ES8800888A1 - Procedimiento para la preparacion de compuestos analogos in-denicos de la mevalonolactona y sus derivados - Google Patents

Procedimiento para la preparacion de compuestos analogos in-denicos de la mevalonolactona y sus derivados

Info

Publication number
ES8800888A1
ES8800888A1 ES549546A ES549546A ES8800888A1 ES 8800888 A1 ES8800888 A1 ES 8800888A1 ES 549546 A ES549546 A ES 549546A ES 549546 A ES549546 A ES 549546A ES 8800888 A1 ES8800888 A1 ES 8800888A1
Authority
ES
Spain
Prior art keywords
6alkyl
hydrogen
3alkyl
benzyloxy
phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549546A
Other languages
English (en)
Other versions
ES549546A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES549546A0 publication Critical patent/ES549546A0/es
Publication of ES8800888A1 publication Critical patent/ES8800888A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS ANALOGOS IDENTICOS DE LA MEVALONOLACTONA. CONSISTE EN LACTONIZAR A UN COMPUESTO DE FORMULA (I) EN FORMA DE ACIDO LIBRE CON CARBODIIMIDA, EN CLORURO DE METILENO Y ENTRE 10 Y 35JC, PARA OBTENER UN COMPUESTO ANALOGO IDENTICO DE LA MEVALONOLACTONA DE FORMULA (I). SIENDO: R, H O (A); R0, (A) O CICLOALQUILO DE C 3 A 7; R1 (A); R2, H, ALQUILO DE C 1 A 4 Y OTROS; R3, H, ALQUILO DE C 1 A 3 Y OTROS; R7, (A); R10, R3; X, (CH2)N O -(CH2)Q-CHFCH-(CH2)Q; Q, UN RADICAL DE FORMULA (II); (A), ALQUILO DE C 1 A 6 PRIMARIO O SECUNDARIO; R, 1 A 3; Y Q, 0 O 1. SE UTILIZAN COMO ANTI-ARTEROSCLEROTICOS.
ES549546A 1984-12-04 1985-12-03 Procedimiento para la preparacion de compuestos analogos in-denicos de la mevalonolactona y sus derivados Expired ES8800888A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67791784A 1984-12-04 1984-12-04

Publications (2)

Publication Number Publication Date
ES549546A0 ES549546A0 (es) 1987-12-01
ES8800888A1 true ES8800888A1 (es) 1987-12-01

Family

ID=24720627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549546A Expired ES8800888A1 (es) 1984-12-04 1985-12-03 Procedimiento para la preparacion de compuestos analogos in-denicos de la mevalonolactona y sus derivados

Country Status (19)

Country Link
EP (1) EP0216785B1 (es)
JP (1) JPS62501009A (es)
KR (1) KR910003427B1 (es)
AT (1) ATE60571T1 (es)
AU (1) AU599580B2 (es)
DE (1) DE3581638D1 (es)
DK (1) DK369086D0 (es)
ES (1) ES8800888A1 (es)
FI (1) FI863121A (es)
GR (1) GR852895B (es)
HU (1) HU198005B (es)
IL (1) IL77199A (es)
MY (1) MY100972A (es)
NZ (1) NZ214402A (es)
PH (1) PH24502A (es)
PL (1) PL147645B1 (es)
PT (1) PT81603B (es)
WO (1) WO1986003488A1 (es)
ZA (1) ZA859303B (es)

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US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
US4876280A (en) * 1988-03-10 1989-10-24 Sandoz Pharm. Corp. Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
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US5189180A (en) * 1989-09-28 1993-02-23 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
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Also Published As

Publication number Publication date
HU198005B (en) 1989-07-28
DK369086A (da) 1986-08-01
PL256608A1 (en) 1988-01-07
HUT40398A (en) 1986-12-28
IL77199A (en) 1990-02-09
PT81603A (en) 1986-01-01
DK369086D0 (da) 1986-08-01
GR852895B (es) 1986-04-01
KR870700063A (ko) 1987-02-28
ES549546A0 (es) 1987-12-01
ATE60571T1 (de) 1991-02-15
WO1986003488A1 (en) 1986-06-19
FI863121A0 (fi) 1986-07-30
ZA859303B (en) 1987-07-29
EP0216785A1 (en) 1987-04-08
PL147645B1 (en) 1989-07-31
EP0216785B1 (en) 1991-01-30
KR910003427B1 (ko) 1991-05-31
FI863121A (fi) 1986-07-30
JPS62501009A (ja) 1987-04-23
AU599580B2 (en) 1990-07-26
PH24502A (en) 1990-07-18
DE3581638D1 (de) 1991-03-07
PT81603B (pt) 1988-04-21
AU5230686A (en) 1986-07-01
NZ214402A (en) 1989-01-27
MY100972A (en) 1991-06-15

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