ES8504192A1 - Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982) - Google Patents
Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982)Info
- Publication number
- ES8504192A1 ES8504192A1 ES523345A ES523345A ES8504192A1 ES 8504192 A1 ES8504192 A1 ES 8504192A1 ES 523345 A ES523345 A ES 523345A ES 523345 A ES523345 A ES 523345A ES 8504192 A1 ES8504192 A1 ES 8504192A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- apovincaminic acid
- acid esters
- apovincaminic
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS TRANS-HIDROXIIMINOOCTAHIDROINDOLO2,3-AQUINOLIZINA RACEMICOS, DE FORMULA GENERAL (I) Y SUS CORRESPONDIENTES COMPUESTOS OPTICAMENTE ACTIVOS.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, LOS DERIVADOS DE HEXAHIDROINDOLO2,3-AQUINOLIZINIO RACEMICOS, DE FORMULA (II), SE RESUELVEN CON ACIDO DIBENZOILTARTARICO, PARA OBTENER LOS CORRESPONDIENTES DERIVADOS DE HEXAHIDROINDOLO 2,3-AQUINOLIZINIO; SEGUNDA, LOS COMPUESTOS OBTENIDOS SE REDUCEN CON UN HIDRURO DE METAL ALCALINO, PARA OBTENER LAS TRANS-OCTAHIDROINDOLO2,3-AQUINOLIZINAS RACEMICAS DE FORMULA (III); Y POR ULTIMO, LOS COMPUESTOS DE FORMULA (III) SE TRATAN CON NITRITO DE BUTILO TERCIARIO EN UN DISOLVENTE HIDROCARBONADO AROMATICO.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU811753A HU186891B (en) | 1981-06-12 | 1981-06-12 | Process for producing esters of apovincaminic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8504192A1 true ES8504192A1 (es) | 1985-04-01 |
ES523345A0 ES523345A0 (es) | 1985-04-01 |
Family
ID=10956018
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513016A Granted ES513016A0 (es) | 1981-06-12 | 1982-06-11 | "procedimiento para la preparacion de esteres de acido cis y-o trans-apovincaminico racemicos". |
ES523345A Granted ES523345A0 (es) | 1981-06-12 | 1983-06-16 | Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982) |
ES538125A Expired ES8604581A1 (es) | 1981-06-12 | 1984-11-30 | Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513016A Granted ES513016A0 (es) | 1981-06-12 | 1982-06-11 | "procedimiento para la preparacion de esteres de acido cis y-o trans-apovincaminico racemicos". |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538125A Expired ES8604581A1 (es) | 1981-06-12 | 1984-11-30 | Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos |
Country Status (24)
Country | Link |
---|---|
US (1) | US4474960A (es) |
JP (2) | JPS5843971A (es) |
AT (1) | AT382619B (es) |
AU (2) | AU551445B2 (es) |
BE (1) | BE893492A (es) |
CA (1) | CA1258071A (es) |
CH (2) | CH659474A5 (es) |
DE (1) | DE3222096A1 (es) |
DK (1) | DK152651C (es) |
ES (3) | ES513016A0 (es) |
FI (1) | FI71142C (es) |
FR (2) | FR2507605B1 (es) |
GB (2) | GB2102415B (es) |
GE (1) | GEP19970819B (es) |
GR (1) | GR76494B (es) |
HU (1) | HU186891B (es) |
IL (1) | IL65922A (es) |
IT (1) | IT1200961B (es) |
NL (1) | NL192452C (es) |
NO (1) | NO821954L (es) |
PT (1) | PT75042B (es) |
SE (2) | SE450383B (es) |
SU (2) | SU1258326A3 (es) |
ZA (1) | ZA823873B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
HU191454B (en) * | 1984-10-05 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt.,Hu | Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof |
HU198207B (en) * | 1985-04-19 | 1989-08-28 | Richter Gedeon Vegyeszet | Process for production of derivatives of eburnamenin and medical compositions containing them |
JPH0438474Y2 (es) * | 1986-04-30 | 1992-09-09 | ||
JPS63164190U (es) * | 1987-02-18 | 1988-10-26 | ||
JP2851133B2 (ja) * | 1989-06-21 | 1999-01-27 | リヒター ゲデオン ベジェセティ ジャール アール.テー. | 新規ラセミ及び光学的活性オクタヒドロ―インド―ロ〔2,3―a〕テトラヒドロピラニル〔2,3―c〕キノリジンジエステル誘導体及びその調製方法 |
HU214600B (hu) * | 1995-12-22 | 1998-04-28 | Richter Gedeon Vegyészeti Gyár Rt. | Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására |
WO2003020702A2 (en) | 2001-08-31 | 2003-03-13 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain |
WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
WO2018069312A1 (en) * | 2016-10-11 | 2018-04-19 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Treatment of synucleinopathies |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3770724A (en) * | 1970-03-31 | 1973-11-06 | Roussel Uclaf | Process for preparing pentacyclic alkaloids |
HU163143B (es) * | 1971-05-07 | 1973-06-28 | ||
US4033969A (en) * | 1972-06-19 | 1977-07-05 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vincamine derivatives |
US4033960A (en) * | 1973-07-31 | 1977-07-05 | Bayer Aktiengesellschaft | 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation |
AU499923B2 (en) * | 1975-06-27 | 1979-05-03 | Richter Gedeon Vegyeszeti Gyar N | Indoloquinolizine derivatives & their production |
FR2389625B1 (es) * | 1977-05-06 | 1980-04-18 | Roussel Uclaf | |
FR2459799A1 (fr) * | 1979-06-22 | 1981-01-16 | Synthelabo | Synthese de la ()-vincamine |
JPS55100383A (en) * | 1979-01-25 | 1980-07-31 | Sumitomo Chem Co Ltd | Preparation of novel nitrogen-containing polycyclic compound |
AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
HU181495B (en) * | 1979-05-31 | 1983-07-28 | Richter Gedeon Vegyeszet | Process for producing hydroxy-imino-eburnane derivatives |
HU180927B (en) * | 1979-07-13 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing 1k-hydroximino-e-homoe-eburane de rivatives |
FR2468605A1 (fr) * | 1979-10-30 | 1981-05-08 | Richter Gedeon Vegyeszet | Procede de preparation d'ester de l'acide apovincaminique |
HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
-
1981
- 1981-06-12 HU HU811753A patent/HU186891B/hu not_active IP Right Cessation
-
1982
- 1982-05-31 IL IL65922A patent/IL65922A/xx not_active IP Right Cessation
- 1982-06-02 ZA ZA823873A patent/ZA823873B/xx unknown
- 1982-06-02 FI FI821963A patent/FI71142C/fi not_active IP Right Cessation
- 1982-06-08 GR GR68366A patent/GR76494B/el unknown
- 1982-06-09 PT PT75042A patent/PT75042B/pt not_active IP Right Cessation
- 1982-06-09 SE SE8203580A patent/SE450383B/sv not_active IP Right Cessation
- 1982-06-10 CH CH5868/84A patent/CH659474A5/de not_active IP Right Cessation
- 1982-06-10 CH CH3597/82A patent/CH656128A5/de not_active IP Right Cessation
- 1982-06-10 FR FR8210103A patent/FR2507605B1/fr not_active Expired
- 1982-06-11 IT IT67752/82A patent/IT1200961B/it active
- 1982-06-11 AU AU84798/82A patent/AU551445B2/en not_active Ceased
- 1982-06-11 DK DK262982A patent/DK152651C/da not_active IP Right Cessation
- 1982-06-11 GB GB08217030A patent/GB2102415B/en not_active Expired
- 1982-06-11 BE BE0/208331A patent/BE893492A/fr not_active IP Right Cessation
- 1982-06-11 AT AT0227182A patent/AT382619B/de not_active IP Right Cessation
- 1982-06-11 NL NL8202396A patent/NL192452C/nl not_active IP Right Cessation
- 1982-06-11 US US06/387,676 patent/US4474960A/en not_active Expired - Lifetime
- 1982-06-11 SU SU3452054A patent/SU1258326A3/ru active
- 1982-06-11 NO NO821954A patent/NO821954L/no unknown
- 1982-06-11 ES ES513016A patent/ES513016A0/es active Granted
- 1982-06-11 DE DE19823222096 patent/DE3222096A1/de not_active Withdrawn
- 1982-06-12 JP JP57099997A patent/JPS5843971A/ja active Pending
- 1982-12-14 FR FR8220957A patent/FR2515653B1/fr not_active Expired
-
1983
- 1983-02-22 SU SU833557652A patent/SU1376947A3/ru active
- 1983-06-11 CA CA000405030A patent/CA1258071A/en not_active Expired
- 1983-06-16 ES ES523345A patent/ES523345A0/es active Granted
-
1984
- 1984-11-30 ES ES538125A patent/ES8604581A1/es not_active Expired
-
1985
- 1985-01-07 GB GB08500325A patent/GB2151629B/en not_active Expired
-
1986
- 1986-03-13 AU AU54712/86A patent/AU568790B2/en not_active Ceased
-
1987
- 1987-01-02 SE SE8700015A patent/SE461654B/sv not_active IP Right Cessation
-
1991
- 1991-09-26 JP JP3317577A patent/JPH0714932B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-07 GE GEAP1993974A patent/GEP19970819B/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040916 |