ES8706705A1 - Procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftilpropionicos - Google Patents

Procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftilpropionicos

Info

Publication number
ES8706705A1
ES8706705A1 ES554088A ES554088A ES8706705A1 ES 8706705 A1 ES8706705 A1 ES 8706705A1 ES 554088 A ES554088 A ES 554088A ES 554088 A ES554088 A ES 554088A ES 8706705 A1 ES8706705 A1 ES 8706705A1
Authority
ES
Spain
Prior art keywords
formula
image
alpha
new process
optical resolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554088A
Other languages
English (en)
Other versions
ES554088A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Chemicals Italiana SpA
Original Assignee
Alfa Chemicals Italiana SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chemicals Italiana SpA filed Critical Alfa Chemicals Italiana SpA
Publication of ES8706705A1 publication Critical patent/ES8706705A1/es
Publication of ES554088A0 publication Critical patent/ES554088A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Glass Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA RESOLUCION OPTICA DE MEZCLAS RACEMICAS DE ACIDOS ALFA-NAFTILPROPIONICOS DE FORMULA (I). COMPRENDE LA REACCION DE UNA MEZCLA RACEMICA DE COMPUESTOS DE FORMULA (II) CON EL ENANTIOMERO, DEXTROGIRO O LEVOGIRO DE UN AMINOACIDO DE FORMULA (III), SEGUIDA DE LA RESOLUCION DEL PAR DE AMIDAS FORMADA POR CALENTAMIENTO A UNA TEMPERATURA ENTRE 50GC Y EL PUNTO DE EBULLICION DE LA MEZCLA, EN UN DISOLVENTE INERTE, CRISTALIZACION DE LA AMIDA DIASTEREOISOMERICA INDIVIDUAL; Y, FINALMENTE, HIDROLISIS ACIDA A LA TEMPERATURA DE EBULLICION, PARA OBTENER UN COMPUESTO DE FORMULA (II) EN LA QUE R1 ES ALQUILO C1-6 Y R2 ES HIDROGENO O HALOGENO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIINFLAMATORIAS. *FORMULA*
ES554088A 1985-04-18 1986-04-17 Procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftilpropionicos Expired ES8706705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03407/85A IT1203605B (it) 1985-04-18 1985-04-18 Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici

Publications (2)

Publication Number Publication Date
ES8706705A1 true ES8706705A1 (es) 1987-07-01
ES554088A0 ES554088A0 (es) 1987-07-01

Family

ID=11106610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554088A Expired ES8706705A1 (es) 1985-04-18 1986-04-17 Procedimiento para la resolucion optica de mezclas racemicas de acidos alfa-naftilpropionicos

Country Status (20)

Country Link
US (1) US4724102A (es)
EP (1) EP0204911B1 (es)
JP (1) JPS61289057A (es)
KR (1) KR860008115A (es)
AT (1) ATE53989T1 (es)
AU (1) AU580668B2 (es)
CA (1) CA1266057A (es)
DE (2) DE204911T1 (es)
DK (1) DK176786A (es)
ES (1) ES8706705A1 (es)
FI (1) FI861821A (es)
GR (1) GR861003B (es)
HU (1) HU196052B (es)
IL (1) IL78517A (es)
IT (1) IT1203605B (es)
NO (1) NO164090C (es)
NZ (1) NZ215636A (es)
PT (1) PT82415B (es)
YU (1) YU44699B (es)
ZA (1) ZA862387B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
CA2023954C (en) * 1989-10-17 1999-05-04 Hiroyuki Nohira Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5196575A (en) * 1992-02-19 1993-03-23 Hoechst Celanese Corp. Supercritical separation of isomers of functional organic compounds at moderate conditions
US5278334A (en) * 1992-10-01 1994-01-11 Ethyl Corporation Racemization process
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB899023A (en) * 1960-09-06 1962-06-20 Pfizer & Co C Resolving optically active ª--phenoxy alkanoic acids
BR6915470D0 (pt) * 1969-03-24 1973-03-13 Syntex Corp Processo para preparar derivados de acido 2-(6'substituido 2'naftil)propionico e de seus sais
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
US3904683A (en) * 1972-08-10 1975-09-09 Syntex Corp Process for the resolution of d- and 1-2-(6-methoxy-2-naphthyl) propionic acid
US3988365A (en) * 1973-04-11 1976-10-26 Syntex Corporation Resolution of 2-(6-methoxy-2-napthyl)propionic acid
DE2826952A1 (de) * 1978-06-20 1980-01-10 Bayer Ag Enantiomerentrennung von chiralen carbonsaeuren
US4246193A (en) * 1979-11-26 1981-01-20 Syntex Corporation Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
US4322548A (en) * 1980-02-13 1982-03-30 Kay Fries, Inc. Resolution of racemic mandelic acid
IT1154663B (it) * 1980-07-30 1987-01-21 Alfa Chimica Italiana Spa Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico
CA1190751A (en) * 1982-06-18 1985-07-23 J. Barry W. Bailey Process and apparatus for continuous converting of copper and non-ferrous mattes

Also Published As

Publication number Publication date
NO861497L (no) 1986-10-20
NO164090C (no) 1990-08-29
EP0204911A3 (en) 1988-08-03
FI861821A0 (fi) 1986-04-30
AU5593986A (en) 1986-10-23
IL78517A0 (en) 1986-08-31
JPS61289057A (ja) 1986-12-19
DE3672127D1 (de) 1990-07-26
US4724102A (en) 1988-02-09
IL78517A (en) 1990-02-09
KR860008115A (ko) 1986-11-12
ATE53989T1 (de) 1990-07-15
HU196052B (en) 1988-09-28
EP0204911A2 (en) 1986-12-17
YU54886A (en) 1988-02-29
PT82415A (en) 1986-05-01
DE204911T1 (de) 1987-05-21
IT8503407A0 (it) 1985-04-18
HUT40607A (en) 1987-01-28
YU44699B (en) 1990-12-31
ES554088A0 (es) 1987-07-01
NO164090B (no) 1990-05-21
GR861003B (en) 1986-08-12
DK176786A (da) 1986-10-19
DK176786D0 (da) 1986-04-17
PT82415B (pt) 1988-03-03
FI861821A (fi) 1986-10-19
IT1203605B (it) 1989-02-15
AU580668B2 (en) 1989-01-27
ZA862387B (en) 1986-11-26
NZ215636A (en) 1989-05-29
CA1266057A (en) 1990-02-20
EP0204911B1 (en) 1990-06-20

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506