WO2012160052A1 - Nébuliseur - Google Patents

Nébuliseur Download PDF

Info

Publication number
WO2012160052A1
WO2012160052A1 PCT/EP2012/059463 EP2012059463W WO2012160052A1 WO 2012160052 A1 WO2012160052 A1 WO 2012160052A1 EP 2012059463 W EP2012059463 W EP 2012059463W WO 2012160052 A1 WO2012160052 A1 WO 2012160052A1
Authority
WO
WIPO (PCT)
Prior art keywords
nebulizer
container
housing part
fluid
rider
Prior art date
Application number
PCT/EP2012/059463
Other languages
English (en)
Inventor
Holger Holakovsky
Ralf Thoemmes
Marc Rohrschneider
Florian Witte
Kevin Peter DEANE
Douglas Ivan Jennings
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Priority to EP12722157.0A priority Critical patent/EP2714279B1/fr
Priority to JP2014511842A priority patent/JP6160842B2/ja
Publication of WO2012160052A1 publication Critical patent/WO2012160052A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0081—Locking means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/108—Means for counting the number of dispensing strokes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/02—Housing
    • G06M1/026—Connecting or supporting parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/042—Force radial
    • F04C2270/0421—Controlled or regulated

Definitions

  • the present invention relates to a nebulizer according to the preamble of claim 1.
  • WO 2006/125577 A2 discloses a nebulizer.
  • the nebulizer comprises, as a reservoir for fluid which is to be atomized or nebulizer, an insertable rigid container having an inner bag containing the fluid and a pressure generator with a drive spring for delivering and atomizing the fluid.
  • the container is secured against removal.
  • the nebulizer of its housing may be designed such that it can not be opened after the container has been inserted.
  • the container is pre-installed in nebulizer in the delivery state.
  • the pre-installed container is held by a transportation lock unmova- ble within the housing in the delivery state in order to avoid any undesired opening of the container.
  • the nebulizer Before being used for the first time the nebulizer is completely closed.
  • the pre-installed container is opened by a delivery tube piercing a sealing and a septum to fluidically connect to the inner bag of the container. Further, the transportation lock is opened so that the container can move inside the nebulizer back and forth.
  • the drive spring By rotating the lower housing part of the nebulizer the drive spring can be put under tension and fluid can be sucked into a compression chamber of the pressure generator. Simultaneously, the container is moved into the lower housing part in a stroke movement within the nebulizer and when tensioned for the first time the container may be pierced through its base by a piercing element in the lower housing part to allow venting of the container. After manual operation of a locking element the drive spring is released and the fluid in the pressure chamber is put under pressure by the drive spring and is delivered or atomized through a nozzle into a mouthpiece as an aerosol, without the use of propellant gas.
  • WO 2007/022898 A2 discloses a similar nebulizer.
  • a container can be inserted into a housing of the nebulizer.
  • the housing is closed by a lower or bottom housing part.
  • the container is moving axially forth and back during conveying of the fluid to be nebulized, during pressure generation and/or during nebulization.
  • a counter can be arranged in the housing part. The counter locks the nebulizer against further use if a predetermined number of operations has been reached or exceeded. Then, the housing part may be replaced together with the counter and the container.
  • the container may be connected inseparably with the housing part.
  • Object of the present invention is to provide a nebulizer with simple assembly or construction.
  • the nebulizer comprises an operation counter counting uses of the nebulizer with the associated container, wherein the operation counter is inseparable from the housing part for replacement together with the container and housing part.
  • the operation counter comprises a first lead screw and an associated, first rider both supported by the housing part.
  • the operation counter or its rider or an associated opening lock can block opening of the nebulizer or detachment of the housing part and, thus, can block container replacement until a predetermined number of uses has been reached or exceeded with the associated or current container.
  • the operation counter or its rider can lock the nebulizer against further use, in particular against conveying of fluid into a pressure generator of the nebulizer, tensioning of a drive spring of the nebulizer, rotation of the housing part, pressure generation and/or nebulization, when a predetermined number of uses has been reached or exceeded with the associated or current container.
  • the operation counter or its rider may provide or control a double-function of the nebulizer.
  • the operation counter associated to a container controls preferably opening of the nebulizer or container replacement as well as blocking of the nebulizer against further use with the respective container.
  • this double-function is achieved or controlled preferably by a common component, here the (first) rider.
  • the container is pre-assembled into the (lower) housing part.
  • the operation counter can be combined with or used together with a container counter provided at the nebulizer, in particular at an upper part or inner part of the nebulizer.
  • the nebulizer can be used with multiple containers, but is blocked against further use or container replacement after a predetermined number of containers has been inserted and/or used.
  • Fig. 1 a schematic section of a known nebulizer in a non-tensioned state
  • Fig. 2 a schematic section, rotated through 90° compared with Fig. 1, of the known nebulizer in a tensioned state;
  • Fig. 3 a schematic section of a nebulizer in a delivery state with a partly closed housing and with a pre-installed, closed container;
  • Fig. 4 a schematic section of the nebulizer according to Fig. 3 in an activated, tensioned state with the completely closed housing and with the opened container;
  • Fig. 5 a schematic section of the nebulizer according to Fig. 4 in a non- tensioned state; a schematic section of a nebulizer according to the present invention with a partly closed housing and with a securing means in a housing part holding unmoveably a container in the nebulizer; a perspective view of the securing means;
  • Fig. 8 a side view of the securing means holding the associated container unmoveably
  • Fig. 9 a schematic partial view of a part of the nebulizer with opened securing means so that the container can move;
  • Fig. 10 a schematic view of an inner member of the nebulizer with an operation counter
  • Fig. 1 1 another schematic view of the inner member with a container counter
  • Fig. 12 a schematic view of the inner part member with the operation counter similar to Fig. 10, but according to a modified embodiment
  • Fig. 13 a schematic section of the nebulizer with separated housing part and container.
  • Figs. 1 and 2 show a known nebulizer 1 for atomizing a fluid 2, particularly a highly effective pharmaceutical composition, medicament or the like, dia- grammatically shown in a non-tensioned state (Fig. 1) and in a tensioned state (Fig. 2).
  • the nebulizer 1 is constructed in particular as a portable inhaler and preferably operates only mechanical and/or without propellant gas.
  • the fluid 2 preferably a liquid, more particularly a pharmaceutical composition
  • an aerosol 14 Fig. 1 is formed, which can be breathed in or inhaled by a user.
  • the inhaling is done at least once a day, more particularly several times a day, preferably at set intervals, depending on the complain or illness from which a patient is suffering.
  • the nebulizer 1 is provided with or comprises an insertable or replaceable container 3 containing the fluid 2.
  • the container 3 thus forms a reservoir for the fluid 2, which is to be nebulized.
  • the container 3 contains multiple doses of fluid 2 or active substance, in particular sufficient to provide up to 200 dosage units or doses, for example, i.e. to allow up to 200 sprays or applications.
  • the dose can vary, in particular depending on the fluid 2 or medicament.
  • the nebulizer 1 can be adapted respectively.
  • the number of doses contained in the container 3 and/or the total volume of the fluid 2 contained in the container 3 can vary depending on the fluid 2 or respective medicament and/or depending on the container 3 and/or depending on the necessary medication or the like.
  • the container 3 can be replaced or exchanged, wherein the number of containers 3, which can be used with the same nebulizer 1, is preferably restricted , e.g. to a total number of four or five containers 3.
  • the container 3 is preferably substantially cylindrical or cartridge-shaped and once the nebulizer 1 has been opened the container 3 can be inserted therein preferably from below and changed if desired. It is preferably of rigid construction, the fluid 2 in particular being held in a collapsible bag 4 in the container 3.
  • the nebulizer 1 comprises preferably a pressure generator 5 for conveying and nebulizing the fluid 2, particularly in a preset and optionally in an adjustable dosage amount.
  • the pressure generator 5 comprises preferably a holder 6 for releasable holding the container 3, a drive spring 7 associated to the holder 6, only partly shown, a blocking element 8 which can catch and block the holder 6 and can be manually operated to release the holder 6 allowing drive spring 7 to expand, a conveying element, such as a conveying tube 9, a non-return valve 10, a pressure chamber 1 1 and/or a nozzle 12 for nebulizing the fluid 2 into a mouthpiece 13.
  • the completely inserted container 3 is fixed or held in the nebulizer 1 via the holder 6 such that the conveying tube 9 penetrates into the container 3.
  • the holder 6 is preferably constructed so that the container 3 can be exchanged.
  • the nebulizer 1 operates with a spring pressure of 5 to 200 MPa, preferably 10 to 100 MPa on the fluid 2 and/or with a volume of fluid 2 delivered per stroke of 10 to 50 ⁇ , preferably 10 to 20 ⁇ , most preferably about 15 ⁇ .
  • the fluid 2 is converted into or nebulized as aerosol 14 the droplets of which have an aerodynamic diameter of up to 20 ⁇ , preferably 3 to 10 ⁇ .
  • the generated jet spray has an angle of 20° to 160°, preferably 80° to 100°.
  • a user or patient can inhale the aerosol 14, preferably while an air supply can be sucked into the mouthpiece 13 through at least one optional air supply opening 15.
  • the nebulizer 1 or drive spring 7 can be manually activated or ten- sioned, in particular by actuation of an actuation member.
  • the nebulizer 1 comprises preferably an upper housing part 16 and an inner part 17 which is rotatable relative thereto (Fig. 2) having an upper part 17a and a lower part 17b (Fig. 1), while an in particular manually operable (lower) housing part 18 is releasable fixed, particularly fitted or held onto the inner part 17, preferably by means of a retaining element 19.
  • the housing parts 16 and 18 form a housing of the nebulizer 1.
  • the housing can be opened and/or the housing part 18 can be detached from the nebulizer 1 or its housing.
  • the actuation member preferably the housing part 18, can be actuated, here rotated relative to the upper housing part 16, carrying with it of driving the inner part 17.
  • the drive spring 7 is tensioned in the axial direction by means of a gear or transmission (not shown) formed between the inner part 17, in particular its upper part 17a, and the holder 6 and acting on the holder 6.
  • the container 3 is moved axially downwards until the container 3 assumes an end position as shown in Fig. 2.
  • the drive spring 7 is under tension and can be caught or held by the blocking member 8.
  • the container 3 is moved back into its original position (non-tensioned position or state shown in Fig. 1) by the drive spring 7.
  • the container 3 executes a lifting or stroke or linear movement or a back and forth movement during the tensioning process or conveying of fluid 2 and/or during the pressure generation or ne- bulization (process).
  • the housing part 18 preferably forms a cap-like lower housing part and fits around or over a lower free end portion of the container 3.
  • an aeration means such as an axially acting spring 20 arranged in the housing part 18, comes in con- tact with base 21 of the container 3 and pierces the container 3 or a base seal thereon with a piercing element 22 when the container 3 makes contact with it for the first time, to allow air in or aeration.
  • the nebulizer 1 comprises preferably a container counter 23, which counts the number of containers 3 that have been or still can be used with or inserted into the nebulizer 1 , preferably by detecting tensioning of the nebulizer 1 or its drive spring 7 or rotation of the inner part 17 relative to the upper part 16 of the housing.
  • the container counter 23 or a lock preferably formed by a locking element or spring and actuated by the container counter 23 locks any (further) actuation or use of the nebulizer 1, e.g.
  • FIG. 3 A preferred construction and mode of the inhaler or nebulizer 1 will now be described in more detail with reference to Fig. 3 to 5, but emphasizing only essential differences from the nebulizer 1 according to Figs. 1 and 2.
  • the remarks relating to Figs. 1 and 2 thus apply preferably accordingly or in a similar manner, while any desired combinations of features of the nebulizer 1 according to Figs. 1 and 2 and the nebulizer 1 described below are possible.
  • Fig. 3 shows the nebulizer 1 in a delivery state with preferably pre-installed container 3 which is still closed. In this state, the housing of the nebulizer 1 is not completely closed, in particular the housing part 18 is not completely pushed on the inner part 17.
  • Fig. 4 and 5 show the nebulizer 1 in an activated and/or tensioned state with the housing completely closed and with the container 3 opened. In Fig. 4, the nebulizer 1 or drive spring 7 is tensioned, i.e. the container 3 is in its lower position.
  • Fig. 5 shows the nebulizer 1 in a non- tensioned state, e.g. after the delivery or discharge of one dose of the fluid 2; the container 3 is in its upper position.
  • the container 3 comprises a fluid outlet 24 for outputting the fluid 2 to be dispensed.
  • the fluid outlet 24 allows a fluidic connection between the container 3 or its bag 4 on one hand and the nebulizer 1 , its pressure generator 5 or the conveying element on the other hand.
  • the fluid outlet 24 has an inner closure 25 that is preferably formed by a septum, a membrane, a plastic seal or the like and/or is provided inside the container 3.
  • a second or outer closure 26 can be provided such that successive opening is possible by means of one common element, in particular the conveying element or conveying tube 9 or the like, and/or by piercing.
  • the first or inner closure 25 is formed or supported by a closure part 27 extending from the outlet or head end of the container 3 into the container 3 or bag 4.
  • the second or outer closure 26 is preferably located adjacent to the head or axial end of the container 3 and/or held or connected to a flange 28, which can be formed by the closure part 27 or any other suitable part.
  • a flange 28 can be formed by the closure part 27 or any other suitable part.
  • the container 3 has been pre-installed, i.e. inserted into the nebulizer 1.
  • the container 3 or its fluid outlet 24 is not yet opened.
  • the second closure 26 is already opened, but not the first closure 25. This is achieved in particular in that the housing of the nebulizer 1 is closed only partly, i.e. not completely, in the delivery state.
  • the container 3 is attached to or held by or secured in the housing part 18, in particular by a transportation lock 29, which is preferably arranged within or at the housing part 18.
  • the transportation lock 29 holds the container 3 preferably temporarily, in particular before attaching the housing part 18 to the nebulizer 1 and/or in the delivery state.
  • the transportation lock 29 holds the container 3 fixed during the fluidic connection of container 3 and/or during the mechanic connection of container 3, here with holder 6.
  • the transportation lock 29 holds the container 3 fixed during opening, in particular piercing, the container 3.
  • the nebulizer 1 or the housing part 18 is preferably secured, in particular by means of a securing member 30, e.g. a banderole, such that the container 3 and/or housing part 18 are held sufficiently spaced from the nebulizer 1 or upper housing part 16 and/or prevented from being completely inserted or pushed on the conveying element or tube 9, the housing or inner housing part 17 or the like and/or such that (complete) opening of the container 3, namely of the first closure 25, is prevented.
  • a securing member 30, e.g. a banderole such that the container 3 and/or housing part 18 are held sufficiently spaced from the nebulizer 1 or upper housing part 16 and/or prevented from being completely inserted or pushed on the conveying element or tube 9, the housing or inner housing part 17 or the like and/or such that (complete) opening of the container 3, namely of the first closure 25, is prevented.
  • a user can push the housing part 18 fully on in the axial direction and thereby open the container 3, i.e. first closure 25, by inserting the conveying element or conveying tube 9.
  • Figs. 4 and 5 show this activated state with the housing part 18 pushed fully on and/or the container 3 open (fluidically connected to the nebulizer 1 or its pressure generator 5 or the conveying element or tube 9).
  • Fig. 4 shows the nebulizer 1 or container 3 in the activated state
  • the container 3, i.e. first closure 25, is open, i.e. the container 3 or its fluid 2 is fluidically connected to the nebulizer 1 or its pressure generator 5, and the housing part 18 has been pushed fully on in the axial direction.
  • the holder 6 In order to bring the holder 6 into (complete) engagement with the container 3 at the head end and then be able to move the container 3 back and/or forth for the suction/tensioning and pressing strokes, it may be necessary to tension the nebulizer 1 or it drive spring 7 for the first time.
  • Fig. 4 shows the nebulizer 1 in this tensioned and activated state.
  • the holder 6 is engaged with the container 3 and the conveying tube 9 has been fully inserted into the container 3.
  • Fig. 5 shows the nebulizer 1 in the relaxed, non-tensioned state, i.e. after ato- mization or discharge of a dose of the fluid 2.
  • the holder 6 and the container 3 are in the upper position.
  • the holder 6 is still engaged with the container 3 and remains engaged during the further uses of the nebulizer 1.
  • the container 3 is still open and fluidically connected, i.e. the nebulizer 1 remains activated.
  • the transportation lock 29 is provided to prevent unwanted opening of the container 3, particularly of the first closure 25, in the delivery state of the nebulizer 1, and/or to prevent (axial) movement of the container 3 relative to the associated housing part 18 before complete closing of the nebulizer 1 .
  • the transportation lock 29 is provided.
  • the transportation lock 29 prevents the container 3 from undesirably moving axially.
  • the opening of the transportation lock 29 occurs automatically when closing the nebulizer 1 or its housing completely, i.e. when snapping or pushing on the housing part 18 completely towards the upper housing part 16.
  • this (preferably linear, axial or telescopic) closing movement the transportation lock 29 is opened and the container 3 released (preferably not totally) in axial direction preferably only in a last part of the closing movement and/or just little before the final completely closed position is reached or just when the final completely closed position is reached.
  • the closing movement of the nebulizer 1 opens the transportation lock 29 preferably automatically.
  • the transportation lock 29 is opened by the direct or indirect interaction with or actuation by the housing of the nebulizer 1, the inner part 17 or its lower part 17b, a holding ring 43 bearing the spring 7 or the like.
  • the container 3 and/or first closure 25 are opened as well as the transportation lock 29 by means of a common actuation, here the closing movement of the nebulizer 1 or its housing or lower part 18.
  • Figs. 4 and 5 show the transportation lock 29 in the open position, i.e. wherein the container 3 is free to move axially.
  • Fig. 6 shows in a very schematic, partially sectional view the nebulizer 1 according to a preferred embodiment of the present invention.
  • the nebulizer 1 is shown in a transitional state from the delivery state to the activated state with not completely closed housing or housing part 18.
  • the housing part 18 has already been pushed on the inner part 17 more than initially provided in the delivery state such as shown in Fig. 3. Therefore, the container 3 has already been opened in the state shown in Fig. 6.
  • the securing member 30, which preferably secures the housing part 18 in the delivery state against pushing on the inner part 17, has already been released or opened or removed in the state shown in Fig. 6.
  • the container 3 and the associated, preferably inseparable housing part 18 are pre-installed or pre-mounted to the nebulizer 1 or inner part 17 in the delivery state.
  • the housing part 18 and the container 3 can be attached to the nebulizer 1 when using the nebulizer 1 for the first time, i.e. when closing the nebulizer 1.
  • the nebulizer 1 or its housing comprises a securing means 35 for holding the container 3 such that the container 3 is moveable back and forth for the conveying of the fluid 2, pressure generation and/or nebulization, but is inseparable from the housing or housing part 18, and/or such that the container 3 is unmoveably held in the delivery state of the nebulizer 1 and/or before closing the nebulizer 1.
  • the securing means 35 forms the transportation lock 29.
  • the securing means 35 is located or arranged preferably at or in the housing part 18 as shown in Fig. 6.
  • Fig. 7 shows in a perspective view a preferred embodiment of the securing means 35.
  • Fig. 8 shows the securing means 35 connected with the container 3.
  • the securing means 35 comprises or consists of a metal and/or stamping part and/or consists of a single, unitary part as shown in Fig. 7.
  • the securing means 35 is made of steel, in particular spring steel.
  • the securing means 35 is produced from sheet material by cutting, stamping or the like and/or by bending.
  • the securing means 35 or the part forms a cage, in particular, encompasses the container 3 or an end portion thereof.
  • the securing means 35 comprises holding elements 36 and/or supporting elements 37.
  • the elements 36 and 37 are preferably designed like arms, fingers leaves or the like.
  • the elements 36, 37 are alternately distributed over a circumference of the container 3 and/or extend at least essentially axially or in the direction of the back and forth movement of the container 3.
  • the elements 36 and 37 are held by or connected with a base 38 of the securing means 35.
  • the securing means 35 or base 38 comprises or holds the piercing element 22 for piercing the container 3, i.e. opening the container base 21 or its venting hole 34 in the activated and tensioned state, i.e. when the container 3 reaches its lower end position.
  • the piercing element 22 is formed by a respective bending of a spring portion 39 of the securing means 35 or its base 38.
  • the spring portion 39 can support or facilitate the (complete or final) connection of the container 3 to holder 6.
  • the securing means 35 or base 38 comprises preferably at least one or multiple fixing portions 40 for fixing the securing means 35 at or in the nebulizer 1 or housing or housing part 18.
  • the fixing portions 40 may fix the securing means 35 when the securing means 35 is pressed into the housing part 18 by cooperating with the side wall of the housing part 18.
  • the securing means 35 could be connected with the housing part 18 or the like in any other suitable manner.
  • the securing means 35 does not only prevent the separation of the container 3 from the nebulizer 1, its housing or housing part 18, but also forms the transportation lock 29 for holding the container 3 unmovable in the housing in the delivery state of the nebulizer 1.
  • Fig. 6 and 8 shows this state or situation when the container 3 is held (axially) unmovable by the securing means 35, i.e. when the transportation lock 29 is closed.
  • the contain- er 3 or its preferably radially protruding end or edge 41 of the container 3 or base 21 is held between the holding element(s) 36 and supporting element(s) 37, in particular between respectively formed or bent ends of the elements 36 and 37.
  • the container end or edge 41 is caught between end portions 36a and 37a of the elements 36 and 37.
  • the holding elements 36 grip or extend over the edge 41 and the supporting elements 37 or its end portions 37a grip or extend under the edge 41 or container base 21 so that the edge 41 and container 3 are securely held preventing any axial movement of the container 3 relative to the securing means 35 and relative to the associated housing part 18 in this state, i.e. with locked securing means 35 / transportation lock 29.
  • the supporting elements 37 or its end portions 37a hold or support the container 3 for opening by inserting the conveying element or tube 9, preferably wherein a press fitt is formed between the conveying element or tube 9 and the container 3 or closure part 27, and/or for (completely) connecting the container (head) to the holder 6.
  • the transportation lock 29 or securing means 35 or supporting elements 37 or end portions 37a form preferably a counter-bearing for the container 3 during closing of the nebulizer 1.
  • the holding element 36 and the supporting elements 37 are distributed alter- natingly around the container 3 or edge 41.
  • the end portions 36a of the holding elements 36 end in a first radial plane and the end portions 37a of the supporting elements 37 end in another, second radial plane, wherein the two planes are axially offset to hold the edge 41 in between and/or wherein the second plane is located axially between the first plane and the lower end position of the container 3 or the lower end of the housing part 18 or the piercing element 22.
  • the end portions 36a end on another radius (outer radius) than the end portions 37a and/or are axially spaced therefrom.
  • the end portions 36a and/or 37a are preferably form like claws or the like and/or extend preferably radially inwardly.
  • the elements 36 and/or 37 can flex with its free ends radially outwardly.
  • the ends of the end portions 36a may be inclined such that the container 3 may be inserted into or connected with the securing means 35 by a respective axial force so that the holding elements 36 flex outwardly to allow passing of edge 41.
  • the holding elements 36 can be flexed outwardly also by a suitable tool (not shown) or the like when the container 3 is inserted, in particular with its edge 41, into the securing means 35.
  • the holding elements 36 prevent separation of the container 3 from the securing means 35 and, thus, from the associated housing part 18 or the like.
  • the supporting elements 37 or its end portions 37a can be flexed radially outwardly in order to open the axial holding or transportation lock 29 (this will be explained in detail with reference to Fig. 9 in the following). Then, the container 3 can axially move, in particular back and forth and/or with its edge 41 between the first plane and the piercing element 22 in the present embodiment.
  • the supporting elements 37 comprise actuation portions 37b (preferably formed at the free ends and/or between adjacent end portions 37a).
  • the actuation portions 37b form axial extensions which may be radially offset.
  • the actuation portion 37b cooperate with an associated control member 42 or multiple control members 42 of the nebulizer 1 such that the locking elements 37 are flexed radially outwardly when (completely) closing the housing to open the transportation lock 29 (here primarily formed by the locking elements 37 or its end portions 37a).
  • Fig. 6 shows schematically the control member 42 axially spaced from the associated actuation portion 37b as the housing has not yet been closed (completely).
  • Fig. 9 shows a lower part of the completely closed nebulizer 1 with opened transportation lock 29, i.e. with radially outwardly flexed supporting elements 37.
  • Fig. 9 shows that the control member 42 has an inclined guiding surface or the like to convert the axial closing movement into the radial opening movement of the actuation portion 37b and, thus, of the associated supporting element 37 to open the transportation lock 29, in particular when the housing has been completely closed or when the housing part 18 has been pushed completely on the nebulizer 1.
  • the control member 42 is preferably formed as an axial protrusion. It can be formed by or at a ring 43 or any other bearing means of the nebulizer 1 for counter-bearing the drive spring 7 in the inner part 17 or by or at any other suitable component if the nebulizer such as the inner part 17.
  • the control member 42 may be formed like an axial protruding ring or shoulder or ridge which extends along the ring 43.
  • the control member 42 may additionally secure the holding elements 36 against axial opening when the housing is completely closed as schematically shown in Fig. 9.
  • the control member 42 contacts the holding elements) 36 or its end portions 36a peripherally on the outer side to prevent any outward flexing.
  • the securing means 35 or its holding elements 36 are secured against opening so that the container 3 is securely held within the securing means 35 or the cage formed by the securing means 35 or holding elements 36.
  • Fig. 9 shows the container 3 in its lower position when the piercing element 22 can pierce the venting hole 34 or an associated seal attached to the container base 21.
  • the securing means 35 has multiple functions. It holds the container 3 (in the activated state / with completely closed housing) such that it can move back and forth, in particular during conveying of the fluid 2, during pressure generation and/or during nebulization, wherein the container 3 is inseparable from the housing or the housing part 18. Further, the securing means 35 forms the transportation lock 29 and/or holds the container 3 unmovable in the delivery state of the nebulizer 1 and/or for opening the container 3 and/or for connecting the container 3 to the holder 6 and/or conveying tube 9. Additionally or alternatively, the securing means 35 comprises an opening means, here the piercing element 22, for opening the venting hole 34 of the container 3.
  • the securing means 35 forms a cage which cannot be separated from the container 3 after connecting it with the container 3.
  • the transportation lock 29 and the supporting elements 37 are kept opened during the normal use of the nebulizer 1 , in particular as long as the housing is (completely) closed.
  • the control member 42 may disengage from the actuation portions 37b so that the supporting elements 37 can close or flex inwardly again.
  • the supporting elements 37 may grip with its end portions 37a over the edge 41 of the container 3 such that an additional lock is formed which prevents that the container 3 can be separated from the securing means 35 / housing part 18.
  • the securing means 35 prevents separation of the container 3 from the housing part 18. Therefore, the container 3 can be replaced or exchanged only together with the housing part 18 if the housing part 18 can be detached from the nebulizer 1 or inner part 17 at all. If the nebulizer 1 is in a state that it cannot be openend, i.e. is blocked against opening, the container 3 cannot be replaced.
  • Fig. 10 shows in a schematic view the nebulizer 1, wherein an outer part or shell of the (lower) housing part 18 and the securing means 35 are not shown. Instead, an inner member 44 of the housing part 18 is shown. The inner member 44 is connected, attached or pushed on the nebulizer 1 or, in particular, its inner part 17.
  • the inner member 44 is rigidly and/or inseparably connected with the housing part 18.
  • the inner member 44 is arranged within or received by the housing part 18.
  • the housing part 18 encompasses its inner part 44 normally.
  • the nebulizer 1 comprises an operation counter 45 for counting uses or operations of the nebulizer 1 with the associated or current container 3.
  • the operation counter 45 is arranged at or within the housing part 18, e.g. between the housing part 18 and its inner member 44.
  • the operation counter 45 is inseparable from the housing part 18 for replacement together with the container 3 and the housing part 18.
  • the operation counter 45 comprises preferably a first lead screw 46 and an associated, first rider 47.
  • both the first lead screw 46 and the first rider 47 are supported by the housing part 18 directly or indirectly, e.g. between the housing part 18 and its inner member 44 and/or by any other suitable bearing means attached thereto.
  • the operation counter 45 or first lead screw 46 is preferably driven by the rotation of the housing part 18 and/or inner member 17 relative to the nebulizer 1 or its upper housing part 16, in particular during conveying of fluid 2 into the pressure generator 5 or into the pressure chamber 1 1 and/or during tensioning of the drive spring 7.
  • the first lead screw 46 extends parallel to this rotational axis.
  • the first lead screw 46 comprises a gear 48 at its upper end extending into the nebulizer 1 or upper housing part 16 and, in particular, meshing with an inner toothing 49.
  • a gear 48 at its upper end extending into the nebulizer 1 or upper housing part 16 and, in particular, meshing with an inner toothing 49.
  • other constructional solutions are possible.
  • the first rider 47 meshes with the first lead screw 46 and is linearly and/or axially moveable depending on the rotation of the first lead screw 46.
  • the operation counter 45 locks the nebulizer 1 against further use, in particular against conveying of fluid 2 into the pressure generator 5 or pressure chamber 1 1, against tensioning of the drive spring 7, against rotation of the housing part 18, against pressure generation and/or nebulization, in a first locked state when a predetermined number of uses has been reached or exceeded with the current or associated container 3.
  • the nebulizer 1 or operation counter 45 comprises preferably a first lock or locking element 50, in particular a spring.
  • the first locking element 50 is arranged at and/or guided by and/or attached to and/or inseparable from the housing part 18 and/or its inner member 44.
  • the first locking element 50 can be shifted or moved preferably axially towards or into the nebulizer 1 or its upper housing part 16 and/or between the inner part 17 and upper housing part 16 and/or such that it expands in axial direction, preferably such that the locking element 50 blocks in this locking position or upwardly moved or shifted position (shown in dashed line in Fig. 10) any further rotation of the inner part 17 and/or lower housing part 18, in particular relative to upper housing part 16.
  • This can be achieved, in particular in that the locking element 50 or spring is axially biased and/or can engage into at least one respective recess or the like and/or can catch a stop or the like in the locking position so that the desired blocking effect is achieved in the locking position of the first locking element 50.
  • the spring or locking element 50 can be formed by a bent or biased metal sheet part or the like, which can expand or open when moved upwards or into the locking position, but can not be moved back into the lower position as it blocks itself, i.e. by abutment at the inner part 17, inner member 44 and/or housing part 18.
  • the first locking element 50 is preferably moved into the locking position or is moved sufficiently to overcome a respective catch, resistance or the like for moving into the locking position by the first rider 47, in particular by a respective abutting portion 51 of the first rider 47 when the first rider 47 reaches an upper position (indicated in dashed line in Fig. 10).
  • the lock or locking element 50 blocks or locks the nebulizer 1 against further use.
  • This state is called first locked state.
  • this first locked state is reversible or can be reset by replacing or exchanging the housing part 18 together with the container 3 and the operation counter 45.
  • the locking element 50 will be withdrawn and detached together with the housing part 18 by the replacement of the housing part 18.
  • the nebulizer 1 is blocked against opening or detachment of the housing part 18 until a predetermined number of uses has been reached or exceeded with the current or associated container 3.
  • the nebulizer 1 comprises a first opening lock 52 which blocks opening of the nebulizer 1 or detachment of the housing part 18 and, thus, blocks container replacement.
  • This first opening lock 52 is preferably opened by the operation counter 45 or its first rider 47 when the predetermined number of uses has been reached or exceeded with the associated or current container 3.
  • the first opening lock 52 comprises a first locking portion 53 which is preferably flexible and/or arm-like.
  • the first locking portion 53 is formed by or attached to the housing part 18 and/or its inner member 44.
  • other constructional solutions are possible as well.
  • the first locking portion 53 blocks automatically the nebulizer 1 or housing part 18 against opening or detachment when closing the nebulizer 1, in particular when pushing the housing part 18 onto the nebulizer 1 or its inner part 17.
  • the first locking portion 53 flexes over a protrusion or stop
  • the first opening lock 52 or first locking portion 53 is opened or unlocked by the counter device 45 or the first rider 47 when the predetermined number of uses has been reached or exceeded with the associated or current container 3.
  • the first rider 47 comprises preferably an actuation portion
  • the actuation portion 55 which can actuate or flex the first opening lock 52 or first locking portion 53.
  • the actuation portion 55 comprises an inclined surface cooperating or interfering with the first opening lock 52, in particular with a preferably inclined control portion 56 of the locking potion 53 or the like, such that the first rider 47 or its actuation portion 55 can flex the first locking portion 53 (preferably in circumferential direction as indicated in Fig. 10 in dashed line) out of engagement or interference with stop 54 so that the first opening lock 52 is opened and the housing part 18 can be detached from the nebulizer 1 for container replacement.
  • the first opening lock 52 or its first locking portion 53 is shown in the unlocked or flexed position in dashed line as in dashed line as in its lower position, but not in its upper position wherein it opens or flexes the first locking portion 53 and actuates the first locking element 50.
  • Fig. 1 1 shows the nebulizer 1 in a view similar to Fig. 10, but from the opposite side.
  • the housing part 18 and the securing means 35 are not shown in Fig. 1 1 , but the inner member 44 of the housing part 18 is shown attached to the inner part 17.
  • Fig. 1 1 shows a preferred realization of the container counter 23.
  • the container counter 23 counts the number of containers 3, which have been used or still can be used, and/or the total or overall number of uses or operations of the nebulizer 1 which have already performed or which still can be performed (with all containers 3).
  • the container counter 23 can restrict the total number of uses or operations that are possible with the nebulizer 1.
  • the container counter 23 comprises preferably a second lead screw 57 and an associated, second rider 58 in the present embodiment.
  • the container counter 23 is preferably attached to or inseparable from the nebulizer 1 or inner part 17.
  • the second lead screw 57 and second rider 58 are supported by or beared at the inner part 17.
  • the container counter 23 or the second lead screw 57 is driven by the rotation of the housing part 18 and/or inner part 17, in particular relative to the nebulizer 1 or upper housing part 16, and/or during conveying of fluid 2 into the pressure generator 5 or pressure chamber 1 1 and/or during tensioning of the drive spring 7.
  • the second lead screw 57 comprises at its upper end a gear 59 meshing with the inner toothing 49.
  • a gear 59 meshing with the inner toothing 49.
  • the nebulizer 1 or container counter 23 comprises preferably a second lock or locking element 60, as schematically shown in Fig. 1.
  • the second locking element 60 is formed by a preferably pre -biased spring or the like.
  • the second locking element 60 can be actuated or moved by the container counter 23 or its second rider 58, in particular by an abutting or pushing portion 61 schematically shown in Fig. 1.
  • the second rider 58 moves from its lower position shown in Fig.
  • the portion 61 can move or push the second locking element 60 into a locking position where the locking element 60 can expand and/or lock the nebulizer 1 against further use, in particular by locking or blocking the inner part 17 against rotation relative to the upper housing part 16.
  • This locked state is called second locked state or final locked state.
  • the nebulizer 1 is locked against further use in the second locked state when a predetermined number of total uses has been reached or exceeded with all containers 3 and/or when a predetermined number of containers 3 has been inserted or used with the nebulizer 1.
  • the second locked state is preferably not reversible, i.e. is final.
  • the nebulizer 1 or container counter 23 comprises preferably a second opening lock 62 which blocks opening of the nebulizer 1 or detachment of the housing part 18 and, thus, blocks container replacement in the second locked state.
  • the second opening lock 62 is closed when or before a predetermined number of used or inserted containers 3 has been reached or exceeded and/or before reaching the second locked state and/or when a predetermined number of uses of the nebulizer 1 has been reached or exceeded .
  • the second opening lock 62 is associated to the container counter 23 for blocking opening of the nebulizer 1.
  • the second opening lock 62 comprises preferably a second locking portion 63.
  • the second locking portion 63 is preferably flexible and/or arm-like or hook-like.
  • the second locking portion 63 is preferably formed by or attached to the housing part 18 its inner member 44.
  • other constructional solutions are possible as well.
  • the second locking portion 63 can lock or interfere or abut against a stop 64 in the locking or flexed position shown in dashed line in Fig. 1 1.
  • the stop 64 is preferably formed at or by the inner part 17 and/or by a radial protrusion or the like. Thus, detachment of the housing 17 is blocked in the locking position by the closed second opening lock 62 in the second locked state.
  • the container counter 23 or second rider 58 operates or actuates the second opening lock 62, in particular flexes or moves the second locking portion 63 into the locking position.
  • the second rider 58 comprises preferably an actuation portion 65, in particular with an inclined surface, which interferes or cooperates with the second locking portion 63, in particular with a preferably inclined control portion 66 of the second locking portion 63, such that the second opening lock 62 is closed and/or the second locking portion 63 is flexed or moved into the locking position (shown in dashed line) when the second rider 58 approaches or reaches its upper position shown in dashed line in Fig. 1 1.
  • the second locking portion 63 is preferably formed by or attached to the housing part 18 its inner member 44.
  • other constructional solutions are possible as well.
  • the second locking element 60 is only optional and that the second opening lock 62 can be sufficient in combination with first locking element 50 or the first opening lock 52 to lock the nebulizer 1 in the second locked state against any further use.
  • the second locking element 60 provides or allows preferably the strongest locking of the nebulizer 1.
  • Fig. 12 shows an alternative embodiment in a view similar to Fig. 10, wherein the construction of the first locking element 50 is modified or changed.
  • the first locking element 50 can be formed by the first rider 47 itself or its abutting portion 51.
  • the rider 57 or a portion thereof extends preferably upwards and/or in axial direction such that, in the upper position (locking position) of the first rider 47 shown in Fig. 12, the desired rotational locking of the nebulizer 1 is achieved.
  • the first rider 47 can be biased upwardly by a spring 68, e.g. arranged around the first lead screw 46.
  • the threading 67 of the first lead screw 46 is preferably shortened such that the meshing of the first rider 47 with the first lead screw 46 ends before the first rider 47 reaches its upper position and is biased by the force of the spring 68 into its final upper position.
  • other constructional solutions are possible as well.
  • the operation counter 45 is preferably associated or connected to the housing part 18.
  • the container counter 23 is preferably associated or connected to the nebulizer 1 or inner part 17.
  • the two counters 23 and 45 are preferably separated positively when detaching or opening the nebulizer 1 or housing part 18, in particular when replacing the housing part 18 together with the respective container 3 and the operation counter 45.
  • Fig. 13 shows in a schematic section the nebulizer 1 with separated housing part 18 and container 3, preferably before connecting the housing part 18 and container 3 to the nebulizer 1.
  • the nebulizer 1 can be delivered also in this state, i.e. with separated housing part 18 and separated container 3.
  • the nebulizer 1 is delivered with multiple containers 3 each inseparably connected to a respective housing part 18 and operation counter 45.
  • the operation counter 45 or first lead screw 46 on one hand and the container counter 23 or second lead screw 57 are located on opposite sides or in positions offset by exactly or about 180° at the inner part 17 or housing part 18, respectively.
  • Fig. 13 shows how the inner member 44 is held or received in the housing part 18, in particular by a respective snap fit, press fit or the like.
  • the first opening lock 52 is associated to and/or operated by the operation counter 45.
  • the second opening lock 62 is associated to and/or operated by the container counter 23.
  • the first locked state is reversible or can be reset, in particular by replacing the housing part 18 and/or operation counter 45 and/or first locking element 50.
  • the second locked state is irreversible and/or forms a final locked state of the nebulizer 1.
  • the operation counter 45 is located in an area where the retaining element 19 was located initially.
  • the operation counter 45 and/or first opening locked 52 can replace the retaining element 19.
  • the retaining element 19 can be omitted or can be located differently and/or realized by another constructional solution (not shown).
  • the operation counter 45 and/or container counter 23 may comprise associated markings, scales or the like, in particular to show or indicate the current count, such as the number of operations already performed or still possible with the current container 3, the total number of operations already performed or still possible with all containers 3 and/or the number of containers 3 already inserted or used or that can still be inserted or used. Alternatively or additionally, any necessary or performed container change can be shown or indicated.
  • the respective count is indicated or shown by the respective rider 47 or 58, in particular by the position of the respective rider 47 or 58.
  • the nebulizer 1 or housing part 18 is at least partially transparent and/or provided with a window or the like so that the respective count or rider position is visible for the user.
  • the container counter 23 can be omitted if desired.
  • the housing parts 18, that can be connected to the same nebulizer 1 may be different such that, in particular, the last housing part 18 is designed such and/or corporates with the nebulizer 1 such that the opening lock 52 does not open any more, e.g. by omitting the actuation portion 55.
  • the housing parts 18 can be marked differently at least the one which is to be used last. Thus, a user will use the different housing part 18 in a predetermined or desired sequence and/or at least one designated housing part 18 last.
  • the housing parts 18 may be numbered or provided with colours and/or any other markings.
  • the nebulizer 1 shown in Figs. 10 to 13 comprises a cover 69 covering the mouthpiece 13. This cover 69 is opened before using the nebulizer 1 , in particular before inhaling.
  • the proposed nebulizer 1 is preferably designed to be portable and in particular is a mobile hand operated device.
  • the proposed solution may, however, be used not only in the nebulizers 1 specifically described here but also in other nebulizers or inhalers, e.g. powder inhalers or so-called metered dose inhalers.
  • the fluid 2 is a liquid, as already mentioned, especially an aqueous pharmaceutical formulation or an ethanolic pharmaceutical formulation. However, it may also be some other pharmaceutical formulation, a suspension or the like.
  • the fluid 2 may also comprise particles or powder.
  • some other kind of supply device may be provided, especially an expulsion opening (not shown) or a supply channel (not shown) for supplying the fluid to or powder or the like into the mouthpiece 13.
  • the optional air supply opening 15 then serves to supply ambient air preferably in parallel so as to general or allow an airflow with a sufficient volume for breathing in or inhaling through the mouthpiece 13.
  • the fluid 2 may also be atomized by means of a propellant gas.
  • Preferred ingredients and/or formulations of the preferably medicinal fluid 2 are listed in particular in WO 2009/1 15200 Al, preferably pages 25 to 40, which is incorporated herewith by reference.
  • these may be aqueous or non-aqueous solutions, mixtures, formulations containing ethanol or free from solvent, or the like.
  • first closure 60 second locking element second closure 61 pushing portion closure part 62 second opening lock flange 70 63 second locking portion transportation lock 64 stop
  • venting hole 69 cover

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  • Veterinary Medicine (AREA)
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  • Biomedical Technology (AREA)
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Abstract

L'invention concerne un nébuliseur (1) comprenant un contenant amovible (3) contenant un fluide, une partie logement (18, 44) détachable du nébuliseur (1) afin de remplacer le contenant (3), et un compteur de doses (45) inséparable de la partie logement (18, 44). Le compteur de doses (45) comprend une vis mère (45) et un curseur associé (47) qui sont tous les deux maintenus par la partie logement (18, 44).
PCT/EP2012/059463 2011-05-23 2012-05-22 Nébuliseur WO2012160052A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12722157.0A EP2714279B1 (fr) 2011-05-23 2012-05-22 Nébuliseur
JP2014511842A JP6160842B2 (ja) 2011-05-23 2012-05-22 ネブライザ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11004236 2011-05-23
EP11004236.3 2011-05-23

Publications (1)

Publication Number Publication Date
WO2012160052A1 true WO2012160052A1 (fr) 2012-11-29

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Application Number Title Priority Date Filing Date
PCT/EP2012/059463 WO2012160052A1 (fr) 2011-05-23 2012-05-22 Nébuliseur

Country Status (4)

Country Link
US (1) US9827384B2 (fr)
EP (1) EP2714279B1 (fr)
JP (1) JP6160842B2 (fr)
WO (1) WO2012160052A1 (fr)

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US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
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US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
US20220047823A1 (en) * 2018-09-27 2022-02-17 Shl Medical Ag Locking mechanism for an aerosol dispenser
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USD929565S1 (en) * 2018-07-13 2021-08-31 Laboratorios Liconsa, S.A. Inhaler
TWI683677B (zh) * 2018-11-16 2020-02-01 微邦科技股份有限公司 霧化給藥裝置之鎖定結構
CN111195382B (zh) * 2018-11-16 2022-04-19 微邦科技股份有限公司 雾化给药装置的锁定结构
CN110338465A (zh) * 2019-07-16 2019-10-18 深圳麦克韦尔科技有限公司 换气阀及电子雾化装置
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