ES8604581A1 - Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos - Google Patents

Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos

Info

Publication number
ES8604581A1
ES8604581A1 ES538125A ES538125A ES8604581A1 ES 8604581 A1 ES8604581 A1 ES 8604581A1 ES 538125 A ES538125 A ES 538125A ES 538125 A ES538125 A ES 538125A ES 8604581 A1 ES8604581 A1 ES 8604581A1
Authority
ES
Spain
Prior art keywords
image
apovincaminic acid
acid esters
apovincaminic
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538125A
Other languages
English (en)
Other versions
ES538125A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8604581A1 publication Critical patent/ES8604581A1/es
Publication of ES538125A0 publication Critical patent/ES538125A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS CIS HIDROXIIMINOOCTAHIDROINDOLO2,3-AQUINOLIZINA. COMPRENDE: A) HIDROGENAR CATALITICAMENTE A DERIVADOS DE HEXAHIDROINDOLO2,3-AQUINOLIZINIO DE FORMULA (V) PARA OBTENER LA CIS OCTAHIDROINDOLO2,3-AQUINOLIZINAS DE FORMULA (IV); Y B) HACER REACCIONAR EL RESULTADO DE A) CON NITRITO DE BUTILO TERCIARIO EN UN DISOLVENTE HIDROCARBONADO AROMATICO Y, SUBSIGUIENTEMENTE, CON UN ALCOHOLATO TERCIARIO DE METAL ALCALINO, PARA DAR COMPUESTOS CIS RACEMICOS DE FORMULA (II). SIENDO: R1, R2 Y R3 GRUPOS ALCOHOLITO, IGUALES O DIFERENTES, DE 1 A 6 C; Y X UN RADICAL ACIDO O UN ALCANOLATO DE 1 A 6 C. SE PUEDEN UTILIZAR PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES538125A 1981-06-12 1984-11-30 Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos Expired ES8604581A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU811753A HU186891B (en) 1981-06-12 1981-06-12 Process for producing esters of apovincaminic acid

Publications (2)

Publication Number Publication Date
ES8604581A1 true ES8604581A1 (es) 1986-02-01
ES538125A0 ES538125A0 (es) 1986-02-01

Family

ID=10956018

Family Applications (3)

Application Number Title Priority Date Filing Date
ES513016A Granted ES513016A0 (es) 1981-06-12 1982-06-11 "procedimiento para la preparacion de esteres de acido cis y-o trans-apovincaminico racemicos".
ES523345A Expired ES8504192A1 (es) 1981-06-12 1983-06-16 Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982)
ES538125A Expired ES8604581A1 (es) 1981-06-12 1984-11-30 Procedimiento para la preparacion de derivados cis hidroxiiminooctahidroindolo(2,3-a)quinolizina racemicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES513016A Granted ES513016A0 (es) 1981-06-12 1982-06-11 "procedimiento para la preparacion de esteres de acido cis y-o trans-apovincaminico racemicos".
ES523345A Expired ES8504192A1 (es) 1981-06-12 1983-06-16 Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982)

Country Status (24)

Country Link
US (1) US4474960A (es)
JP (2) JPS5843971A (es)
AT (1) AT382619B (es)
AU (2) AU551445B2 (es)
BE (1) BE893492A (es)
CA (1) CA1258071A (es)
CH (2) CH656128A5 (es)
DE (1) DE3222096A1 (es)
DK (1) DK152651C (es)
ES (3) ES513016A0 (es)
FI (1) FI71142C (es)
FR (2) FR2507605B1 (es)
GB (2) GB2102415B (es)
GE (1) GEP19970819B (es)
GR (1) GR76494B (es)
HU (1) HU186891B (es)
IL (1) IL65922A (es)
IT (1) IT1200961B (es)
NL (1) NL192452C (es)
NO (1) NO821954L (es)
PT (1) PT75042B (es)
SE (2) SE450383B (es)
SU (2) SU1258326A3 (es)
ZA (1) ZA823873B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182411B (en) * 1981-11-03 1984-01-30 Richter Gedeon Vegyeszet Process for preparing eburnamonine derivatives
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU198207B (en) * 1985-04-19 1989-08-28 Richter Gedeon Vegyeszet Process for production of derivatives of eburnamenin and medical compositions containing them
JPH0438474Y2 (es) * 1986-04-30 1992-09-09
JPS63164190U (es) * 1987-02-18 1988-10-26
BE1004471A3 (fr) * 1989-06-21 1992-12-01 Richter Gedeon Vegyeszet Nouveaux derives diester d'octahydro-indolo-[2,3-a]-tetrahydropyranyl [2,3-c] quinolizine racemiques et optiquement actifs et procede pour les preparer.
HU214600B (hu) * 1995-12-22 1998-04-28 Richter Gedeon Vegyészeti Gyár Rt. Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
ES2429132T3 (es) 2001-08-31 2013-11-13 The Rockefeller University Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro
SG10201507362TA (en) 2009-08-05 2015-10-29 Intra Cellular Therapies Inc Novel Regulatory Proteins And Inhibitors
EP3525788B1 (en) * 2016-10-11 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Treatment of synucleinopathies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
HU163143B (es) * 1971-05-07 1973-06-28
US4033969A (en) * 1972-06-19 1977-07-05 Agence Nationale De Valorisation De La Recherche (Anvar) Vincamine derivatives
US4033960A (en) * 1973-07-31 1977-07-05 Bayer Aktiengesellschaft 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation
AU499923B2 (en) * 1975-06-27 1979-05-03 Richter Gedeon Vegyeszeti Gyar N Indoloquinolizine derivatives & their production
FR2389625B1 (es) * 1977-05-06 1980-04-18 Roussel Uclaf
FR2459799A1 (fr) * 1979-06-22 1981-01-16 Synthelabo Synthese de la ()-vincamine
JPS55100383A (en) * 1979-01-25 1980-07-31 Sumitomo Chem Co Ltd Preparation of novel nitrogen-containing polycyclic compound
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
HU181495B (en) * 1979-05-31 1983-07-28 Richter Gedeon Vegyeszet Process for producing hydroxy-imino-eburnane derivatives
HU180927B (en) * 1979-07-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
FR2468605A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede de preparation d'ester de l'acide apovincaminique
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid

Also Published As

Publication number Publication date
IT1200961B (it) 1989-01-27
FR2507605B1 (fr) 1985-12-13
ES8400433A1 (es) 1983-10-16
SU1258326A3 (ru) 1986-09-15
PT75042A (en) 1982-07-01
SE450383B (sv) 1987-06-22
GR76494B (es) 1984-08-10
ES523345A0 (es) 1985-04-01
IL65922A (en) 1985-07-31
DK152651B (da) 1988-04-05
IT8267752A0 (it) 1982-06-11
IL65922A0 (en) 1982-08-31
FR2507605A1 (fr) 1982-12-17
AT382619B (de) 1987-03-25
FR2515653A1 (fr) 1983-05-06
AU568790B2 (en) 1988-01-07
CA1258071A (en) 1989-08-01
AU551445B2 (en) 1986-05-01
HU186891B (en) 1985-10-28
PT75042B (en) 1984-10-09
GB2151629A (en) 1985-07-24
ES513016A0 (es) 1983-10-16
JPH0517474A (ja) 1993-01-26
AU8479882A (en) 1982-12-16
FR2515653B1 (fr) 1985-12-06
NL8202396A (nl) 1983-01-03
GB2151629B (en) 1986-01-02
GB2102415A (en) 1983-02-02
ATA227182A (de) 1986-08-15
ES8504192A1 (es) 1985-04-01
FI821963A0 (fi) 1982-06-02
SE461654B (sv) 1990-03-12
BE893492A (fr) 1982-12-13
DE3222096A1 (de) 1983-01-05
JPS5843971A (ja) 1983-03-14
GEP19970819B (en) 1997-01-30
NL192452C (nl) 1997-08-04
FI71142B (fi) 1986-08-14
SE8700015D0 (sv) 1987-01-02
GB2102415B (en) 1986-01-02
JPH0714932B2 (ja) 1995-02-22
GB8500325D0 (en) 1985-02-13
ES538125A0 (es) 1986-02-01
CH656128A5 (de) 1986-06-13
DK262982A (da) 1982-12-13
FI71142C (fi) 1986-11-24
AU5471286A (en) 1986-07-31
SU1376947A3 (ru) 1988-02-23
US4474960A (en) 1984-10-02
ZA823873B (en) 1983-05-25
NL192452B (nl) 1997-04-01
SE8700015L (sv) 1987-01-02
SE8203580L (sv) 1982-12-13
DK152651C (da) 1988-08-22
CH659474A5 (de) 1987-01-30
NO821954L (no) 1982-12-13

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