JPS6450872A - Production of 1,5-benzothiazepine derivative - Google Patents

Production of 1,5-benzothiazepine derivative

Info

Publication number
JPS6450872A
JPS6450872A JP62208482A JP20848287A JPS6450872A JP S6450872 A JPS6450872 A JP S6450872A JP 62208482 A JP62208482 A JP 62208482A JP 20848287 A JP20848287 A JP 20848287A JP S6450872 A JPS6450872 A JP S6450872A
Authority
JP
Japan
Prior art keywords
formula
derivative
reaction
lower alkyl
nonsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62208482A
Other languages
Japanese (ja)
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP62208482A priority Critical patent/JPS6450872A/en
Priority to IE195088A priority patent/IE61169B1/en
Priority to FI883116A priority patent/FI93009C/en
Priority to CA000571434A priority patent/CA1312077C/en
Priority to IL8702688A priority patent/IL87026A/en
Priority to CN88104429A priority patent/CN1031374A/en
Priority to BG85117A priority patent/BG49047A3/en
Priority to GR880100516A priority patent/GR1000452B/en
Priority to NO883526A priority patent/NO170541C/en
Priority to HU431688A priority patent/HU201917B/en
Priority to HU584688A priority patent/HU203741B/en
Priority to ES8802539A priority patent/ES2007993A6/en
Priority to PT88300A priority patent/PT88300B/en
Priority to SU884356329A priority patent/RU1784041C/en
Priority to AT0206388A priority patent/AT395424B/en
Priority to KR1019880010577A priority patent/KR890003723A/en
Publication of JPS6450872A publication Critical patent/JPS6450872A/en
Priority to TW079103691A priority patent/TW207536B/zh
Priority to NO913422A priority patent/NO913422D0/en
Priority to NO922254A priority patent/NO172488C/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

PURPOSE:To readily obtain the titled compound useful as a drug, having hypotensive action, vasodilating action on cerebral blood vessel and crown blood vessel, by condensing an N-nonsubstituted 1,5-benzothiqazepine derivative as a raw material with an aminoethanol derivative. CONSTITUTION:An N-nonsubstituted 1,5-benzothiazepine derivative shown by formula I (R<1> is lower alkyl or lower alkoxy; R<2> is H or lower alkanoyl; one of R<3> and R<4> is lower alkyl or halogen atom. and the other H) is used as a raw material and condensed with an aminoethanol derivative shown by formula II (R<5> and R<6> are lower alkyl; Z is H, lower alkylsulfonyl, arylsulfonyl or sulfo). In the reaction, when Z of the compound shown by formula II is preferably H, the reaction is carried out in the presence of a dehydrating agent and when Z is lower alkylsulfonyl, the reaction is done is the presence of an alkali reagent to give a compound shown by formula III.
JP62208482A 1987-08-12 1987-08-21 Production of 1,5-benzothiazepine derivative Pending JPS6450872A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP62208482A JPS6450872A (en) 1987-08-21 1987-08-21 Production of 1,5-benzothiazepine derivative
IE195088A IE61169B1 (en) 1987-08-21 1988-06-27 Process for preparing 1.5-benzothiazepine derivatives
FI883116A FI93009C (en) 1987-08-21 1988-06-29 Process for the preparation of 1,5-benzothiazepine derivatives
CA000571434A CA1312077C (en) 1987-08-21 1988-07-07 Process for preparing 1,5-benzothiazepine derivatives
IL8702688A IL87026A (en) 1987-08-21 1988-07-07 Preparation of 1,5-benzothiazepine derivatives by reacting 2-phenyl-3-hydroxy n-unsubstituted benzothiazepinone with n,n-dialkyl amino ethanol derivatives
CN88104429A CN1031374A (en) 1987-08-21 1988-07-16 1, the preparation method of 5-Benzothiazepine derivatives
BG85117A BG49047A3 (en) 1987-08-21 1988-08-02 Method for preparing of 1, 5- benzothiazepine derivatives
GR880100516A GR1000452B (en) 1987-08-21 1988-08-04 Preparation method for 1,5-binzodiapezine derivatives
NO883526A NO170541C (en) 1987-08-21 1988-08-09 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1,5-BENZOTIAZEPINE DERIVATIVES
HU431688A HU201917B (en) 1987-08-12 1988-08-11 Process for producing 1,5-benzothiazepine derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HU584688A HU203741B (en) 1987-08-12 1988-08-11 New process for producing halogeno-1,5-benzothiazepine derivatives
ES8802539A ES2007993A6 (en) 1987-08-21 1988-08-12 Production of 1,5-benzothiazepine derivative
PT88300A PT88300B (en) 1987-08-21 1988-08-18 PROCESS FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES
SU884356329A RU1784041C (en) 1987-08-21 1988-08-19 Process for producing 1,5-benzothiazepine derivatives or their pharmaceutically acceptable acid-additive salts
AT0206388A AT395424B (en) 1987-08-21 1988-08-19 Process for the preparation of novel 1,5-benzothiazepine derivatives
KR1019880010577A KR890003723A (en) 1987-08-21 1988-08-20 Method for preparing 1,5-benzothiazepine derivative
TW079103691A TW207536B (en) 1987-08-21 1990-05-07
NO913422A NO913422D0 (en) 1987-08-21 1991-09-02 PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES.
NO922254A NO172488C (en) 1987-08-21 1992-06-09 PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62208482A JPS6450872A (en) 1987-08-21 1987-08-21 Production of 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
JPS6450872A true JPS6450872A (en) 1989-02-27

Family

ID=16556895

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62208482A Pending JPS6450872A (en) 1987-08-12 1987-08-21 Production of 1,5-benzothiazepine derivative

Country Status (15)

Country Link
JP (1) JPS6450872A (en)
KR (1) KR890003723A (en)
CN (1) CN1031374A (en)
AT (1) AT395424B (en)
BG (1) BG49047A3 (en)
CA (1) CA1312077C (en)
ES (1) ES2007993A6 (en)
FI (1) FI93009C (en)
GR (1) GR1000452B (en)
IE (1) IE61169B1 (en)
IL (1) IL87026A (en)
NO (1) NO170541C (en)
PT (1) PT88300B (en)
RU (1) RU1784041C (en)
TW (1) TW207536B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS61122281A (en) * 1984-11-17 1986-06-10 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and preparation thereof
JPS61225175A (en) * 1985-03-28 1986-10-06 Sawai Seiyaku Kk Production of 1,5-benzothiazepine derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
HU195795B (en) * 1985-11-06 1988-07-28 Richter Gedeon Vegyeszet Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS61122281A (en) * 1984-11-17 1986-06-10 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and preparation thereof
JPS61225175A (en) * 1985-03-28 1986-10-06 Sawai Seiyaku Kk Production of 1,5-benzothiazepine derivative

Also Published As

Publication number Publication date
BG49047A3 (en) 1991-07-15
ATA206388A (en) 1992-05-15
FI883116A (en) 1989-02-22
IE881950L (en) 1989-02-21
GR1000452B (en) 1992-07-30
CA1312077C (en) 1992-12-29
IL87026A0 (en) 1988-12-30
CN1031374A (en) 1989-03-01
FI93009B (en) 1994-10-31
FI93009C (en) 1995-02-10
NO883526L (en) 1989-02-22
KR890003723A (en) 1989-04-17
AT395424B (en) 1992-12-28
PT88300A (en) 1989-06-30
PT88300B (en) 1995-03-31
RU1784041C (en) 1992-12-23
IL87026A (en) 1995-01-24
IE61169B1 (en) 1994-10-05
GR880100516A (en) 1989-05-25
NO170541B (en) 1992-07-20
ES2007993A6 (en) 1989-07-01
FI883116A0 (en) 1988-06-29
NO170541C (en) 1992-10-28
TW207536B (en) 1993-06-11
NO883526D0 (en) 1988-08-09

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