GR1000515B - Μεθοδος παρασκευης οπτικως ενεργων παραγωγων οξοισοινδολινυλιου. - Google Patents
Μεθοδος παρασκευης οπτικως ενεργων παραγωγων οξοισοινδολινυλιου.Info
- Publication number
- GR1000515B GR1000515B GR880100137A GR880100137A GR1000515B GR 1000515 B GR1000515 B GR 1000515B GR 880100137 A GR880100137 A GR 880100137A GR 880100137 A GR880100137 A GR 880100137A GR 1000515 B GR1000515 B GR 1000515B
- Authority
- GR
- Greece
- Prior art keywords
- type
- visually active
- alkyl
- active compound
- give
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η εφεύρεση αναφέρεται σε μια νέο μέθοδο παρασκευής οπτικώς ενεργών ενώσεων του τύπου (Ι) όπου το R είναι αλκύλιο C1-C4, και το R1 είναι υδρογόνο, αλκύλιο C1-C4 ή (χημικός τύπος) όπου το n είναι 1 ή 2 και έκαστο των R2 και R3, τα οποία μπορεί να είναι ίδια ή διάφορα, είναι υδρογόνο ή αλκύλιο C1-C4 και των φυσιολογικώς αποδεκτών αλάτων τους, όπου η μέθοδος περιλαμβάνει: (α) τον διαχωρισμό μιας ρακεμικής ενώσεως του τύπου (II)(χημικός τύπος) όπου τα R και R1 είναι ως καθορίσθη ανωτέρω, στα οπτικά ισομερή της, για να δώσει μιαν οπτικώς ενεργόν ένωσιν του τύπου (II) όπως έχει ή ως άλας (β) την αντίδραση μιας οπτικώς ενεργού ενώσεως του τύπου (ΙΙ) που λαμβάνεται κατ' αυτόν τον τρόπον, ως έχει ή ως άλας, με ο-φθαλικόν ανυδρίτη για να δώσει μίαν οπτικώς ενεργό φθαλιμιδοένωσιν του τύπου (III)(χημικός τύπος) όπου τα R και R1 είναι ως ανεφέρθη ανωτέρω, και (γ) την αναγωγή της οπτικώς ενεργού ενώσεως του τύπου (III) και, εάν επιθυμείται, την εστεροποίηση μιας έτσι λαμβανομένης οπτικώς ενεργού ενώσεως (Ι) όπου το R1 είναι υδρογόνο για να δώσει την αντίστοιχη οπτικώς ενεργού ένωσιν του τύπου (I) όπου το R1 είναι αλκύλιο C1-C4 ή ομάς ω
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878705601A GB8705601D0 (en) | 1987-03-10 | 1987-03-10 | Oxo-isoindolinyl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR880100137A GR880100137A (en) | 1989-01-31 |
| GR1000515B true GR1000515B (el) | 1992-07-30 |
Family
ID=10613660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR880100137A GR1000515B (el) | 1987-03-10 | 1988-03-08 | Μεθοδος παρασκευης οπτικως ενεργων παραγωγων οξοισοινδολινυλιου. |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPH0759555B2 (el) |
| KR (1) | KR880011096A (el) |
| CN (1) | CN1017527B (el) |
| AT (1) | AT392068B (el) |
| AU (1) | AU605253B2 (el) |
| BE (1) | BE1003280A3 (el) |
| CH (1) | CH675419A5 (el) |
| DE (1) | DE3807595A1 (el) |
| DK (1) | DK168568B1 (el) |
| ES (1) | ES2006361A6 (el) |
| FI (1) | FI93725C (el) |
| FR (1) | FR2612185B1 (el) |
| GB (2) | GB8705601D0 (el) |
| GR (1) | GR1000515B (el) |
| HU (1) | HU201011B (el) |
| IE (1) | IE60565B1 (el) |
| IL (1) | IL85651A (el) |
| IT (1) | IT1227787B (el) |
| MY (1) | MY103898A (el) |
| NL (1) | NL8800575A (el) |
| NO (1) | NO174666C (el) |
| NZ (1) | NZ223805A (el) |
| PH (1) | PH26254A (el) |
| PT (1) | PT86933B (el) |
| SE (1) | SE500710C2 (el) |
| SU (1) | SU1731046A3 (el) |
| UA (1) | UA12840A1 (el) |
| YU (1) | YU46565B (el) |
| ZA (1) | ZA881686B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
| CN100400633C (zh) * | 2006-03-30 | 2008-07-09 | 中国日用化学工业研究院 | 一种手洗餐具洗涤剂及制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154525A1 (de) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindolinderivate und Verfahren zu ihrer Herstellung |
| GB1344663A (en) * | 1970-11-10 | 1974-01-23 | Erba Carlo Spa | Isoindoline compounds |
| US4010274A (en) | 1973-07-27 | 1977-03-01 | Carlo Erba | Isoindoline derivatives having platelet anti-aggregating activity |
| JPS516959A (en) * | 1974-07-04 | 1976-01-20 | Wakamoto Pharma Co Ltd | Isoindorinjudotaino seizohoho |
| US4400520A (en) * | 1980-09-10 | 1983-08-23 | Hisamitsu Pharmaceutical Co., Inc. | Novel process for preparing isoindoline derivatives |
| IT1201408B (it) * | 1985-03-22 | 1989-02-02 | Montedison Spa | Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi |
| JPH07120969B2 (ja) * | 1989-03-30 | 1995-12-20 | クラリオン株式会社 | スペクトラム拡散変調装置 |
-
1987
- 1987-03-10 GB GB878705601A patent/GB8705601D0/en active Pending
-
1988
- 1988-02-22 PH PH46539A patent/PH26254A/en unknown
- 1988-03-04 CH CH826/88A patent/CH675419A5/de not_active IP Right Cessation
- 1988-03-07 FR FR888802872A patent/FR2612185B1/fr not_active Expired - Fee Related
- 1988-03-07 AT AT0058988A patent/AT392068B/de not_active IP Right Cessation
- 1988-03-07 AU AU12679/88A patent/AU605253B2/en not_active Ceased
- 1988-03-07 IL IL85651A patent/IL85651A/xx not_active IP Right Cessation
- 1988-03-08 IT IT8819683A patent/IT1227787B/it active
- 1988-03-08 GR GR880100137A patent/GR1000515B/el unknown
- 1988-03-08 ES ES8800684A patent/ES2006361A6/es not_active Expired
- 1988-03-08 YU YU46788A patent/YU46565B/sh unknown
- 1988-03-08 DE DE3807595A patent/DE3807595A1/de not_active Withdrawn
- 1988-03-08 NL NL8800575A patent/NL8800575A/nl not_active Application Discontinuation
- 1988-03-08 KR KR1019880002373A patent/KR880011096A/ko not_active Application Discontinuation
- 1988-03-08 HU HU881124A patent/HU201011B/hu not_active IP Right Cessation
- 1988-03-09 GB GB8805631A patent/GB2204579B/en not_active Expired - Fee Related
- 1988-03-09 JP JP63055954A patent/JPH0759555B2/ja not_active Expired - Lifetime
- 1988-03-09 NO NO881055A patent/NO174666C/no unknown
- 1988-03-09 NZ NZ223805A patent/NZ223805A/en unknown
- 1988-03-09 SU SU884355276A patent/SU1731046A3/ru active
- 1988-03-09 DK DK128988A patent/DK168568B1/da not_active IP Right Cessation
- 1988-03-09 SE SE8800846A patent/SE500710C2/sv unknown
- 1988-03-09 FI FI881075A patent/FI93725C/fi not_active IP Right Cessation
- 1988-03-09 UA UA4355276A patent/UA12840A1/uk unknown
- 1988-03-09 CN CN88101200A patent/CN1017527B/zh not_active Expired
- 1988-03-09 ZA ZA881686A patent/ZA881686B/xx unknown
- 1988-03-09 BE BE8800258A patent/BE1003280A3/fr not_active IP Right Cessation
- 1988-03-09 PT PT86933A patent/PT86933B/pt not_active IP Right Cessation
- 1988-03-10 MY MYPI88000246A patent/MY103898A/en unknown
- 1988-08-07 IE IE64888A patent/IE60565B1/en not_active IP Right Cessation
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