KR890003723A - Method for preparing 1,5-benzothiazepine derivative - Google Patents

Method for preparing 1,5-benzothiazepine derivative Download PDF

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Publication number
KR890003723A
KR890003723A KR1019880010577A KR880010577A KR890003723A KR 890003723 A KR890003723 A KR 890003723A KR 1019880010577 A KR1019880010577 A KR 1019880010577A KR 880010577 A KR880010577 A KR 880010577A KR 890003723 A KR890003723 A KR 890003723A
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KR
South Korea
Prior art keywords
group
hydrogen
benzothiazepine derivative
producing
condensation reaction
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KR1019880010577A
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Korean (ko)
Inventor
히로즈미 이노우에
쓰네히로 하라다
마사아끼 나가사와
Original Assignee
아다찌 게이지로
다나베세이야꾸 가부시끼가이샤
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Application filed by 아다찌 게이지로, 다나베세이야꾸 가부시끼가이샤 filed Critical 아다찌 게이지로
Publication of KR890003723A publication Critical patent/KR890003723A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

1,5-벤조티아제핀 유도체 제조방법1,5-benzothiazepine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

하기식(Ⅱ)로 표시되는 화합물을 하기식(Ⅲ)으로 표시되는 아미노에탄올과 축합 반응시키고, 필요하다면 의약적으로 허용 가능한 그의 산부가염으로 변환시킴을 특징으로 하는 하기식(Ⅰ)로 표시되는 1,5-벤조티아제핀 유도체 또는 의약적으로 허용 가능한 그의 산부가염의 제조방법.A compound represented by the following formula (I) characterized by condensation reaction of amino ethanol represented by the following formula (III) with a compound represented by the following formula (II) and, if necessary, converted into a pharmaceutically acceptable acid addition salt thereof. A method for producing a 1,5-benzothiazepine derivative or a pharmaceutically acceptable acid addition salt thereof. 상기식중 R1은 저급 알킬기 또는 저급 알콕시기이고, R2는 수소 또는 저급 알카노일기이고, R3및 R4의 어느하나는 저급 알킬기 또는 할로겐 원자이고 다른 하나는 수소이고, R5및 R6각각은 저급 알킬기이고, Z는 수소, 저급 알킬술포닐기, 아릴술포닐기 또는 술포기이다.Wherein R 1 is a lower alkyl group or a lower alkoxy group, R 2 is hydrogen or a lower alkanoyl group, one of R 3 and R 4 is a lower alkyl group or a halogen atom and the other is hydrogen, R 5 and R 6 each is a lower alkyl group, Z is a hydrogen giving, a lower alkylsulfonyl group, arylsulfonyl group, or alcohol. 제1항에 있어서, 축합 반응은 0°C 내지 150°C에서 용매내에서 수행되는 1,5-벤조티아제핀 유도체의 제조방법.The method of claim 1, wherein the condensation reaction is carried out in a solvent at 0 ° C to 150 ° C. 제2항에 있어서, 축합 반응은 식(Ⅲ)의 화합물 중의 Z가 수소일때 탈수제 존재에서 수행되는 1,5-벤조티아제핀 유도체의 제조방법.The method for preparing a 1,5-benzothiazepine derivative according to claim 2, wherein the condensation reaction is carried out in the presence of a dehydrating agent when Z in the compound of formula (III) is hydrogen. 제3항에 있어서, 탈수제는 트리페닐포스핀 및 디에틸아조디카르복실레이트 혼합물, 트리페닐포스핀 및 디메틸아조디카르복실레이트 혼합물, 또는 술푸릴디이미다졸 및 수소화나트륨 혼합물인 1,5-벤조티아제핀 유도체의 제조방법.The 1,5-benzoate of claim 3, wherein the dehydrating agent is a triphenylphosphine and diethylazodicarboxylate mixture, a triphenylphosphine and dimethylazodicarboxylate mixture, or a sulfuryldiimidazole and sodium hydride mixture. Method for preparing thiazine derivatives. 제2항에 있어서, 축합 반응은 식(Ⅲ)의 화합물중의 Z가 저급 알킬술포닐기, 아릴술포닐기 또는 술포기일때 알칼리제 존재에서 수행되는 1,5-벤조티아제핀 유도체의 제조방법.The process for producing a 1,5-benzothiazepine derivative according to claim 2, wherein the condensation reaction is carried out in the presence of an alkali agent when Z in the compound of formula (III) is a lower alkylsulfonyl group, an arylsulfonyl group, or a sulfo group. 제5항에 있어서, 알칼리제는 수산화알칼리금속, 탄산알칼리금속, 탄산수소알칼리금속 또는 수소화알칼리금속인 1,5-벤조티아제핀 유도체의 제조방법.The method for producing a 1,5-benzothiazepine derivative according to claim 5, wherein the alkali agent is an alkali metal hydroxide, an alkali metal carbonate, an alkali hydrogen carbonate metal or an alkali metal hydride. 제1항에 있어서, 수득된 화합물은 산으로 초리하여 의약적으로 허용 가능한 산부가염으로 변환시키는 1,5-벤조티아제핀 유도체 제조방법.The method for producing a 1,5-benzothiazepine derivative according to claim 1, wherein the obtained compound is isolated with an acid and converted into a pharmaceutically acceptable acid addition salt.
KR1019880010577A 1987-08-21 1988-08-20 Method for preparing 1,5-benzothiazepine derivative KR890003723A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62208482A JPS6450872A (en) 1987-08-21 1987-08-21 Production of 1,5-benzothiazepine derivative
JP208482/1987 1987-08-21

Publications (1)

Publication Number Publication Date
KR890003723A true KR890003723A (en) 1989-04-17

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ID=16556895

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KR1019880010577A KR890003723A (en) 1987-08-21 1988-08-20 Method for preparing 1,5-benzothiazepine derivative

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Country Link
JP (1) JPS6450872A (en)
KR (1) KR890003723A (en)
CN (1) CN1031374A (en)
AT (1) AT395424B (en)
BG (1) BG49047A3 (en)
CA (1) CA1312077C (en)
ES (1) ES2007993A6 (en)
FI (1) FI93009C (en)
GR (1) GR1000452B (en)
IE (1) IE61169B1 (en)
IL (1) IL87026A (en)
NO (1) NO170541C (en)
PT (1) PT88300B (en)
RU (1) RU1784041C (en)
TW (1) TW207536B (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
GB8315364D0 (en) * 1983-06-03 1983-07-06 Tanabe Seiyaku Co 8-chloro-1 5-benzothiazepine derivatives
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8406318D0 (en) * 1984-03-10 1984-04-11 Tanabe Seiyaku Co 1 5-benzothiazepine derivatives
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
JPS61225175A (en) * 1985-03-28 1986-10-06 Sawai Seiyaku Kk Production of 1,5-benzothiazepine derivative
HU195795B (en) * 1985-11-06 1988-07-28 Richter Gedeon Vegyeszet Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Also Published As

Publication number Publication date
FI93009C (en) 1995-02-10
PT88300B (en) 1995-03-31
IE61169B1 (en) 1994-10-05
GR880100516A (en) 1989-05-25
PT88300A (en) 1989-06-30
TW207536B (en) 1993-06-11
NO883526L (en) 1989-02-22
RU1784041C (en) 1992-12-23
ES2007993A6 (en) 1989-07-01
CN1031374A (en) 1989-03-01
IL87026A0 (en) 1988-12-30
FI93009B (en) 1994-10-31
NO883526D0 (en) 1988-08-09
NO170541B (en) 1992-07-20
IE881950L (en) 1989-02-21
AT395424B (en) 1992-12-28
CA1312077C (en) 1992-12-29
ATA206388A (en) 1992-05-15
JPS6450872A (en) 1989-02-27
GR1000452B (en) 1992-07-30
BG49047A3 (en) 1991-07-15
IL87026A (en) 1995-01-24
FI883116A0 (en) 1988-06-29
FI883116A (en) 1989-02-22
NO170541C (en) 1992-10-28

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