KR890701564A - How to prepare quinoline carboxylic acid derivative - Google Patents

How to prepare quinoline carboxylic acid derivative

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Publication number
KR890701564A
KR890701564A KR1019890700325A KR890700325A KR890701564A KR 890701564 A KR890701564 A KR 890701564A KR 1019890700325 A KR1019890700325 A KR 1019890700325A KR 890700325 A KR890700325 A KR 890700325A KR 890701564 A KR890701564 A KR 890701564A
Authority
KR
South Korea
Prior art keywords
compound
hydrogen
general structure
general formula
acid
Prior art date
Application number
KR1019890700325A
Other languages
Korean (ko)
Other versions
KR970005911B1 (en
Inventor
이스트반 헤르메츠
게쟈 케레스츄리
렐르 바스바리
아그네스 호르바스
마리아 바로그
페테르 리트리
Original Assignee
기율라 스주크,타마스 스주츠
치노인 교기스져 에스 베게스제티 테르메케크 기야라 알티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU285887A external-priority patent/HU200175B/en
Priority claimed from HU873146A external-priority patent/HU199822B/en
Application filed by 기율라 스주크,타마스 스주츠, 치노인 교기스져 에스 베게스제티 테르메케크 기야라 알티 filed Critical 기율라 스주크,타마스 스주츠
Publication of KR890701564A publication Critical patent/KR890701564A/en
Application granted granted Critical
Publication of KR970005911B1 publication Critical patent/KR970005911B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

내용 없음No content

Description

퀴놀린 카복실산 유도체를 제조하는 방법How to prepare quinoline carboxylic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

일반구조식(Ⅱ)의 화합물을Compound of general formula (II) (여기서, R은 할로겐 혹은 2개 내지 6개의 탄소원자를 함유하는 지방족 아실옥시기 혹은 7개 내지 11개의 탄소원자로써 방향족 아실옥시기, R4는 불소 혹은 염)을 일반구조식(Ⅲ)의 피페라진 유도체와 반응시켜서Wherein R is halogen or an aliphatic acyloxy group containing from 2 to 6 carbon atoms or an aromatic acyloxy group from 7 to 11 carbon atoms, R 4 is fluorine or a salt. By reacting with derivatives (여기서, R5는 수소 혹은 메칠) 일반구조식(Ⅳ) 화합물을 얻어서Wherein R 5 is hydrogen or methyl to obtain a compound of general structure (IV) (여기서 R, R, RU, R 위에서 기술한 바와 같다) 분리하거나, 분리하지 않고 가수분해시킨 후 필요하다면 염으로 전환시키거나, 혹은 염으로부터 분리해서 일반구조식(Ⅰ) 화합물 및 그 약학적으로 사용가능한 염을 제조하는 방법.Where R, R, R U , R are as described above.Hydrogenated or isolated without hydrolysis, and then converted to salt if necessary, or separated from salt to form general formula (I) compounds and pharmaceutically Methods of Making Usable Salts. (여기서, R1은 1개 혹은 2개의 할로겐 원자로 치환 또는 비치환의 폐닐기, 혹은 일반구조식 CH2CR6R7R8기 (여기서 R6, R7과 R8은 수소 혹은 할로겐), R2는 피페라지닐 혹은 4-메칠-피페라지닐, R3는 수소 혹은 불소)이다.(Wherein R 1 is a substituted or unsubstituted ringyl group with one or two halogen atoms, or a general structure CH 2 CR 6 R 7 R 8 group (where R 6 , R 7 and R 8 is hydrogen or halogen), R 2 Is piperazinyl or 4-methyl-piperazinyl, R 3 is hydrogen or fluorine). 제1항에서 일반 구조시기(Ⅱ)의 화합물을 유기용매(바람직하게는 산아미이드, 설폭사이드, 케톤, 알콜, 에테르, 에스테르) 존재하에서 일반구조식(Ⅲ)의 아민화합물과 반응시키는 방법.A method according to claim 1, wherein the compound of general structure (II) is reacted with an amine compound of general structure (III) in the presence of an organic solvent (preferably acidamide, sulfoxide, ketone, alcohol, ether, ester). 제2항에서, 유기용매로서 디메칠 설폭사이드를 사용하는 방법.The process of claim 2 wherein dimethyl sulfoxide is used as the organic solvent. 제1항에서, 일반구조식(Ⅱ) 화합물을 산 결합제 존재하에서 일반구조식(Ⅲ) 화합물과 반응시키는 방법.The process of claim 1 wherein the compound of general formula (II) is reacted with compound of general formula (III) in the presence of an acid binder. 제4항에서, 산결합제로써는 아민 혹은 일반구조식(Ⅳ)의 화합물을 과량 사용하는 방법.The method of claim 4, wherein an acid binder is used in excess of an amine or a compound of general structure (IV). 제1항에서, 가수분해를 산매개체 중에서 실시하는 방법.The method of claim 1 wherein the hydrolysis is carried out in an acid medium. 제6항에서, 산매개체로써 유기 혹은 무기산(바람직하게는 염산, 설퓨릭산, 초산)을 사용하는 방법.7. A process according to claim 6, wherein organic or inorganic acids (preferably hydrochloric acid, sulfuric acid, acetic acid) are used as acid medium. 제1항에서, 가수분해를 알카리 매개체 중에서 실시하는 방법.The method of claim 1 wherein the hydrolysis is carried out in alkaline mediators. 제8항에서, 알칼리 매개체로써 알칼리류 금속하이드록사이드류, 알칼리토류금속 하이드록사이드, 유기염기(바람직하게는 트리에칠아민 수용액)를 사용하는 방법.The method according to claim 8, wherein alkali metal hydroxides, alkaline earth metal hydroxides, and organic bases (preferably triethylamine aqueous solution) are used as alkali mediators. 일반구조식(Ⅳ)의 화합물.Compound of general structure (IV). (여기서, R1은 1개 내지 2개의 할로겐 원자로 치환 혹은 비치환의 페닐기, 혹은 일반구조식 -CH2CR6R7R8기, (R6,R7,R8은 수소 또는 할로겐), R2는 피페라지닐 혹은 4-메칠-피페라지닐, R3는 수소 혹은 불소)이다.(Wherein R 1 is a substituted or unsubstituted phenyl group with 1 to 2 halogen atoms, or a general formula —CH 2 CR 6 R 7 R 8 group, (R 6 , R 7 , R 8 is hydrogen or halogen), R 2 Is piperazinyl or 4-methyl-piperazinyl, R 3 is hydrogen or fluorine). ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is to be disclosed based on the initial application.
KR1019890700325A 1987-06-24 1988-05-20 Process for preparing quinoline carboxylic acid derivatives KR970005911B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
HU2858/87 1987-06-24
HU285887A HU200175B (en) 1987-06-24 1987-06-24 Process for producing quinolinecarboxylic acid derivatives
HU3146/87 1987-07-10
HU873146A HU199822B (en) 1987-07-10 1987-07-10 Process for production of derivatives of quinoline carbonic acid
HU3146/ 1987-07-10
PCT/HU1988/000036 WO1988010253A1 (en) 1987-06-24 1988-05-20 Process for the preparation of quinoline carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
KR890701564A true KR890701564A (en) 1989-12-21
KR970005911B1 KR970005911B1 (en) 1997-04-22

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Application Number Title Priority Date Filing Date
KR1019890700325A KR970005911B1 (en) 1987-06-24 1988-05-20 Process for preparing quinoline carboxylic acid derivatives

Country Status (11)

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EP (1) EP0329719A1 (en)
JP (1) JP2693988B2 (en)
KR (1) KR970005911B1 (en)
CN (1) CN1025028C (en)
CA (1) CA1325010C (en)
CS (1) CS274677B2 (en)
DK (1) DK84089A (en)
ES (1) ES2006994A6 (en)
FI (1) FI91400C (en)
WO (1) WO1988010253A1 (en)
YU (1) YU46570B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562852A (en) * 1984-08-20 1986-01-07 Britt Franklin J Safety valve
US4606367A (en) * 1985-04-04 1986-08-19 Britt Franklin J Apparatus and method for relieving pressure within a high pressure tank
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
DE548224T1 (en) * 1990-09-11 1993-10-14 Schering Corp METHOD FOR THE PRODUCTION OF ALBUTERO AND ARYLGLYOXAL, ACETAL, HEMIACETAL AND HYDRATE INTERMEDIATES.
JP3165742B2 (en) * 1991-07-16 2001-05-14 中外製薬株式会社 Method for producing quinolone carboxylic acid derivative
US5869661A (en) * 1991-07-16 1999-02-09 Chugai Seiyaku Kabushiki Kaisha Method of producing a quinolonecarboxylic acid derivative
ES2049636B1 (en) * 1992-04-15 1994-12-16 Genesis Para La Investigacion PROCEDURE FOR THE PREPARATION OF QUINOLINCARBOXILIC ACID DERIVATIVES.
ES2077490B1 (en) * 1992-11-18 1996-10-16 Marga Investigacion TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.
ES2092963B1 (en) * 1995-04-12 1997-12-16 Sint Quimica Sa PROCEDURE FOR THE PREPARATION OF ACID 1-CICLOPROPIL-6-FLUORO-1, 4-DIHIDRO-7- (1S, 4S) -5-METHYL-2,5-DIAZABICICLO (2.2.1) HEPT-2-IL) -4 -OXO-3-QUINOLINCARBOXILICO AND ITS SALTS.
ES2095809B1 (en) * 1995-07-27 1997-12-16 Sint Quimica Sa PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS.
FR2916446B1 (en) 2007-05-24 2009-08-21 Biocodex Sa NOVEL PROCESS FOR SYNTHESIZING FLUOROQUINOLONES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59122470A (en) * 1982-12-27 1984-07-14 Dai Ichi Seiyaku Co Ltd Preparation of quinoline-3-carboxylic acid derivative
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such

Also Published As

Publication number Publication date
CN1032166A (en) 1989-04-05
YU121788A (en) 1989-12-31
KR970005911B1 (en) 1997-04-22
CN1025028C (en) 1994-06-15
JP2693988B2 (en) 1997-12-24
CS412388A2 (en) 1990-11-14
YU46570B (en) 1993-11-16
FI91400B (en) 1994-03-15
WO1988010253A1 (en) 1988-12-29
FI890723A0 (en) 1989-02-15
JPH02500366A (en) 1990-02-08
FI890723A (en) 1989-02-15
DK84089D0 (en) 1989-02-23
FI91400C (en) 1994-06-27
ES2006994A6 (en) 1989-05-16
CS274677B2 (en) 1991-09-15
EP0329719A1 (en) 1989-08-30
CA1325010C (en) 1993-12-07
DK84089A (en) 1989-02-23

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