CA2738317C - Imaging analyzer for testing analytes - Google Patents

Imaging analyzer for testing analytes Download PDF

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Publication number
CA2738317C
CA2738317C CA2738317A CA2738317A CA2738317C CA 2738317 C CA2738317 C CA 2738317C CA 2738317 A CA2738317 A CA 2738317A CA 2738317 A CA2738317 A CA 2738317A CA 2738317 C CA2738317 C CA 2738317C
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Canada
Prior art keywords
analyzer
sample
imaging
container
image
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Application number
CA2738317A
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English (en)
French (fr)
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CA2738317A1 (en
Inventor
Bruce Walsh
Boris Blanter
Matthew Barra
Brian Connelly
Greg Yantz
Paul Gervasio
Don Straus
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First Light Diagnostics Inc
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First Light Biosciences Inc
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Families Citing this family (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4363980B2 (ja) 2001-09-06 2009-11-11 ジェノミック プロファイリング システムズ インコーポレイティッド 複製細胞の迅速な検出
CA2623408C (en) 2005-09-26 2014-04-01 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US9557217B2 (en) * 2007-02-13 2017-01-31 Bti Holdings, Inc. Universal multidetection system for microplates
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
US8278108B2 (en) * 2009-01-29 2012-10-02 Hitachi High-Technologies Corporation Automatic analyzer
CN102413936B (zh) * 2009-05-06 2016-08-03 比奥卡尔齐斯股份有限公司 用于切削样本载体的设备
WO2011089603A1 (en) * 2010-01-21 2011-07-28 Biocep Ltd. Magnetic separation of rare cells
JP5632453B2 (ja) * 2010-03-15 2014-11-26 アークレイ株式会社 情報取得装置、測定システム、及び情報取得方法
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
EP2579045B1 (en) * 2010-05-24 2021-09-15 Hitachi High-Tech Corporation Sample test automation system
CN103140755B (zh) 2010-07-22 2016-03-16 哈希公司 用于碱度分析的芯片上实验室
AU2013245472B2 (en) * 2010-08-25 2014-11-06 Concateno Uk Limited Sample Testing Apparatus and Method
GB2483077A (en) * 2010-08-25 2012-02-29 Concateno Uk Ltd Sample testing assay apparatus and method
JP6150171B2 (ja) * 2010-10-07 2017-06-21 シリコン バイオディバイスイズ，インク． 標的検体を検出するための装置
IT1403792B1 (it) * 2010-12-30 2013-10-31 St Microelectronics Srl Analizzatore per analisi biochimiche e metodo per la determinazione di concentrazioni di sostanze fluorescenti in una soluzione
JP5922678B2 (ja) * 2011-01-08 2016-05-24 アクセス メディカル システムズ，リミティド 免疫学的検定試験のためのシステム
WO2013045695A2 (en) * 2011-09-30 2013-04-04 Pz Cormay S.A. Method for delivering a sample of body fluid to an analysing system, a syringe designed for use therein and a kit comprising such a syringe
WO2013070730A2 (en) 2011-11-07 2013-05-16 Rapid Micro Biosystems, Inc. Cassette for sterility testing
US9381524B2 (en) 2011-11-08 2016-07-05 Becton, Dickinson And Company System and method for automated sample preparation
CA2856094C (en) * 2011-11-20 2017-03-21 Fio Corporation A quality control sensor method, system and device for use with biological/environmental rapid diagnostic test devices
US8741235B2 (en) * 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
US20150044098A1 (en) * 2012-01-30 2015-02-12 Scanadu Incorporated Hyperspectral imaging systems, units, and methods
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9050594B2 (en) 2012-02-13 2015-06-09 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
KR20140143139A (ko) * 2012-03-08 2014-12-15 소니 주식회사 핵산 증폭 반응용 마이크로 칩의 제조 방법
ES2805025T3 (es) * 2012-04-12 2021-02-10 Becton Dickinson Co Métodos, sistemas y dispositivos para detectar e identificar microorganismos en muestras de cultivo microbiológicas
US20130280698A1 (en) * 2012-04-24 2013-10-24 Arizona Board Of Regents, Acting For And On Behalf Of Northern Arizona University Rapid multiplex lateral flow assay device
US9063037B2 (en) * 2012-05-02 2015-06-23 Stat-Diagnostica & Innovation, S.L. Swab elution chamber in a test cartridge
US10132736B2 (en) * 2012-05-24 2018-11-20 Abbvie Inc. Methods for inspection of protein particles in a liquid beneficial agent
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
US10274490B2 (en) * 2012-06-12 2019-04-30 The General Hospital Corporation Magnetic labeling of bacteria
CN102721643B (zh) * 2012-06-28 2015-07-15 北京利德曼生化股份有限公司 一种增加340nm处光强的光学系统和方法
US9657290B2 (en) * 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
US9588037B2 (en) * 2012-07-13 2017-03-07 The Regents Of The University Of California High throughput lens-free three-dimensional tracking of sperm
TW201404878A (zh) * 2012-07-27 2014-02-01 Hsian-Chang Chen 自動快速分析生物細胞的裝置和其相關的方法
CA2881028C (en) 2012-09-06 2021-11-02 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
CA2887635C (en) * 2012-10-11 2021-01-26 Siemens Healthcare Diagnostics Inc. Automation maintenance carrier
US9135515B2 (en) * 2012-10-22 2015-09-15 Qiagen Gaithersburg, Inc. Automated pelletized sample vision inspection apparatus and methods
US9957553B2 (en) * 2012-10-24 2018-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
DK2912174T3 (da) 2012-10-25 2019-08-26 Neumodx Molecular Inc Fremgangsmåde og materialer til isolering af nukleinsyrematerialer
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US9176154B2 (en) * 2012-12-12 2015-11-03 Bio-Rad Laboratories, Inc. Calibration process and system
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
CN107015013B (zh) 2013-01-31 2018-12-21 卢米耐克斯公司 准备测定的系统和方法
JP6328147B2 (ja) * 2013-02-14 2018-05-23 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 試薬検査装置での偽陽性を低減する装置および方法
KR102358124B1 (ko) 2013-03-11 2022-02-08 큐 헬스 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
EP2972371B1 (en) 2013-03-14 2018-09-05 Second Genome, Inc. Microbial ecology shift assay
AU2013202805B2 (en) * 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US10254279B2 (en) 2013-03-29 2019-04-09 Nima Labs, Inc. System and method for detection of target substances
CN105051523B (zh) * 2013-03-29 2019-02-01 索尼公司 数据处理装置、光学检测系统、数据处理方法、以及数据处理程序
US10466236B2 (en) 2013-03-29 2019-11-05 Nima Labs, Inc. System and method for detecting target substances
WO2014160861A1 (en) 2013-03-29 2014-10-02 6SensorLabs, Inc. A portable device for detection of harmful substances
CA2908241C (en) * 2013-03-29 2021-09-07 Mie University Vital stain
EP2801854B1 (en) * 2013-05-10 2017-07-19 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
EP3036542B1 (en) * 2013-06-21 2021-02-17 Imigene Inc. A method for assaying a blood sample obtained from a subject
EP2837937A1 (en) * 2013-08-15 2015-02-18 Roche Diagniostics GmbH Method for the detection of the prozone effect of photometric assays
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
JP6295578B2 (ja) 2013-09-30 2018-03-20 凸版印刷株式会社 反応容器、核酸解析装置、および核酸解析方法
EP3318329A1 (en) 2013-10-01 2018-05-09 Genmark Diagnostics Inc. Module with collapsible fluid chamber and onboard fluid chamber compression element
EP2868377B1 (en) * 2013-10-31 2016-09-14 Roche Diagniostics GmbH Cartridge for stirring and dispensing a fluid, automatic analyzer and method of analyzing a biological sample
CN103645130B (zh) * 2013-11-03 2016-08-17 湖南欧杰生物科技发展有限公司 人或动物排泌物内有形成分高通量定量分析方法
JP2015104105A (ja) * 2013-11-28 2015-06-04 キヤノン株式会社 画像取得装置、及び画像取得方法
JP6326828B2 (ja) * 2014-01-27 2018-05-23 セイコーエプソン株式会社 センサーユニット複合体、ラマン分光装置、及び電子機器
JP2017507730A (ja) 2014-03-12 2017-03-23 セラノス， インコーポレイテッドＴｈｅｒａｎｏｓ， Ｉｎｃ． 体液サンプル収集のためのシステム、機器、及び方法
WO2015143387A1 (en) 2014-03-21 2015-09-24 Maxim Demetrios Samuel Portable instrument for in vitro detection and quantification of biomarkers
CN103868902B (zh) * 2014-04-03 2016-03-30 福州大学 一种生物荧光检测探头
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015175433A1 (en) 2014-05-12 2015-11-19 Cellomics, Inc. Automated imaging of chromophore labeled samples
EP3155368B1 (en) * 2014-06-10 2020-07-29 Siemens Healthcare Diagnostics Inc. Drawer vision system
KR101626045B1 (ko) * 2014-07-29 2016-06-01 경희대학교 산학협력단 눈물 방울을 이용한 바이러스 감염진단 방법 및 기기
US9339817B2 (en) * 2014-08-15 2016-05-17 Counsyl, Inc. High-throughput sample processing systems and methods of use
EP3189455B1 (en) 2014-09-03 2020-12-02 Beckman Coulter, Inc. Integrated console environment for diagnostic instruments, methods and apparatus
EP3001177A1 (de) * 2014-09-29 2016-03-30 Grundfos Holding A/S Vorrichtung zum Erfassen von Partikeln in einer Flüssigkeit
CN104297476A (zh) * 2014-10-11 2015-01-21 南昌大学 一种检测鼠伤寒沙门氏菌的试纸盒
CN104297474A (zh) * 2014-10-11 2015-01-21 南昌大学 一种检测细菌的检测组合
CN104316686A (zh) * 2014-10-11 2015-01-28 南昌大学 一种检测大肠杆菌o157:h7的试纸盒
CN104297475A (zh) * 2014-10-11 2015-01-21 南昌大学 一种检测单核增生李斯特菌的试纸盒
CN104458416A (zh) * 2014-11-24 2015-03-25 武汉钢铁(集团)公司 一种拉伸试验数据处理方法
CN114277081A (zh) 2015-02-22 2022-04-05 里兰斯坦福初级大学理事会 微筛选装置、方法和产品
EP4582813A3 (en) 2015-06-26 2025-08-27 Abbott Laboratories Rotating device in a diagnostic analyzer
KR102721910B1 (ko) 2015-07-17 2024-10-25 큐 헬스 인코퍼레이티드 분석물질의 증진된 검출 및 정량을 위한 시스템 및 방법
CN104931357A (zh) * 2015-07-20 2015-09-23 西安科技大学 一种煤岩试件力学特性测试系统及其测试方法
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017024070A1 (en) * 2015-08-03 2017-02-09 Field Water Testing, Llc Apparatus, system, and method for water contaminant testing
EP3859425B1 (en) 2015-09-17 2024-04-17 S.D. Sight Diagnostics Ltd. Methods and apparatus for detecting an entity in a bodily sample
JP6663605B2 (ja) * 2015-09-24 2020-03-13 国立大学法人名古屋大学 免疫測定用キット及び免疫測定方法
WO2017059103A1 (en) * 2015-09-30 2017-04-06 Nima Labs, Inc. System and method for detecting target substances
EP3361231B1 (en) * 2015-10-07 2021-02-17 AFI Corporation Inspection device, inspection system, and inspection method
CN106645768A (zh) * 2015-10-28 2017-05-10 韩国帕克特生物科技有限公司 水平流动方式的试剂盒自动移送装置
EP3313977B1 (en) * 2016-01-29 2020-08-19 Hewlett-Packard Development Company, L.P. Sample-reagent mixture thermal cycling
CA3018536A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Distinguishing between blood sample components
CN105784661B (zh) * 2016-04-06 2021-01-01 北京雷根生物技术有限公司 一种减少荧光衰减的封片剂
JP6942148B2 (ja) 2016-05-11 2021-09-29 エス．ディー．サイト ダイアグノスティクス リミテッド 試料に対する光学測定の実施
WO2017195205A1 (en) 2016-05-11 2017-11-16 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
EP3252455A1 (fr) * 2016-05-30 2017-12-06 Biomérieux Dispositif et procede d'acquisition d'une particule presente dans un echantillon
JP2019146487A (ja) * 2016-06-16 2019-09-05 株式会社ワンビシアーカイブズ クライオボックス運搬および保管用容器
CA3130176C (en) * 2016-06-17 2023-10-31 Siemens Healthcare Diagnostics Inc. Devices, methods, and kits for multiplexing a fluid sample via fluid sample reuse
US10427152B2 (en) * 2016-07-12 2019-10-01 Wi, Inc. Disposable diagnostic device with vented priming fluid passage for volumetric control of sample and reagents and method of performing a diagnosis therewith
US11047870B2 (en) 2016-07-21 2021-06-29 Siemens Healthcare Diagnostics Inc. Photometric cuvette mapping
WO2018031304A1 (en) * 2016-08-08 2018-02-15 Tru Tag Technologies, Inc. Identification of a tagged liquid
CA3035978C (en) 2016-09-09 2021-05-18 Bly Ip Inc. Systems and methods for analyzing core using x-ray fluorescence
US9988781B2 (en) * 2016-09-22 2018-06-05 International Business Machines Corporation Sand cleaning vehicle and a method of cleaning sand using the same
WO2018065109A1 (en) * 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Cartridge and method for testing a sample
IT201600103909A1 (it) * 2016-10-17 2018-04-17 Marco Flavio Michele Vismara Sistema e metodo di acquisizione, trasmissione ed elaborazione di dati ematochimici
WO2018089953A1 (en) 2016-11-14 2018-05-17 Orca Biosystems, Inc. Methods and apparatuses for sorting target particles
EP3327596A1 (en) 2016-11-23 2018-05-30 F. Hoffmann-La Roche AG Supplementing measurement results of automated analyzers
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US10426143B2 (en) * 2017-01-31 2019-10-01 Florida Atlantic University Board Of Trustees Systems and methods for larval fish enumeration and growth monitoring
CN106840817A (zh) * 2017-03-14 2017-06-13 骏实生物科技(上海)有限公司 一种全自动循环肿瘤细胞阳性富集装置
EP3602003A1 (en) 2017-03-31 2020-02-05 Life Technologies Corporation Apparatuses, systems and methods for imaging flow cytometry
CN106881160A (zh) * 2017-05-03 2017-06-23 山东大学 一种白假丝酵母菌微流控芯片
CN107129930B (zh) * 2017-06-09 2019-11-26 北京百康芯生物科技有限公司 一种全集成核酸检测微流控芯片及其使用方法
US10687676B2 (en) * 2017-06-09 2020-06-23 Hamilton Sundstrand Corporation Microgravity urine collection and storage
US11926811B2 (en) * 2017-07-17 2024-03-12 Amino Labs North Incorporated Personal laboratory for genetic engineering, culturing and analysis of microorganisms and biochemicals
EP3655047A1 (en) * 2017-07-21 2020-05-27 Germitec Bioassay carrier and preparation thereof
WO2019050802A1 (en) * 2017-09-05 2019-03-14 Beckman Coulter, Inc. COLLECTION AND PREPARATION OF BLOOD SAMPLES FOR INTERVENTION DIAGNOSES
AU2018369859B2 (en) 2017-11-14 2024-01-25 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
US20200388389A1 (en) * 2017-11-20 2020-12-10 Siemens Healthcare Diagnostics Inc. Multiple diagnostic engine environment
CN111344795B (zh) 2017-11-20 2024-01-12 美国西门子医学诊断股份有限公司 用于管理多重诊断引擎环境的用户接口
JP7034689B2 (ja) * 2017-12-01 2022-03-14 株式会社日立ハイテク 自動分析装置
CN108108764B (zh) * 2017-12-26 2021-12-24 东南大学 一种基于随机森林的视觉slam回环检测方法
CN108398410A (zh) * 2018-02-06 2018-08-14 广州常晖电子科技有限公司 一种具有实时拍照功能的磷光及荧光测试装置
CN111788483B (zh) * 2018-03-12 2024-12-27 索尼公司 细胞评价设备和细胞评价系统
US11358148B2 (en) * 2018-03-30 2022-06-14 Idexx Laboratories, Inc. Point-of-care diagnostic systems and containers for same
EP3773314B1 (en) * 2018-04-09 2024-02-21 Lütfi Keçici Direct automatic transfer device for hair transplantation
WO2019204187A1 (en) * 2018-04-15 2019-10-24 Optofluidic Bioassay, Llc Differential pressure assisted drainage system
US12031985B2 (en) 2018-04-19 2024-07-09 First Light Diagnostics, Inc. Detection of targets
CN112074739B (zh) * 2018-05-02 2025-05-09 哈恩-席卡德应用研究学会 用于自动化系统的免疫测定
WO2019236435A1 (en) * 2018-06-07 2019-12-12 Merck Sharp & Dohme Corp. Lyosphere critical reagent kit
CN108827889B (zh) * 2018-06-13 2021-02-05 江西中医药大学 一种基于光学特性的胶类材料鉴别方法
US12172108B2 (en) 2018-08-16 2024-12-24 Emd Millipore Corporation Closed bioprocessing device
TR201812047A2 (tr) * 2018-08-17 2018-09-21 Luetfi Kecici Di̇rekt kil eki̇mi̇ otomati̇k transfer ci̇hazinda yapilan geli̇şti̇rme
AU2019338531A1 (en) * 2018-09-14 2021-04-15 William Marsh Rice University Apparatus and methods for multiplexed amplification and detection of DNA using convectional heating and label-free microarray
USD903898S1 (en) 2018-09-24 2020-12-01 Gentueri Inc. Sampling assembly
US11471889B2 (en) 2018-09-24 2022-10-18 Gentueri Inc. Sample assembly
WO2020073018A2 (en) * 2018-10-04 2020-04-09 First Light Diagnostics, Inc. Test cartridges
CA3114778A1 (en) * 2018-10-05 2020-04-09 Dots Technology Corp. Systems and methods for allergen detection
GB201818412D0 (en) * 2018-11-12 2018-12-26 Lumiradx Tech Ltd A magnetic assembly for use in a device for conducting assays
US11592395B2 (en) * 2019-03-22 2023-02-28 Kaya17 Inc. Wide-area-sample based reader design for diagnostic detection of bio-particles
JP7174066B2 (ja) * 2018-12-06 2022-11-17 株式会社日立ハイテク 自動分析装置
US10820852B2 (en) * 2018-12-18 2020-11-03 International Business Machines Corporation Allergic early detection wearable device
CN114207445B (zh) * 2018-12-21 2025-05-06 科诺塔股份有限公司 流动测定分析仪
CA3125901A1 (en) * 2019-01-07 2020-07-16 1866402 Ontario Limited Blood separation and analysis device and methods
CN109998480A (zh) * 2019-02-01 2019-07-12 中国科学院苏州生物医学工程技术研究所 体内药物活体筛选系统
WO2020236763A1 (en) * 2019-05-18 2020-11-26 Rpi Consulting Llc Systems and methods for aspirating, dispensing, and transporting samples for analysis
WO2020242994A1 (en) * 2019-05-24 2020-12-03 University Of North Texas Nondestructive ultrasonic elastographic imaging for evaluation of materials
CN114174799A (zh) * 2019-05-30 2022-03-11 贝克曼库尔特有限公司 用于固定生物标本以进行显微成像的方法和系统
CN110146478B (zh) * 2019-06-17 2020-03-24 滨州医学院 一种微生物培养皿的在线监测装置
CN112213300B (zh) * 2019-07-09 2024-02-13 苏州宇测生物科技有限公司 一种分子定量检测装置
CN114641580A (zh) * 2019-07-23 2022-06-17 斯奈普Dna 检测和监测病原体的系统和方法
KR102241251B1 (ko) * 2019-07-26 2021-04-16 주식회사 수젠텍 다중 블롯 검사 자동화 시스템
US20210043284A1 (en) * 2019-08-11 2021-02-11 HealthBlock, Inc. Deniable digital health diagnoses
WO2021045061A1 (ja) * 2019-09-02 2021-03-11 富士レビオ株式会社 レクチン結合性物質測定方法及びレクチン結合性物質測定キット、並びに、これらに用いるブロック化標識レクチン
WO2021051129A1 (en) * 2019-09-09 2021-03-18 Cerillo, Llc A solid-state, multi-well plate reader
US20220333053A1 (en) * 2019-09-10 2022-10-20 The Johns Hopkins University Device and method for genetic analysis of plant materials in remote testing sites
WO2021051202A1 (en) * 2019-09-19 2021-03-25 Invidx Corp. Point-of-care testing cartridge and system
WO2021061796A1 (en) * 2019-09-23 2021-04-01 Cellanyx Diagnostics, Llc Automated cell processing and differential interference contrast microscopy devices and methods
WO2021079305A1 (en) 2019-10-22 2021-04-29 S.D. Sight Diagnostics Ltd Accounting for errors in optical measurements
WO2021092612A1 (en) * 2019-11-08 2021-05-14 Colgate-Palmolive Company Apparatus, system, and method for testing biological samples
CA3062471A1 (en) * 2019-11-21 2021-05-21 Photon Etc. Inc. Infrared imaging system and related method
US12320750B2 (en) 2019-11-25 2025-06-03 Surgvision Gmbh Testing of a luminescence imaging apparatus with inclined containers of luminescence substance
AU2020400401A1 (en) 2019-12-12 2022-06-02 S.D. Sight Diagnostics Ltd Analyzing an analyte disposed within a medium
AU2020400400A1 (en) 2019-12-12 2022-05-26 S.D. Sight Diagnostics Ltd Detecting platelets in a blood sample
US12189112B2 (en) 2019-12-12 2025-01-07 S.D. Sight Diagnostics Ltd. Artificial generation of color blood smear image
CN113495043B (zh) * 2020-03-18 2023-11-10 江苏长电科技股份有限公司 微尺度衍射图像检测装置
US12270821B2 (en) * 2020-03-18 2025-04-08 The Board Of Trustees Of The University Of Illinois Device and method for assessing oxidative potential of ambient particulate matter
WO2021195497A1 (en) * 2020-03-26 2021-09-30 Orb Xyz, Inc. Detecting an analyte in a medium
AU2021250481A1 (en) * 2020-04-03 2022-12-01 Kenota Inc. Flow assay cartridge
WO2021203291A1 (zh) * 2020-04-08 2021-10-14 深圳华大生命科学研究院 无透镜显微成像系统、方法及生化物质检测系统、方法
WO2021211714A1 (en) * 2020-04-17 2021-10-21 Academia Sinica Fusion protein and method of detecting bacteria having pseudaminic acid
CN111443073B (zh) * 2020-04-30 2021-06-01 北京大学 一种micro LED芯片的显微拉曼结合光致发光检测装置及其方法
WO2021246348A1 (ja) * 2020-06-01 2021-12-09 株式会社Provigate 液体収集器
US20230228686A1 (en) * 2020-06-11 2023-07-20 Siemens Healthcare Diagnostics Inc. Reagent strip counterfeit protection
EP3933479A1 (en) * 2020-07-03 2022-01-05 Leica Microsystems CMS GmbH Microscope for microscopic examination of a sample
WO2022026546A1 (en) * 2020-07-28 2022-02-03 Grindstone Diagnostics Llc Pregnancy detection tool and methods
JP7692467B2 (ja) * 2020-08-12 2025-06-13 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 内蔵光源を有する回路板
US20230238088A1 (en) * 2020-08-31 2023-07-27 Abbott Rapid Diagnostics Informatics, Inc. System and method for rapid results and reporting of diagnostic test results
US11585042B2 (en) 2020-09-30 2023-02-21 Haier Us Appliance Solutions, Inc. Dryer appliance with additive dispenser
US12523606B2 (en) 2020-10-06 2026-01-13 Riken Method for detecting target substance, fluid device, and kit
KR102426842B1 (ko) * 2020-10-07 2022-07-29 에이치비솔루션㈜ 유리패널 크랙 검사장치
TWI776251B (zh) * 2020-10-08 2022-09-01 中原大學 基於目標分子吸附之磁控量測系統
WO2022077074A1 (en) * 2020-10-15 2022-04-21 Avicena Systems Limited High-throughput screening apparatus
CN112429848A (zh) * 2020-12-04 2021-03-02 安徽中环环保科技股份有限公司 疏浚底泥快速启动a2/o系统的方法及成功启动的判断方法
US20240299940A1 (en) * 2021-01-06 2024-09-12 Dots Technology Corp. Target detection systems and methods
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US20220369957A1 (en) * 2021-05-19 2022-11-24 Satio, Inc. Self-contained dermal patch for blood analysis
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
CN113155880B (zh) * 2021-05-08 2023-06-27 电子科技大学 一种采用无人机和xrf技术对土壤重金属污染的检测方法
BR102021011067A2 (pt) * 2021-06-08 2023-03-28 Hi Technologies S.A Método para detecção de sequências de ácidos nucleicos, provenientes de amostras biológicas, com interesse médico, agrícola e biotecnológico e aparelho correspondente
WO2022265996A1 (en) * 2021-06-14 2022-12-22 University Of Washington Systems, devices, and methods for diagnostics measurements
WO2023021339A1 (en) * 2021-08-19 2023-02-23 Hygieacare, Inc. Non-invasive sampling of inner-colonic microbiome
CN113731523B (zh) * 2021-09-23 2022-08-19 潢川县鹏升畜产品有限公司 肝素钠粗品提取用实验台
EP4416488A1 (en) * 2021-10-15 2024-08-21 Diamidex Methods for detecting microorganisms
CA3236139A1 (en) * 2021-11-11 2023-05-19 Marcin Kowalewski Specimen collection device
WO2023096908A1 (en) * 2021-11-23 2023-06-01 Trustees Of Tufts College Detection and identification of defects using artificial intelligence analysis of multi-dimensional information data
DE102022102711A1 (de) 2022-02-04 2023-08-10 Lpkf Laser & Electronics Aktiengesellschaft Vorrichtung und ein zur Durchführung bestimmtes Verfahren zur Untersuchung und/oder Behandlung einer insbesondere biologischen oder medizinischen Probe
USD1037483S1 (en) 2022-03-15 2024-07-30 Cue Health Inc. Sample collection device
USD1037484S1 (en) 2022-03-15 2024-07-30 Cue Health Inc. Sample collection device
CN114646769B (zh) * 2022-03-18 2023-05-12 广东凯金新能源科技股份有限公司 一种用于石墨振实检测的自动化检测系统及其使用方法
WO2023244945A1 (en) * 2022-06-13 2023-12-21 University Of Washington Diagnostic system including a base and single-use fluidic disposables
CN115069316B (zh) * 2022-06-21 2023-08-04 扬州大学 一种能同时检测多种体液的芯片
CN115201463A (zh) * 2022-07-15 2022-10-18 上池诊断科技(深圳)有限公司 一种便于移动检测的荧光免疫分析仪器
US11913967B2 (en) 2022-07-22 2024-02-27 Spaero Inc. System and method for determining dispensing volume for a liquid handler
USD1042874S1 (en) 2022-07-25 2024-09-17 Cue Health Inc. Sample collection device
KR102514095B1 (ko) * 2022-10-01 2023-03-24 엘아이에스 주식회사 진단 스트립의 형광량을 측정하기 위한 스트립 삽입형 시간분해능을 가진 형광(trf) 리더기
USD1087801S1 (en) 2022-11-30 2025-08-12 Siro Diagnostics, Inc. Sample collection device
WO2024155632A1 (en) * 2023-01-17 2024-07-25 Institute For Environmental Health, Inc. Automated microbiological laboratory for quantitative microbiology using in situ assembled culture devices
CN120303388A (zh) * 2023-01-17 2025-07-11 环境健康协会公司 用于定量和定性微生物学分析的自动化微生物实验室
WO2024163586A1 (en) * 2023-02-02 2024-08-08 University Of Washington Devices and methods for quantitative measurement of one or more analytes over a range of concentrations
CN116299749A (zh) * 2023-02-09 2023-06-23 珠海格力新元电子有限公司 遥控器弹簧视觉自动检测方法及检测机构
WO2025072554A1 (en) * 2023-09-26 2025-04-03 The Regents Of The University Of California Systems and methods for dynamic and real-time biological experiment control
US20250142196A1 (en) * 2023-10-31 2025-05-01 Arkray, Inc. Control method and computer-readable storage medium
WO2025172513A1 (en) * 2024-02-16 2025-08-21 F. Hoffmann-La Roche Ag A test carrier system
EP4672180A1 (en) * 2024-06-25 2025-12-31 bioMérieux IMPROVED FLUORESCENCE IMAGE PROCESSING FOR MICROORGANISM DETECTION

Family Cites Families (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2672431A (en) 1949-11-25 1954-03-16 Goetz Alexander Means for performing microbiological assays of aerosols and hydrosols
US2761813A (en) 1953-01-21 1956-09-04 Goetz Alexander Means and method of producing and controlling cultures of microorganisms
US3021848A (en) 1958-12-08 1962-02-20 Arther L Isley Tobacco hand opener
US3981776A (en) 1967-02-16 1976-09-21 Rolf Saxholm Magnetically responsive, biologically active substance and associated methods and apparatus
US3694317A (en) 1968-05-31 1972-09-26 Stanley Scher Method of and instrument for micro-biological analysis
US4097586A (en) 1970-06-11 1978-06-27 Biological Developments, Inc. Immunochemical assay method
US4587213A (en) 1971-09-29 1986-05-06 Malecki George J Methods and means of determining microorganism population
GB1566098A (en) 1975-11-14 1980-04-30 Nat Res Dev Separation of solid and liquid components of mixtures
GB1575805A (en) 1976-03-12 1980-10-01 Technicon Instr Automatic diagnostic apparatus
US4157323A (en) 1976-06-09 1979-06-05 California Institute Of Technology Metal containing polymeric functional microspheres
GB1582956A (en) 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4086060A (en) * 1976-10-22 1978-04-25 Jocelyn Dickson Disposable manipulative laboratory device for transferring biological fluids
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4115535A (en) 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4222744A (en) 1978-09-27 1980-09-16 Becton Dickinson & Company Assay for ligands
EP0030086B2 (en) 1979-11-13 1990-03-14 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Test-tube assembly, kit for making it and method of manual immunoassay
US4565783A (en) 1981-01-27 1986-01-21 Minnesota Mining And Manufacturing Company Dry culture media
US4614585A (en) 1981-03-02 1986-09-30 Sybron Corporation Frangible bonded disposable filtration unit with recoverable filter
US4454233A (en) 1981-10-21 1984-06-12 Wang Associates Method of tagged immunoassay
US4436826A (en) 1981-10-21 1984-03-13 Wang Associates Tagged immunoassay
JPS59500448A (ja) 1981-11-04 1984-03-22 ユセフ，カマル・アブドゥ− 長期間培養用微生物培養プレ−ト
US4477578A (en) 1982-03-04 1984-10-16 Medical & Scientific, Inc. Method and apparatus for performing assays
US4455370A (en) 1982-05-17 1984-06-19 E. I. Du Pont De Nemours And Company Transferring separated components in gel electrophoresis via nylon membrane
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4582810A (en) 1983-09-30 1986-04-15 Becton, Dickinson And Company Immuno-agglutination particle suspensions
US4693972A (en) 1984-01-16 1987-09-15 Becton, Dickinson And Company Composition and method for rapid detection of microorganisms in clinical samples
GB8401368D0 (en) 1984-01-19 1984-02-22 Amersham Int Plc Assay method
FR2558847B1 (fr) 1984-01-31 1986-06-20 Millipore Sa Dispositif et procede de controle microbiologique de liquides
FI842992A0 (fi) 1984-07-26 1984-07-26 Labsystems Oy Immunologiskt definitionsfoerfarande.
EP0171174A3 (en) 1984-08-06 1986-04-23 James W. Gorman Petri dish which can be locked in different positions to admit ambient atmosphere at different rates
FI844027A7 (fi) 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
US5958790A (en) 1984-12-20 1999-09-28 Nycomed Imaging As Solid phase transverse diffusion assay
US5073497A (en) 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
FI850481A0 (fi) * 1985-02-06 1985-02-06 Labsystems Oy Foerfarande foer bestaemning av motmedel eller antigener.
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5238810A (en) 1986-09-22 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus thereof
FR2605330B1 (fr) 1986-10-20 1989-01-20 Millipore Sa Recipient destine a recevoir un ou plusieurs milieux de culture pour microorganismes.
US4922092A (en) 1986-11-26 1990-05-01 Image Research Limited High sensitivity optical imaging apparatus
US4750820A (en) 1987-04-01 1988-06-14 Minnesota Mining And Manufacturing Company Zoom lens having magnification factors in the range of 20X to 47X for micrographic applications
WO1989004372A1 (en) 1987-11-05 1989-05-18 Berg James D Rapid process for detecting pathogenic microorganisms
US4988618A (en) 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
EP0344276B1 (en) 1987-12-01 1993-06-23 Boehringer Mannheim Corporation Methods and devices for conducting assays
US4959301A (en) 1988-04-22 1990-09-25 Massachusetts Institute Of Technology Process for rapidly enumerating viable entities
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
FR2638240B1 (fr) 1988-10-21 1991-10-18 Biocom Sa Platine pour l'analyse rapide et indexee sous microscope de filtres et d'autres supports porteurs d'echantillons multiples et procede d'analyse de ces echantillons utilisant cette platine
FR2638101B1 (fr) 1988-10-21 1991-09-06 Biocom Sa Dispositif de filtration parallele d'une pluralite d'echantillons avec controle automatique des volumes filtres et du colmatage ainsi qu'avec indexation du filtre, et procede de filtration
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
JPH02278155A (ja) 1989-04-19 1990-11-14 Jeol Ltd 生化学自動分析装置
US5089413A (en) 1989-05-19 1992-02-18 Minnesota Mining And Manufacturing Company Method and apparatus for culturing with microbiological dry culture medium
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US4988302A (en) 1989-06-08 1991-01-29 Difco Laboratories Incorporated Culture media package
US5166079A (en) * 1989-07-19 1992-11-24 Pb Diagnostic Systems, Inc. Analytical assay method
JPH0383598A (ja) 1989-08-29 1991-04-09 Sapporo Breweries Ltd 微生物の迅速検査法
CA2022614A1 (en) 1989-08-31 1991-03-01 Richard R. Matner Colony blotting method and device
JPH03102240A (ja) 1989-09-14 1991-04-26 Toshiba Corp 粒径測定装置
US5130733A (en) 1989-11-24 1992-07-14 Minolta Camera Kabushiki Kaisha Camera having a pseudo format
GB9020352D0 (en) 1990-09-18 1990-10-31 Anagen Ltd Assay or reaction apparatus
FR2657543B1 (fr) 1990-01-26 1992-12-18 Biocom Sa Dispositif modulaire pour le recueil, l'incubation, la filtration d'echantillons multiples.
EP0493745A1 (en) 1990-12-21 1992-07-08 Dojindo Laboratories Fluorescent compound, complex, reagent, and specific binding assay employing said reagent
US5258284A (en) 1991-01-22 1993-11-02 University Of Maryland, School Of Medicine Nucleic acid probes specific for pathogenic strains of vibrio vulnificus and method employing the same
IL100867A (en) 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
US5464749A (en) 1991-07-22 1995-11-07 Bayer Corporation Immunoassay of free substances in biological fluids
FR2679660B1 (fr) 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5232838A (en) 1991-12-09 1993-08-03 Minnesota Mining And Manufacturing Company Culture media device and method of use
FR2686895B1 (fr) 1992-01-30 1994-03-25 Labarthe Jean Christophe Boite de culture.
US5541069A (en) 1992-02-28 1996-07-30 Quidel Corporation Assay having improved dose response curve
DE563858T1 (de) 1992-04-01 1994-03-03 Nihon Millipore Kogyo K K Verfahren zur Bestimmung der Anzahl lebender Mikroorganismen.
AU4681393A (en) * 1992-07-17 1994-02-14 Aprogenex, Inc. Background-reducing compounds for probe-mediated in-situ fluorimetric assays
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
JP3228812B2 (ja) 1993-02-10 2001-11-12 日本マイクロリス株式会社 生菌数を測定する方法
EP0698084B1 (en) 1993-05-14 1998-06-24 Minnesota Mining And Manufacturing Company Method for rapid quantification of microorganism growth
US5552272A (en) * 1993-06-10 1996-09-03 Biostar, Inc. Detection of an analyte by fluorescence using a thin film optical device
US5681530A (en) 1993-06-11 1997-10-28 Ortho Diagnostic Systems Inc. Transport system for fluid analysis instrument
US5474910A (en) 1993-10-15 1995-12-12 Alfano; Robert R. Method and device for detecting biological molecules and/or microorganisms within a desired area or space
JP3553953B2 (ja) 1993-12-17 2004-08-11 ミネソタ マイニング アンド マニュファクチャリング カンパニー 使い捨て微生物培養器のための自動培養及び画像形成装置
JP3102240B2 (ja) 1993-12-24 2000-10-23 東洋インキ製造株式会社 化粧シート
FR2716003B1 (fr) 1994-02-04 1996-04-26 Biocom Sa Procédé d'analyse automatique d'éléments en faible concentration sur un support d'objets de faible occurrence et dispositif pour la mise en Óoeuvre dudit procédé.
US6051393A (en) * 1994-03-29 2000-04-18 Jones; Sonja K. Method of detecting malignant and pre-malignant conditions of the cervix, and test kits therefor
FR2719602B1 (fr) 1994-05-05 1996-07-26 Biocom Sa Procédé et installation pour la numérisation de cellules et micro-organismes, notamment des produits alimentaires ou des fluides biologiques.
WO1995031481A1 (en) 1994-05-18 1995-11-23 The Research And Development Institute, Inc. Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms
US5538857A (en) 1994-06-01 1996-07-23 Isolab, Inc. Assay for enzyme activity from a red blood sample using a direct microfluorometric assay
US5624850A (en) * 1994-06-06 1997-04-29 Idetek, Inc. Immunoassays in capillaries
US5792617A (en) 1994-08-18 1998-08-11 Rotman; M. Boris Cell proliferation-based amplified detection of analytes
US5861270A (en) 1994-11-07 1999-01-19 Universiteit Gent Enzymatic method for detecting coliform bacteria or E. coli
EP0713087B1 (en) 1994-11-17 1999-04-14 Chemunex Apparatus and process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence
EP0746865B1 (en) 1994-12-08 2003-03-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5694478A (en) 1994-12-15 1997-12-02 Minnesota Mining And Manufacturing Company Method and apparatus for detecting and identifying microbial colonies
US5606413A (en) 1995-01-19 1997-02-25 Northrop Grumman Corporation Real time spectroscopic imaging system and method
US5993740A (en) 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
JPH08201391A (ja) * 1995-01-20 1996-08-09 Olympus Optical Co Ltd マ−カ−粒子を用いた免疫学的測定方法
EP0744656A1 (en) 1995-05-20 1996-11-27 Agfa-Gevaert N.V. Apparatus for the wet processing of photographic sheet material
US5681712A (en) 1995-06-02 1997-10-28 Minnesota Mining And Manufacturing Company Surface colony counting device and method of use
US5843766A (en) 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
FR2735255B1 (fr) 1995-06-12 1998-06-19 Biocom Sa Procede de numerisation de particules faiblement luminescentes
JP3851369B2 (ja) 1995-08-24 2006-11-29 ミレニウム・バイオロジクス・インコーポレイテッド マルチウェル骨細胞培養装置
US6573063B2 (en) 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE19608320A1 (de) 1996-02-22 1997-08-28 Biosquant Gmbh Schnellverfahren zur Bestimmung der mikrobiellen Qualität von Wasser und wasserhaltigen Proben
US5736405A (en) 1996-03-21 1998-04-07 Nalco Chemical Company Monitoring boiler internal treatment with fluorescent-tagged polymers
DE19616151A1 (de) 1996-04-23 1997-10-30 Boehringer Mannheim Gmbh Videosystem zur Auswertung analytischer Testelemente
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
RU2251572C2 (ru) 1996-04-25 2005-05-10 Дженикон Сайенсиз Корпорейшн, Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Анализ аналитов с использованием частиц в качестве метки
JP2000503773A (ja) 1996-05-23 2000-03-28 ユニリーバー・ナームローゼ・ベンノートシヤープ 特異的結合アッセイの改良
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
DE19631997C2 (de) 1996-08-08 2001-04-19 Dornier Gmbh Vorrichtung zur mikrogravitationstauglichen Prozessierung von Zellkulturen
US5861251A (en) 1996-10-15 1999-01-19 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
CA2702219C (en) 1996-11-06 2013-01-08 Sequenom, Inc. High density immobilization of nucleic acids
US6122396A (en) 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5804386A (en) 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
DE69833185T2 (de) 1997-01-29 2006-08-10 Pall Corp. Filtrationsanordnung
EP0983498B1 (en) 1997-02-27 2004-05-26 Cellomics, Inc. A system for cell-based screening
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
US5958704A (en) 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
WO1998043067A1 (en) 1997-03-25 1998-10-01 Immunivest Corporation Apparatus and methods for capture and analysis of particulate entities
US5852498A (en) 1997-04-04 1998-12-22 Kairos Scientific Inc. Optical instrument having a variable optical filter
JP3529014B2 (ja) 1997-04-24 2004-05-24 株式会社 シナップス 細胞培養容器
EP1935983B1 (en) 1997-05-05 2011-06-22 ChemoMetec A/S Method for determination of biological particles in blood
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
WO1999008233A1 (en) 1997-08-07 1999-02-18 Imaging Research Inc. A digital imaging system for assays in well plates, gels and blots
US6048723A (en) 1997-12-02 2000-04-11 Flexcell International Corporation Flexible bottom culture plate for applying mechanical load to cell cultures
FR2773218B1 (fr) 1997-12-31 2000-03-10 Stago International Dispositif, procede et appareil de mise en oeuvre du procede, pour effectuer un dosage d'au moins un composant particulier dans un echantillon de produit
US6180418B1 (en) 1998-01-20 2001-01-30 The United States Of America As Represented By The Secretary Of The Navy Force discrimination assay
WO1999037814A1 (en) 1998-01-22 1999-07-29 Luminex Corporation Microparticles with multiple fluorescent signals
EP1061127A4 (en) 1998-02-03 2005-11-16 Hakuju Inst For Health Science METHOD FOR INSPECTING MICROORGANISMS AND OTHER, AND DETECTION UNIT
US20020028471A1 (en) * 1998-02-20 2002-03-07 Oberhardt Bruce J. Cell analysis methods and apparatus
WO1999047637A1 (en) 1998-03-19 1999-09-23 Amanzi Technologies Limited Microbiological testing of a liquid sample
US6140653A (en) 1998-03-27 2000-10-31 Vysis, Inc. Large-field fluorescence imaging apparatus
US5968766A (en) 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US5914245A (en) 1998-04-20 1999-06-22 Kairos Scientific Inc. Solid phase enzyme kinetics screening in microcolonies
WO1999058948A2 (en) 1998-05-13 1999-11-18 Ddx, Inc. Enumeration method of analyte detection
US6306589B1 (en) 1998-05-27 2001-10-23 Vysis, Inc. Biological assays for analyte detection
JPH11346795A (ja) 1998-06-05 1999-12-21 Nikken Seibutsu Igaku Kenkyusho:Kk 細菌の検出方法
US6093869A (en) 1998-06-29 2000-07-25 The Procter & Gamble Company Disposable article having a responsive system including a feedback control loop
US6627446B1 (en) 1998-07-02 2003-09-30 Amersham Biosciences (Sv) Corp Robotic microchannel bioanalytical instrument
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6051395A (en) 1998-08-25 2000-04-18 Biometric Imaging, Inc. Method and compound for detecting low levels of microorganisms
EP1742058B1 (de) 1998-08-28 2011-11-30 febit holding GmbH Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
US5972641A (en) 1998-08-28 1999-10-26 Colifast Systems Asa Rapid coliform detection system
US6130931A (en) * 1998-09-17 2000-10-10 Process Control, Inc. X-ray fluorescence elemental analyzer
JP3669184B2 (ja) * 1998-11-13 2005-07-06 松下電器産業株式会社 免疫学的測定方法及び免疫学的測定装置
GB9902971D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Assay
JP3991495B2 (ja) * 1999-03-25 2007-10-17 東ソー株式会社 分析装置
US6235540B1 (en) 1999-03-30 2001-05-22 Coulter International Corp. Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
US6473698B1 (en) * 1999-04-22 2002-10-29 University Of Louisville Research Foundation, Inc. Method and apparatus for automated rolling leukocyte velocity measurement in vivo
US20020004246A1 (en) 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
WO2001061348A1 (en) 2000-02-16 2001-08-23 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
US6472166B1 (en) 2000-02-17 2002-10-29 Wardlaw Partners Lp Method for determining the effects of a growth-altering agent on a microbial colony
FR2808276B1 (fr) * 2000-04-26 2004-04-02 Renaud Nalin Procede d'extraction indirecte de l'adn d'organismes non cultivables et adn susceptible d'etre obtenu par ledit procede
JP2001224355A (ja) 2000-05-25 2001-08-21 Kyodo Seihin Kk 両面シャーレ
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US20020155033A1 (en) * 2000-10-06 2002-10-24 Protasis Corporation Fluid Separate conduit cartridge
JP3762862B2 (ja) 2000-10-26 2006-04-05 株式会社 シナップス 細胞培養容器
DE60140929D1 (de) 2000-11-14 2010-02-11 Roche Diagnostics Gmbh Immunoassay für HIV-Protease-Hemstoffe
GB0029154D0 (en) 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
CN2486557Y (zh) 2001-01-19 2002-04-17 中国科学院化学研究所 一种细胞培养装置
US20020137106A1 (en) 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US6664528B1 (en) 2001-07-06 2003-12-16 Palantyr Research, Llc Imaging system and methodology employing reciprocal space optical design
US6790655B2 (en) 2001-08-03 2004-09-14 Corning Incorporated Removable splash guards for culture plates
CA2455118C (en) 2001-08-03 2012-01-17 Nanosphere, Inc. Nanoparticle imaging system and method
JP4363980B2 (ja) 2001-09-06 2009-11-11 ジェノミック プロファイリング システムズ インコーポレイティッド 複製細胞の迅速な検出
US20050148085A1 (en) 2001-09-16 2005-07-07 Chemometec A/S Method and a system for detecting and optinally isolating a rare event particle
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
JP2003294596A (ja) 2002-03-29 2003-10-15 Asahi Kasei Corp 混合機構
US8663909B2 (en) 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
US6852527B2 (en) 2002-06-06 2005-02-08 Inovyx, Inc. Apparatus and method for the measurement of cells in biological samples
US6602704B1 (en) 2002-06-24 2003-08-05 Biomerieux, Inc. Sample contact plate with latchable cover
JP3896924B2 (ja) 2002-08-07 2007-03-22 松下電器産業株式会社 生体試料の観察装置および観察方法
US7261900B2 (en) 2002-08-09 2007-08-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant modified Bacillus anthracis protective antigen for use in vaccines
US7449307B2 (en) 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
FR2855613B1 (fr) 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
US7381370B2 (en) * 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
US20050042145A1 (en) 2003-08-22 2005-02-24 Sysmex Corporation Container for analyzer, detection container, reaction container and packing container for storing detection container
JP4381752B2 (ja) * 2003-09-02 2009-12-09 シスメックス株式会社 光学的定量方法及び光学的定量装置
US20050226779A1 (en) 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
US6969606B2 (en) 2003-10-27 2005-11-29 Pml Microbiologicals, Inc. Lockable contact plate
JP4208820B2 (ja) 2003-11-28 2009-01-14 株式会社東芝 核酸検出カセット
CN1921803B (zh) 2004-02-23 2011-01-26 伊西康公司 诊断拭子和活组织检查穿刺器,以及用在这些系统中的诊断帽
US20050191687A1 (en) 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
US20050220670A1 (en) * 2004-03-31 2005-10-06 Thomas Palmieri Multipath access system for use in an automated immunoassay analyzer
EP2752874A1 (en) * 2004-06-07 2014-07-09 Fluidigm Corporation Method and apparatus for imaging a device under temperature control
AU2005329068A1 (en) 2004-07-29 2006-09-21 Kim Laboratories, Inc. Ultrasensitive sensor and rapid detection of analytes
US20060216696A1 (en) 2004-08-23 2006-09-28 Goguen Jon D Rapid plague detection system
US20070212681A1 (en) 2004-08-30 2007-09-13 Benjamin Shapiro Cell canaries for biochemical pathogen detection
US7727471B2 (en) 2004-09-09 2010-06-01 Palo Alto Research Center Incorporated Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
JP2006087336A (ja) 2004-09-22 2006-04-06 Shimadzu Corp 細胞分析装置
US20060121055A1 (en) 2004-12-06 2006-06-08 Becton, Dickinson And Company, Inc. Compositions with enhanced immunogenicity
JP2006162466A (ja) 2004-12-08 2006-06-22 Kyowa Medex Co Ltd 測定すべき物質の測定方法および測定試薬
US20080003571A1 (en) * 2005-02-01 2008-01-03 Mckernan Kevin Reagents, methods, and libraries for bead-based sequencing
EP1866653A4 (en) * 2005-03-07 2009-08-26 Novx Systems Inc ANALYSIS MACHINE
EP1865305A1 (en) 2005-03-31 2007-12-12 Kabushiki Kaisha Toshiba Fluorescent measuring device, fluorescent measuring method, container for fluorescent measurement, and method for manufacturing the container for fluorescent measurement
US20070014695A1 (en) 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
JP4911423B2 (ja) * 2005-06-10 2012-04-04 富士電機株式会社 微生物の計測方法
US9488665B2 (en) * 2005-09-13 2016-11-08 Chrome Red Technologies, Llc Magnetic particle tagged reagents and techniques
CA2623408C (en) * 2005-09-26 2014-04-01 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7820430B2 (en) 2005-11-28 2010-10-26 Industrial Technology Research Institute Micro device for cell culture
CA2533219A1 (en) * 2005-12-02 2007-06-02 Hudson Control Group, Inc. Systems and methods for automated proteomics research
WO2008030631A2 (en) * 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
WO2007134189A2 (en) 2006-05-10 2007-11-22 Board Of Regents, The University Of Texas System Detecting tumor biomarker in oral cancer
JPWO2007145091A1 (ja) 2006-06-15 2009-10-29 株式会社ニコン 細胞培養装置
WO2008005998A2 (en) 2006-07-07 2008-01-10 Georgia Tech Research Corporation Centimeter-scale, integrated diagnostics incubator for biological culturing
ES2649986T3 (es) * 2006-07-24 2018-01-16 Becton Dickinson And Company Aparato y procedimiento para la concentración de partículas de ensayo
US8131476B2 (en) * 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
JP2008096223A (ja) 2006-10-10 2008-04-24 Sysmex Corp 分析装置
US7863035B2 (en) 2007-02-15 2011-01-04 Osmetech Technology Inc. Fluidics devices
JP2008209330A (ja) * 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 磁気分離器およびそれを用いた分析装置
WO2008108027A1 (ja) * 2007-03-02 2008-09-12 Shimadzu Corporation 反応容器プレート及び反応処理装置
US7763405B2 (en) 2007-03-23 2010-07-27 Xerox Corporation Photoconductors containing fluorinated components
CN103418295B (zh) * 2007-06-21 2015-11-18 简.探针公司 用于混合检测腔室的内容物的仪器和方法
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
FR2957932B1 (fr) 2010-03-24 2012-04-13 Biomerieux Sa Boite de petri comportant des moyens de retenue du milieu de culture gelose
WO2013070730A2 (en) 2011-11-07 2013-05-16 Rapid Micro Biosystems, Inc. Cassette for sterility testing
MX375939B (es) 2012-04-16 2025-03-07 Rapid Micro Biosystems Inc Dispositivo para cultivar celulas.

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