MX2018003183A - Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas. - Google Patents

Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas.

Info

Publication number
MX2018003183A
MX2018003183A MX2018003183A MX2018003183A MX2018003183A MX 2018003183 A MX2018003183 A MX 2018003183A MX 2018003183 A MX2018003183 A MX 2018003183A MX 2018003183 A MX2018003183 A MX 2018003183A MX 2018003183 A MX2018003183 A MX 2018003183A
Authority
MX
Mexico
Prior art keywords
antigen binding
binding proteins
tetravalent bispecific
tetraspecific
tetraspecific antigen
Prior art date
Application number
MX2018003183A
Other languages
English (en)
Inventor
Kannan Gunasekaran
J Belouski Edward
Hortter Michelle
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2015/050115 external-priority patent/WO2016044224A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2018003183A publication Critical patent/MX2018003183A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a proteínas de enlace de antígeno biespecífico y tetraespecífico tetravalentes que son capaces de enlazarse a múltiples objetivos. También se describen composiciones farmacéuticas que comprenden las proteínas de enlace de antígeno biespecífico y tetraespecífico así como métodos para producirlas.
MX2018003183A 2015-09-15 2016-09-15 Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas. MX2018003183A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562218977P 2015-09-15 2015-09-15
PCT/US2015/050115 WO2016044224A1 (en) 2014-09-15 2015-09-15 Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof
PCT/US2016/052006 WO2017049004A1 (en) 2015-09-15 2016-09-15 Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
MX2018003183A true MX2018003183A (es) 2018-08-23

Family

ID=58289899

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003183A MX2018003183A (es) 2015-09-15 2016-09-15 Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas.

Country Status (8)

Country Link
US (1) US20180237542A1 (es)
EP (1) EP3350216A1 (es)
JP (1) JP6932700B2 (es)
AU (1) AU2016323440B2 (es)
CA (1) CA2998174A1 (es)
MA (1) MA42821A (es)
MX (1) MX2018003183A (es)
WO (1) WO2017049004A1 (es)

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CN117946278A (zh) * 2017-06-25 2024-04-30 西雅图免疫公司 多特异性抗体及其制备和使用方法
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Also Published As

Publication number Publication date
US20180237542A1 (en) 2018-08-23
AU2016323440A1 (en) 2018-04-05
AU2016323440B2 (en) 2023-07-13
JP2018529764A (ja) 2018-10-11
WO2017049004A1 (en) 2017-03-23
JP6932700B2 (ja) 2021-09-08
MA42821A (fr) 2018-07-25
CA2998174A1 (en) 2017-03-23
EP3350216A1 (en) 2018-07-25

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