CA1160629A - 4,5-deoxymaytansinoids, their production and use - Google Patents

4,5-deoxymaytansinoids, their production and use

Info

Publication number
CA1160629A
CA1160629A CA000387161A CA387161A CA1160629A CA 1160629 A CA1160629 A CA 1160629A CA 000387161 A CA000387161 A CA 000387161A CA 387161 A CA387161 A CA 387161A CA 1160629 A CA1160629 A CA 1160629A
Authority
CA
Canada
Prior art keywords
alkyl
hydrogen
process according
compound
deoxymaytansinol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000387161A
Other languages
English (en)
French (fr)
Inventor
Hiroshi Akimoto
Akiyoshi Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of CA1160629A publication Critical patent/CA1160629A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA000387161A 1980-10-08 1981-10-02 4,5-deoxymaytansinoids, their production and use Expired CA1160629A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1980/000240 WO1982001188A1 (en) 1980-10-08 1980-10-08 4,5-deoxymaytansinoide compounds and process for preparing same
JP80/00240 1980-10-08

Publications (1)

Publication Number Publication Date
CA1160629A true CA1160629A (en) 1984-01-17

Family

ID=13706099

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000387161A Expired CA1160629A (en) 1980-10-08 1981-10-02 4,5-deoxymaytansinoids, their production and use

Country Status (5)

Country Link
US (1) US4371533A (enExample)
EP (1) EP0049528A1 (enExample)
JP (1) JPS5798286A (enExample)
CA (1) CA1160629A (enExample)
WO (1) WO1982001188A1 (enExample)

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