ATE476985T1 - Von thrombozyten stammende wachstumsfaktorzusammensetzungen und anwendungsverfahren dafür - Google Patents

Von thrombozyten stammende wachstumsfaktorzusammensetzungen und anwendungsverfahren dafür

Info

Publication number
ATE476985T1
ATE476985T1 AT05803356T AT05803356T ATE476985T1 AT E476985 T1 ATE476985 T1 AT E476985T1 AT 05803356 T AT05803356 T AT 05803356T AT 05803356 T AT05803356 T AT 05803356T AT E476985 T1 ATE476985 T1 AT E476985T1
Authority
AT
Austria
Prior art keywords
growth factor
derived growth
thrombocyte
methods
factor compositions
Prior art date
Application number
AT05803356T
Other languages
English (en)
Inventor
Samuel Lynch
Original Assignee
Biomimetic Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomimetic Therapeutics Inc filed Critical Biomimetic Therapeutics Inc
Application granted granted Critical
Publication of ATE476985T1 publication Critical patent/ATE476985T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2400/00—Materials characterised by their function or physical properties
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Composite Materials (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
AT05803356T 2004-10-14 2005-10-12 Von thrombozyten stammende wachstumsfaktorzusammensetzungen und anwendungsverfahren dafür ATE476985T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96531904A 2004-10-14 2004-10-14
US11/159,533 US7473678B2 (en) 2004-10-14 2005-06-23 Platelet-derived growth factor compositions and methods of use thereof
PCT/US2005/036447 WO2006044334A2 (en) 2004-10-14 2005-10-12 Platelet-derived growth factor compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE476985T1 true ATE476985T1 (de) 2010-08-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT05803356T ATE476985T1 (de) 2004-10-14 2005-10-12 Von thrombozyten stammende wachstumsfaktorzusammensetzungen und anwendungsverfahren dafür

Country Status (19)

Country Link
US (11) US7473678B2 (de)
EP (5) EP3170505B1 (de)
JP (2) JP5137577B2 (de)
KR (3) KR20110013492A (de)
CN (2) CN105561384A (de)
AT (1) ATE476985T1 (de)
AU (2) AU2005295919B2 (de)
BR (1) BRPI0516105B8 (de)
CA (2) CA2583823C (de)
DE (1) DE602005022911D1 (de)
DK (1) DK1812076T3 (de)
ES (2) ES2454841T3 (de)
IL (1) IL182480A (de)
MX (1) MX2007004459A (de)
NO (1) NO20071974L (de)
NZ (2) NZ582976A (de)
PT (1) PT1812076E (de)
WO (1) WO2006044334A2 (de)
ZA (1) ZA200703515B (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
NZ571113A (en) * 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP2311505B1 (de) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren zur Behandlung von Knochen
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2007269712B2 (en) * 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
WO2008151193A1 (en) * 2007-06-04 2008-12-11 Biomimetic Therapeutics, Inc. Compositions and methods for treating the vertebral column
EP2462895B1 (de) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren für Behandlungen von Arthodese
AU2013203287B2 (en) * 2006-11-03 2015-12-17 Biomimetic Therapeutics, Llc. Compositions and methods for arthrodetic procedures
US20080154372A1 (en) * 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US20100151025A1 (en) * 2007-02-20 2010-06-17 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw
FR2914191A1 (fr) * 2007-03-29 2008-10-03 Proteins & Peptides Man Composition angiogenique.
CA2685956A1 (en) * 2007-05-04 2008-11-13 Perth Bone & Tissue Bank A method for treating inflammation and controlled-release material capable of providing same
ES2327480B1 (es) 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
CA2691024A1 (en) 2007-06-19 2008-12-24 Baxter Healthcare S.A. Fibrin gel for controlled release of pdgf and uses thereof
WO2009022338A2 (en) 2007-08-16 2009-02-19 Saher Hamed Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications
JP5829400B2 (ja) * 2008-01-24 2015-12-09 レメドー バイオメッド リミテッド 骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物
JP5864106B2 (ja) * 2008-02-07 2016-02-17 バイオミメティック セラピューティクス， エルエルシー 仮骨延長のための組成物および方法
FR2933304A1 (fr) * 2008-07-07 2010-01-08 Adocia Composition synergique osteogenique
US8613951B2 (en) * 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
WO2010005725A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
ES2765240T3 (es) 2008-06-16 2020-06-08 Pfizer Nanopartículas poliméricas cargadas de fármaco y procedimientos de fabricación y uso de las mismas
CN101357239B (zh) * 2008-08-29 2013-01-09 广东省人民医院 偏磷酸钙作为非硬组织工程材料的用途
NZ602861A (en) * 2008-09-09 2014-03-28 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (ja) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
KR20110100269A (ko) * 2008-12-19 2011-09-09 바이오미메틱 세라퓨틱스, 인크. 감소된 프로테아제 활성을 갖는 골 이식편 및 선택 방법 및 용도
CN101486996B (zh) * 2009-02-06 2012-10-10 浙江大学 一种非动物源性细胞培养血清替代物及其应用
KR20110135949A (ko) * 2009-03-05 2011-12-20 바이오미메틱 세라퓨틱스, 인크. 혈소판-유래 성장 인자 조성물 및 골연골성 결함의 치료 방법
US8298567B2 (en) * 2009-04-22 2012-10-30 Michigan Molecular Institute Hyperbranched polyurea delivery system for binding and release of growth factors
DE102009024616A1 (de) * 2009-06-08 2010-12-23 Telos Gmbh Sterilisierbare Implantatbeschichtung und Verfahren zu deren Herstellung
EP2509634B1 (de) 2009-12-11 2019-03-06 Pfizer Inc Stabile formulierungen zur lyophilisation therapeutischer partikel
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
AU2011217784B2 (en) 2010-02-22 2014-10-09 Biomimetic Therapeutics, Llc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
CN102397534B (zh) * 2010-09-07 2013-10-23 中国人民解放军总医院 胰岛素在制备促进颌骨组织愈合的药物中的用途
CN103313733A (zh) 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 骨空隙填充剂
WO2012105219A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 抗体療法の効果増強剤
WO2012105224A1 (ja) * 2011-01-31 2012-08-09 オリンパス株式会社 ワクチン・アジュバント
CN102652833B (zh) * 2011-03-02 2013-07-31 中国科学院过程工程研究所 一种胃部靶向药物载体及其制备方法
US9265830B2 (en) 2011-04-20 2016-02-23 Warsaw Orthopedic, Inc. Implantable compositions and methods for preparing the same
US20130108670A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating full thickness burn injuries
WO2013062995A1 (en) 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
EP2895156B1 (de) 2012-09-17 2019-05-08 Pfizer Inc. Verfahren zur herstellung therapeutischer nanopartikel
EP3848058A1 (de) * 2012-12-20 2021-07-14 Omrix Biopharmaceuticals Ltd. Inaktivierte virale biologische mischung
CN103961693B (zh) * 2013-01-24 2016-09-14 熊慧 一种恶性肿瘤治疗性疫苗及其组合物
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US20150140096A1 (en) * 2013-11-21 2015-05-21 Vivex Biomedical Inc. Composition and method of preparation of bone allograft from endosteal portion of bone and isolated bone periosteum
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
TWI693937B (zh) 2014-03-14 2020-05-21 美商輝瑞大藥廠 包含治療劑之治療性奈米顆粒及其製造及使用方法
EP3903772A1 (de) * 2014-05-30 2021-11-03 The Research Foundation for The State University of New York Zusammensetzungen und verfahren zur förderung der knochenbildung
CN104147595A (zh) * 2014-08-29 2014-11-19 姜红江 自体细胞生长因子制剂、制备方法及其制备用途
JP6871855B2 (ja) 2014-10-14 2021-05-19 サムエル リンチ， 創傷を処置するための組成物
CN104587525A (zh) * 2014-12-19 2015-05-06 深圳中元生物科技有限公司 包含血小板及透明质酸的支架及其制备方法
CN104548212B (zh) * 2014-12-31 2018-05-11 新科沃再生医学（苏州）有限公司 一种促进牙髓及牙本质再生的组合物
CN105732809B (zh) * 2014-12-31 2019-08-06 广东众生药业股份有限公司 抗血小板衍生因子的抗体
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
CN104983672B (zh) * 2015-06-26 2017-11-14 青岛大学 一种温敏溶胶的制备方法
CN105153612A (zh) * 2015-08-31 2015-12-16 苏州莱特复合材料有限公司 用于矫形支架的复合材料及其制备方法
JP2019517566A (ja) * 2016-06-10 2019-06-24 ライデン、ブロック 創傷パッキングを用いて創傷を治療するためのシステム及び方法
US20230120120A1 (en) * 2016-11-18 2023-04-20 Cutting Edge Technology, LLC Pharmaceutical formulation
CN106754658A (zh) * 2016-12-22 2017-05-31 江西宜信堂医疗科技有限公司 一种培养牙髓干细胞的培养基及其制备方法
CN106754678A (zh) * 2016-12-24 2017-05-31 叶宗耀 一种适用于牙髓干细胞体外培养的培养基及其制备方法
KR20190130643A (ko) * 2017-04-03 2019-11-22 위스콘신 얼럼나이 리서어치 화운데이션 생물학적 활성 분자의 지속적인 전달을 위한 미네랄 코팅된 마이크로입자
CN107349468B (zh) * 2017-07-02 2020-12-04 江西瑞济生物工程技术股份有限公司 一种羊膜干细胞凝胶及其制备方法和应用
CN107456607A (zh) * 2017-07-03 2017-12-12 广州医科大学附属口腔医院 一种双功能化的新型“sandwich”结构的引导牙周组织再生膜及其制备方法和应用
CN107670103A (zh) * 2017-09-15 2018-02-09 天津大学 聚乙烯吡络烷酮改性的骨水泥及制备方法
KR20200136978A (ko) * 2018-03-28 2020-12-08 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 치료제의 표적화된 전달을 위한 엑소좀의 용도
CN108653817B (zh) * 2018-05-24 2021-02-02 上海其胜生物制剂有限公司 一种新型胶原刺激剂的制备方法
AU2020239268A1 (en) * 2019-03-14 2021-10-21 Biomimetic Therapeutics, Llc Platelet-derived growth factor formulations for enhancing bone fusion
US20220313784A1 (en) * 2019-07-12 2022-10-06 Vasanthi PALANIVEL Compositions for treatment of asherman's syndrome, methods for preparing the same and applications thereof
US20220395558A1 (en) * 2019-07-12 2022-12-15 Vasanthi PALANIVEL Compositions for treatment of erectile dysfunction, methods for preparing the same and applications thereof
US20220339190A1 (en) * 2019-07-12 2022-10-27 Vasanthi PALANIVEL Compositions for treatment of infertility caused by poor semen quality, methods for preparing the same and applications thereof
US20220249554A1 (en) * 2019-07-12 2022-08-11 Vasanthi PALANIVEL Compositions and methods for managing female infertility
WO2021009660A1 (en) * 2019-07-12 2021-01-21 Vasanthi Palanivel Composition and methods for improving thickness and receptivity of endometrial lining
US20220249612A1 (en) * 2019-07-15 2022-08-11 Vasanthi PALANIVEL Compositions for treatment of azoospermia, methods for preparing the same and applications thereof
CN111569004B (zh) * 2020-06-15 2022-07-08 钟瑾 一种用于慢性牙周炎的药物凝胶及其制备方法与用途
CN111533825B (zh) * 2020-06-17 2022-03-01 昆山京昆油田化学科技有限公司 一种氨基葡萄糖接枝海藻酸钠衍生物及其制备方法和应用
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
CN112121229B (zh) * 2020-09-27 2022-09-09 天晴干细胞股份有限公司 一种抑制炎症和促进牙槽骨修复的组织工程材料及其制备方法和应用
JP7025070B1 (ja) 2021-05-14 2022-02-24 セルソース株式会社 血液由来成長因子含有組成物及びその調製方法
CN113476666B (zh) * 2021-06-28 2022-09-09 苏州大学附属第一医院 一种可注射型长效缓释褪黑素的关节软骨修复材料、制备方法及其应用
US11890154B2 (en) 2021-06-30 2024-02-06 Khalid AL HEZAIMI Pulp capping methods
CN113827778B (zh) * 2021-11-03 2022-10-21 浙江赛灵特医药科技有限公司 一种注射式骨修复剂及其应用
CN115006609A (zh) * 2022-05-24 2022-09-06 曹建中 一种适用于骨折内固定术前制作的可降解材料及其制备方法及应用
CN115058053B (zh) * 2022-06-30 2023-06-27 浙江大学滨江研究院 一种基于明胶衍生物冷冻大孔凝胶的制备方法及其应用
CN117731831B (zh) * 2023-12-23 2024-06-25 北京市意华健科贸有限责任公司 一种壳聚糖羟基磷灰石复合材料及其制备方法与应用

Family Cites Families (270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US652473A (en) * 1900-01-10 1900-06-26 Allan A Cole Trunk-brace.
US2124316A (en) * 1937-10-23 1938-07-19 Schonfeld Paul Warp fabric
US3943072A (en) * 1971-12-15 1976-03-09 United Kingdom Atomic Energy Authority Separation of molecules
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
USRE33221E (en) * 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
US4654314A (en) 1983-07-09 1987-03-31 Sumitomo Cement Co., Ltd. Porous ceramic material and processes for preparing same
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4849407A (en) * 1986-08-13 1989-07-18 Zymogenetics, Inc. Biologically active mosaic proteins
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5629191A (en) * 1985-01-03 1997-05-13 Integra Lifesciences Corporation Method of making a porous matrix particle
US5516896A (en) * 1985-02-25 1996-05-14 Zymogenetics, Inc. Biologically active B-chain homodimers
US5045633A (en) 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5113354B1 (en) * 1986-02-07 1993-11-09 System for optimizing data transmissions associated with addressable buffer devices
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
EP0289584B1 (de) 1986-11-14 1993-05-05 Institute of Molecular Biology, Inc. Wundheilung und knochenregeneration
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
CA1322714C (en) * 1986-11-14 1993-10-05 Harry N. Antoniades Wound healing and bone regeneration
US5019559A (en) * 1986-11-14 1991-05-28 President And Fellows Of Harvard College Wound healing using PDGF and IGF-II
US5219759A (en) * 1987-04-22 1993-06-15 Chiron Corporation Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US5457093A (en) * 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US4874746A (en) 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF
US5759815A (en) * 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US4904259A (en) 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US5219576A (en) * 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US5034375A (en) * 1988-08-10 1991-07-23 Institute Of Molecular Biology, Inc. Process of wound healing using PDGF and EGF
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5035887A (en) * 1989-09-07 1991-07-30 Institute Of Moelcular Biology, Inc. Wound healing composition of IL-1 and PDGF or IGF-1
US5599558A (en) 1989-09-15 1997-02-04 Curative Technologies, Inc. Selecting amounts of platelet releasate for efficacious treatment of tissue
US5112354A (en) 1989-11-16 1992-05-12 Northwestern University Bone allograft material and method
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
US5071655A (en) 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
WO1991011515A2 (en) 1990-02-01 1991-08-08 University Of South Florida Leukocyte-derived growth factor
TW199858B (de) * 1990-03-30 1993-02-11 Fujirebio Kk
DE69031218T2 (de) 1990-04-10 1997-12-11 Harvard College Wundheilung
JPH06500991A (ja) 1990-05-16 1994-01-27 ジェネティックス・インスティテュート・インコーポレイテッド 骨および軟骨誘導蛋白質
DE69132918T2 (de) 1990-11-27 2002-10-31 American National Red Cross, Washington Gewebeabdeckung und wachstumsfaktor enthaltende verbindungen zur förderung beschleunigter wundheilung
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
DK0592562T3 (da) 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
KR100259827B1 (ko) 1991-11-04 2000-06-15 브루스 엠. 에이센, 토마스 제이 데스로저 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
WO1993008825A1 (en) 1991-11-04 1993-05-13 Zymogenetics, Inc. Pdgf gel formulation
UA48105C2 (uk) 1992-02-12 2002-08-15 Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Вон Фармака Мбх ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ)
WO1993020859A1 (en) 1992-04-20 1993-10-28 Board Of Regents Of The University Of Washington Sustained release compositions for delivery of growth factors
IL106278A0 (en) 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
ATE194658T1 (de) 1992-09-03 2000-07-15 Univ California Das dorsalgewebe beeinflussender faktor
EP0679163A4 (de) 1993-01-12 1997-07-16 Univ Johns Hopkins Med Wachstums-differentierungsfaktor-3.
JP3645258B2 (ja) 1993-01-12 2005-05-11 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−５
EP0678101A4 (de) 1993-01-12 1997-07-16 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-9.
DE69432815T2 (de) 1993-03-19 2003-12-11 The Johns Hopkins University School Of Medicine, Baltimore Wachstumsfaktor-8
JP3699111B2 (ja) * 1993-03-29 2005-09-28 ザイモジェネティクス，インコーポレイティド Ｐｄｇｆおよびビタミンｄを含有する骨芽細胞の成長を刺激する組成物
BR9406716A (pt) 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-10) polipeptideo de proteina-10 morfogenética de osso purificada (BMP-10) e molécula de DNA quimérica
KR100227406B1 (ko) 1993-05-12 1999-12-01 브루스 엠. 에이센 Bmp-11 조성물
AU7205894A (en) 1993-06-08 1995-01-03 Neogenix, Inc. Purified natural and synthetic compounds for the treatment of osteoarthritis
EP0804214A4 (de) 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-6
CA2165778A1 (en) 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-7
US5531794A (en) * 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
WO1995010539A1 (en) 1993-10-08 1995-04-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
JP3362267B2 (ja) * 1993-12-29 2003-01-07 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
EP0741783B1 (de) 1993-12-30 2009-03-18 President And Fellows Of Harvard College "hedgehog-like" proteine von wirbeltieren, die embryonale strukturen induzieren
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
JPH07250688A (ja) 1994-01-28 1995-10-03 Sagami Chem Res Center ＴＧＦ−βスーパーファミリー蛋白質をコードするヒト新規ｃＤＮＡ
AU1743495A (en) 1994-02-04 1995-08-21 Cell Therapeutics, Inc. Composition for wound healing, neuron growth and vascularization
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
CA2187355C (en) 1994-04-08 2009-10-13 Richard L. Dunn An adjunctive polymer system for use with medical device
AU2297395A (en) * 1994-04-20 1995-11-16 Institute Of Molecular Biology, Inc. Administration of platelet-derived growth factor and bone seeking drugs for osteoporosis and bone regeneration
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
DK0776337T3 (da) 1994-07-08 2005-12-12 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-11
ES2151607T3 (es) 1994-07-13 2001-01-01 Univ Johns Hopkins Med Factor 12 de crecimiento y de diferenciacion.
US6180606B1 (en) * 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5651766A (en) 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
WO1996013226A1 (en) 1994-10-31 1996-05-09 Sepracor Inc. Method for the treatment of periodontal disease and a pharmaceutical composition useful in said method
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6287341B1 (en) * 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6541037B1 (en) * 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
DE69637332T2 (de) * 1995-10-11 2008-10-09 Novartis Vaccines and Diagnostics, Inc., Emeryville Kombinierung von PDGF, KGF, IGF und IGFBP für Wundheilung
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US5783217A (en) * 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5747273A (en) * 1996-05-07 1998-05-05 Diagnostic Systems Laboratories, Inc. Immunoassay of total insulin-like growth factor binding protein-1
CA2252860C (en) * 1996-05-28 2011-03-22 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
FR2749756B1 (fr) * 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US6972130B1 (en) 1996-10-16 2005-12-06 Etex Corporation Bioceramic compositions
US6037519A (en) 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
DE19646782C2 (de) 1996-11-13 2000-05-25 Merck Patent Gmbh Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen
JP4341859B2 (ja) * 1996-12-13 2009-10-14 ノバルティス バクシンズ アンド ダイアグノスティックス， インコーポレーテッド 酵母での異種タンパク質の発現の方法
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
FR2758988B1 (fr) 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
JP4388602B2 (ja) * 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
WO1998038949A1 (en) * 1997-03-04 1998-09-11 Implico B.V. An artefact suitable for use as a bone implant
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
US20030032586A1 (en) 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
GB2325934A (en) * 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US6063624A (en) 1997-06-09 2000-05-16 Baxter International Inc. Platelet suspensions and methods for resuspending platelets
US20010014682A1 (en) 1997-07-25 2001-08-16 Smithkline Beecham Corporation Fibrinogen receptor antagonists
ATE220564T1 (de) 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
US6136029A (en) 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6090998A (en) * 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
WO1999030726A1 (en) 1997-12-15 1999-06-24 Page Roy C Improved method for attaching dental and orthopedic implants, ligaments, and tendons to bone
US20020076429A1 (en) 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US20020018796A1 (en) * 1998-01-28 2002-02-14 John F. Wironen Thermally sterilized bone paste
JP2000004875A (ja) 1998-06-23 2000-01-11 Teijin Ltd 増殖因子の産生誘導方法
SE514908C2 (sv) 1998-07-13 2001-05-14 Gs Dev Ab Medel för benrekonstruktion
EP1100488B1 (de) 1998-07-28 2003-04-23 SYNTHES AG Chur Verwendung von kreatinsubstanzen zur behandlung von knochen- und knorpelzellen und geweben
US20030114936A1 (en) 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
US6663870B2 (en) * 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6231528B1 (en) 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
EP1025871A1 (de) 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Verwendung eines melanonhemmenden Faktors zur Reperatur von Knorpelgewebe und Knochen
EP1150726B1 (de) * 1999-02-04 2003-11-05 SDGI Holdings, Inc. Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
ES2259286T3 (es) * 1999-03-15 2006-10-01 Implant Innovations, Inc. Sistema de recogida de trombocitos.
US6296602B1 (en) * 1999-03-17 2001-10-02 Transfusion Technologies Corporation Method for collecting platelets and other blood components from whole blood
AU4173000A (en) 1999-03-19 2000-10-09 Regents Of The University Of Michigan, The Mineralization and cellular patterning on biomaterial surfaces
CN1238083C (zh) * 1999-04-12 2006-01-25 丰收技术股份有限公司 制造富含血小板的血浆和/或血小板浓缩液的方法和设备
SE515227C2 (sv) * 1999-04-28 2001-07-02 Bruce Medical Ab Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen
US6468543B1 (en) * 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
US6710025B1 (en) * 1999-05-26 2004-03-23 The Brigham And Women's Hospital, Inc. Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
US6312952B1 (en) 1999-05-27 2001-11-06 The Research Foundation Of State University Of New York In vitro cell culture device including cartilage and methods of using the same
DE19926083A1 (de) 1999-06-08 2000-12-14 Universitaetsklinikum Freiburg Biologisches Gelenkkonstrukt
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
DE19940717A1 (de) * 1999-08-26 2001-03-01 Gerontocare Gmbh Resorblerbares Knochenersatz- und Knochenaufbaumaterial
US6280191B1 (en) * 1999-09-03 2001-08-28 Christopher B. Gordon Distractor suitable for permanent implantation into bone
AU1430601A (en) 1999-11-02 2001-05-14 Eli Lilly And Company Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders
JP4809963B2 (ja) * 1999-11-11 2011-11-09 オリンパス株式会社 骨補填材
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
AU1622801A (en) 1999-11-18 2001-05-30 Regents Of The University Of Michigan, The Sustained drug delivery from structural matrices
EP1255576B1 (de) 1999-12-09 2003-08-20 Biosyntech Canada Inc. Mineral-polymer hybrid-zusammensetzung
CA2328818A1 (en) * 1999-12-16 2001-06-16 Isotis B.V. Porous ceramic body
US20030103960A1 (en) 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
AU2607701A (en) * 1999-12-29 2001-07-09 Regeneration Technologies, Inc. System for reconstituting pastes and methods of using same
US20030152606A1 (en) * 2000-01-28 2003-08-14 Thomas Gerber Inorganic resorbable bone substitute material and production method
WO2001057083A1 (en) 2000-02-04 2001-08-09 Zymogenetics, Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
IT1316769B1 (it) * 2000-02-18 2003-05-12 Getters Spa Pannello evacuato per isolamento termico con ridotta conduzione dicalore ai bordi
CA2399224A1 (en) 2000-02-18 2001-08-23 Regeneration Technologies, Inc. Implantable tissues infused with growth factors and other additives
US7022506B2 (en) * 2000-02-23 2006-04-04 The Trustees Of The University Of Pennsylvania Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee
AU2001239874A1 (en) 2000-03-03 2001-09-17 Smith & Nephew, Inc. Shaped particle and composition for bone deficiency and method of making the particle
US20030055511A1 (en) * 2000-03-03 2003-03-20 Schryver Jeffrey E. Shaped particle comprised of bone material and method of making the particle
DE60123218T2 (de) 2000-03-09 2007-10-11 Zimmer Orthobiologics, Inc., Austin Produkt zur biologischen bindegewebsverankerung an knochen
JP2003526677A (ja) * 2000-03-14 2003-09-09 ザ・ユニバーシテイ・オブ・ウエスタン・オンタリオ 骨形成に影響を与える組成物および方法
US20020006437A1 (en) * 2000-05-01 2002-01-17 Grooms Jamie M. Non-migration tissue capsule
EP1287506A2 (de) * 2000-05-19 2003-03-05 Europrint Holdings Limited Verfahren und vorrichtung zur durchführung eines spiels
US20020022885A1 (en) 2000-05-19 2002-02-21 Takahiro Ochi Biomaterial
US7081240B1 (en) 2000-06-28 2006-07-25 Zimmer Orthobiologics, Inc. Protein mixtures for wound healing
KR100880622B1 (ko) 2000-06-29 2009-01-30 바이오신텍 캐나다 인코포레이티드 연골 및 다른 조직의 복구 및 재생용 조성물 및 방법
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
DK177997B1 (da) 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Knoglemateriale og collagenkombination til opheling af beskadigede led
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US6739112B1 (en) * 2000-08-21 2004-05-25 Nu Vasive, Inc. Bone allograft packaging system
US6773723B1 (en) 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
WO2002036147A1 (en) 2000-10-31 2002-05-10 Orquest, Inc. Mineralized collagen-polysaccharide matrix for bone and cartilage repair
US20020127265A1 (en) 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US7192604B2 (en) * 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
EP1359951A2 (de) 2001-01-25 2003-11-12 Regeneration Technologies, Inc. Injizierbare poröse knochentransplantatmaterialien
US7005135B2 (en) * 2001-01-30 2006-02-28 Ethicon Inc. Glass scaffolds with controlled resorption rates and methods for making same
CA2438934A1 (en) 2001-02-23 2002-09-06 Wyeth Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) * 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20030049328A1 (en) * 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
US20040171630A1 (en) 2001-06-19 2004-09-02 Yuntae Kim Tyrosine kinase inhibitors
JP2003010310A (ja) * 2001-06-27 2003-01-14 Olympus Optical Co Ltd 頭蓋骨用骨補填材料および補填方法
US20030109537A1 (en) * 2001-07-09 2003-06-12 Turner Russell T. Methods and materials for treating bone conditions
US7020382B2 (en) * 2001-07-12 2006-03-28 Thomson Licensing Modifying video by inserting shadow intra pictures
EP1429817B8 (de) 2001-09-24 2007-09-12 Millenium Biologix Technologies Inc. Poröse keramische komposit-knochenimplantate
DE60224822T2 (de) * 2001-10-19 2009-01-22 Zymogenetics, Inc., Seattle Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
WO2003043576A2 (en) 2001-11-20 2003-05-30 Depuy Products, Inc. Flowable osteogenic and chondrogenic compositions
WO2003055418A1 (en) * 2001-12-21 2003-07-10 Lagow Richard J Calcium phosphate bone replacement materials and methods of use thereof
EP1499267A4 (de) 2002-02-05 2008-10-29 Depuy Mitek Inc Bioresorbierbare osteokonduktive zusammensetzungen für die knochenregeneration
EP1483298A4 (de) 2002-02-11 2007-03-14 Zymogenetics Inc Materialien und verfahren zur herstellung dimerer wachstumsfaktoren
WO2003070186A2 (en) 2002-02-20 2003-08-28 The Cleveland Clinic Foundation Composition and method for inducing bone growth and healing
DK175356B1 (da) 2002-02-28 2004-09-06 Coloplast As Stomiindretning
JP3739715B2 (ja) * 2002-03-19 2006-01-25 オリンパス株式会社 人工骨および組織工学用担体
KR100460685B1 (ko) 2002-04-10 2004-12-09 재단법인서울대학교산학협력재단 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법
US7514248B2 (en) 2002-04-18 2009-04-07 University Of Florida Research Foundation, Inc. Process for making organic/inorganic composites
US7288535B2 (en) * 2002-05-02 2007-10-30 Osteoscreen, Inc. Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates
EP1501357A4 (de) * 2002-05-06 2009-10-21 Genentech Inc Verwendung von vegf für die behandlung von knochendefekten
US7368125B2 (en) * 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7041309B2 (en) 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
CA2432583A1 (en) 2002-06-20 2003-12-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Method of preparing alpha- and beta-tricalcium phosphate powders
US20040002770A1 (en) * 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
ATE295744T1 (de) * 2002-07-11 2005-06-15 Biomet Deutschland Gmbh Verfahren zur herstellung poröser calciumphosphatstückchen und -granulaten aus der gelatineverarbeitung
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
CN1403165A (zh) * 2002-09-26 2003-03-19 东南大学 用于硬组织修复的活性组合物及其制备方法
ES2584606T3 (es) 2002-10-10 2016-09-28 Ono Pharmaceutical Co., Ltd. Microesferas que comprenden ONO-1301
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
JP2004159971A (ja) * 2002-11-14 2004-06-10 Hideki Yoshikawa 骨形成用部材およびその製造方法
ES2269973T3 (es) 2003-02-13 2007-04-01 Synthes Ag Chur Mezcla inyectable para sustituir un tejido oseo.
BRPI0407142A (pt) 2003-02-14 2006-01-10 Depuy Spine Inc Dispositivo de fusão intervertebral formado in situ
US20040243133A1 (en) 2003-03-05 2004-12-02 Therics, Inc. Method and system for manufacturing biomedical articles, such as using biomedically compatible infiltrant metal alloys in porous matrices
US20040193270A1 (en) 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7465446B2 (en) * 2003-05-30 2008-12-16 Medarex, Inc. Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
JP2007503292A (ja) 2003-06-11 2007-02-22 オステオテック インコーポレーテッド 骨インプラント及びその製造方法
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
ATE396669T1 (de) 2003-06-24 2008-06-15 Robert Mathys Foundation Dr H Prothesenvorrichtung zur wiederherstellung von knorpel
DE10328892A1 (de) 2003-06-26 2005-05-12 Curasan Ag Knochenaufbaumittel und Herstellungsverfahren
PL1641913T3 (pl) * 2003-06-27 2016-06-30 Depuy Synthes Products Inc Komórki poporodowe pochodzące z tkanek pępowinowych i sposoby ich wytwarzania i zastosowania
FI20031120A0 (fi) 2003-07-31 2003-07-31 Bci Bioabsorbable Concepts Ltd Monifunktionaalinen implanttilaite
CN1240637C (zh) * 2003-08-12 2006-02-08 四川大学 多孔磷酸钙生物陶瓷材料及其制备方法
US7163920B2 (en) * 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
WO2005035014A1 (ja) 2003-10-15 2005-04-21 Japan Science And Technology Agency 転写因子を利用した骨・軟骨再生用インプラント
CU23352A1 (es) * 2003-10-16 2009-03-16 Centro Nacional De Investigaciones Cientificas Biomateriales compuestos para implantes óseos
WO2005042048A2 (en) 2003-10-22 2005-05-12 Encelle, Inc. Bioactive hydrogel compositions for regenerating connective tissue
US20050098915A1 (en) * 2003-11-07 2005-05-12 Smith & Nephew Inc. Manufacture of bone graft substitutes
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
NZ547198A (en) * 2003-11-14 2008-05-30 Univ Pennsylvania Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
DE10355559A1 (de) 2003-11-21 2005-06-23 Orthogen Ag Transskin
EP1537839A1 (de) 2003-12-02 2005-06-08 Dr. h. c. Robert Mathys Foundation Prothesenvorrchtung zur Knorpelreparatur
WO2005072656A1 (en) 2004-01-27 2005-08-11 Osteotech, Inc. Stabilized bone graft
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US7928059B2 (en) 2004-02-24 2011-04-19 Wisconsin Alumni Research Foundation Use of neuropeptides for traumatic cartilage injury
KR101013999B1 (ko) * 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US8163030B2 (en) 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
EP1804716A2 (de) 2004-09-21 2007-07-11 The Massachusetts Institute Of Technology Gradientengerüst und verfahren zu seiner herstellung
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
WO2006050493A2 (en) 2004-11-03 2006-05-11 The Regents Of The University Of Michigan Biodegradable implant for intertransverse process fusion
US20060149392A1 (en) * 2004-12-07 2006-07-06 Kuo-Huang Hsieh Biomaterials for guided tissue regeneration and drug delivery
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
EP1909810B2 (de) 2005-06-07 2017-08-23 The Regents of the University of Colorado Hemmer der serinprotease-aktivität und ihre verwendung in verfahren und zusammensetzungen zur behandlung von transplantat-abstossung und förderung des transplantat-überlebens
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US7749555B2 (en) 2006-01-25 2010-07-06 Medtronic, Inc Modification of chemical forces of bone constructs
EP1974015A4 (de) 2006-01-27 2012-07-04 Univ California Biomimetische gerüste
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
EP2311505B1 (de) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren zur Behandlung von Knochen
US7833270B2 (en) 2006-05-05 2010-11-16 Warsaw Orthopedic, Inc Implant depots to deliver growth factors to treat osteoporotic bone
CN101453961B (zh) 2006-05-08 2011-08-10 纽瓦西弗公司 胶原酶处理的并且基本上不含血细胞的松质骨
US9161967B2 (en) * 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
WO2008151193A1 (en) 2007-06-04 2008-12-11 Biomimetic Therapeutics, Inc. Compositions and methods for treating the vertebral column
AU2007269712B2 (en) * 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
EP2462895B1 (de) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren für Behandlungen von Arthodese
US20100151025A1 (en) * 2007-02-20 2010-06-17 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw
CA2690457C (en) * 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2009042514A1 (en) * 2007-09-25 2009-04-02 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
JP5864106B2 (ja) 2008-02-07 2016-02-17 バイオミメティック セラピューティクス， エルエルシー 仮骨延長のための組成物および方法
NZ602861A (en) * 2008-09-09 2014-03-28 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
KR20110100269A (ko) 2008-12-19 2011-09-09 바이오미메틱 세라퓨틱스, 인크. 감소된 프로테아제 활성을 갖는 골 이식편 및 선택 방법 및 용도
KR20110135949A (ko) 2009-03-05 2011-12-20 바이오미메틱 세라퓨틱스, 인크. 혈소판-유래 성장 인자 조성물 및 골연골성 결함의 치료 방법

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WO2006044334A2 (en) 2006-04-27
US20170072107A1 (en) 2017-03-16
ES2454841T3 (es) 2014-04-11
DK1812076T3 (da) 2010-11-15
IL182480A (en) 2014-06-30
WO2006044334A3 (en) 2008-02-21
CA2726144A1 (en) 2006-04-27
IL182480A0 (en) 2007-07-24
US20170014482A1 (en) 2017-01-19
ZA200703515B (en) 2008-10-29
CA2583823A1 (en) 2006-04-27
EP1812076A4 (de) 2008-10-01
JP5137577B2 (ja) 2013-02-06
US20220072204A1 (en) 2022-03-10
BRPI0516105A (pt) 2008-08-26
US11571497B2 (en) 2023-02-07
CN105561384A (zh) 2016-05-11
EP2223698B1 (de) 2016-09-28
US20170014545A1 (en) 2017-01-19
US9545377B2 (en) 2017-01-17
BRPI0516105B8 (pt) 2021-05-25
AU2005295919B2 (en) 2009-03-26
JP2008516675A (ja) 2008-05-22
KR20110013492A (ko) 2011-02-09
US11364325B2 (en) 2022-06-21
CN101198343A (zh) 2008-06-11
KR101305922B1 (ko) 2013-09-17
JP2009195739A (ja) 2009-09-03
US20160310639A1 (en) 2016-10-27
EP1812076A2 (de) 2007-08-01
AU2009202532B2 (en) 2012-05-31
NZ554511A (en) 2010-07-30
EP1812076B1 (de) 2010-08-11
US20060084602A1 (en) 2006-04-20
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MX2007004459A (es) 2007-08-14
US20070259814A1 (en) 2007-11-08
NO20071974L (no) 2007-07-11
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US20090074753A1 (en) 2009-03-19
US7473678B2 (en) 2009-01-06
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EP3170505B1 (de) 2021-03-17
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US20220176021A1 (en) 2022-06-09
US11318230B2 (en) 2022-05-03
EP3170505A1 (de) 2017-05-24
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EP2223698A1 (de) 2010-09-01

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