GB899023A - Resolving optically active ª--phenoxy alkanoic acids - Google Patents

Resolving optically active ª--phenoxy alkanoic acids

Info

Publication number
GB899023A
GB899023A GB4333060A GB4333060A GB899023A GB 899023 A GB899023 A GB 899023A GB 4333060 A GB4333060 A GB 4333060A GB 4333060 A GB4333060 A GB 4333060A GB 899023 A GB899023 A GB 899023A
Authority
GB
United Kingdom
Prior art keywords
optically active
lysine
alkanoic acids
phenoxy alkanoic
separating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4333060A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB899023A publication Critical patent/GB899023A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for separating an optically active a -phenoxy alkanoic acid of from 9 to 11 carbon atoms from a mixture with its antipode comprises treating a solution of said mixture in an inert organic solvent with an optically active lysine, separating the lysine salt of one of said antipodes by fractional crystallization and recovering the desired optically active acid. In examples is described the resolution of DL-a - isovaleric - and - a - methyl - butyric acids with L-lysine and of DL-a -phenoxypropionic-and -butyric acids with D-lysine. Optically active lysines may be prepared by passing an aqueous solution of optically active lysine hydrochlorides through a bed of an anion-exchange resin.
GB4333060A 1960-09-06 1960-12-16 Resolving optically active ª--phenoxy alkanoic acids Expired GB899023A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5392960A 1960-09-06 1960-09-06

Publications (1)

Publication Number Publication Date
GB899023A true GB899023A (en) 1962-06-20

Family

ID=21987516

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4333060A Expired GB899023A (en) 1960-09-06 1960-12-16 Resolving optically active ª--phenoxy alkanoic acids

Country Status (1)

Country Link
GB (1) GB899023A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431295A (en) * 1964-11-12 1969-03-04 Stamicarbon Process for the preparation of optically active lysine
EP0204911A2 (en) * 1985-04-18 1986-12-17 ALFA WASSERMANN S.p.A. A new process for the optical resolution of racemic mixtures of alpha-naphthylpropionic acids
WO1994003457A1 (en) * 1992-07-30 1994-02-17 Laboratorio Chimico Internazionale S.P.A. A process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole
US5332834A (en) * 1992-12-02 1994-07-26 Hoechst Celanese Corporation Racemization of an enantomerically enriched α-aryl carboxylic acid
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431295A (en) * 1964-11-12 1969-03-04 Stamicarbon Process for the preparation of optically active lysine
EP0204911A2 (en) * 1985-04-18 1986-12-17 ALFA WASSERMANN S.p.A. A new process for the optical resolution of racemic mixtures of alpha-naphthylpropionic acids
EP0204911A3 (en) * 1985-04-18 1988-08-03 Alfa Chemicals Italiana S.P.A. A new process for the optical resolution of racemic mixtures of alpha-naphthylpropionic acids
WO1994003457A1 (en) * 1992-07-30 1994-02-17 Laboratorio Chimico Internazionale S.P.A. A process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole
US5610316A (en) * 1992-07-30 1997-03-11 Laboratorio Chimico Internazionale S.P.A. Process for the preparation of (-)-eserethole from mixtures of (-) and (+)-eserethole
US5332834A (en) * 1992-12-02 1994-07-26 Hoechst Celanese Corporation Racemization of an enantomerically enriched α-aryl carboxylic acid
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
EP0672029A1 (en) * 1992-12-02 1995-09-20 Hoechst Celanese Corporation SELECTIVE PRECIPITATION OF $g(a)-ARYL CARBOXYLIC ACID SALTS
EP0672029A4 (en) * 1992-12-02 1996-02-07 Hoechst Celanese Corp SELECTIVE PRECIPITATION OF -g(a)-ARYL CARBOXYLIC ACID SALTS.

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