BE1003280A3 - OPTICALLY ACTIVE OXO-ISOINDOLINIC DERIVATIVES. - Google Patents

OPTICALLY ACTIVE OXO-ISOINDOLINIC DERIVATIVES. Download PDF

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Publication number
BE1003280A3
BE1003280A3 BE8800258A BE8800258A BE1003280A3 BE 1003280 A3 BE1003280 A3 BE 1003280A3 BE 8800258 A BE8800258 A BE 8800258A BE 8800258 A BE8800258 A BE 8800258A BE 1003280 A3 BE1003280 A3 BE 1003280A3
Authority
BE
Belgium
Prior art keywords
optically active
isoindolinic
derivatives
radical
alkyl radical
Prior art date
Application number
BE8800258A
Other languages
French (fr)
Inventor
Carniel Giovanni
Orzi Fabrizio
Ceroni Giorgio
Miorini Bruno
Griggi Pierluigi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Application granted granted Critical
Publication of BE1003280A3 publication Critical patent/BE1003280A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nouveau procédé de préparation de composés optiquement actifs, répondant à la formule dans laquelle R représente un radical alkyle en C1 -C4 et R1 représente un atome d'hydrogène, un radical alkyle en C1 -C4 ou un radical -(CH2)n-NR2-R3 où n est égal à 1 ou à 2 et chacun des symboles R2 et R3 qui peuvent être identiques ou différents, représente un atome d'hydrogène ou un radical alkyle en C1-C4, et de leurs sels physiologiquement compatibles. L'invention a aussi pour objet des composés optiquement actifs de la formule (I) dans laquelle R représente le radical éthyle, composés qui montrent, plus particulièrement, une remarquable activité inhibitrice de la thrombo-agglutination.New process for the preparation of optically active compounds, corresponding to the formula in which R represents a C1-C4 alkyl radical and R1 represents a hydrogen atom, a C1-C4 alkyl radical or a - (CH2) n-NR2 radical -R3 where n is equal to 1 or 2 and each of the symbols R2 and R3 which may be identical or different, represents a hydrogen atom or a C1-C4 alkyl radical, and of their physiologically compatible salts. The invention also relates to optically active compounds of formula (I) in which R represents the ethyl radical, compounds which show, more particularly, a remarkable inhibitory activity of thromboagglutination.

BE8800258A 1987-03-10 1988-03-09 OPTICALLY ACTIVE OXO-ISOINDOLINIC DERIVATIVES. BE1003280A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878705601A GB8705601D0 (en) 1987-03-10 1987-03-10 Oxo-isoindolinyl derivatives

Publications (1)

Publication Number Publication Date
BE1003280A3 true BE1003280A3 (en) 1992-02-18

Family

ID=10613660

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800258A BE1003280A3 (en) 1987-03-10 1988-03-09 OPTICALLY ACTIVE OXO-ISOINDOLINIC DERIVATIVES.

Country Status (29)

Country Link
JP (1) JPH0759555B2 (en)
KR (1) KR880011096A (en)
CN (1) CN1017527B (en)
AT (1) AT392068B (en)
AU (1) AU605253B2 (en)
BE (1) BE1003280A3 (en)
CH (1) CH675419A5 (en)
DE (1) DE3807595A1 (en)
DK (1) DK168568B1 (en)
ES (1) ES2006361A6 (en)
FI (1) FI93725C (en)
FR (1) FR2612185B1 (en)
GB (2) GB8705601D0 (en)
GR (1) GR1000515B (en)
HU (1) HU201011B (en)
IE (1) IE60565B1 (en)
IL (1) IL85651A (en)
IT (1) IT1227787B (en)
MY (1) MY103898A (en)
NL (1) NL8800575A (en)
NO (1) NO174666C (en)
NZ (1) NZ223805A (en)
PH (1) PH26254A (en)
PT (1) PT86933B (en)
SE (1) SE500710C2 (en)
SU (1) SU1731046A3 (en)
UA (1) UA12840A1 (en)
YU (1) YU46565B (en)
ZA (1) ZA881686B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
IT1256450B (en) * 1992-11-26 1995-12-05 Soldato Piero Del NITRIC ESTERS WITH PHARMACOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
CN100400633C (en) * 2006-03-30 2008-07-09 中国日用化学工业研究院 Detergent for washing dishware with hand and its preparation method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2258088A1 (en) * 1970-11-05 1974-04-18 Erba Carlo Spa Dextrorotatory isoindoline derivs - with analgesic and anti-inflammatory activity
EP0047674A1 (en) * 1980-09-10 1982-03-17 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindolin derivatives
EP0195717A2 (en) * 1985-03-22 1986-09-24 Montedison S.p.A. Process for the biotechnological preparation of optically active alpha-arylalkanoic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1344663A (en) * 1970-11-10 1974-01-23 Erba Carlo Spa Isoindoline compounds
US4010274A (en) * 1973-07-27 1977-03-01 Carlo Erba Isoindoline derivatives having platelet anti-aggregating activity
JPS516959A (en) * 1974-07-04 1976-01-20 Wakamoto Pharma Co Ltd Isoindorinjudotaino seizohoho
JPH07120969B2 (en) * 1989-03-30 1995-12-20 クラリオン株式会社 Spread spectrum modulator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2258088A1 (en) * 1970-11-05 1974-04-18 Erba Carlo Spa Dextrorotatory isoindoline derivs - with analgesic and anti-inflammatory activity
EP0047674A1 (en) * 1980-09-10 1982-03-17 Hisamitsu Pharmaceutical Co., Inc. Novel process for preparing isoindolin derivatives
EP0195717A2 (en) * 1985-03-22 1986-09-24 Montedison S.p.A. Process for the biotechnological preparation of optically active alpha-arylalkanoic acids

Also Published As

Publication number Publication date
GR880100137A (en) 1989-01-31
CH675419A5 (en) 1990-09-28
FR2612185A1 (en) 1988-09-16
YU46788A (en) 1990-04-30
IL85651A0 (en) 1988-08-31
GR1000515B (en) 1992-07-30
AU1267988A (en) 1988-09-08
ATA58988A (en) 1990-07-15
JPS63238058A (en) 1988-10-04
CN1017527B (en) 1992-07-22
IT8819683A0 (en) 1988-03-08
NO174666B (en) 1994-03-07
ZA881686B (en) 1989-11-29
HU201011B (en) 1990-09-28
NO174666C (en) 1994-06-15
NZ223805A (en) 1990-11-27
ES2006361A6 (en) 1989-04-16
NO881055D0 (en) 1988-03-09
IE880648L (en) 1988-09-10
YU46565B (en) 1993-11-16
GB8805631D0 (en) 1988-04-07
AT392068B (en) 1991-01-25
DK168568B1 (en) 1994-04-25
GB8705601D0 (en) 1987-04-15
NO881055L (en) 1988-09-12
FR2612185B1 (en) 1992-08-28
NL8800575A (en) 1988-10-03
SE8800846L (en) 1988-09-11
AU605253B2 (en) 1991-01-10
JPH0759555B2 (en) 1995-06-28
FI93725C (en) 1995-05-26
KR880011096A (en) 1988-10-26
PT86933A (en) 1988-04-01
SE8800846D0 (en) 1988-03-09
PT86933B (en) 1992-05-29
IE60565B1 (en) 1994-07-27
IT1227787B (en) 1991-05-07
DE3807595A1 (en) 1988-09-22
FI93725B (en) 1995-02-15
MY103898A (en) 1993-10-30
HUT47247A (en) 1989-02-28
GB2204579B (en) 1991-01-30
IL85651A (en) 1991-07-18
FI881075A0 (en) 1988-03-09
DK128988D0 (en) 1988-03-09
PH26254A (en) 1992-04-01
GB2204579A (en) 1988-11-16
FI881075A (en) 1988-09-11
UA12840A1 (en) 1997-02-28
CN88101200A (en) 1988-10-26
SE500710C2 (en) 1994-08-15
SU1731046A3 (en) 1992-04-30
DK128988A (en) 1988-09-11

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.R.L.

Effective date: 19950331