MX341351B - Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia. - Google Patents

Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia.

Info

Publication number
MX341351B
MX341351B MX2010011819A MX2010011819A MX341351B MX 341351 B MX341351 B MX 341351B MX 2010011819 A MX2010011819 A MX 2010011819A MX 2010011819 A MX2010011819 A MX 2010011819A MX 341351 B MX341351 B MX 341351B
Authority
MX
Mexico
Prior art keywords
epilepsy
adenosine
silk
release
epileptogenesis
Prior art date
Application number
MX2010011819A
Other languages
English (en)
Other versions
MX2010011819A (es
Inventor
L Kaplan David
Boison Detlev
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of MX2010011819A publication Critical patent/MX2010011819A/es
Publication of MX341351B publication Critical patent/MX341351B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención se relaciona a formulaciones de liberación sostenida que comprenden biopolímero de fibronía de seda y adenosina, que proporcionan una liberación focal, sostenida de adenosina en niveles terapéuticos para el tratamiento de la epilepsia y/o la prevención de la epileptogénesis. Una modalidad proporciona un implante de liberación de adenosina, basado en seda que alivia las convulsiones o previene la epileptogénesis. Otra modalidad proporciona un método para tratar la epilepsia o prevenir la epileptogénesis que comprende administrar focalmente adenosina en un sistema de suministro de adenosina basado en seda, de liberación sostenida.
MX2010011819A 2008-05-15 2009-05-15 Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia. MX341351B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5341308P 2008-05-15 2008-05-15
PCT/US2009/044117 WO2009140588A1 (en) 2008-05-15 2009-05-15 Silk polymer-based adenosine release: therapeutic potential for epilepsy

Publications (2)

Publication Number Publication Date
MX2010011819A MX2010011819A (es) 2010-11-30
MX341351B true MX341351B (es) 2016-08-17

Family

ID=41319072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010011819A MX341351B (es) 2008-05-15 2009-05-15 Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia.

Country Status (6)

Country Link
US (1) US9040073B2 (es)
EP (1) EP2299988A4 (es)
JP (1) JP5727366B2 (es)
CA (1) CA2721961A1 (es)
MX (1) MX341351B (es)
WO (1) WO2009140588A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
WO2005012606A2 (en) 2003-04-10 2005-02-10 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
CN103633099B (zh) 2004-06-04 2016-09-28 伊利诺伊大学评议会 可拉伸半导体元件、可拉伸电路及其制造方法
WO2008106485A2 (en) 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
KR101839659B1 (ko) 2007-05-29 2018-03-16 트러스티즈 오브 터프츠 칼리지 음파 처리를 이용한 실크 피브로인 겔화 방법
US9504575B2 (en) * 2008-02-07 2016-11-29 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
CA2721961A1 (en) 2008-05-15 2009-11-19 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
US8501172B2 (en) * 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
BRPI0920453A2 (pt) 2008-10-09 2015-12-22 Tufts College pelicula de seda, construção para engenharia de tecido, metodos para preparar uma película de seda, para cobrir uma superfície de um substrato com uma composição de seda, e para embutir pelo menos um agente ativo em uma película de seda, e, substrato coberto com película de sedal
US9427499B2 (en) 2008-11-17 2016-08-30 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti-adhesion barriers and anti-thrombotic materials
US20120070427A1 (en) 2009-06-01 2012-03-22 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
EP2453931A4 (en) 2009-07-14 2014-04-30 Tufts College WOUND HEALING SYSTEMS WITH AN ELECTRO-SPONSORED SILK MATERIAL
WO2011046652A2 (en) 2009-07-20 2011-04-21 Trustees Of Tufts College All-protein implantable, resorbable reflectors
EP2483460B1 (en) 2009-09-28 2015-09-02 Trustees Of Tufts College Method to prepare drawn silk egel fibers
JP5730317B2 (ja) 2009-09-29 2015-06-10 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法
US9723122B2 (en) 2009-10-01 2017-08-01 Mc10, Inc. Protective cases with integrated electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
JP6046491B2 (ja) 2009-12-16 2016-12-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ コンフォーマル電子機器を使用した生体内での電気生理学
WO2011109691A2 (en) 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
CN102892356B (zh) 2010-03-17 2016-01-13 伊利诺伊大学评议会 基于生物可吸收基质的可植入生物医学装置
JP6081358B2 (ja) 2010-09-01 2017-02-15 トラスティーズ・オブ・タフツ・カレッジＴｒｕｓｔｅｅｓ Ｏｆ Ｔｕｆｔｓ Ｃｏｌｌｅｇｅ 絹フィブロインおよびポリエチレングリコールをベースとする生体材料
EP2611492A2 (en) 2010-09-03 2013-07-10 Tufts University/Trustees of Tufts College Plasmonic nanoparticle-doped silk materials
WO2012054582A2 (en) 2010-10-19 2012-04-26 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
WO2013103424A2 (en) * 2011-10-11 2013-07-11 Tufts University Silk-based multifunctional biomedical platform
EP2786644B1 (en) 2011-12-01 2019-04-10 The Board of Trustees of the University of Illionis Transient devices designed to undergo programmable transformations
WO2013130156A2 (en) 2011-12-05 2013-09-06 Tufts University Signal enhancement by silk photonic crystals
ES2856873T3 (es) 2012-02-06 2021-09-28 Childrens Medical Center Biomaterial multicapa para la regeneración de tejidos y la cicatrización de las heridas
EP2830492B1 (en) 2012-03-30 2021-05-19 The Board of Trustees of the University of Illinois Appendage mountable electronic devices conformable to surfaces and method of making the same
WO2013163407A1 (en) 2012-04-25 2013-10-31 Trustees Of Tufts College Silk microspheres and methods for surface lubrication
US9018177B2 (en) 2012-10-12 2015-04-28 L'oreal S.A. Cosmetic compositions for increasing bioavailability of the active compounds baicalin and/or vitamin C
US9023826B2 (en) 2012-10-12 2015-05-05 L'oreal S.A. Compositions containing adenosine and the hydrotropes caffeine and nicotinamide for cosmetic use
US9107853B2 (en) 2012-10-12 2015-08-18 L'oreal S.A. Compositions containing phenolic compounds and hydrotropes for cosmetic use
US9072919B2 (en) 2012-10-12 2015-07-07 L'oreal S.A. Synergistic antioxidant cosmetic compositions containing at least one of baicalin and taxifolin, at least one of caffeine and nicotinamide, at least one of vitamin C and resveratrol and ferulic acid
EP2906547B2 (en) 2012-10-12 2022-10-26 L'Oréal Cosmetic compositions containing at least one hydrotrope and at least one active compound
US9669242B2 (en) 2013-07-01 2017-06-06 L'oreal Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use
JP2018524566A (ja) 2015-06-01 2018-08-30 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 代替的ｕｖセンシング手法
BR112017025609A2 (pt) 2015-06-01 2018-08-07 The Board Of Trustees Of The University Of Illinois sistemas eletrônicos miniaturizados com potência sem fio e capacidades de comunicação de campo próximo
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL29013C (es) * 1929-12-23
US3424164A (en) 1966-05-20 1969-01-28 Ethicon Inc Silk suture
JPS5838449B2 (ja) * 1979-04-17 1983-08-23 カネボウ株式会社 微粉末状絹フィプロインの製造法
JPS60142259A (ja) 1983-12-29 1985-07-27 Kanebo Ltd 固定化抗体
JPS60259677A (ja) 1984-05-31 1985-12-21 水島　繁三郎 動物蛋白吸着再生繊維からなる原糸、織物、編物及びその製造方法
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
JPS63190604A (ja) * 1987-02-03 1988-08-08 Agency Of Ind Science & Technol 新規の水−アルコ−ル分離膜
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
JPH0694518B2 (ja) 1987-11-02 1994-11-24 工業技術院長 絹フィブロイン多孔質体の製造方法
GB8800078D0 (en) * 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
JPH01254621A (ja) * 1988-04-01 1989-10-11 Terumo Corp 薬剤担体および徐放性薬剤ならびにそれらの製造方法
US5290494A (en) * 1990-03-05 1994-03-01 Board Of Regents, The University Of Texas System Process of making a resorbable implantation device
US5989894A (en) * 1990-04-20 1999-11-23 University Of Wyoming Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA
CA2100863A1 (en) * 1991-01-23 1992-07-24 David A. Bullough Adenosine kinase inhibitors
JPH06346314A (ja) 1993-06-02 1994-12-20 Toyobo Co Ltd 再生絹フィブロイン繊維およびその製造方法
JPH08295697A (ja) 1995-04-26 1996-11-12 Kanebo Ltd 高濃度絹フィブロイン水溶液の製造方法
JPH1036676A (ja) 1996-07-26 1998-02-10 Kanebo Ltd タンパク質水溶液の濃縮方法
KR100431659B1 (ko) * 1997-06-18 2004-05-17 독립행정법인농업생물자원연구소 견 피브로인 및 견 세리신을 주성분으로 하는 창상피복재 및 그의 제조방법
US6110902A (en) * 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
EP1006945A1 (en) 1997-07-01 2000-06-14 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6123819A (en) * 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
JP3101711B2 (ja) * 1997-11-20 2000-10-23 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子からなる吸着体／徐放体及びその製造方法
US5994099A (en) * 1997-12-31 1999-11-30 The University Of Wyoming Extremely elastic spider silk protein and DNA coding therefor
US6110590A (en) * 1998-04-15 2000-08-29 The University Of Akron Synthetically spun silk nanofibers and a process for making the same
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US6592623B1 (en) * 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
JP3151665B2 (ja) 1999-03-23 2001-04-03 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子／ポリアリルアミン複合体およびその製造方法
AU1412201A (en) 1999-11-15 2001-05-30 Akira Hachimori Molecularly composite polymeric material of fibroin/cellulose and process for producing the same
JP2003521350A (ja) 2000-02-03 2003-07-15 ネクシア バイオテクノロジーズ， インコーポレイテッド クモの糸を含む外科用縫合糸
IT1316885B1 (it) * 2000-10-02 2003-05-13 Consorzio Per Gli Studi Uni Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
JP2002128691A (ja) * 2000-10-24 2002-05-09 National Institute Of Agrobiological Sciences セリシン含有素材、その製造方法およびその使用方法
CA2405850A1 (en) * 2001-03-14 2002-10-10 Tetsuo Asakura Method for producing fiber and film of silk and silk-like material
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
US20030068446A1 (en) 2001-10-02 2003-04-10 Northwestern University Protein and peptide nanoarrays
GB0126118D0 (en) 2001-10-31 2002-01-02 Vollrath Friedrich W L Precursor feedstock for forming filaments
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
JP3803962B2 (ja) 2001-12-28 2006-08-02 独立行政法人科学技術振興機構 絹タンパク質フィルムとその製造方法
US7057023B2 (en) * 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
JP3772207B2 (ja) * 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
WO2004000915A2 (en) * 2002-06-24 2003-12-31 Tufts University Silk biomaterials and methods of use thereof
EP1565203B1 (en) 2002-11-01 2013-11-20 Trustees Of Tufts College Templated native silk smectic gels
US7842780B2 (en) * 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
WO2005012606A2 (en) * 2003-04-10 2005-02-10 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
US20050220853A1 (en) * 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
CA2608862C (en) 2004-06-11 2020-05-05 Trustees Of Tufts College Silk-based drug delivery system
WO2006076711A2 (en) * 2005-01-14 2006-07-20 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
US9290579B2 (en) * 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
US8354501B2 (en) * 2005-08-02 2013-01-15 Trustees Of Tufts College Methods for stepwise deposition of silk fibroin coatings
US8585753B2 (en) * 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US20100028451A1 (en) * 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
US20100068740A1 (en) * 2006-11-03 2010-03-18 Trustees Of Tufts College Microfluidic device with a cylindrical microchannel and a method for fabricating same
US20100046902A1 (en) * 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
JP2010509593A (ja) * 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ バイオポリマーセンサーおよびその製造方法
US8574461B2 (en) * 2006-11-03 2013-11-05 Tufts University Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same
CA2704769C (en) * 2006-11-03 2016-01-12 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
WO2008106485A2 (en) * 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
KR101839659B1 (ko) * 2007-05-29 2018-03-16 트러스티즈 오브 터프츠 칼리지 음파 처리를 이용한 실크 피브로인 겔화 방법
WO2009023615A1 (en) * 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US9599891B2 (en) * 2007-11-05 2017-03-21 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
US9504575B2 (en) * 2008-02-07 2016-11-29 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
US8206774B2 (en) * 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
US9068282B2 (en) * 2008-04-08 2015-06-30 Trustees Of Tufts College System and method for making biomaterial structures
CA2721961A1 (en) 2008-05-15 2009-11-19 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
WO2009155397A2 (en) * 2008-06-18 2009-12-23 Trustees Of Tufts College Edible holographic silk products
US8501172B2 (en) * 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
WO2011006133A2 (en) 2009-07-10 2011-01-13 Trustees Of Tufts College Bioengineered silk protein-based nucleic acid delivery systems

Also Published As

Publication number Publication date
EP2299988A1 (en) 2011-03-30
EP2299988A4 (en) 2013-10-16
CA2721961A1 (en) 2009-11-19
WO2009140588A1 (en) 2009-11-19
US20110152214A1 (en) 2011-06-23
MX2010011819A (es) 2010-11-30
JP5727366B2 (ja) 2015-06-03
US9040073B2 (en) 2015-05-26
JP2011520912A (ja) 2011-07-21

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