AU2018390960B2 - Immune cell organoid co-cultures - Google Patents
Immune cell organoid co-cultures Download PDFInfo
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- AU2018390960B2 AU2018390960B2 AU2018390960A AU2018390960A AU2018390960B2 AU 2018390960 B2 AU2018390960 B2 AU 2018390960B2 AU 2018390960 A AU2018390960 A AU 2018390960A AU 2018390960 A AU2018390960 A AU 2018390960A AU 2018390960 B2 AU2018390960 B2 AU 2018390960B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/32—T-cell receptors [TCR]
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/50—Colon
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Multimedia (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2023203677A AU2023203677A1 (en) | 2017-12-21 | 2023-06-13 | Immune cell organoid co-cultures |
| AU2024219545A AU2024219545A1 (en) | 2017-12-21 | 2024-09-10 | Immune cell organoid co-cultures |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1721615.1 | 2017-12-21 | ||
| GBGB1721615.1A GB201721615D0 (en) | 2017-12-21 | 2017-12-21 | Immune cell organoid co-cultures |
| PCT/EP2018/086716 WO2019122388A1 (en) | 2017-12-21 | 2018-12-21 | Immune cell organoid co-cultures |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023203677A Division AU2023203677A1 (en) | 2017-12-21 | 2023-06-13 | Immune cell organoid co-cultures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018390960A1 AU2018390960A1 (en) | 2020-07-09 |
| AU2018390960B2 true AU2018390960B2 (en) | 2023-03-16 |
Family
ID=61131463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018390960A Active AU2018390960B2 (en) | 2017-12-21 | 2018-12-21 | Immune cell organoid co-cultures |
| AU2023203677A Abandoned AU2023203677A1 (en) | 2017-12-21 | 2023-06-13 | Immune cell organoid co-cultures |
| AU2024219545A Pending AU2024219545A1 (en) | 2017-12-21 | 2024-09-10 | Immune cell organoid co-cultures |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023203677A Abandoned AU2023203677A1 (en) | 2017-12-21 | 2023-06-13 | Immune cell organoid co-cultures |
| AU2024219545A Pending AU2024219545A1 (en) | 2017-12-21 | 2024-09-10 | Immune cell organoid co-cultures |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12517112B2 (https=) |
| EP (1) | EP3729084A1 (https=) |
| JP (2) | JP7561028B2 (https=) |
| KR (1) | KR20200105852A (https=) |
| CN (1) | CN111989569A (https=) |
| AU (3) | AU2018390960B2 (https=) |
| BR (1) | BR112020012565A2 (https=) |
| CA (1) | CA3086290A1 (https=) |
| GB (1) | GB201721615D0 (https=) |
| IL (1) | IL275354A (https=) |
| SG (1) | SG11202005891TA (https=) |
| WO (1) | WO2019122388A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10006904B2 (en) | 2011-12-19 | 2018-06-26 | Umc Utrecht Holding B.V. | Rapid quantitative assay to measure CFTR function in a primary intestinal culture model |
| CA2949171A1 (en) | 2014-05-16 | 2015-11-19 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| US10395772B1 (en) * | 2018-10-17 | 2019-08-27 | Tempus Labs | Mobile supplementation, extraction, and analysis of health records |
| GB201819224D0 (en) | 2018-11-26 | 2019-01-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Hepatocyte expansion methods |
| EP3891755A4 (en) | 2018-12-03 | 2022-09-07 | Tempus Labs, Inc. | IDENTIFICATION, EXTRACTION AND PREDICTION SYSTEM FOR CLINICAL CONCEPTS AND RELATED PROCEDURES |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| MX2021014439A (es) * | 2019-05-28 | 2022-05-19 | Xilis Inc | Metodos y aparatos para microorganoesferas derivadas de pacientes. |
| WO2021067338A1 (en) * | 2019-09-30 | 2021-04-08 | Kloxin April | Indirect three-dimensional co-culture of dormant tumor cells and uses thereof |
| CN114585746A (zh) * | 2019-10-17 | 2022-06-03 | 公立大学法人横滨市立大学 | 药物毒性评价方法 |
| WO2021092226A1 (en) * | 2019-11-05 | 2021-05-14 | Em-O-Em Diagnostics, Inc. | Embryo transfer outcome prediction using endometrial organoids and spent embryo culture medium |
| WO2021097074A1 (en) * | 2019-11-13 | 2021-05-20 | New York University | Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury |
| CN111040997A (zh) * | 2019-12-20 | 2020-04-21 | 北京科途医学科技有限公司 | 一种具有肿瘤免疫微环境的前列腺癌类器官培养及冻存方法 |
| CN111089977A (zh) * | 2019-12-30 | 2020-05-01 | 浙江科途医学科技有限公司 | 一种利用类器官检测溶瘤病毒有效性的方法 |
| CN113249325B (zh) * | 2020-02-11 | 2023-02-17 | 合肥中科普瑞昇生物医药科技有限公司 | 食管鳞癌原代细胞的培养基及培养方法 |
| CN111411084A (zh) * | 2020-04-28 | 2020-07-14 | 江苏信安佳医疗科技有限公司 | 一种用于构建肝肿瘤无支架类器官的培养基及培养方法 |
| US20230212510A1 (en) * | 2020-05-04 | 2023-07-06 | City Of Hope | Methods for organoids production |
| KR102578640B1 (ko) * | 2020-08-14 | 2023-09-15 | 주식회사 넥스트앤바이오 | 미세유체 칩을 활용한 오가노이드의 제조 방법 |
| CN112143699A (zh) * | 2020-09-11 | 2020-12-29 | 上海市第十人民医院 | 一种结直肠癌类器官免疫微环境重构的方法 |
| KR102571223B1 (ko) * | 2020-09-28 | 2023-08-29 | 연세대학교 산학협력단 | 인간 편도 유래 오가노이드와 면역세포 3차원 공배양 방법 |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| AU2021353004A1 (en) | 2020-09-30 | 2023-04-13 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US20230357722A1 (en) * | 2020-10-02 | 2023-11-09 | The Johns Hopkins University | Methods for identifying modulators of natural killer cell interactions |
| WO2022098275A1 (en) * | 2020-11-03 | 2022-05-12 | Iscaff Pharma Ab | Uses of patient-derived scaffolds |
| JP2023550651A (ja) * | 2020-11-24 | 2023-12-04 | デューク ユニバーシティ | 液滴オルガノイドに基づく癌免疫学アッセイ及び其れを使用する方法 |
| CN112481193A (zh) * | 2020-11-26 | 2021-03-12 | 海西纺织新材料工业技术晋江研究院 | 三维培养肠及肠癌组织类器官的标准化培养基及培养方法 |
| WO2022125585A1 (en) * | 2020-12-07 | 2022-06-16 | The Regents Of The University Of California | Tissue organoid bioprinting and high-throughput screening methodology |
| CN112553289A (zh) * | 2020-12-17 | 2021-03-26 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种评价car-t细胞有效性的方法 |
| US20240069011A1 (en) * | 2020-12-29 | 2024-02-29 | 2cureX A/S | Predicting efficacy of or resistance to treatment of colon cancer |
| EP4271995A4 (en) * | 2020-12-31 | 2024-11-20 | Elephas Biosciences Corporation | EX VIVO SYSTEMS AND METHODS FOR DETERMINING THE EFFECT OF A DRUG OR OTHER AGENT ON A TISSUE |
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| AU2023203677A1 (en) | 2023-07-13 |
| JP2024045127A (ja) | 2024-04-02 |
| KR20200105852A (ko) | 2020-09-09 |
| IL275354A (en) | 2020-07-30 |
| BR112020012565A2 (pt) | 2020-11-24 |
| AU2024219545A1 (en) | 2024-10-03 |
| GB201721615D0 (en) | 2018-02-07 |
| SG11202005891TA (en) | 2020-07-29 |
| WO2019122388A1 (en) | 2019-06-27 |
| NZ765695A (en) | 2024-01-26 |
| EP3729084A1 (en) | 2020-10-28 |
| CN111989569A (zh) | 2020-11-24 |
| AU2018390960A1 (en) | 2020-07-09 |
| JP7561028B2 (ja) | 2024-10-03 |
| CA3086290A1 (en) | 2019-06-27 |
| US20210208131A1 (en) | 2021-07-08 |
| US12517112B2 (en) | 2026-01-06 |
| JP2021508249A (ja) | 2021-03-04 |
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