BG50501A3 - Method for 1, 5- benzthiazepine derivatives production - Google Patents
Method for 1, 5- benzthiazepine derivatives productionInfo
- Publication number
- BG50501A3 BG50501A3 BG085116A BG8511688A BG50501A3 BG 50501 A3 BG50501 A3 BG 50501A3 BG 085116 A BG085116 A BG 085116A BG 8511688 A BG8511688 A BG 8511688A BG 50501 A3 BG50501 A3 BG 50501A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- radical
- benzthiazepine
- hydrogen
- methyl
- general formula
- Prior art date
Links
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 title abstract 2
- -1 alkanoyl radical Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Получените по метода съединения намират приложение в лекарствената химия. 1,5-бензтиазепиновите произвоодни с обща формулав която r1 е метилов или метоксирадикал, r2 водород или нисш алканоилов радикал, единият r3 или r4 е метилов радикал, флуорен или хлорен атом, а другият водород, r5 и r6 нисш алкилов радикал, и техните фармацевтично приемливи кисели адитивни соли се получават при взаимодействие на съединение с обща формулав която r1, r2, r3 и r4 имат посочените значения, а х1 е реактивоспособен остатък, с амин с формула в която r5 и r6 имат посочените значения. 4 претенцииThe compounds obtained by the method are used in medicinal chemistry. 1,5-Benzthiazepine derivatives of general formula in which r1 is methyl or methoxy radical, r2 hydrogen or lower alkanoyl radical, one r3 or r4 is methyl radical, fluorine or chlorine atom and the other hydrogen, r5 and r6 lower alkyl radical, and their pharmaceutical acceptable acid addition salts are obtained by reacting a compound of the general formula wherein r 1 , r 2 , r 3 , and r 4 are as defined, and x 1 is a reactive radical, with an amine of the formula wherein r 5 and r 6 are as defined. 4 claims
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62202027A JPS6445376A (en) | 1987-08-12 | 1987-08-12 | Production of 1,5-benzothiazepine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG50501A3 true BG50501A3 (en) | 1992-08-14 |
Family
ID=16450708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG085116A BG50501A3 (en) | 1987-08-12 | 1988-08-02 | Method for 1, 5- benzthiazepine derivatives production |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS6445376A (en) |
| KR (1) | KR890003722A (en) |
| CN (1) | CN1030570C (en) |
| AT (1) | AT395010B (en) |
| BG (1) | BG50501A3 (en) |
| CA (1) | CA1337346C (en) |
| ES (1) | ES2007990A6 (en) |
| FI (1) | FI883115A (en) |
| GR (1) | GR1000385B (en) |
| IE (1) | IE61168B1 (en) |
| IL (1) | IL86978A0 (en) |
| NO (1) | NO170017C (en) |
| PT (1) | PT88250B (en) |
| SU (1) | SU1709908A3 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| US3895006A (en) * | 1974-04-19 | 1975-07-15 | Squibb & Sons Inc | 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones |
| SE449611B (en) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES |
| US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
| GB8315364D0 (en) * | 1983-06-03 | 1983-07-06 | Tanabe Seiyaku Co | 8-chloro-1 5-benzothiazepine derivatives |
| GB8406318D0 (en) * | 1984-03-10 | 1984-04-11 | Tanabe Seiyaku Co | 1 5-benzothiazepine derivatives |
| JPS60204776A (en) * | 1984-03-30 | 1985-10-16 | Roller Japan Kk | 1,5-benzothiazepine derivative |
| JPS61103877A (en) * | 1984-10-24 | 1986-05-22 | Tanabe Seiyaku Co Ltd | Benzothiazepine derivative and its preparation |
-
1987
- 1987-08-12 JP JP62202027A patent/JPS6445376A/en active Pending
-
1988
- 1988-06-27 IE IE194988A patent/IE61168B1/en not_active IP Right Cessation
- 1988-06-29 FI FI883115A patent/FI883115A/en not_active Application Discontinuation
- 1988-07-04 IL IL86978A patent/IL86978A0/en not_active IP Right Cessation
- 1988-07-07 CA CA000571438A patent/CA1337346C/en not_active Expired - Fee Related
- 1988-07-11 CN CN88104387A patent/CN1030570C/en not_active Expired - Fee Related
- 1988-08-02 BG BG085116A patent/BG50501A3/en unknown
- 1988-08-04 GR GR880100515A patent/GR1000385B/en unknown
- 1988-08-09 NO NO883525A patent/NO170017C/en unknown
- 1988-08-10 KR KR1019880010209A patent/KR890003722A/en not_active Application Discontinuation
- 1988-08-11 SU SU884356317A patent/SU1709908A3/en active
- 1988-08-11 ES ES8802522A patent/ES2007990A6/en not_active Expired
- 1988-08-11 AT AT0202388A patent/AT395010B/en not_active IP Right Cessation
- 1988-08-11 PT PT88250A patent/PT88250B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO170017B (en) | 1992-05-25 |
| FI883115A0 (en) | 1988-06-29 |
| NO170017C (en) | 1992-09-02 |
| IL86978A0 (en) | 1988-12-30 |
| AT395010B (en) | 1992-08-25 |
| ES2007990A6 (en) | 1989-07-01 |
| CA1337346C (en) | 1995-10-17 |
| SU1709908A3 (en) | 1992-01-30 |
| CN1031229A (en) | 1989-02-22 |
| FI883115A (en) | 1989-02-13 |
| GR880100515A (en) | 1989-05-25 |
| NO883525L (en) | 1989-02-13 |
| CN1030570C (en) | 1995-12-27 |
| NO883525D0 (en) | 1988-08-09 |
| GR1000385B (en) | 1992-06-30 |
| KR890003722A (en) | 1989-04-17 |
| IE61168B1 (en) | 1994-10-05 |
| PT88250A (en) | 1989-06-30 |
| IE881949L (en) | 1989-02-12 |
| PT88250B (en) | 1995-03-01 |
| JPS6445376A (en) | 1989-02-17 |
| ATA202388A (en) | 1992-01-15 |
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