AU2015266880B2 - Tri-Specific Binding Molecules and methods of use thereof - Google Patents

Tri-Specific Binding Molecules and methods of use thereof Download PDF

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AU2015266880B2
AU2015266880B2 AU2015266880A AU2015266880A AU2015266880B2 AU 2015266880 B2 AU2015266880 B2 AU 2015266880B2 AU 2015266880 A AU2015266880 A AU 2015266880A AU 2015266880 A AU2015266880 A AU 2015266880A AU 2015266880 B2 AU2015266880 B2 AU 2015266880B2
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Bhaswati Barat
Ezio Bonvini
Stephen James Burke
Gurunadh Reddy Chichili
Ling Huang
Leslie S. Johnson
Chia-Ying Kao Lam
Liqin Liu
Paul A. Moore
Kalpana SHAH
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Macrogenics Inc
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Macrogenics Inc
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2317/626—Diabody or triabody
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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AU2015266880A 2014-05-29 2015-05-29 Tri-Specific Binding Molecules and methods of use thereof Active AU2015266880B2 (en)

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US201462004571P 2014-05-29 2014-05-29
US62/004,571 2014-05-29
US201462008229P 2014-06-05 2014-06-05
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US201562107824P 2015-01-26 2015-01-26
US62/107,824 2015-01-26
PCT/US2015/033076 WO2015184203A1 (en) 2014-05-29 2015-05-29 Tri-specific binding molecules and methods of use thereof

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AU2015266797A Active AU2015266797C1 (en) 2014-05-29 2015-05-29 Tri-Specific Binding Molecules that specifically bind to multiple Cancer Antigens and methods of use thereof
AU2018260975A Active AU2018260975B2 (en) 2014-05-29 2018-11-09 Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof
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US (5) US10633440B2 (ru)
EP (3) EP3152235B1 (ru)
JP (5) JP6685934B2 (ru)
KR (3) KR102355609B1 (ru)
CN (4) CN106573050B (ru)
AP (1) AP2016009586A0 (ru)
AU (4) AU2015266880B2 (ru)
BR (2) BR112016027893A2 (ru)
CA (2) CA2950008C (ru)
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PL (2) PL3152235T3 (ru)
RU (2) RU2020111366A (ru)
SG (4) SG10201913680PA (ru)
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TW (5) TW202208442A (ru)
WO (2) WO2015184203A1 (ru)
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JP6618362B2 (ja) 2013-01-14 2019-12-11 ゼンコア インコーポレイテッド 新規異種二量体タンパク質
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
CN105283201B (zh) 2013-03-14 2019-08-02 斯克利普斯研究所 靶向剂抗体偶联物及其用途
DK2970486T3 (en) 2013-03-15 2018-08-06 Xencor Inc MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS
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