ES2077490B1 - TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS. - Google Patents

TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.

Info

Publication number
ES2077490B1
ES2077490B1 ES9202560A ES9202560A ES2077490B1 ES 2077490 B1 ES2077490 B1 ES 2077490B1 ES 9202560 A ES9202560 A ES 9202560A ES 9202560 A ES9202560 A ES 9202560A ES 2077490 B1 ES2077490 B1 ES 2077490B1
Authority
ES
Spain
Prior art keywords
quinolon
application
quinolin
solvates
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9202560A
Other languages
Spanish (es)
Other versions
ES2077490A1 (en
Inventor
Nicolau Francisco E Palomo
Oller Jose Maria Solis
Coll Antonio Luis Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Marga Para la Investigacion SA
Original Assignee
Centro Marga Para la Investigacion SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Marga Para la Investigacion SA filed Critical Centro Marga Para la Investigacion SA
Priority to ES9202560A priority Critical patent/ES2077490B1/en
Publication of ES2077490A1 publication Critical patent/ES2077490A1/en
Application granted granted Critical
Publication of ES2077490B1 publication Critical patent/ES2077490B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

ESTERES TRIMETILSILILICO Y SOLVATOS DE QUELATOS DE ACIDOS QUINOLIN-3-CARBOXILICOS. PREPARACION Y APLICACION AL PROCESO DE QUINOLONAS. SE DESCRIBEN NUEVOS PRODUCTOS IA Y IB; DONDE, X, X1 Y X2 REPRESENTAN INDISTINTAMENTE HIDROGENO, HALOGENO, AMINO O METILO; R ALQUILO, CICLOALQUILO, ARILO; X2R PUEDE FORMAR UN HETEROCICLO; R1 HALOGENO O ACILOXI; M BORO O ALUMINIO, N UN VALOR DE 0,5 A 2,0 Y (A) UN GRUPO AMINO. *FIG* LA SILILACION DE II (A = X1) CON HEXAMETILDISILAZANO, RINDE IA EL CUAL SE COMBINA CON UN DERIVADOR DE BORO (M) PARA FORMAR EL SOLVATO IB. MEDIANTE SUSTITUCION DE X1 POR UNA AMINA (A) Y SIGUIENTE HIDROLISIS, AJUSTANDO EL PH 6, 0-7, 2, RESULTA LA QUINOLONA II. LOS COMPUESTOS IA Y IB SON DE INTERES EN EL PROCESO DE QUINOLONAS, PRODUCTO DE APLICACION EN MEDICINA HUMANA Y ANIMAL.TRIMETILSILILICO ESTERS AND SOLVATES OF QUINOLIN-3-CARBOXILIC ACID CHELATES. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS. NEW PRODUCTS IA AND IB ARE DESCRIBED; WHERE X, X1 AND X2 INDISTINCATELY REPRESENT HYDROGEN, HALOGEN, AMINO OR METHYL; R ALKYL, CYCLLOALKYL, ARYL; X2R MAY FORM A HETERO CYCLE; R1 HALOGEN OR ACILOXI; M BORO OR ALUMINUM, N A VALUE OF 0.5 TO 2.0 AND (A) AN AMINO GROUP. * FIG * SILILATION OF II (A = X1) WITH HEXAMETILDISILAZANO, YIELDS IA WHICH COMBINES WITH A BORON DERIVATOR (M) TO FORM SOLVATE IB. THROUGH SUBSTITUTION OF X1 BY AN AMINE (A) AND FOLLOWING HYDROLYSIS, ADJUSTING PH 6, 0-7, 2, THE QUINOLONE II RESULTS. COMPOUNDS IA AND IB ARE OF INTEREST IN THE QUINOLON PROCESS, A PRODUCT FOR APPLICATION IN HUMAN AND ANIMAL MEDICINE.

ES9202560A 1992-11-18 1992-11-18 TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS. Expired - Lifetime ES2077490B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202560A ES2077490B1 (en) 1992-11-18 1992-11-18 TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202560A ES2077490B1 (en) 1992-11-18 1992-11-18 TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.

Publications (2)

Publication Number Publication Date
ES2077490A1 ES2077490A1 (en) 1995-11-16
ES2077490B1 true ES2077490B1 (en) 1996-10-16

Family

ID=8279146

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202560A Expired - Lifetime ES2077490B1 (en) 1992-11-18 1992-11-18 TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.

Country Status (1)

Country Link
ES (1) ES2077490B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2232309B1 (en) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. SIMPLIFIED PROCEDURE FOR OBTAINING GATIFLOXACINO.
ES2284380B1 (en) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINO AND MOXIFLOXACINO CHLORHYDRATE.
CA2669427A1 (en) * 2006-11-13 2008-05-22 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
CN103360410B (en) * 2012-04-06 2016-01-13 天方药业有限公司 Ofloxacine USP 23 preparation method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196218B (en) * 1985-12-09 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing quinoline carboxylic acid boric acid anhydrides
CA1306750C (en) * 1985-12-09 1992-08-25 Istvan Hermecz Process for the preparation of quinoline carboxylic acide
ES2001463A6 (en) * 1986-12-19 1988-05-16 Chinoin Gyogyszer Es Vegyeszet N-Methylamino-4-oxo-quinoline-3-carboxylic acid derivs. prepn.
ES2001464A6 (en) * 1986-12-19 1988-05-16 Chinoin Gyogyszer Es Vegyeszet Prepn. of oxo-di:hydroxy piperazino:quinoline carboxylic acid cpds.
ES2002445A6 (en) * 1986-12-19 1988-08-01 Chinoin Gyogyszer Es Vegyeszet Prepn. of oxo-di:hydroxy piperazino:quinoline carboxylic acid cpds.
NZ224150A (en) * 1987-04-08 1990-11-27 Chinoin Gyogyszer Es Vegyeszet Preparation of piperazinyl-substituted quinoline derivatives
SI8810667A8 (en) * 1987-04-08 1996-04-30 Chinoin Gyogyszer Es Vegyeszet Anhydride of quinoline carboxylic acid of boron acid and process for their production.
JP2693988B2 (en) * 1987-06-24 1997-12-24 キノイン ギオギスゼル エス ベギエスゼチ テルメケク ギヤラ アールティー． Method for producing quinoline carboxylic acid derivative
HU203746B (en) * 1988-12-22 1991-09-30 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives

Also Published As

Publication number Publication date
ES2077490A1 (en) 1995-11-16

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