DK152651C - Fremgangsmaade til fremstilling af racemiske cis- og/eller trans-apovincaminsyreestere samt cis- og trans-hydroxyiminooktahydroindolo oe2,3-aaaquinoliziner og syreadditionssalte deraf til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af racemiske cis- og/eller trans-apovincaminsyreestere samt cis- og trans-hydroxyiminooktahydroindolo oe2,3-aaaquinoliziner og syreadditionssalte deraf til brug ved fremgangsmaaden

Info

Publication number
DK152651C
DK152651C DK262982A DK262982A DK152651C DK 152651 C DK152651 C DK 152651C DK 262982 A DK262982 A DK 262982A DK 262982 A DK262982 A DK 262982A DK 152651 C DK152651 C DK 152651C
Authority
DK
Denmark
Prior art keywords
trans
cis
hydroxyiminooktahydroindolo
aaaquinolizin
apovincamin
Prior art date
Application number
DK262982A
Other languages
English (en)
Other versions
DK152651B (da
DK262982A (da
Inventor
Csaba Szantay
Lajos Szabo
Gyoergy Kalaus
Janos Kreidl
Laszlo Czibula
Gyoergy Visky
Andras Nemes
Maria Farkas
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK262982A publication Critical patent/DK262982A/da
Publication of DK152651B publication Critical patent/DK152651B/da
Application granted granted Critical
Publication of DK152651C publication Critical patent/DK152651C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DK262982A 1981-06-12 1982-06-11 Fremgangsmaade til fremstilling af racemiske cis- og/eller trans-apovincaminsyreestere samt cis- og trans-hydroxyiminooktahydroindolo oe2,3-aaaquinoliziner og syreadditionssalte deraf til brug ved fremgangsmaaden DK152651C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU175381 1981-06-12
HU811753A HU186891B (en) 1981-06-12 1981-06-12 Process for producing esters of apovincaminic acid

Publications (3)

Publication Number Publication Date
DK262982A DK262982A (da) 1982-12-13
DK152651B DK152651B (da) 1988-04-05
DK152651C true DK152651C (da) 1988-08-22

Family

ID=10956018

Family Applications (1)

Application Number Title Priority Date Filing Date
DK262982A DK152651C (da) 1981-06-12 1982-06-11 Fremgangsmaade til fremstilling af racemiske cis- og/eller trans-apovincaminsyreestere samt cis- og trans-hydroxyiminooktahydroindolo oe2,3-aaaquinoliziner og syreadditionssalte deraf til brug ved fremgangsmaaden

Country Status (24)

Country Link
US (1) US4474960A (da)
JP (2) JPS5843971A (da)
AT (1) AT382619B (da)
AU (2) AU551445B2 (da)
BE (1) BE893492A (da)
CA (1) CA1258071A (da)
CH (2) CH656128A5 (da)
DE (1) DE3222096A1 (da)
DK (1) DK152651C (da)
ES (3) ES513016A0 (da)
FI (1) FI71142C (da)
FR (2) FR2507605B1 (da)
GB (2) GB2102415B (da)
GE (1) GEP19970819B (da)
GR (1) GR76494B (da)
HU (1) HU186891B (da)
IL (1) IL65922A (da)
IT (1) IT1200961B (da)
NL (1) NL192452C (da)
NO (1) NO821954L (da)
PT (1) PT75042B (da)
SE (2) SE450383B (da)
SU (2) SU1258326A3 (da)
ZA (1) ZA823873B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182411B (en) * 1981-11-03 1984-01-30 Richter Gedeon Vegyeszet Process for preparing eburnamonine derivatives
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU198207B (en) * 1985-04-19 1989-08-28 Richter Gedeon Vegyeszet Process for production of derivatives of eburnamenin and medical compositions containing them
JPH0438474Y2 (da) * 1986-04-30 1992-09-09
JPS63164190U (da) * 1987-02-18 1988-10-26
BE1004471A3 (fr) * 1989-06-21 1992-12-01 Richter Gedeon Vegyeszet Nouveaux derives diester d'octahydro-indolo-[2,3-a]-tetrahydropyranyl [2,3-c] quinolizine racemiques et optiquement actifs et procede pour les preparer.
HU214600B (hu) * 1995-12-22 1998-04-28 Richter Gedeon Vegyészeti Gyár Rt. Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
ES2429132T3 (es) 2001-08-31 2013-11-13 The Rockefeller University Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro
SG10201507362TA (en) 2009-08-05 2015-10-29 Intra Cellular Therapies Inc Novel Regulatory Proteins And Inhibitors
EP3525788B1 (en) * 2016-10-11 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Treatment of synucleinopathies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
HU163143B (da) * 1971-05-07 1973-06-28
US4033969A (en) * 1972-06-19 1977-07-05 Agence Nationale De Valorisation De La Recherche (Anvar) Vincamine derivatives
US4033960A (en) * 1973-07-31 1977-07-05 Bayer Aktiengesellschaft 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
AU499923B2 (en) * 1975-06-27 1979-05-03 Richter Gedeon Vegyeszeti Gyar N Indoloquinolizine derivatives & their production
FR2389625B1 (da) * 1977-05-06 1980-04-18 Roussel Uclaf
FR2459799A1 (fr) * 1979-06-22 1981-01-16 Synthelabo Synthese de la ()-vincamine
JPS55100383A (en) * 1979-01-25 1980-07-31 Sumitomo Chem Co Ltd Preparation of novel nitrogen-containing polycyclic compound
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
HU181495B (en) * 1979-05-31 1983-07-28 Richter Gedeon Vegyeszet Process for producing hydroxy-imino-eburnane derivatives
HU180927B (en) * 1979-07-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
FR2468605A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede de preparation d'ester de l'acide apovincaminique
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid

Also Published As

Publication number Publication date
IT1200961B (it) 1989-01-27
FR2507605B1 (fr) 1985-12-13
ES8400433A1 (es) 1983-10-16
SU1258326A3 (ru) 1986-09-15
PT75042A (en) 1982-07-01
SE450383B (sv) 1987-06-22
GR76494B (da) 1984-08-10
ES523345A0 (es) 1985-04-01
IL65922A (en) 1985-07-31
DK152651B (da) 1988-04-05
IT8267752A0 (it) 1982-06-11
IL65922A0 (en) 1982-08-31
FR2507605A1 (fr) 1982-12-17
AT382619B (de) 1987-03-25
FR2515653A1 (fr) 1983-05-06
AU568790B2 (en) 1988-01-07
CA1258071A (en) 1989-08-01
AU551445B2 (en) 1986-05-01
HU186891B (en) 1985-10-28
PT75042B (en) 1984-10-09
GB2151629A (en) 1985-07-24
ES513016A0 (es) 1983-10-16
JPH0517474A (ja) 1993-01-26
ES8604581A1 (es) 1986-02-01
AU8479882A (en) 1982-12-16
FR2515653B1 (fr) 1985-12-06
NL8202396A (nl) 1983-01-03
GB2151629B (en) 1986-01-02
GB2102415A (en) 1983-02-02
ATA227182A (de) 1986-08-15
ES8504192A1 (es) 1985-04-01
FI821963A0 (fi) 1982-06-02
SE461654B (sv) 1990-03-12
BE893492A (fr) 1982-12-13
DE3222096A1 (de) 1983-01-05
JPS5843971A (ja) 1983-03-14
GEP19970819B (en) 1997-01-30
NL192452C (nl) 1997-08-04
FI71142B (fi) 1986-08-14
SE8700015D0 (sv) 1987-01-02
GB2102415B (en) 1986-01-02
JPH0714932B2 (ja) 1995-02-22
GB8500325D0 (en) 1985-02-13
ES538125A0 (es) 1986-02-01
CH656128A5 (de) 1986-06-13
DK262982A (da) 1982-12-13
FI71142C (fi) 1986-11-24
AU5471286A (en) 1986-07-31
SU1376947A3 (ru) 1988-02-23
US4474960A (en) 1984-10-02
ZA823873B (en) 1983-05-25
NL192452B (nl) 1997-04-01
SE8700015L (sv) 1987-01-02
SE8203580L (sv) 1982-12-13
CH659474A5 (de) 1987-01-30
NO821954L (no) 1982-12-13

Similar Documents

Publication Publication Date Title
DK490482A (da) Derivater af cis,endo-2-azabicyclo-(3.3.0)-octan-3-carboxylsyren, fremgangsmaade til deres fremstilling, midler med indhold deraf samt deres anvendelse
DK74482A (da) Fremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden anvendelige udgangsforbindelser
DK335686D0 (da) Fremgangsmaade til fremstilling af 1-carba-3-cephem-4-carboxylsyrer ogderivater deraf samt mellemprodukter til brug ved fremgangsmaaden
DK254688D0 (da) Fremgangsmaade til fremstilling af folininsyre
DK562281A (da) Fremgangsmaade mikroorgansimer og kulturmedium til fremstilling af antibioteket a-4696 som kompleks eller enkelte faktorer eller pharmaceutisk acceptable syreadditionssalte deraf samt kompleksets anvendelse som vaekstfremmende middel
DK148795C (da) Anologifremgangsmaade til fremstilling af 3-(2-morpholino-ethyl-amino)-5-phenyl-pyridazin eller farmaceutisk acceptable syreadditionssalte deraf
DK53083D0 (da) Fremgangsmade til fremstilling af 2-(phenyl-methylen)-cycloalkylaminer og-azetidiner eller syreadditionssalte deraf
DK151017C (da) Analogifremgangsmaade til fremstilling af substituerede n-(4-indolyl-piperidino-alkyl)-benzimidazoloner eller fysiologisk acceptable syreadditionssalte deraf
DK341281A (da) Fremgangsmaade til fremstilling af 3,3-dialkyldenzodiazepinderivater eller syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelrser
DK90494A (da) Fremgangsmåde til fremstilling af 2,3,4,5,-tetrafluorbenzoesyre
DK152651C (da) Fremgangsmaade til fremstilling af racemiske cis- og/eller trans-apovincaminsyreestere samt cis- og trans-hydroxyiminooktahydroindolo oe2,3-aaaquinoliziner og syreadditionssalte deraf til brug ved fremgangsmaaden
DK536281A (da) Fremgangsmaade til fremstilling af carbonsyrederivater
DK296382A (da) Fremgangsmaade til fremstilling af optisk ren d- eller l-maelkesyre
DK153279A (da) 1,3-dibenzoesyreestere af 17alfa-ethynyl-7alfa-methyl-1,3,5(10)-oestratrien-1,3,17beta-trioler samt fremgangsmaade til fremstilling deraf
DK134580A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK430379A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK158457C (da) Analogifremgangsmaade til fremstilling af 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaensyre eller salte heraf
DK438482A (da) Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
DK3282A (da) Fremgangsmaade til fremstilling af 2,2-dimethyl-3-vinyl-cyclopropancarboxylsyrer samt deres estere
DK63582A (da) Fremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden anvendelige udgangsmaterialer
DK113695A (da) Fremgangsmåde til fremstilling af N-hydroxy-2-azetidinoner eller syreadditionssalte deraf
DK553982A (da) Fremgangsmaade til fremstilling af omt-esterderivater eller syreadditionssalte deraf
DK163816C (da) 1,4-dihalogenbutan-2,3-dioner til brug som mellemprodukter ved fremstillingen af 2-(2-aminothiazol-4-yl)glyoxylsyrederivater eller salte heraf og fremgangsmaade til fremstilling af mellemprodukterne
DK161338C (da) Fremgangsmaade til fremstilling af 2-hydroxyaclacinomycin a, b og n eller syreadditionssalte deraf samt en rekombinant mikroorganisme til anvendelse derved
DK153539C (da) Fremgangsmaade til fremstilling af 3,3-dimethyl-2-oxosmoersyre eller salte deraf

Legal Events

Date Code Title Description
PBP Patent lapsed