ES2006361A6 - Un procedimiento para preparar derivados de insoindolinilo opticamente activos. - Google Patents
Un procedimiento para preparar derivados de insoindolinilo opticamente activos.Info
- Publication number
- ES2006361A6 ES2006361A6 ES8800684A ES8800684A ES2006361A6 ES 2006361 A6 ES2006361 A6 ES 2006361A6 ES 8800684 A ES8800684 A ES 8800684A ES 8800684 A ES8800684 A ES 8800684A ES 2006361 A6 ES2006361 A6 ES 2006361A6
- Authority
- ES
- Spain
- Prior art keywords
- optically active
- compound
- alkyl
- formula
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ISOINDOLINILO OPTICAMENTE ACTIVOS DE FORMULA (I):O UNA SAL DEL MISMO FISIOLOGICAMENTE ACEPTABLE; QUE CONSISTE EN: A) RESOLVER UN COMPUESTO RACEMICO DE FORMULA (II)EN SUS ISOMEROS OPTICOS, PARA DAR UN COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (II) EN FORMA LIBRE O DE SAL; B) HACER REACCIONAR EL COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (II), OBTENIDO EN LA ETAPA ANTERIOR, EN FORMA LIBRE O DE SAL, CON ANHIDRIDO O-FTALICO PARA DAR UN FTALIMIDO COMPUESTO OPTICAMENTE ACTIVO, DE FORMULA (III)C)REDUCIR EL COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (III); Y, SI SE QUIERE, ESTERIFICAR UN COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (I) PARA DAR EL CORRESPONDIENTE COMPUESTO OPTICAMENTE ACTIVO DE FORMULA (I) O SALIFICARLO CON UNA BASE FISIOLOGICAMENTE ACEPTABLE PARA DAR UNA SAL DEL MISMO FISIOLOGICAMENTE ACEPTABLE.LOS COMPUESTOS DE FORMULA (I), PRESENTAN POTENTE ACTIVIDAD INHIBIDORA DE LA AGREGACION DE PLAQUETAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878705601A GB8705601D0 (en) | 1987-03-10 | 1987-03-10 | Oxo-isoindolinyl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2006361A6 true ES2006361A6 (es) | 1989-04-16 |
Family
ID=10613660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8800684A Expired ES2006361A6 (es) | 1987-03-10 | 1988-03-08 | Un procedimiento para preparar derivados de insoindolinilo opticamente activos. |
Country Status (29)
Country | Link |
---|---|
JP (1) | JPH0759555B2 (es) |
KR (1) | KR880011096A (es) |
CN (1) | CN1017527B (es) |
AT (1) | AT392068B (es) |
AU (1) | AU605253B2 (es) |
BE (1) | BE1003280A3 (es) |
CH (1) | CH675419A5 (es) |
DE (1) | DE3807595A1 (es) |
DK (1) | DK168568B1 (es) |
ES (1) | ES2006361A6 (es) |
FI (1) | FI93725C (es) |
FR (1) | FR2612185B1 (es) |
GB (2) | GB8705601D0 (es) |
GR (1) | GR1000515B (es) |
HU (1) | HU201011B (es) |
IE (1) | IE60565B1 (es) |
IL (1) | IL85651A (es) |
IT (1) | IT1227787B (es) |
MY (1) | MY103898A (es) |
NL (1) | NL8800575A (es) |
NO (1) | NO174666C (es) |
NZ (1) | NZ223805A (es) |
PH (1) | PH26254A (es) |
PT (1) | PT86933B (es) |
SE (1) | SE500710C2 (es) |
SU (1) | SU1731046A3 (es) |
UA (1) | UA12840A1 (es) |
YU (1) | YU46565B (es) |
ZA (1) | ZA881686B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
CN100400633C (zh) * | 2006-03-30 | 2008-07-09 | 中国日用化学工业研究院 | 一种手洗餐具洗涤剂及制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2154525A1 (de) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindolinderivate und Verfahren zu ihrer Herstellung |
GB1344663A (en) * | 1970-11-10 | 1974-01-23 | Erba Carlo Spa | Isoindoline compounds |
US4010274A (en) | 1973-07-27 | 1977-03-01 | Carlo Erba | Isoindoline derivatives having platelet anti-aggregating activity |
JPS516959A (en) * | 1974-07-04 | 1976-01-20 | Wakamoto Pharma Co Ltd | Isoindorinjudotaino seizohoho |
US4400520A (en) * | 1980-09-10 | 1983-08-23 | Hisamitsu Pharmaceutical Co., Inc. | Novel process for preparing isoindoline derivatives |
IT1201408B (it) * | 1985-03-22 | 1989-02-02 | Montedison Spa | Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi |
JPH07120969B2 (ja) * | 1989-03-30 | 1995-12-20 | クラリオン株式会社 | スペクトラム拡散変調装置 |
-
1987
- 1987-03-10 GB GB878705601A patent/GB8705601D0/en active Pending
-
1988
- 1988-02-22 PH PH46539A patent/PH26254A/en unknown
- 1988-03-04 CH CH826/88A patent/CH675419A5/de not_active IP Right Cessation
- 1988-03-07 IL IL85651A patent/IL85651A/xx not_active IP Right Cessation
- 1988-03-07 AU AU12679/88A patent/AU605253B2/en not_active Ceased
- 1988-03-07 AT AT0058988A patent/AT392068B/de not_active IP Right Cessation
- 1988-03-07 FR FR888802872A patent/FR2612185B1/fr not_active Expired - Fee Related
- 1988-03-08 GR GR880100137A patent/GR1000515B/el unknown
- 1988-03-08 IT IT8819683A patent/IT1227787B/it active
- 1988-03-08 DE DE3807595A patent/DE3807595A1/de not_active Withdrawn
- 1988-03-08 HU HU881124A patent/HU201011B/hu not_active IP Right Cessation
- 1988-03-08 NL NL8800575A patent/NL8800575A/nl not_active Application Discontinuation
- 1988-03-08 ES ES8800684A patent/ES2006361A6/es not_active Expired
- 1988-03-08 YU YU46788A patent/YU46565B/sh unknown
- 1988-03-08 KR KR1019880002373A patent/KR880011096A/ko not_active Application Discontinuation
- 1988-03-09 UA UA4355276A patent/UA12840A1/uk unknown
- 1988-03-09 SU SU884355276A patent/SU1731046A3/ru active
- 1988-03-09 JP JP63055954A patent/JPH0759555B2/ja not_active Expired - Lifetime
- 1988-03-09 DK DK128988A patent/DK168568B1/da not_active IP Right Cessation
- 1988-03-09 NO NO881055A patent/NO174666C/no unknown
- 1988-03-09 GB GB8805631A patent/GB2204579B/en not_active Expired - Fee Related
- 1988-03-09 FI FI881075A patent/FI93725C/fi not_active IP Right Cessation
- 1988-03-09 NZ NZ223805A patent/NZ223805A/en unknown
- 1988-03-09 ZA ZA881686A patent/ZA881686B/xx unknown
- 1988-03-09 BE BE8800258A patent/BE1003280A3/fr not_active IP Right Cessation
- 1988-03-09 CN CN88101200A patent/CN1017527B/zh not_active Expired
- 1988-03-09 PT PT86933A patent/PT86933B/pt not_active IP Right Cessation
- 1988-03-09 SE SE8800846A patent/SE500710C2/sv unknown
- 1988-03-10 MY MYPI88000246A patent/MY103898A/en unknown
- 1988-08-07 IE IE64888A patent/IE60565B1/en not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19991108 |