KR920002547A - Method for preparing omeprazole intermediate - Google Patents

Method for preparing omeprazole intermediate Download PDF

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Publication number
KR920002547A
KR920002547A KR1019900010995A KR900010995A KR920002547A KR 920002547 A KR920002547 A KR 920002547A KR 1019900010995 A KR1019900010995 A KR 1019900010995A KR 900010995 A KR900010995 A KR 900010995A KR 920002547 A KR920002547 A KR 920002547A
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KR
South Korea
Prior art keywords
formula
compound
bromine
iii
organic solvent
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KR1019900010995A
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Korean (ko)
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KR940007306B1 (en
Inventor
김진규
이성호
Original Assignee
김생기
영진약품공업 주식회사
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Priority to KR1019900010995A priority Critical patent/KR940007306B1/en
Publication of KR920002547A publication Critical patent/KR920002547A/en
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Publication of KR940007306B1 publication Critical patent/KR940007306B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

오메프라졸 중간체의 제조방법Method for preparing omeprazole intermediate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

다음 구조식(Ⅱ)의 화합물을 유기용매와 알카리 수용액의 혼합용매중에서 브롬과 반응시켜 다음 구조식(Ⅲ)의 화합들을 얻고, 이 구조식(Ⅲ)의 화합물을 메톡시음이온(-OCH3)과 치환반응시켜서 되는 것을 특징으로 하는 다음 구조식(Ⅰ)로 표시되는 오메프라졸 중간체의 제조방법.The compound of formula (II) is reacted with bromine in a mixed solvent of an organic solvent and an aqueous alkali solution to obtain the compounds of formula (III), and the compound of formula (III) is substituted with methoxy anion (-OCH 3 ). Method for producing an omeprazole intermediate represented by the following structural formula (I), characterized in that 상기식에서 R은 H 또는 CH3이다.In which R is H or CH 3 . 제1항에 있어서, 유기용매로는 메틸렌클로라이드, 클로로포름, 사염화탄소, 이황화탄소, 니트로벤젠, 초산 및 디옥산중에서 선택하여 사용하고, 알카리수용액은 Na, K, Mg 및 Ca의 수산화물 중에서 선택하여 사용함을 특징으로 하는 방법.The method of claim 1, wherein the organic solvent is selected from methylene chloride, chloroform, carbon tetrachloride, carbon disulfide, nitrobenzene, acetic acid and dioxane, and the alkaline aqueous solution is selected from hydroxides of Na, K, Mg and Ca. How to feature. 제1항에 있어서, 알카리 수용액의 사용량은 상기 구조식(Ⅱ)의 화합물에 대하여 1 내지 2몰, 브롬의 사용량은 2 내지 3물로 되도록 하는 것을 특징으로 하는 방법.The method of claim 1, wherein the aqueous alkali solution is used in an amount of 1 to 2 moles, and bromine is used in an amount of 2-3 water based on the compound of the formula (II). 제1항에 있어서, 구조식(Ⅱ)의 화합물과 브롬을 반응시킬때는 60 내지 70℃의 온도에서 반응시키는 것을 특징으로 하는 방법.The method of claim 1, wherein the reaction of the compound of formula (II) with bromine is carried out at a temperature of 60 to 70 ℃. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: This is to be disclosed by the original application.
KR1019900010995A 1990-07-19 1990-07-19 Process for preparation of omeprazole KR940007306B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900010995A KR940007306B1 (en) 1990-07-19 1990-07-19 Process for preparation of omeprazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019900010995A KR940007306B1 (en) 1990-07-19 1990-07-19 Process for preparation of omeprazole

Publications (2)

Publication Number Publication Date
KR920002547A true KR920002547A (en) 1992-02-28
KR940007306B1 KR940007306B1 (en) 1994-08-12

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ID=19301445

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900010995A KR940007306B1 (en) 1990-07-19 1990-07-19 Process for preparation of omeprazole

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KR (1) KR940007306B1 (en)

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Publication number Publication date
KR940007306B1 (en) 1994-08-12

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