MX2016015398A - Moleculas de union tri-especificas y metodos de uso de las mismas. - Google Patents

Moleculas de union tri-especificas y metodos de uso de las mismas.

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Publication number
MX2016015398A
MX2016015398A MX2016015398A MX2016015398A MX2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A MX 2016015398 A MX2016015398 A MX 2016015398A
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MX
Mexico
Prior art keywords
binding
epitopes
tri
specific binding
binding molecules
Prior art date
Application number
MX2016015398A
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English (en)
Inventor
s johnson Leslie
Huang Ling
Bonvini Ezio
Shah Kalpana
Reddy Chichili Gurunadh
Ying Kao LAM Chia-
James BURKE Stephen
Liu Liqin
Barat Bhaswati
A Moore Paul
Original Assignee
Macrogenics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54699839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016015398(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of MX2016015398A publication Critical patent/MX2016015398A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

La presente invención se relaciona con las Moléculas de Unión Tri-Específicas, que son Moléculas de Polipéptido de cadena múltiple que poseen tres Dominios de Unión y, son por tanto capaces de mediar la unión coordinada a los tres epítopos. Los Dominios de Unión pueden seleccionarse de manera que las Moléculas de Unión Tri-Específicas son capaces de unirse a cualquiera de los tres diferentes epítopos. Los epítopos pueden ser epítopos del mismo antígeno o epítopos de dos o tres diferentes antígenos. En una modalidad preferida, uno de los epítopos será capaz de unirse a CD3, el segundo de los epítopos será capaz de unirse a CD8, y el tercero de los epítopos será capaz de unirse a un epítopo de un Antígeno Asociado con la Enfermedad. La invención también proporciona también un anticuerpo de unión a ROR1 novedoso, así como derivados de los mismos y usos de tales composiciones.
MX2016015398A 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas. MX2016015398A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462004571P 2014-05-29 2014-05-29
US201462008229P 2014-06-05 2014-06-05
US201562107824P 2015-01-26 2015-01-26
PCT/US2015/033076 WO2015184203A1 (en) 2014-05-29 2015-05-29 Tri-specific binding molecules and methods of use thereof

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MX2016015398A true MX2016015398A (es) 2017-02-22

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MX2016015398A MX2016015398A (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas y metodos de uso de las mismas.
MX2016015479A MX2016015479A (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos.
MX2020014221A MX2020014221A (es) 2014-05-29 2016-11-24 Moleculas de union tri-especificas y metodos de uso de las mismas.

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MX2016015479A MX2016015479A (es) 2014-05-29 2015-05-29 Moleculas de union tri-especificas que se unen especificamente a varios antigenos de cancer y metodos de uso de los mismos.
MX2020014221A MX2020014221A (es) 2014-05-29 2016-11-24 Moleculas de union tri-especificas y metodos de uso de las mismas.

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US (6) US10647768B2 (es)
EP (3) EP3148580B1 (es)
JP (5) JP6685934B2 (es)
KR (3) KR102364383B1 (es)
CN (4) CN106414497B (es)
AP (1) AP2016009586A0 (es)
AU (4) AU2015266880B2 (es)
BR (2) BR112016027912A2 (es)
CA (2) CA2950008C (es)
CL (2) CL2016003040A1 (es)
EA (1) EA035419B9 (es)
ES (2) ES2890079T3 (es)
IL (2) IL249266B (es)
MA (1) MA40069A (es)
MX (3) MX2016015398A (es)
NZ (2) NZ726520A (es)
PE (2) PE20170766A1 (es)
PH (2) PH12016502369A1 (es)
PL (2) PL3148580T3 (es)
RU (2) RU2718692C2 (es)
SG (4) SG10201913324PA (es)
TN (1) TN2016000525A1 (es)
TW (5) TWI742423B (es)
WO (2) WO2015184203A1 (es)
ZA (1) ZA201607995B (es)

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US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
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EP2943511B1 (en) 2013-01-14 2019-08-07 Xencor, Inc. Novel heterodimeric proteins
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US10106624B2 (en) 2013-03-15 2018-10-23 Xencor, Inc. Heterodimeric proteins
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WO2014145907A1 (en) 2013-03-15 2014-09-18 Xencor, Inc. Targeting t cells with heterodimeric proteins
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
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