MY103898A - Optically active oxo-isoindolinyi derivatives - Google Patents

Optically active oxo-isoindolinyi derivatives

Info

Publication number
MY103898A
MY103898A MYPI88000246A MYPI19880246A MY103898A MY 103898 A MY103898 A MY 103898A MY PI88000246 A MYPI88000246 A MY PI88000246A MY PI19880246 A MYPI19880246 A MY PI19880246A MY 103898 A MY103898 A MY 103898A
Authority
MY
Malaysia
Prior art keywords
optically active
formula
compound
alkyl
isoindolinyi
Prior art date
Application number
MYPI88000246A
Inventor
Ceroni Giorgio
Orzi Fabrizio
Griggi Pierluigi
Carniel Giovanni
Miorini Bruno
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of MY103898A publication Critical patent/MY103898A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

OPTICALLY ACTIVE OXO-ISOINDOLINYL COMPOUNDS OF FORMULA (I) (FORMULA 1) WHEREIN R IS C1-C4 ALKYL; AND R1 IS HYDROGEN, C1-C4 ALKYL OR (FORMULA) WHEREIN N IS 1 OR 2 AND EACH OF R2 AND R3, WHICH MAY BE THE SAME OR DIFFERENT, IS HYDROGEN OR C1-C4 ALKYL, OR PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF, ARE PREPARED BY RESOLVING A RACEMIC COMPOUND OF FORMULA (II) (FORMULA II) INTO ITS OPTICAL ISOMERS, TO GIVE AN OPTICALLY ACTIVE COMPOUND OF FORMULA (II) AS SUCH OR AS A SALT; REACTING THE SAID COMPOUND OR SALT WITH O-PHTHALIC ANHYDRIDE TO GIVE THE CORRESPONDING OPTICALLY ACTIVE PHTHALIMIDO COMPOUND; AND REDUCING THE OPTICALLY ACTIVE PHTHALIMIDO COMPOUND. THE PRODUCT OBTAINED CAN BE ESTERIFIED OR SALIFIED AS DESIRED. THE RESULTANT OPTICALLY ACTIVE COMPOUNDS, IN PARTICULAR THAT IN WHICH R IS ETHYL, EXHIBIT PLATELET AGGREGATION-INHIBITING ACTIVITY.
MYPI88000246A 1987-03-10 1988-03-10 Optically active oxo-isoindolinyi derivatives MY103898A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878705601A GB8705601D0 (en) 1987-03-10 1987-03-10 Oxo-isoindolinyl derivatives

Publications (1)

Publication Number Publication Date
MY103898A true MY103898A (en) 1993-10-30

Family

ID=10613660

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI88000246A MY103898A (en) 1987-03-10 1988-03-10 Optically active oxo-isoindolinyi derivatives

Country Status (29)

Country Link
JP (1) JPH0759555B2 (en)
KR (1) KR880011096A (en)
CN (1) CN1017527B (en)
AT (1) AT392068B (en)
AU (1) AU605253B2 (en)
BE (1) BE1003280A3 (en)
CH (1) CH675419A5 (en)
DE (1) DE3807595A1 (en)
DK (1) DK168568B1 (en)
ES (1) ES2006361A6 (en)
FI (1) FI93725C (en)
FR (1) FR2612185B1 (en)
GB (2) GB8705601D0 (en)
GR (1) GR1000515B (en)
HU (1) HU201011B (en)
IE (1) IE60565B1 (en)
IL (1) IL85651A (en)
IT (1) IT1227787B (en)
MY (1) MY103898A (en)
NL (1) NL8800575A (en)
NO (1) NO174666C (en)
NZ (1) NZ223805A (en)
PH (1) PH26254A (en)
PT (1) PT86933B (en)
SE (1) SE500710C2 (en)
SU (1) SU1731046A3 (en)
UA (1) UA12840A1 (en)
YU (1) YU46565B (en)
ZA (1) ZA881686B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
IT1256450B (en) * 1992-11-26 1995-12-05 Soldato Piero Del NITRIC ESTERS WITH PHARMACOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
CN100400633C (en) * 2006-03-30 2008-07-09 中国日用化学工业研究院 Detergent for washing dishware with hand and its preparation method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2154525A1 (en) * 1970-11-05 1972-06-15 Carlo Erba S.P.A., Mailand (Italien) Isoindoline derivatives and processes for their preparation
GB1344663A (en) * 1970-11-10 1974-01-23 Erba Carlo Spa Isoindoline compounds
US4010274A (en) 1973-07-27 1977-03-01 Carlo Erba Isoindoline derivatives having platelet anti-aggregating activity
JPS516959A (en) * 1974-07-04 1976-01-20 Wakamoto Pharma Co Ltd Isoindorinjudotaino seizohoho
US4400520A (en) * 1980-09-10 1983-08-23 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindoline derivatives
IT1201408B (en) * 1985-03-22 1989-02-02 Montedison Spa PROCESS FOR THE BIOTECHNOLOGICAL PREPARATION OF OPTICALLY ACTIVE ALFA-ARILALCANOIC ACIDS
JPH07120969B2 (en) * 1989-03-30 1995-12-20 クラリオン株式会社 Spread spectrum modulator

Also Published As

Publication number Publication date
FI93725C (en) 1995-05-26
IT1227787B (en) 1991-05-07
DK128988A (en) 1988-09-11
PH26254A (en) 1992-04-01
SE500710C2 (en) 1994-08-15
NO174666C (en) 1994-06-15
NZ223805A (en) 1990-11-27
FI881075A0 (en) 1988-03-09
IT8819683A0 (en) 1988-03-08
CH675419A5 (en) 1990-09-28
HU201011B (en) 1990-09-28
HUT47247A (en) 1989-02-28
GB2204579B (en) 1991-01-30
CN1017527B (en) 1992-07-22
SE8800846D0 (en) 1988-03-09
KR880011096A (en) 1988-10-26
YU46565B (en) 1993-11-16
IL85651A (en) 1991-07-18
NO881055D0 (en) 1988-03-09
SE8800846L (en) 1988-09-11
GR1000515B (en) 1992-07-30
JPH0759555B2 (en) 1995-06-28
NL8800575A (en) 1988-10-03
YU46788A (en) 1990-04-30
SU1731046A3 (en) 1992-04-30
NO881055L (en) 1988-09-12
AT392068B (en) 1991-01-25
FI881075A (en) 1988-09-11
CN88101200A (en) 1988-10-26
IL85651A0 (en) 1988-08-31
PT86933B (en) 1992-05-29
BE1003280A3 (en) 1992-02-18
DK128988D0 (en) 1988-03-09
PT86933A (en) 1988-04-01
GB8705601D0 (en) 1987-04-15
GB2204579A (en) 1988-11-16
IE880648L (en) 1988-09-10
ATA58988A (en) 1990-07-15
DE3807595A1 (en) 1988-09-22
FR2612185B1 (en) 1992-08-28
FR2612185A1 (en) 1988-09-16
AU605253B2 (en) 1991-01-10
DK168568B1 (en) 1994-04-25
GB8805631D0 (en) 1988-04-07
ES2006361A6 (en) 1989-04-16
JPS63238058A (en) 1988-10-04
AU1267988A (en) 1988-09-08
IE60565B1 (en) 1994-07-27
UA12840A1 (en) 1997-02-28
FI93725B (en) 1995-02-15
NO174666B (en) 1994-03-07
GR880100137A (en) 1989-01-31
ZA881686B (en) 1989-11-29

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