CA2525994C - Silk biomaterials and methods of use thereof - Google Patents
Silk biomaterials and methods of use thereof Download PDFInfo
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- CA2525994C CA2525994C CA2525994A CA2525994A CA2525994C CA 2525994 C CA2525994 C CA 2525994C CA 2525994 A CA2525994 A CA 2525994A CA 2525994 A CA2525994 A CA 2525994A CA 2525994 C CA2525994 C CA 2525994C
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- silk
- fiber
- peo
- cells
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Classifications
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- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
- D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
- D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
- D01F6/94—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of other polycondensation products
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/165—Ethers
- D06M13/17—Polyoxyalkyleneglycol ethers
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
- D06M15/11—Starch or derivatives thereof
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Nonwoven Fabrics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39092902P | 2002-06-24 | 2002-06-24 | |
| US60/390,929 | 2002-06-24 | ||
| US40273802P | 2002-08-12 | 2002-08-12 | |
| US60/402,738 | 2002-08-12 | ||
| US43029102P | 2002-12-02 | 2002-12-02 | |
| US60/430,291 | 2002-12-02 | ||
| PCT/US2003/019968 WO2004000915A2 (en) | 2002-06-24 | 2003-06-24 | Silk biomaterials and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2525994A1 CA2525994A1 (en) | 2003-12-31 |
| CA2525994C true CA2525994C (en) | 2012-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2525994A Expired - Lifetime CA2525994C (en) | 2002-06-24 | 2003-06-24 | Silk biomaterials and methods of use thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7674882B2 (https=) |
| EP (4) | EP2662211A1 (https=) |
| JP (3) | JP4638735B2 (https=) |
| AU (1) | AU2003249366A1 (https=) |
| CA (1) | CA2525994C (https=) |
| WO (1) | WO2004000915A2 (https=) |
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| CA2413353C (en) * | 2000-06-29 | 2013-01-29 | Rita Kandel | Intervertebral disc |
| US6902932B2 (en) * | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| US20110009960A1 (en) * | 2001-11-16 | 2011-01-13 | Allergan, Inc. | Prosthetic fabric structure |
| EP2662211A1 (en) * | 2002-06-24 | 2013-11-13 | Tufts University | Silk biomaterials and methods of use thereof |
| WO2004062697A2 (en) | 2003-01-07 | 2004-07-29 | Tufts University | Silk fibroin materials and use thereof |
| CA2562415C (en) | 2003-04-10 | 2015-10-27 | Tufts University | Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof |
| US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| WO2005000483A1 (en) | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| JP5299810B2 (ja) | 2004-02-27 | 2013-09-25 | アムジエン・インコーポレーテツド | 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法 |
| GB0405045D0 (en) | 2004-03-05 | 2004-04-07 | Spinox Ltd | Composite materials |
| JP4526851B2 (ja) * | 2004-03-31 | 2010-08-18 | 明彦 谷岡 | 多糖類のナノスケールの繊維および成形体 |
| CN102683391B (zh) | 2004-06-04 | 2015-11-18 | 伊利诺伊大学评议会 | 用于制造并组装可印刷半导体元件的方法和设备 |
| US8178656B2 (en) | 2004-06-11 | 2012-05-15 | Trustees Of Tufts College | Silk-based drug delivery system |
| GB2417904A (en) * | 2004-09-14 | 2006-03-15 | Spinox Ltd | Tubular prosthesis for nerve regeneration |
| CA2580349C (en) * | 2004-09-14 | 2014-06-17 | Newrotex Limited | Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue |
| US9248015B2 (en) | 2005-03-11 | 2016-02-02 | Wake Forest University Health Services | Production of tissue engineered heart valves |
| CA2602029C (en) | 2005-03-11 | 2014-07-15 | Wake Forest University Health Sciences | Tissue engineered blood vessels |
| WO2006099332A2 (en) | 2005-03-11 | 2006-09-21 | Wake Forest University Health Sciences | Production of tissue engineered digits and limbs |
| US20060204539A1 (en) | 2005-03-11 | 2006-09-14 | Anthony Atala | Electrospun cell matrices |
| CN100577720C (zh) * | 2005-03-21 | 2010-01-06 | 中国科学院化学研究所 | 可生物降解及吸收的聚合物纳米纤维膜材料及制法和用途 |
| US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
| US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
| ATE526378T1 (de) | 2005-08-02 | 2011-10-15 | Tufts College | Verfahren zur stufenweisen ablagerung von seidenfibroinbeschichtungen |
| DE102005042455A1 (de) * | 2005-09-06 | 2007-04-12 | Medizinische Hochschule Hannover | Nervenimplantat |
| CN100382772C (zh) * | 2005-09-28 | 2008-04-23 | 南通大学 | 含蚕丝丝素的医用神经移植物的制备方法 |
| WO2007063820A1 (ja) * | 2005-12-02 | 2007-06-07 | Sunstar Suisse Sa | エレクトロスピニング法により形成された生体適合性のナノ又はマイクロファイバー不織布を有する生体適合材、及びその製造方法 |
| US20080038236A1 (en) * | 2006-03-06 | 2008-02-14 | Artecel Sciences, Inc. | Biocompatible scaffolds and adipose-derived stem cells |
| EP1852470A1 (en) * | 2006-05-03 | 2007-11-07 | Technische Universität München | Multilayer Silk Protein Films |
| CN100404081C (zh) * | 2006-06-09 | 2008-07-23 | 浙江大学 | 一种网状组织工程支架 |
| US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
| CN100364621C (zh) * | 2006-08-30 | 2008-01-30 | 黄福华 | 人造血管丝素蛋白预凝涂层 |
| CN100364619C (zh) * | 2006-08-30 | 2008-01-30 | 郑军 | 人造血管丝素、胶原蛋白共混预凝涂层 |
| US20110180951A1 (en) * | 2006-09-18 | 2011-07-28 | Wee Eong Teo | Fiber structures and process for their preparation |
| US8195021B2 (en) * | 2006-11-03 | 2012-06-05 | Tufts University/Trustees Of Tufts College | Biopolymer optical waveguide and method of manufacturing the same |
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| EP2662211A1 (en) | 2002-06-24 | 2013-11-13 | Tufts University | Silk biomaterials and methods of use thereof |
| CN1732014B (zh) | 2002-11-01 | 2013-05-22 | 塔夫茨大学理事会 | 模板天然丝近晶状凝胶 |
| US7169898B2 (en) * | 2002-12-04 | 2007-01-30 | Alexander Steinkasserer | Soluble CD83 proteins and use thereof for the treatment or prevention of a disease or medical condition caused by dysfunction or undesired function of a cellular immune response involving T cells |
| WO2004062697A2 (en) * | 2003-01-07 | 2004-07-29 | Tufts University | Silk fibroin materials and use thereof |
| CA2562415C (en) * | 2003-04-10 | 2015-10-27 | Tufts University | Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof |
| WO2005000483A1 (en) * | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| US8178656B2 (en) * | 2004-06-11 | 2012-05-15 | Trustees Of Tufts College | Silk-based drug delivery system |
| US7960509B2 (en) * | 2005-01-14 | 2011-06-14 | Trustees Of Tufts College | Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials |
| US9290579B2 (en) | 2005-04-20 | 2016-03-22 | Trustees Of Tufts College | Covalently immobilized protein gradients in three-dimensional porous scaffolds |
| ATE526378T1 (de) * | 2005-08-02 | 2011-10-15 | Tufts College | Verfahren zur stufenweisen ablagerung von seidenfibroinbeschichtungen |
| WO2008118133A2 (en) * | 2006-09-26 | 2008-10-02 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| US20100068740A1 (en) * | 2006-11-03 | 2010-03-18 | Trustees Of Tufts College | Microfluidic device with a cylindrical microchannel and a method for fabricating same |
| US8195021B2 (en) * | 2006-11-03 | 2012-06-05 | Tufts University/Trustees Of Tufts College | Biopolymer optical waveguide and method of manufacturing the same |
| US8529835B2 (en) | 2006-11-03 | 2013-09-10 | Tufts University | Biopolymer sensor and method of manufacturing the same |
| WO2008118211A2 (en) * | 2006-11-03 | 2008-10-02 | Trustees Of Tufts College | Biopolymer photonic crystals and method of manufacturing the same |
| JP2010509645A (ja) * | 2006-11-03 | 2010-03-25 | トラスティーズ オブ タフツ カレッジ | ナノパターンが形成されたバイオポリマー光学デバイスおよびその製造方法 |
| WO2008106485A2 (en) * | 2007-02-27 | 2008-09-04 | Trustees Of Tufts College | Tissue-engineered silk organs |
| KR20100029217A (ko) * | 2007-05-29 | 2010-03-16 | 트러스티즈 오브 터프츠 칼리지 | 음파 처리를 이용한 실크 피브로인 겔화 방법 |
| US8206774B2 (en) * | 2008-03-13 | 2012-06-26 | Trustees Of Tufts College | Diazonium salt modification of silk polymer |
| JP2010067203A (ja) * | 2008-09-12 | 2010-03-25 | Fujitsu Ltd | 生産順決定支援方法、生産順決定支援装置、およびコンピュータプログラム |
-
2003
- 2003-06-24 EP EP20130166547 patent/EP2662211A1/en not_active Withdrawn
- 2003-06-24 AU AU2003249366A patent/AU2003249366A1/en not_active Abandoned
- 2003-06-24 JP JP2004530973A patent/JP4638735B2/ja not_active Expired - Lifetime
- 2003-06-24 EP EP12152178.5A patent/EP2447055B1/en not_active Expired - Lifetime
- 2003-06-24 WO PCT/US2003/019968 patent/WO2004000915A2/en not_active Ceased
- 2003-06-24 CA CA2525994A patent/CA2525994C/en not_active Expired - Lifetime
- 2003-06-24 EP EP03761306.4A patent/EP1558444B1/en not_active Expired - Lifetime
- 2003-06-24 EP EP17205284.7A patent/EP3351376B1/en not_active Expired - Lifetime
-
2004
- 2004-12-23 US US11/020,650 patent/US7674882B2/en not_active Expired - Lifetime
-
2010
- 2010-01-15 US US12/688,014 patent/US8071722B2/en not_active Expired - Lifetime
- 2010-08-19 JP JP2010183530A patent/JP2011019923A/ja not_active Withdrawn
-
2014
- 2014-03-06 JP JP2014043805A patent/JP5855151B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4638735B2 (ja) | 2011-02-23 |
| AU2003249366A8 (en) | 2004-01-06 |
| EP1558444A2 (en) | 2005-08-03 |
| WO2004000915A2 (en) | 2003-12-31 |
| EP2447055B1 (en) | 2017-12-06 |
| JP5855151B2 (ja) | 2016-02-09 |
| EP3351376B1 (en) | 2023-04-12 |
| US7674882B2 (en) | 2010-03-09 |
| US8071722B2 (en) | 2011-12-06 |
| JP2006504450A (ja) | 2006-02-09 |
| CA2525994A1 (en) | 2003-12-31 |
| JP2014138877A (ja) | 2014-07-31 |
| EP1558444B1 (en) | 2016-09-21 |
| JP2011019923A (ja) | 2011-02-03 |
| AU2003249366A1 (en) | 2004-01-06 |
| EP2662211A1 (en) | 2013-11-13 |
| EP3351376A1 (en) | 2018-07-25 |
| EP1558444A4 (en) | 2010-10-13 |
| US20100196447A1 (en) | 2010-08-05 |
| EP2447055A1 (en) | 2012-05-02 |
| US20050260706A1 (en) | 2005-11-24 |
| WO2004000915A3 (en) | 2004-12-09 |
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