IE881949L - Process for preparing benzothiazepine derivatives - Google Patents

Process for preparing benzothiazepine derivatives

Info

Publication number
IE881949L
IE881949L IE881949A IE194988A IE881949L IE 881949 L IE881949 L IE 881949L IE 881949 A IE881949 A IE 881949A IE 194988 A IE194988 A IE 194988A IE 881949 L IE881949 L IE 881949L
Authority
IE
Ireland
Prior art keywords
compound
expressed
formula
cerebral
lower alkyl
Prior art date
Application number
IE881949A
Other versions
IE61168B1 (en
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of IE881949L publication Critical patent/IE881949L/en
Publication of IE61168B1 publication Critical patent/IE61168B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To readily obtain the titled compound useful as a medicinal compound having excellent hypotensive, cerebral coronary vasodilator and/or blood platelet agglutination inhibitory action, by reacting a specific compound with amines as raw materials. CONSTITUTION:An compound expressed by formula I (R<1> is lower alkyl or lower alkoxy; R<2> is H or lower alkanoyl; either of R<3> and R<4> is lower alkyl or halogen and the other is H; X' is reactive residue) is reacted with an amine expressed by formula II (R<5> and R<6> are lower alkyl) or salt thereof in a suitable solvent in the presence or absence of a deacidifying agent, preferably at ambient temperature - while being heated to afford the aimed compound, expressed by formula III and useful for treating.preventing cerebropathy, such as cerebral vasospasm, cerebral ischemia or cerebral infraction, and cardiopathy, such as angina pectoris. The above-mentioned compound is treated with an acid to provide an acid addition salt. Furthermore, since the aforementioned reaction proceeds without accompanying racemization, the aimed compound can also be obtained as an optically active substance by using the optically active compound expressed by formula I. [JP1045376A]
IE194988A 1987-08-12 1988-06-27 Process for preparing 1.5-benzothiazepine derivatives IE61168B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62202027A JPS6445376A (en) 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative

Publications (2)

Publication Number Publication Date
IE881949L true IE881949L (en) 1989-02-12
IE61168B1 IE61168B1 (en) 1994-10-05

Family

ID=16450708

Family Applications (1)

Application Number Title Priority Date Filing Date
IE194988A IE61168B1 (en) 1987-08-12 1988-06-27 Process for preparing 1.5-benzothiazepine derivatives

Country Status (14)

Country Link
JP (1) JPS6445376A (en)
KR (1) KR890003722A (en)
CN (1) CN1030570C (en)
AT (1) AT395010B (en)
BG (1) BG50501A3 (en)
CA (1) CA1337346C (en)
ES (1) ES2007990A6 (en)
FI (1) FI883115A (en)
GR (1) GR1000385B (en)
IE (1) IE61168B1 (en)
IL (1) IL86978A0 (en)
NO (1) NO170017C (en)
PT (1) PT88250B (en)
SU (1) SU1709908A3 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
US3895006A (en) * 1974-04-19 1975-07-15 Squibb & Sons Inc 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
GB8315364D0 (en) * 1983-06-03 1983-07-06 Tanabe Seiyaku Co 8-chloro-1 5-benzothiazepine derivatives
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8406318D0 (en) * 1984-03-10 1984-04-11 Tanabe Seiyaku Co 1 5-benzothiazepine derivatives
JPS60204776A (en) * 1984-03-30 1985-10-16 Roller Japan Kk 1,5-benzothiazepine derivative
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Also Published As

Publication number Publication date
FI883115A0 (en) 1988-06-29
NO883525D0 (en) 1988-08-09
IL86978A0 (en) 1988-12-30
CN1030570C (en) 1995-12-27
NO170017B (en) 1992-05-25
CA1337346C (en) 1995-10-17
GR880100515A (en) 1989-05-25
CN1031229A (en) 1989-02-22
AT395010B (en) 1992-08-25
NO170017C (en) 1992-09-02
FI883115A (en) 1989-02-13
ATA202388A (en) 1992-01-15
ES2007990A6 (en) 1989-07-01
BG50501A3 (en) 1992-08-14
JPS6445376A (en) 1989-02-17
PT88250A (en) 1989-06-30
NO883525L (en) 1989-02-13
GR1000385B (en) 1992-06-30
SU1709908A3 (en) 1992-01-30
PT88250B (en) 1995-03-01
IE61168B1 (en) 1994-10-05
KR890003722A (en) 1989-04-17

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Legal Events

Date Code Title Description
MM4A Patent lapsed