BG65210B1 - Трициклични инхибитори на поли (adp-рибоза) полимерази - Google Patents
Трициклични инхибитори на поли (adp-рибоза) полимерази Download PDFInfo
- Publication number
- BG65210B1 BG65210B1 BG105811A BG10581101A BG65210B1 BG 65210 B1 BG65210 B1 BG 65210B1 BG 105811 A BG105811 A BG 105811A BG 10581101 A BG10581101 A BG 10581101A BG 65210 B1 BG65210 B1 BG 65210B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- mmol
- compound
- azepino
- tetrahydro
- indol
- Prior art date
Links
- PAEUZJKWTOXSSZ-UHFFFAOYSA-N CC(C1CCNC2=O)(c(cc(cc3)Cl)c3OC)Nc3c1c2ccc3 Chemical compound CC(C1CCNC2=O)(c(cc(cc3)Cl)c3OC)Nc3c1c2ccc3 PAEUZJKWTOXSSZ-UHFFFAOYSA-N 0.000 description 1
- 0 CC(c(cc1)ccc1-c1c(CC*C(c2ccc3)=O)c2c3[n]1)(O)O Chemical compound CC(c(cc1)ccc1-c1c(CC*C(c2ccc3)=O)c2c3[n]1)(O)O 0.000 description 1
- YGKFIAAXOPULHQ-UHFFFAOYSA-N CC1(c2c(CCNC(c3ccc4)=O)c3c4[nH]2)Nc2cccc3c2C1CCNC3=O Chemical compound CC1(c2c(CCNC(c3ccc4)=O)c3c4[nH]2)Nc2cccc3c2C1CCNC3=O YGKFIAAXOPULHQ-UHFFFAOYSA-N 0.000 description 1
- HRRKUAOEQZZFTI-UHFFFAOYSA-N Nc1cccc(C#Cc([nH]c2ccc3)c(CCN4)c2c3C4=O)c1 Chemical compound Nc1cccc(C#Cc([nH]c2ccc3)c(CCN4)c2c3C4=O)c1 HRRKUAOEQZZFTI-UHFFFAOYSA-N 0.000 description 1
- SMOVFEYGLHYNFG-UHFFFAOYSA-N O=C(c1ccc2)NN=CC3c1c2NC3c(cc1)ccc1Cl Chemical compound O=C(c1ccc2)NN=CC3c1c2NC3c(cc1)ccc1Cl SMOVFEYGLHYNFG-UHFFFAOYSA-N 0.000 description 1
- DKFFSRBSODVODR-UHFFFAOYSA-N OC(c1c(CCNC(c2ccc3)=O)c2c3[nH]1)=O Chemical compound OC(c1c(CCNC(c2ccc3)=O)c2c3[nH]1)=O DKFFSRBSODVODR-UHFFFAOYSA-N 0.000 description 1
- XUXOKQNSYHQLKM-UHFFFAOYSA-N OC1NCCc2c(-c(cc3)cc4c3[nH]cc4)[nH]c3cccc1c23 Chemical compound OC1NCCc2c(-c(cc3)cc4c3[nH]cc4)[nH]c3cccc1c23 XUXOKQNSYHQLKM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11543199P | 1999-01-11 | 1999-01-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
BG105811A BG105811A (en) | 2002-05-31 |
BG65210B1 true BG65210B1 (bg) | 2007-07-31 |
Family
ID=22361361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG105811A BG65210B1 (bg) | 1999-01-11 | 2001-08-10 | Трициклични инхибитори на поли (adp-рибоза) полимерази |
Country Status (40)
Families Citing this family (118)
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