ES2007993A6 - Production of 1,5-benzothiazepine derivative - Google Patents

Production of 1,5-benzothiazepine derivative

Info

Publication number
ES2007993A6
ES2007993A6 ES8802539A ES8802539A ES2007993A6 ES 2007993 A6 ES2007993 A6 ES 2007993A6 ES 8802539 A ES8802539 A ES 8802539A ES 8802539 A ES8802539 A ES 8802539A ES 2007993 A6 ES2007993 A6 ES 2007993A6
Authority
ES
Spain
Prior art keywords
formula
derivative
reaction
lower alkyl
nonsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802539A
Other languages
Spanish (es)
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES2007993A6 publication Critical patent/ES2007993A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To readily obtain the titled compound useful as a drug, having hypotensive action, vasodilating action on cerebral blood vessel and crown blood vessel, by condensing an N-nonsubstituted 1,5-benzothiqazepine derivative as a raw material with an aminoethanol derivative. CONSTITUTION:An N-nonsubstituted 1,5-benzothiazepine derivative shown by formula I (R<1> is lower alkyl or lower alkoxy R<2> is H or lower alkanoyl one of R<3> and R<4> is lower alkyl or halogen atom. and the other H) is used as a raw material and condensed with an aminoethanol derivative shown by formula II (R<5> and R<6> are lower alkyl Z is H, lower alkylsulfonyl, arylsulfonyl or sulfo). In the reaction, when Z of the compound shown by formula II is preferably H, the reaction is carried out in the presence of a dehydrating agent and when Z is lower alkylsulfonyl, the reaction is done is the presence of an alkali reagent to give a compound shown by formula III.
ES8802539A 1987-08-21 1988-08-12 Production of 1,5-benzothiazepine derivative Expired ES2007993A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62208482A JPS6450872A (en) 1987-08-21 1987-08-21 Production of 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
ES2007993A6 true ES2007993A6 (en) 1989-07-01

Family

ID=16556895

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802539A Expired ES2007993A6 (en) 1987-08-21 1988-08-12 Production of 1,5-benzothiazepine derivative

Country Status (15)

Country Link
JP (1) JPS6450872A (en)
KR (1) KR890003723A (en)
CN (1) CN1031374A (en)
AT (1) AT395424B (en)
BG (1) BG49047A3 (en)
CA (1) CA1312077C (en)
ES (1) ES2007993A6 (en)
FI (1) FI93009C (en)
GR (1) GR1000452B (en)
IE (1) IE61169B1 (en)
IL (1) IL87026A (en)
NO (1) NO170541C (en)
PT (1) PT88300B (en)
RU (1) RU1784041C (en)
TW (1) TW207536B (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
GB8315364D0 (en) * 1983-06-03 1983-07-06 Tanabe Seiyaku Co 8-chloro-1 5-benzothiazepine derivatives
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8406318D0 (en) * 1984-03-10 1984-04-11 Tanabe Seiyaku Co 1 5-benzothiazepine derivatives
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
JPS61225175A (en) * 1985-03-28 1986-10-06 Sawai Seiyaku Kk Production of 1,5-benzothiazepine derivative
HU195795B (en) * 1985-11-06 1988-07-28 Richter Gedeon Vegyeszet Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Also Published As

Publication number Publication date
RU1784041C (en) 1992-12-23
NO170541B (en) 1992-07-20
JPS6450872A (en) 1989-02-27
IL87026A (en) 1995-01-24
FI883116A0 (en) 1988-06-29
FI93009B (en) 1994-10-31
IE881950L (en) 1989-02-21
NO170541C (en) 1992-10-28
CN1031374A (en) 1989-03-01
KR890003723A (en) 1989-04-17
PT88300A (en) 1989-06-30
NO883526D0 (en) 1988-08-09
TW207536B (en) 1993-06-11
ATA206388A (en) 1992-05-15
CA1312077C (en) 1992-12-29
FI883116A (en) 1989-02-22
IE61169B1 (en) 1994-10-05
PT88300B (en) 1995-03-31
BG49047A3 (en) 1991-07-15
GR880100516A (en) 1989-05-25
FI93009C (en) 1995-02-10
AT395424B (en) 1992-12-28
GR1000452B (en) 1992-07-30
NO883526L (en) 1989-02-22
IL87026A0 (en) 1988-12-30

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