US6096499A
(en)
*
|
1996-03-22 |
2000-08-01 |
Geron Corporation |
Mammalian DNA primase screen and activity modulating agents
|
US6482590B1
(en)
|
1996-12-20 |
2002-11-19 |
Aventis Behring Gmbh |
Method for polynucleotide amplification
|
US6605428B2
(en)
*
|
1996-12-20 |
2003-08-12 |
Roche Diagnostics Gmbh |
Method for the direct, exponential amplification and sequencing of DNA molecules and its application
|
US6399304B1
(en)
*
|
1996-12-20 |
2002-06-04 |
Roche Diagnostics Gmbh |
Sequential activation of one or more enzymatic activities within a thermocycling reaction for synthesizing DNA molecules
|
US20030215857A1
(en)
*
|
1996-12-20 |
2003-11-20 |
Roche Diagnostics Gmbh |
Method for the direct, exponential amplification and sequencing of DNA molecules and its application
|
US6828094B2
(en)
*
|
1996-12-20 |
2004-12-07 |
Roche Diagnostics Gmbh |
Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
US6183998B1
(en)
*
|
1998-05-29 |
2001-02-06 |
Qiagen Gmbh Max-Volmer-Strasse 4 |
Method for reversible modification of thermostable enzymes
|
US6132416A
(en)
*
|
1998-09-01 |
2000-10-17 |
Broselow; James B. |
Universal medication dosing system
|
US6440706B1
(en)
|
1999-08-02 |
2002-08-27 |
Johns Hopkins University |
Digital amplification
|
GB9920194D0
(en)
*
|
1999-08-27 |
1999-10-27 |
Advanced Biotech Ltd |
A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
|
AU2001253129A1
(en)
*
|
2000-04-03 |
2001-10-15 |
Biolink Partners, Inc. |
Reversible chemical modification of nucleic acids and improved method for nucleic acid hybridization
|
US7923205B2
(en)
*
|
2000-08-25 |
2011-04-12 |
Toshikazu Shiba |
Method for protecting personal information
|
US20070037144A1
(en)
*
|
2000-10-20 |
2007-02-15 |
Jay Wohlgemuth |
Leukocyte expression profiling
|
JP2002199877A
(ja)
*
|
2000-11-30 |
2002-07-16 |
Advanced Biotechnologies Ltd |
酵素の可逆的な不活性化およびその酵素を含むキット
|
GB0110501D0
(en)
*
|
2001-04-30 |
2001-06-20 |
Secr Defence Brit |
Amplification process
|
US7026121B1
(en)
*
|
2001-06-08 |
2006-04-11 |
Expression Diagnostics, Inc. |
Methods and compositions for diagnosing and monitoring transplant rejection
|
US6905827B2
(en)
*
|
2001-06-08 |
2005-06-14 |
Expression Diagnostics, Inc. |
Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
|
US7235358B2
(en)
|
2001-06-08 |
2007-06-26 |
Expression Diagnostics, Inc. |
Methods and compositions for diagnosing and monitoring transplant rejection
|
EP1275735A1
(en)
*
|
2001-07-11 |
2003-01-15 |
Roche Diagnostics GmbH |
Composition and method for hot start nucleic acid amplification
|
WO2003042383A1
(fr)
*
|
2001-11-14 |
2003-05-22 |
Toyo Boseki Kabushiki Kaisha |
Promoteurs de replication de l'adn, facteurs associes a l'adn polymerase et utilisation de ces derniers
|
CA2409775C
(en)
*
|
2001-12-03 |
2010-07-13 |
F. Hoffmann-La Roche Ag |
Reversibly modified thermostable enzymes for dna synthesis and amplification in vitro
|
ATE485372T1
(de)
*
|
2002-01-09 |
2010-11-15 |
Sysmex Corp |
Nukleinsäurenachweisverfahren und system dafür
|
US20050221349A1
(en)
*
|
2002-05-30 |
2005-10-06 |
Stuart Wilson |
Methods of detecting target molecules and molecular interactions
|
US6896727B2
(en)
*
|
2002-06-28 |
2005-05-24 |
Seh America, Inc. |
Method of determining nitrogen concentration within a wafer
|
EP1403379A1
(en)
*
|
2002-09-24 |
2004-03-31 |
QIAGEN GmbH |
Enhanced coamplification of nucleic acids
|
WO2004087868A2
(en)
|
2003-03-25 |
2004-10-14 |
Stratagene |
Dna polymerase fusions and uses thereof
|
DE10315640A1
(de)
*
|
2003-04-04 |
2004-10-14 |
Ignatov, Konstantin |
Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
|
US7892745B2
(en)
*
|
2003-04-24 |
2011-02-22 |
Xdx, Inc. |
Methods and compositions for diagnosing and monitoring transplant rejection
|
AU2004203649B2
(en)
|
2003-08-12 |
2006-01-12 |
F. Hoffmann-La Roche Ag |
Thermostable Taq polymerase fragment
|
EP2208797A3
(en)
|
2004-03-01 |
2010-11-24 |
Applied Biosystems, LLC |
Methods, compositions and kits for use in polynucleotide amplification
|
KR100624490B1
(ko)
|
2004-05-27 |
2006-09-20 |
바이오퀘스트(주) |
화학변형 열안정성 dna 중합효소
|
US7311794B2
(en)
|
2004-05-28 |
2007-12-25 |
Wafergen, Inc. |
Methods of sealing micro wells
|
CN101426908B
(zh)
*
|
2004-06-09 |
2014-06-11 |
纽星实验室 |
可逆性修饰的热稳定酶组合物及其制备方法和使用方法
|
US7700281B2
(en)
*
|
2004-06-30 |
2010-04-20 |
Usb Corporation |
Hot start nucleic acid amplification
|
JP2008502352A
(ja)
*
|
2004-06-30 |
2008-01-31 |
アプレラ コーポレイション |
ポリヌクレオチドをライゲーションするための、方法、反応混合物およびキット
|
US7645575B2
(en)
*
|
2004-09-08 |
2010-01-12 |
Xdx, Inc. |
Genes useful for diagnosing and monitoring inflammation related disorders
|
US20060051796A1
(en)
*
|
2004-09-09 |
2006-03-09 |
Inga Boell |
Real time PCR with the addition of pyrophosphatase
|
EP1634965B1
(en)
|
2004-09-09 |
2010-01-20 |
Roche Diagnostics GmbH |
Real time PCR with the addition of pyrophosphatase
|
EP1791982B1
(en)
|
2004-09-21 |
2011-01-05 |
Life Technologies Corporation |
TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (MIRNAs)
|
RU2495046C2
(ru)
*
|
2004-10-18 |
2013-10-10 |
Брандейс Юнивесити |
Реагент и способ предотвращения по меньшей мере одного ошибочного старта в амплификации полимеразной цепной реакции, наборы реагентов и олигонуклеотидов для осуществления амплификации посредством полимеразной цепной реакции
|
US20060228726A1
(en)
*
|
2005-01-06 |
2006-10-12 |
Martin Patrick K |
Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
|
WO2006076650A2
(en)
*
|
2005-01-12 |
2006-07-20 |
Applera Corporation |
Compositions, methods, and kits for selective amplification of nucleic acids
|
EP1885889A4
(en)
*
|
2005-05-11 |
2010-01-20 |
Expression Diagnostics Inc |
METHOD FOR MONITORING THE OPERATING STATUS OF TRANSPLANTS OVER GENLISTS
|
ATE489473T1
(de)
*
|
2005-07-15 |
2010-12-15 |
Life Technologies Corp |
Analyse von boten-rna und mikro-rna im gleichen reaktionsansatz
|
US20070128620A1
(en)
|
2005-07-15 |
2007-06-07 |
Applera Corporation |
Hot start reverse transcription by primer design
|
US20070059713A1
(en)
|
2005-09-09 |
2007-03-15 |
Lee Jun E |
SSB-DNA polymerase fusion proteins
|
JP5438320B2
(ja)
|
2005-10-03 |
2014-03-12 |
アプライド バイオシステムズ リミテッド ライアビリティー カンパニー |
核酸を増幅するための組成物、方法およびキット
|
DE102005047617A1
(de)
*
|
2005-10-05 |
2007-04-19 |
Qiagen Gmbh |
Polymerase-Kettenreaktions-Verfahren unter Einsatz einer DNA-Polymerase mit Proofreading-Eigenschaft
|
GB0600228D0
(en)
|
2006-01-06 |
2006-02-15 |
Fermentas Uab |
Inactivation method
|
ES2364983T3
(es)
*
|
2006-02-27 |
2011-09-20 |
F. Hoffmann-La Roche Ag |
Reacción en cadena de polimerasa con arranque en caliente por secuestro de magnesio.
|
DE102006015960A1
(de)
*
|
2006-04-04 |
2007-10-11 |
Qiagen Gmbh |
Gemisch reversibel inhibierter Enzyme
|
CA2648580A1
(en)
*
|
2006-04-07 |
2008-05-02 |
Xdx, Inc. |
Steroid responsive nucleic acid expression and prediction of disease activity
|
US8232091B2
(en)
*
|
2006-05-17 |
2012-07-31 |
California Institute Of Technology |
Thermal cycling system
|
DE602007013223D1
(de)
*
|
2006-06-01 |
2011-04-28 |
Trilink Biotechnologies San Diego |
Chemisch modifizierte oligonukleotidprimer zur nukleinsäureamplifikation
|
US11001881B2
(en)
|
2006-08-24 |
2021-05-11 |
California Institute Of Technology |
Methods for detecting analytes
|
US8435774B2
(en)
*
|
2006-06-28 |
2013-05-07 |
Qiagen Gmbh |
Enhancing reactivation of thermostable reversibly inactivated enzymes
|
US7915014B2
(en)
*
|
2006-07-17 |
2011-03-29 |
Brandeis University |
Specialized oligonucleotides and their use in nucleic acid amplification and detection
|
US11525156B2
(en)
|
2006-07-28 |
2022-12-13 |
California Institute Of Technology |
Multiplex Q-PCR arrays
|
WO2008014485A2
(en)
|
2006-07-28 |
2008-01-31 |
California Institute Of Technology |
Multiplex q-pcr arrays
|
ATE538216T1
(de)
*
|
2006-07-31 |
2012-01-15 |
Wanli Bi |
Nukleinsäureverstärkung mithilfe eines reversibel modifizierten oligonukleotids
|
US9045522B2
(en)
|
2006-07-31 |
2015-06-02 |
Wanli Bi |
Nucleic acid amplification using a reversibly modified oligonucleotide
|
WO2008021431A2
(en)
*
|
2006-08-14 |
2008-02-21 |
Xdx, Inc. |
Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
|
US11560588B2
(en)
|
2006-08-24 |
2023-01-24 |
California Institute Of Technology |
Multiplex Q-PCR arrays
|
EP2102367A2
(en)
*
|
2006-11-09 |
2009-09-23 |
XDX, Inc. |
Methods for diagnosing and monitoring the status of systemic lupus erythematosus
|
KR100825279B1
(ko)
*
|
2006-11-30 |
2008-04-25 |
한국해양연구원 |
Dnα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자
|
US7902345B2
(en)
|
2006-12-05 |
2011-03-08 |
Sequenom, Inc. |
Detection and quantification of biomolecules using mass spectrometry
|
CN101711257A
(zh)
|
2007-01-22 |
2010-05-19 |
瓦弗根公司 |
用于高通量化学反应的装置
|
US20090036325A1
(en)
*
|
2007-05-25 |
2009-02-05 |
Applera Corporation |
Directed assembly of amplicons to enhance read pairing signature with massively parallel short read sequencers
|
GB0711683D0
(en)
*
|
2007-06-16 |
2007-07-25 |
Enigma Diagnostics Ltd |
Compositions
|
EP2167686A1
(en)
*
|
2007-06-16 |
2010-03-31 |
Enigma Diagnostics Ltd. |
Compositions
|
WO2009029648A2
(en)
*
|
2007-08-27 |
2009-03-05 |
Applera Corporation |
Methods and compositions for pcr
|
WO2009032781A2
(en)
|
2007-08-29 |
2009-03-12 |
Sequenom, Inc. |
Methods and compositions for universal size-specific polymerase chain reaction
|
WO2009087394A1
(en)
*
|
2008-01-11 |
2009-07-16 |
Genesys Ltd |
Cren7 chimeric protein
|
GB0803628D0
(en)
*
|
2008-02-28 |
2008-04-02 |
Genesys Ltd |
Enzyme
|
GB0804721D0
(en)
*
|
2008-03-14 |
2008-04-16 |
Genesys Ltd |
Enzyme
|
GB0804722D0
(en)
*
|
2008-03-14 |
2008-04-16 |
Genesys Ltd |
Enzyme
|
CA2658520C
(en)
|
2008-03-19 |
2016-11-08 |
F. Hoffmann-La Roche Ag |
Nucleic acid amplification in the presence of modified randomers
|
EP2113574A1
(en)
|
2008-04-28 |
2009-11-04 |
Biotype AG |
Substances and methods for a DNA based profiling assay
|
EP3150727B1
(en)
*
|
2008-04-30 |
2019-07-10 |
Integrated DNA Technologies Inc. |
Rnase-h-based assays utilizing modified rna monomers
|
US9434988B2
(en)
|
2008-04-30 |
2016-09-06 |
Integrated Dna Technologies, Inc. |
RNase H-based assays utilizing modified RNA monomers
|
US8911948B2
(en)
*
|
2008-04-30 |
2014-12-16 |
Integrated Dna Technologies, Inc. |
RNase H-based assays utilizing modified RNA monomers
|
US10227641B2
(en)
|
2008-04-30 |
2019-03-12 |
Integrated Dna Technologies, Inc. |
RNase H-based assays utilizing modified RNA monomers
|
AU2009257815B2
(en)
|
2008-05-27 |
2014-05-29 |
Trilink Biotechnologies |
Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid
|
EP2300613A4
(en)
*
|
2008-06-18 |
2011-11-09 |
Life Technologies Corp |
THERMALLY STABLE CHEMICALLY MODIFIED POLYMERIAS DNA MUTANTS
|
ES2532632T3
(es)
|
2008-06-30 |
2015-03-30 |
Life Technologies Corporation |
Método de amplificación directa a partir de muestras de ácido nucleico en bruto
|
CN102149824A
(zh)
|
2008-07-03 |
2011-08-10 |
阿莱洛吉克生物科学公司 |
保护亲核基团的组合物和方法
|
US8583380B2
(en)
|
2008-09-05 |
2013-11-12 |
Aueon, Inc. |
Methods for stratifying and annotating cancer drug treatment options
|
US7910720B2
(en)
|
2008-09-09 |
2011-03-22 |
Roche Diagnostics Operations, Inc. |
Polyanion for improved nucleic acid amplification
|
US8206929B2
(en)
|
2009-01-07 |
2012-06-26 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification with allele-specific suppression of sequence variants
|
CN102272319B
(zh)
|
2009-01-08 |
2014-08-27 |
伯乐实验室公司 |
用于提高核酸扩增反应效率的方法和组合物
|
JP5457222B2
(ja)
|
2009-02-25 |
2014-04-02 |
エフ.ホフマン−ラ ロシュ アーゲー |
小型化ハイスループット核酸分析
|
US9347092B2
(en)
*
|
2009-02-25 |
2016-05-24 |
Roche Molecular System, Inc. |
Solid support for high-throughput nucleic acid analysis
|
DE102009010639B4
(de)
*
|
2009-02-26 |
2020-07-02 |
Boehringer Ingelheim Vetmedica Gmbh |
Verfahren und Anordnung zur Inhibierung einer chemischen Reaktion von Substanzen in einer Flüssigkeit vor einer Messung
|
US8039215B2
(en)
|
2009-03-10 |
2011-10-18 |
Roche Molecular Systems, Inc. |
Multiplex quantitative nucleic acid amplification and melting assay
|
WO2010105074A1
(en)
|
2009-03-12 |
2010-09-16 |
Brandeis University |
Reagents and methods for pcr
|
US10196700B2
(en)
|
2009-03-24 |
2019-02-05 |
University Of Chicago |
Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
|
KR101796906B1
(ko)
|
2009-03-24 |
2017-11-10 |
유니버시티 오브 시카고 |
반응을 수행하기 위한 방법
|
US9464319B2
(en)
|
2009-03-24 |
2016-10-11 |
California Institute Of Technology |
Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
|
US9447461B2
(en)
|
2009-03-24 |
2016-09-20 |
California Institute Of Technology |
Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
|
EP2411539B1
(en)
|
2009-03-25 |
2018-10-03 |
Life Technologies Corporation |
Discriminatory positive/extraction control dna
|
WO2010115160A2
(en)
*
|
2009-04-03 |
2010-10-07 |
Helixis, Inc. |
Devices and methods for heating biological samples
|
US8987685B2
(en)
*
|
2009-09-09 |
2015-03-24 |
Pcr Max Limited |
Optical system for multiple reactions
|
WO2011044444A2
(en)
*
|
2009-10-09 |
2011-04-14 |
Life Technologies Corporation |
cDNA SYNTHESIS USING A REVERSIBLY INACTIVATED REVERSE TRANSCRIPTASE
|
US20110117559A1
(en)
*
|
2009-11-13 |
2011-05-19 |
Integrated Dna Technologies, Inc. |
Small rna detection assays
|
CA2780678A1
(en)
|
2009-11-19 |
2011-05-26 |
Ou Solis Biodyne |
Compositions for increasing polypeptide stability and activity, and related methods
|
EP2507220B1
(en)
*
|
2009-12-04 |
2016-10-05 |
Biotium Inc. |
Heterocycle-substituted xanthene dyes
|
US8614071B2
(en)
|
2009-12-11 |
2013-12-24 |
Roche Molecular Systems, Inc. |
Preferential amplification of mRNA over DNA using chemically modified primers
|
US9238832B2
(en)
|
2009-12-11 |
2016-01-19 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids
|
WO2011119934A2
(en)
|
2010-03-26 |
2011-09-29 |
Mayo Foundation For Medical Education And Research |
Methods and materials for detecting colorectal neoplasm
|
US9068017B2
(en)
|
2010-04-08 |
2015-06-30 |
Ibis Biosciences, Inc. |
Compositions and methods for inhibiting terminal transferase activity
|
US20110250598A1
(en)
|
2010-04-12 |
2011-10-13 |
Ulrike Fischer |
Detergent free polymerases
|
EP2569452B1
(en)
|
2010-05-14 |
2020-03-25 |
Life Technologies Corporation |
Karyotyping assay
|
US8618253B2
(en)
*
|
2010-05-25 |
2013-12-31 |
Samsung Techwin Co., Ltd. |
Modified RNAse H and detection of nucleic acid amplification
|
WO2011150277A2
(en)
|
2010-05-28 |
2011-12-01 |
Life Technologies Corporation |
Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization
|
ES2536978T3
(es)
|
2010-06-18 |
2015-06-01 |
F. Hoffmann-La Roche Ag |
ADN polimerasas con discriminación incrementada de no correspondencias 3'
|
US8715991B2
(en)
|
2010-06-18 |
2014-05-06 |
Roche Molecular Systems, Inc. |
DNA polymerases with increased 3'-mismatch discrimination
|
US8722380B2
(en)
|
2010-06-18 |
2014-05-13 |
Roche Molecular Systems, Inc. |
DNA polymerases with increased 3′-mismatch discrimination
|
JP5926247B2
(ja)
|
2010-06-18 |
2016-05-25 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
増大した3’末端ミスマッチ識別能を有するdnaポリメラーゼ
|
US8759062B2
(en)
|
2010-06-18 |
2014-06-24 |
Roche Molecular Systems, Inc. |
DNA polymerases with increased 3′- mismatch discrimination
|
AU2011267421B2
(en)
|
2010-06-18 |
2014-04-24 |
F. Hoffmann-La Roche Ag |
DNA polymerases with increased 3'-mismatch discrimination
|
CA2802239C
(en)
|
2010-06-18 |
2016-08-23 |
F. Hoffmann-La Roche Ag |
Dna polymerases with increased 3'-mismatch discrimination
|
WO2011157436A1
(en)
|
2010-06-18 |
2011-12-22 |
Roche Diagnostics Gmbh |
Dna polymerases with increased 3'-mismatch discrimination
|
EP3150723B1
(en)
|
2010-06-21 |
2019-01-30 |
Life Technologies Corporation |
Compositions, kits, and methods for synthesis and/or detection of nucleic acids
|
WO2012038049A2
(en)
|
2010-09-22 |
2012-03-29 |
Roche Diagnostics Gmbh |
Amplification of distant nucleic acid targets using engineered primers
|
IN2013MN00522A
(pt)
|
2010-09-24 |
2015-05-29 |
Univ Leland Stanford Junior |
|
ES2533732T3
(es)
|
2010-10-04 |
2015-04-14 |
F. Hoffmann-La Roche Ag |
Método para lisis celular en un tampón de reacción de RT-PCR
|
CA2810317A1
(en)
|
2010-10-04 |
2012-04-12 |
F. Hoffmann-La Roche Ag |
Method for cell lysis in a pcr reaction buffer
|
WO2012045669A1
(en)
|
2010-10-04 |
2012-04-12 |
Roche Diagnostics Gmbh |
Method for cell lysis and pcr within the same reaction vessel
|
WO2012054730A1
(en)
|
2010-10-22 |
2012-04-26 |
Oslo Universitetssykehus Hf |
Methods and kits for detection of 5-hydroxymethylcytosine
|
CN103370425B
(zh)
*
|
2010-12-17 |
2019-03-19 |
生命技术公司 |
用于核酸扩增的方法、组合物、系统、仪器和试剂盒
|
WO2012125220A2
(en)
|
2011-01-14 |
2012-09-20 |
Life Technologies Corporation |
Methods for isolation, identification, and quantification of mirnas
|
EP2665833B1
(en)
|
2011-01-17 |
2017-04-19 |
Life Technologies Corporation |
Workflow for detection of ligands using nucleic acids
|
AU2012212127B2
(en)
|
2011-02-02 |
2016-06-02 |
Exact Sciences Corporation |
Digital sequence analysis of DNA methylation
|
WO2012110061A1
(en)
|
2011-02-15 |
2012-08-23 |
Roche Diagnostics Gmbh |
Dna polymerases with increased 3'-mismatch discrimination
|
EP2683834B1
(en)
|
2011-03-10 |
2017-12-06 |
Oslo Universitetssykehus HF |
Methods and biomarkers for detection of gastrointestinal cancers
|
WO2012139748A1
(en)
|
2011-04-11 |
2012-10-18 |
Roche Diagnostics Gmbh |
Dna polymerases with improved activity
|
US8993341B2
(en)
|
2011-05-12 |
2015-03-31 |
Exact Sciences Corporation |
Removal of PCR inhibitors
|
ES2773692T3
(es)
|
2011-05-12 |
2020-07-14 |
Exact Sciences Corp |
Aislamiento de ácidos nucleicos
|
US8808990B2
(en)
|
2011-05-12 |
2014-08-19 |
Exact Sciences Corporation |
Serial isolation of multiple DNA targets from stool
|
WO2012170907A2
(en)
|
2011-06-08 |
2012-12-13 |
Life Technologies Corporation |
Polymerization of nucleic acids using proteins having low isoelectric points
|
EP2718260B1
(en)
|
2011-06-08 |
2018-07-25 |
Life Technologies Corporation |
Design and development of novel detergents for use in pcr systems
|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
CN103687943B
(zh)
|
2011-07-28 |
2015-11-25 |
霍夫曼-拉罗奇有限公司 |
具有改进活性的dna聚合酶
|
US9758837B2
(en)
|
2011-08-02 |
2017-09-12 |
The United States Of America, As Represented By The Secretary Of Agriculture |
Sensitive and rapid method for Candidatus Liberibacter species detection
|
WO2013043715A1
(en)
|
2011-09-19 |
2013-03-28 |
Genentech, Inc. |
Combination treatments comprising c-met antagonists and b-raf antagonists
|
ES2656961T3
(es)
|
2011-09-23 |
2018-03-01 |
F. Hoffmann-La Roche Ag |
Uso de G-Clamp para mejorar la PCR específica de alelo
|
JP2014533100A
(ja)
|
2011-11-04 |
2014-12-11 |
オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf |
結腸直腸癌の分析のための方法およびバイオマーカー
|
US9260714B2
(en)
*
|
2011-12-02 |
2016-02-16 |
Roche Molecular Systems, Inc. |
Suppression of non-specific amplification with high-homology oligonucleotides
|
ES2569723T3
(es)
|
2011-12-08 |
2016-05-12 |
F. Hoffmann-La Roche Ag |
Polimerasas de DNA con actividad mejorada
|
CN103987843B
(zh)
|
2011-12-08 |
2015-12-23 |
霍夫曼-拉罗奇有限公司 |
具有改进活性的dna聚合酶
|
ES2716277T3
(es)
|
2011-12-08 |
2019-06-11 |
Hoffmann La Roche |
ADN polimerasas con actividad mejorada
|
EP3425065B1
(en)
|
2011-12-13 |
2021-04-21 |
Oslo Universitetssykehus HF |
Methods and kits for detection of methylation status
|
US9115394B2
(en)
|
2011-12-22 |
2015-08-25 |
Roche Molecular Systems, Inc. |
Methods and reagents for reducing non-specific amplification
|
US9822417B2
(en)
|
2012-01-09 |
2017-11-21 |
Oslo Universitetssykehus Hf |
Methods and biomarkers for analysis of colorectal cancer
|
GB201201547D0
(en)
|
2012-01-30 |
2012-03-14 |
Olink Ab |
Method and product
|
US11617835B2
(en)
|
2012-02-01 |
2023-04-04 |
Cd Acquisitions, Llc |
Apparatuses, methods, and systems for delivering measured doses of medication
|
JP2015505510A
(ja)
|
2012-02-01 |
2015-02-23 |
セルタ ドース,インコーポレイティド |
医薬品送達システム
|
EP4361607A2
(en)
|
2012-02-03 |
2024-05-01 |
California Institute of Technology |
Signal encoding and decoding in multiplexed biochemical assays
|
EP2817627A2
(en)
|
2012-02-21 |
2014-12-31 |
Oslo Universitetssykehus HF |
Methods and biomarkers for detection and prognosis of cervical cancer
|
US9085761B1
(en)
|
2012-06-14 |
2015-07-21 |
Affymetrix, Inc. |
Methods and compositions for amplification of nucleic acids
|
KR20210072137A
(ko)
|
2012-06-14 |
2021-06-16 |
라이프 테크놀로지스 코포레이션 |
폴리머라제 연쇄 반응 (pcr)을 위한 신규 조성물, 방법 및 키트
|
WO2014022827A1
(en)
|
2012-08-03 |
2014-02-06 |
California Institute Of Technology |
Multiplexing and quantification in pcr with reduced hardware and requirements
|
US9212392B2
(en)
|
2012-09-25 |
2015-12-15 |
Exact Sciences Corporation |
Normalization of polymerase activity
|
GB201217405D0
(en)
*
|
2012-09-28 |
2012-11-14 |
Fermentas Uab |
Protein removal agent
|
WO2014071322A1
(en)
|
2012-11-02 |
2014-05-08 |
Life Technologies Corporation |
Small RNA Capture, Detection and Quantification
|
US9710596B2
(en)
|
2012-11-21 |
2017-07-18 |
Exact Sciences Corporation |
Methods for quantifying nucleic acid variations
|
WO2014095951A1
(en)
*
|
2012-12-20 |
2014-06-26 |
Roche Diagnostics Gmbh |
Characterization of thermostable dna polymerase
|
GB201301457D0
(en)
|
2013-01-28 |
2013-03-13 |
Fluorogenics Ltd |
Freeze-dried composition
|
WO2014165210A2
(en)
|
2013-03-12 |
2014-10-09 |
Life Technologies Corporation |
Universal reporter-based genotyping methods and materials
|
ES2712798T3
(es)
|
2013-03-14 |
2019-05-14 |
Exact Sciences Dev Co Llc |
Detección de neoplasias
|
CA2905429A1
(en)
|
2013-03-14 |
2014-10-02 |
Abbott Molecular Inc. |
Minimizing errors using uracil-dna-n-glycosylase
|
WO2014184684A2
(en)
|
2013-05-16 |
2014-11-20 |
Oslo Universitetssykehus Hf |
Methods and biomarkers for detection of hematological cancers
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
US20150232931A1
(en)
|
2013-09-20 |
2015-08-20 |
The Regents Of The University Of Michigan |
Compositions and methods for the analysis of radiosensitivity
|
CN106458885B
(zh)
|
2013-10-25 |
2019-12-10 |
生命技术公司 |
用于聚合酶链式反应系统的新颖化合物及其应用
|
US10253358B2
(en)
|
2013-11-04 |
2019-04-09 |
Exact Sciences Development Company, Llc |
Multiple-control calibrators for DNA quantitation
|
KR101488110B1
(ko)
|
2013-11-29 |
2015-01-29 |
성균관대학교산학협력단 |
나노아케움 이퀴탄스 유래의 Neq HS DNA 중합효소의 돌연변이체 제조 및 이를 이용한 hot-start PCR 응용
|
WO2015085230A1
(en)
|
2013-12-06 |
2015-06-11 |
Bio-Rad Laboratories, Inc. |
Fusion polymerases
|
EP4209600A1
(en)
|
2013-12-19 |
2023-07-12 |
Exact Sciences Corporation |
Synthetic nucleic acid control molecules
|
WO2015107430A2
(en)
|
2014-01-16 |
2015-07-23 |
Oslo Universitetssykehus Hf |
Methods and biomarkers for detection and prognosis of cervical cancer
|
JP2017503521A
(ja)
|
2014-01-22 |
2017-02-02 |
ライフ テクノロジーズ コーポレーション |
高温核酸合成で使用するための新規な逆転写酵素
|
WO2015153283A1
(en)
|
2014-03-31 |
2015-10-08 |
Mayo Foundation For Medical Education And Research |
Detecting colorectal neoplasm
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
EP3207156A1
(en)
|
2014-10-13 |
2017-08-23 |
Life Technologies Corporation |
Methods, kits & compositions for determining gene copy numbers
|
CA3183545A1
(en)
|
2014-12-12 |
2016-06-16 |
Exact Sciences Corporation |
Compositions and methods for performing methylation detection assays
|
CN113897432A
(zh)
|
2014-12-12 |
2022-01-07 |
精密科学公司 |
用于进行甲基化检测测定的组合物和方法
|
EP3795681A3
(en)
|
2014-12-16 |
2021-06-09 |
Life Technologies Corporation |
Polymerase compositions and methods of making and using same
|
US9909169B2
(en)
|
2014-12-17 |
2018-03-06 |
Roche Molecular Systems, Inc. |
Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
|
EP3822361A1
(en)
|
2015-02-20 |
2021-05-19 |
Takara Bio USA, Inc. |
Method for rapid accurate dispensing, visualization and analysis of single cells
|
CN114250278A
(zh)
|
2015-03-13 |
2022-03-29 |
生命技术公司 |
捕获、检测和定量小rna的方法、组合物与试剂盒
|
EP3274440A4
(en)
|
2015-03-27 |
2019-03-06 |
Exact Sciences Corporation |
PROOF OF DISEASES OF THE DISHES
|
CN104845967B
(zh)
|
2015-04-15 |
2020-12-11 |
苏州新海生物科技股份有限公司 |
寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
|
AU2016252998B2
(en)
|
2015-04-24 |
2021-11-04 |
Atila Biosystems Incorporated |
Amplification with primers of limited nucleotide composition
|
US11015217B2
(en)
|
2015-05-29 |
2021-05-25 |
Roche Molecular Systems, Inc. |
Method of inactivating microbes by citraconic anhydride
|
USD938023S1
(en)
|
2015-09-02 |
2021-12-07 |
Certa Dose, Inc. |
Drug delivery syringe
|
GB201518655D0
(en)
|
2015-10-21 |
2015-12-02 |
Olink Ab |
Method for generating proximity probes
|
EP4269577A3
(en)
|
2015-10-23 |
2024-01-17 |
President and Fellows of Harvard College |
Nucleobase editors and uses thereof
|
WO2017075061A1
(en)
|
2015-10-30 |
2017-05-04 |
Exact Sciences Corporation |
Multiplex amplification detection assay and isolation and detection of dna from plasma
|
WO2017123748A1
(en)
|
2016-01-13 |
2017-07-20 |
New England Biolabs, Inc. |
Thermostable variants of t7 rna polymerase
|
EP3402880B1
(en)
|
2016-01-15 |
2024-01-03 |
Thermo Fisher Scientific Baltics UAB |
Thermophilic dna polymerase mutants
|
PL3408408T3
(pl)
|
2016-01-27 |
2019-09-30 |
Devyser Holding Ab |
Selektywna amplifikacja pożądanych regionów kwasów nukleinowych w sekwencji stanowiącej cel
|
WO2017155858A1
(en)
|
2016-03-07 |
2017-09-14 |
Insilixa, Inc. |
Nucleic acid sequence identification using solid-phase cyclic single base extension
|
AU2017248219B2
(en)
|
2016-04-06 |
2023-09-07 |
Life Technologies Corporation |
Compositions, methods, and kits for synthesis and detection of nucleic acids
|
US20170321286A1
(en)
|
2016-05-05 |
2017-11-09 |
Exact Sciences Corporation |
Detection of lung neoplasia by amplification of rna sequences
|
CA3022911A1
(en)
|
2016-05-05 |
2017-11-09 |
Exact Sciences Development Company, Llc |
Detection of lung neoplasia by analysis of methylated dna
|
WO2017197145A1
(en)
|
2016-05-11 |
2017-11-16 |
Certa Dose, Inc. |
Radiological dosing system and method
|
EP3464596A1
(en)
|
2016-06-07 |
2019-04-10 |
Cepheid |
Thermostable polymerase inhibitor compositions and methods
|
CN109477150B
(zh)
|
2016-06-16 |
2023-03-31 |
生命技术公司 |
用于检测微生物的组合物、方法和试剂盒
|
CN109642252A
(zh)
|
2016-06-17 |
2019-04-16 |
加州理工学院 |
核酸反应及相关方法和组合物
|
EP3486321A4
(en)
*
|
2016-06-23 |
2020-01-15 |
Riken |
SYSTEM FOR T CELL RECEPTOR AND B CELL RECEPTOR ANALYSIS USING ONE-STEP RT-PCR WITH MATRIX SWITCHING
|
FR3053968A1
(fr)
|
2016-07-13 |
2018-01-19 |
Biomerieux |
Reactifs pour la protection reversible de molecules biologiques
|
CN109642227B
(zh)
|
2016-07-19 |
2023-02-28 |
精密科学发展有限责任公司 |
来自非人类生物体的核酸对照分子
|
WO2018017740A1
(en)
|
2016-07-19 |
2018-01-25 |
Exact Sciences Development Company, Llc |
Methylated control dna
|
EP3487616B1
(en)
|
2016-07-21 |
2023-08-09 |
Takara Bio USA, Inc. |
Multi-z imaging of wells of multi-well devices and liquid dispensing into the wells
|
SG11201900907YA
(en)
|
2016-08-03 |
2019-02-27 |
Harvard College |
Adenosine nucleobase editors and uses thereof
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
WO2018039599A1
(en)
|
2016-08-26 |
2018-03-01 |
Life Technologies Corporation |
Nucleic acid extraction and amplification controls and methods of use thereof
|
US10858699B2
(en)
|
2016-08-30 |
2020-12-08 |
Integrated Dna Technologies, Inc. |
Cleavable hairpin primers
|
EP4293128A3
(en)
|
2016-09-02 |
2024-03-20 |
Mayo Foundation for Medical Education and Research |
Detecting hepatocellular carcinoma
|
CN110214180A
(zh)
|
2016-10-14 |
2019-09-06 |
哈佛大学的校长及成员们 |
核碱基编辑器的aav递送
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
WO2018127786A1
(en)
|
2017-01-06 |
2018-07-12 |
Oslo Universitetssykehus Hf |
Compositions and methods for determining a treatment course of action
|
CA3049459A1
(en)
|
2017-01-27 |
2018-08-02 |
Exact Sciences Development Company, Llc |
Detection of colon neoplasia by analysis of methylated dna
|
CA3049989A1
(en)
|
2017-02-10 |
2018-08-16 |
Zymergen Inc. |
A modular universal plasmid design strategy for the assembly and editing of multiple dna constructs for multiple hosts
|
CA3053875A1
(en)
|
2017-03-08 |
2018-09-13 |
Etablissement Francais Du Sang |
Rhd gene allele associated with a weak d phenotype and its uses
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
EP3592777A1
(en)
|
2017-03-10 |
2020-01-15 |
President and Fellows of Harvard College |
Cytosine to guanine base editor
|
CN110914426A
(zh)
|
2017-03-23 |
2020-03-24 |
哈佛大学的校长及成员们 |
包含核酸可编程dna结合蛋白的核碱基编辑器
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
CN107312762B
(zh)
*
|
2017-06-23 |
2020-08-11 |
苏州点晶生物科技有限公司 |
一种化学修饰ung酶及其修饰方法和应用
|
WO2019002178A1
(en)
|
2017-06-26 |
2019-01-03 |
Thermo Fisher Scientific Baltics Uab |
DNA MUTANTS THERMOPHILIC POLYMERASES
|
WO2019023680A1
(en)
|
2017-07-28 |
2019-01-31 |
President And Fellows Of Harvard College |
METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
|
USD846383S1
(en)
|
2017-08-10 |
2019-04-23 |
Certa Dose, Inc. |
Carton
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
JP2021500036A
(ja)
|
2017-10-16 |
2021-01-07 |
ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. |
アデノシン塩基編集因子の使用
|
JP2021502825A
(ja)
|
2017-11-13 |
2021-02-04 |
ライフ テクノロジーズ コーポレイション |
尿路微生物検出のための組成物、方法、およびキット
|
US10648025B2
(en)
|
2017-12-13 |
2020-05-12 |
Exact Sciences Development Company, Llc |
Multiplex amplification detection assay II
|
WO2019180137A1
(en)
|
2018-03-21 |
2019-09-26 |
F. Hoffmann-La Roche Ag |
Dna polymerases for efficient and effective incorporation of methylated-dntps
|
US11712522B2
(en)
|
2018-05-01 |
2023-08-01 |
CD Acquistions, LLC |
System and method for sequential delivery of measured doses of medication
|
WO2019222625A1
(en)
|
2018-05-17 |
2019-11-21 |
Certa Dose, Inc. |
Syringe holder for medication dosing
|
JP2021533773A
(ja)
|
2018-08-15 |
2021-12-09 |
ザイマージェン インコーポレイテッド |
ハイスループット代謝操作におけるCRISPRiの適用
|
US11408030B2
(en)
|
2018-09-10 |
2022-08-09 |
Andy Madrid |
Test for detecting Alzheimer's disease
|
EP3850086A1
(en)
|
2018-09-13 |
2021-07-21 |
F. Hoffmann-La Roche AG |
Mutant dna polymerase(s) with improved strand displacement ability
|
WO2020099938A2
(en)
|
2018-11-16 |
2020-05-22 |
Oslo Universitetssykehus Hf |
Methods and compositions for characterizing bladder cancer
|
USD943737S1
(en)
|
2019-01-22 |
2022-02-15 |
Certa Dose, Inc. |
Overdose resistant drug delivery syringe
|
CN113924041A
(zh)
|
2019-03-14 |
2022-01-11 |
因斯利克萨公司 |
基于时间门控的荧光检测的方法和系统
|
BR112021018607A2
(pt)
|
2019-03-19 |
2021-11-23 |
Massachusetts Inst Technology |
Métodos e composições para editar sequências de nucleotídeos
|
CN110283801A
(zh)
*
|
2019-07-16 |
2019-09-27 |
遵义医科大学珠海校区 |
一种dna聚合酶的化学修饰方法
|
WO2021087275A1
(en)
|
2019-10-31 |
2021-05-06 |
Mayo Foundation For Medical Education And Research |
Detecting ovarian cancer
|
EP4055189A1
(en)
|
2019-11-04 |
2022-09-14 |
Mirnax Biosens, S.L. |
Bivalent reverse primer
|
EP3901286A1
(en)
|
2020-04-24 |
2021-10-27 |
Mirnax Biosens, S.L. |
Bivalent reverse primer
|
WO2021168478A1
(en)
|
2020-02-18 |
2021-08-26 |
Life Technologies Corporation |
Compositions, kits and methods for detection of viral sequences
|
CN116096873A
(zh)
|
2020-05-08 |
2023-05-09 |
布罗德研究所股份有限公司 |
同时编辑靶标双链核苷酸序列的两条链的方法和组合物
|
EP4157856A2
(en)
|
2020-05-26 |
2023-04-05 |
Qiagen Beverly, LLC |
Polymerase enzyme
|
AU2021329899A1
(en)
|
2020-08-19 |
2023-03-09 |
Exact Sciences Corporation |
Detecting non-hodgkin lymphoma
|
AU2021350835A1
(en)
|
2020-09-24 |
2023-04-27 |
President And Fellows Of Harvard College |
Prime editing guide rnas, compositions thereof, and methods of using the same
|
CN112359031A
(zh)
*
|
2020-11-16 |
2021-02-12 |
北京丹大生物技术有限公司 |
一种热启动dna聚合酶及其制备方法和应用
|
WO2022150790A2
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