192452 B NL 192452B
Authority
NL
Netherlands
Prior art keywords
optically active
octahydroindolo
preparation
acid esters
pharmaceutical preparations
Prior art date
Application number
NL8202396A
Other languages
English (en)
Other versions
NL8202396A (nl
NL192452C (nl
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of NL8202396A publication Critical patent/NL8202396A/nl
Publication of NL192452B publication Critical patent/NL192452B/nl
Application granted granted Critical
Publication of NL192452C publication Critical patent/NL192452C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
NL8202396A 1981-06-12 1982-06-11 Werkwijze voor de bereiding van optisch actieve apovincaminezuuresters, en van optisch actieve cis- en transisomeren van octahydroindolo-£2,3-a| chinolizinederivaten en farmaceutische preparaten. NL192452C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU175381 1981-06-12
HU811753A HU186891B (en) 1981-06-12 1981-06-12 Process for producing esters of apovincaminic acid

Publications (3)

Publication Number Publication Date
NL8202396A NL8202396A (nl) 1983-01-03
NL192452B true NL192452B (nl) 1997-04-01
NL192452C NL192452C (nl) 1997-08-04

Family

ID=10956018

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8202396A NL192452C (nl) 1981-06-12 1982-06-11 Werkwijze voor de bereiding van optisch actieve apovincaminezuuresters, en van optisch actieve cis- en transisomeren van octahydroindolo-£2,3-a| chinolizinederivaten en farmaceutische preparaten.

Country Status (24)

Country Link
US (1) US4474960A (nl)
JP (2) JPS5843971A (nl)
AT (1) AT382619B (nl)
AU (2) AU551445B2 (nl)
BE (1) BE893492A (nl)
CA (1) CA1258071A (nl)
CH (2) CH656128A5 (nl)
DE (1) DE3222096A1 (nl)
DK (1) DK152651C (nl)
ES (3) ES513016A0 (nl)
FI (1) FI71142C (nl)
FR (2) FR2507605B1 (nl)
GB (2) GB2102415B (nl)
GE (1) GEP19970819B (nl)
GR (1) GR76494B (nl)
HU (1) HU186891B (nl)
IL (1) IL65922A (nl)
IT (1) IT1200961B (nl)
NL (1) NL192452C (nl)
NO (1) NO821954L (nl)
PT (1) PT75042B (nl)
SE (2) SE450383B (nl)
SU (2) SU1258326A3 (nl)
ZA (1) ZA823873B (nl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182411B (en) * 1981-11-03 1984-01-30 Richter Gedeon Vegyeszet Process for preparing eburnamonine derivatives
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU198207B (en) * 1985-04-19 1989-08-28 Richter Gedeon Vegyeszet Process for production of derivatives of eburnamenin and medical compositions containing them
JPH0438474Y2 (nl) * 1986-04-30 1992-09-09
JPS63164190U (nl) * 1987-02-18 1988-10-26
BE1004471A3 (fr) * 1989-06-21 1992-12-01 Richter Gedeon Vegyeszet Nouveaux derives diester d'octahydro-indolo-[2,3-a]-tetrahydropyranyl [2,3-c] quinolizine racemiques et optiquement actifs et procede pour les preparer.
HU214600B (hu) * 1995-12-22 1998-04-28 Richter Gedeon Vegyészeti Gyár Rt. Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
ES2429132T3 (es) 2001-08-31 2013-11-13 The Rockefeller University Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro
SG10201507362TA (en) 2009-08-05 2015-10-29 Intra Cellular Therapies Inc Novel Regulatory Proteins And Inhibitors
EP3525788B1 (en) * 2016-10-11 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Treatment of synucleinopathies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
HU163143B (nl) * 1971-05-07 1973-06-28
US4033969A (en) * 1972-06-19 1977-07-05 Agence Nationale De Valorisation De La Recherche (Anvar) Vincamine derivatives
US4033960A (en) * 1973-07-31 1977-07-05 Bayer Aktiengesellschaft 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
AU499923B2 (en) * 1975-06-27 1979-05-03 Richter Gedeon Vegyeszeti Gyar N Indoloquinolizine derivatives & their production
FR2389625B1 (nl) * 1977-05-06 1980-04-18 Roussel Uclaf
FR2459799A1 (fr) * 1979-06-22 1981-01-16 Synthelabo Synthese de la ()-vincamine
JPS55100383A (en) * 1979-01-25 1980-07-31 Sumitomo Chem Co Ltd Preparation of novel nitrogen-containing polycyclic compound
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
HU181495B (en) * 1979-05-31 1983-07-28 Richter Gedeon Vegyeszet Process for producing hydroxy-imino-eburnane derivatives
HU180927B (en) * 1979-07-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
FR2468605A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede de preparation d'ester de l'acide apovincaminique
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid

Also Published As

Publication number Publication date
IT1200961B (it) 1989-01-27
FR2507605B1 (fr) 1985-12-13
ES8400433A1 (es) 1983-10-16
SU1258326A3 (ru) 1986-09-15
PT75042A (en) 1982-07-01
SE450383B (sv) 1987-06-22
GR76494B (nl) 1984-08-10
ES523345A0 (es) 1985-04-01
IL65922A (en) 1985-07-31
DK152651B (da) 1988-04-05
IT8267752A0 (it) 1982-06-11
IL65922A0 (en) 1982-08-31
FR2507605A1 (fr) 1982-12-17
AT382619B (de) 1987-03-25
FR2515653A1 (fr) 1983-05-06
AU568790B2 (en) 1988-01-07
CA1258071A (en) 1989-08-01
AU551445B2 (en) 1986-05-01
HU186891B (en) 1985-10-28
PT75042B (en) 1984-10-09
GB2151629A (en) 1985-07-24
ES513016A0 (es) 1983-10-16
JPH0517474A (ja) 1993-01-26
ES8604581A1 (es) 1986-02-01
AU8479882A (en) 1982-12-16
FR2515653B1 (fr) 1985-12-06
NL8202396A (nl) 1983-01-03
GB2151629B (en) 1986-01-02
GB2102415A (en) 1983-02-02
ATA227182A (de) 1986-08-15
ES8504192A1 (es) 1985-04-01
FI821963A0 (fi) 1982-06-02
SE461654B (sv) 1990-03-12
BE893492A (fr) 1982-12-13
DE3222096A1 (de) 1983-01-05
JPS5843971A (ja) 1983-03-14
GEP19970819B (en) 1997-01-30
NL192452C (nl) 1997-08-04
FI71142B (fi) 1986-08-14
SE8700015D0 (sv) 1987-01-02
GB2102415B (en) 1986-01-02
JPH0714932B2 (ja) 1995-02-22
GB8500325D0 (en) 1985-02-13
ES538125A0 (es) 1986-02-01
CH656128A5 (de) 1986-06-13
DK262982A (da) 1982-12-13
FI71142C (fi) 1986-11-24
AU5471286A (en) 1986-07-31
SU1376947A3 (ru) 1988-02-23
US4474960A (en) 1984-10-02
ZA823873B (en) 1983-05-25
SE8700015L (sv) 1987-01-02
SE8203580L (sv) 1982-12-13
DK152651C (da) 1988-08-22
CH659474A5 (de) 1987-01-30
NO821954L (no) 1982-12-13

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Legal Events

Date Code Title Description
A1A A request for search or an international-type search has been filed
BT A notification was added to the application dossier and made available to the public
BB A search report has been drawn up
A85 Still pending on 85-01-01
BC A request for examination has been filed
V1 Lapsed because of non-payment of the annual fee

Effective date: 20000101