CA2450740C - Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes Download PDF

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Publication number
CA2450740C
CA2450740C CA002450740A CA2450740A CA2450740C CA 2450740 C CA2450740 C CA 2450740C CA 002450740 A CA002450740 A CA 002450740A CA 2450740 A CA2450740 A CA 2450740A CA 2450740 C CA2450740 C CA 2450740C
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Prior art keywords
compound
6alkyl
treatment
effective amount
substituted
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Expired - Lifetime
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CA002450740A
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English (en)
French (fr)
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CA2450740A1 (en
Inventor
Scott D. Edmondson
Michael H. Fisher
Dooseop Kim
Malcolm Maccoss
Emma R. Parmee
Ann E. Weber
Jinyou Xu
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Merck Sharp and Dohme LLC
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Merck and Co Inc
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CA2450740A1 publication Critical patent/CA2450740A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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CA002450740A 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes Expired - Lifetime CA2450740C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
US60/303,474 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number Publication Date
CA2450740A1 CA2450740A1 (en) 2003-01-16
CA2450740C true CA2450740C (en) 2006-02-14

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CA002450740A Expired - Lifetime CA2450740C (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Country Status (45)

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US (9) US6699871B2 (cg-RX-API-DMAC10.html)
EP (4) EP2226324A1 (cg-RX-API-DMAC10.html)
JP (1) JP3762407B2 (cg-RX-API-DMAC10.html)
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CN (2) CN1290848C (cg-RX-API-DMAC10.html)
AR (1) AR036114A1 (cg-RX-API-DMAC10.html)
AT (2) ATE471148T1 (cg-RX-API-DMAC10.html)
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BE (1) BE2007C047I2 (cg-RX-API-DMAC10.html)
BG (1) BG108493A (cg-RX-API-DMAC10.html)
BR (1) BRPI0210866B8 (cg-RX-API-DMAC10.html)
CA (1) CA2450740C (cg-RX-API-DMAC10.html)
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CY (3) CY2007019I2 (cg-RX-API-DMAC10.html)
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DK (2) DK1625847T3 (cg-RX-API-DMAC10.html)
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FR (2) FR07C0041I2 (cg-RX-API-DMAC10.html)
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PE (1) PE20030654A1 (cg-RX-API-DMAC10.html)
PL (1) PL196278B6 (cg-RX-API-DMAC10.html)
PT (2) PT1412357E (cg-RX-API-DMAC10.html)
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SI (1) SI1412357T1 (cg-RX-API-DMAC10.html)
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