WO2010078512A2 - Production of substituted phenylene aromatic diesters - Google Patents

Production of substituted phenylene aromatic diesters Download PDF

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Publication number
WO2010078512A2
WO2010078512A2 PCT/US2009/069942 US2009069942W WO2010078512A2 WO 2010078512 A2 WO2010078512 A2 WO 2010078512A2 US 2009069942 W US2009069942 W US 2009069942W WO 2010078512 A2 WO2010078512 A2 WO 2010078512A2
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Prior art keywords
tert
butyl
bmpd
methylcatechol
forming
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PCT/US2009/069942
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English (en)
French (fr)
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WO2010078512A3 (en
WO2010078512A4 (en
Inventor
Tak W. Leung
Gary A. Roth
Tao Tao
Kuanqiang Gao
Linfeng Chen
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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Priority to RU2011132141/04A priority Critical patent/RU2553475C2/ru
Priority to MX2011007152A priority patent/MX2011007152A/es
Priority to BRPI0918707A priority patent/BRPI0918707A2/pt
Priority to SG2011048048A priority patent/SG172438A1/en
Priority to JP2011544626A priority patent/JP5461583B2/ja
Application filed by Dow Global Technologies LLC filed Critical Dow Global Technologies LLC
Priority to EP09796927A priority patent/EP2373604A2/en
Priority to CN200980157529.1A priority patent/CN102333749B/zh
Priority to US12/651,142 priority patent/US8507717B2/en
Publication of WO2010078512A2 publication Critical patent/WO2010078512A2/en
Publication of WO2010078512A3 publication Critical patent/WO2010078512A3/en
Publication of WO2010078512A4 publication Critical patent/WO2010078512A4/en
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Definitions

  • the present disclosure relates to the production of substituted phenylene aromatic diesters.
  • Substituted phenylene aromatic diesters are used as internal electron donors in the preparation of procatalyst compositions for the production of olefm-based polymers.
  • Ziegler-Natta catalysts containing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate as internal electron donor show high catalyst activity and high selectivity during polymerization.
  • such catalysts produce olefin-based polymer (such as propylene-based polymer) with high isotacticity and broad molecular weight distribution.
  • the art recognizes the need for olefin-based polymers and propylene-based polymers with improved properties. Desired are multiple and/or alternate synthesis pathways for the production of substituted phenylene aromatic diester to ensure a cost-effective, and reliable supply of the same.
  • the present disclosure is directed to the production of substituted phenylene aromatic diesters and 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate in particular.
  • Disclosed herein are synthesis pathways for the production of a precursor to the 5-tert-butyl- 3 -methyl- 1 ,2-phenylene dibenzoate, namely 5-tert-butyl-3-rnethylcatechol. Provision of this precursor, as presented in this disclosure advantageously simplifies production of 5-tert- butyl-3 -methyl- 1 ,2-phenylene dibenzoate and enables large-scale production thereof with common, inexpensive starting materials.
  • a process which includes reacting, under reaction conditions, 5-tert-butyl-3-methylcatechol
  • WHD/6867784 1 (BMC) with an aromatic carboxylic acid or an aromatic carboxylic acid derivative, and forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
  • a process includes alkylating, under reaction conditions, 3-methylcathecol with tert- butanol or isobutylene, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes oxidizing, under reaction conditions, 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes oxidizing, under reaction conditions, 4-tert-butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes hydrolyzing, under reaction conditions, 2-halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3- aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol.
  • An advantage of the present disclosure is an improved process for the production of substituted phenylene aromatic diester, such as 5 -tert-butyl-3 -methyl- 1,2-phenylene dibenzoate.
  • An advantage of the present disclosure is the provision of a precursor to 5-tert- butyl-3 -methyl 1,2-phenylene dibenzoate, namely, 5 -tert-butyl-3 -methylcatechol.
  • An advantage of the present disclosure is the provision of a plurality of synthesis pathways to produce 5-tert-butyl-3 -methylcatechol.
  • An advantage of the present disclosure is the production of 5 -tert-butyl-3 -methyl- 1 ,2-phenylene dibenzoate using inexpensive starting materials.
  • An advantage of the present disclosure is numerous synthesis pathways for the production of substituted phenylene aromatic diester, such as 5-tert-butyl-3-methyl- 1,2- phenylene dibenzoate, thereby ensuring a reliable supply of same for the production of propylene-based polymers.
  • An advantage of the present disclosure is a process for large scale production of substituted phenylene aromatic diester.
  • An advantage of the present disclosure is an environmentally-safe, non-toxic production process for substituted phenylene aromatic diester.
  • An advantage of the present disclosure is the large scale production of substituted phenylene aromatic diester.
  • An advantage of the present disclosure is a simple, time-effective, and/or cost- effective purification process for substituted phenylene aromatic diester.
  • Figure 1 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure.
  • Figure 2 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure.
  • the present disclosure is directed to the production of substituted phenylene aromatic diester.
  • 5-tert-butyl-3-methylcatechol (or "BMC") is found to be an effective precursor for the production of the substituted phenylene aromatic diester, 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate (or "BMPD”).
  • BMPD is an effective internal electron donor in Ziegler-Natta catalysts.
  • the processes disclosed herein advantageously provide economical (both time and monetary economies), simplified, up-scalable, synthesis pathways to BMC with yields acceptable for commercial/industrial application thereof. Economical access of BMC correspondingly contributes to economical production of 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate.
  • 5-tert-butyl-3-methylcatechol has the structure (I) provided below.
  • a process for producing BMC includes alkylating 3-methylcathecol with tert-butanol or isobutylene under reaction
  • alkylating or “alkylation,” or “alkylation reaction” is the introduction of an alkyl radical into an organic compound.
  • An "organic compound” is a chemical compound that contains a carbon atom.
  • reaction conditions are temperature, pressure, reactant concentrations, solvent concentrations, reactant mixing/addition parameters, and/or other conditions within a reaction vessel that promote reaction between the reagents and formation of the resultant product.
  • alkylation occurs with the addition of an inorganic acid (such as sulfuric acid) to a mixture of the 3-methylcatechol and the tert- butanol in heptane.
  • the process includes the preparation of the 3-methylcatechol.
  • the process includes oxidizing 2-hydroxy-3-methylbenzaldehyde under reaction conditions and forming the 3-methylcatechol (Rx 2).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide, which is added to the 2-hydroxy-3-methylaldehyde in an aqueous basic solution.
  • the process includes the preparation of the 2-hydroxy-3- methylbenzaldehyde (Rx 3).
  • the process includes formylating o-cresol with paraformaldehyde under reaction conditions, and forming 2-hydroxy-3-methylbenzaldehyde.
  • the 2- hydroxy-3- methylbenzaldehyde is subsequently oxidized to form the 3-methylcatechol.
  • the formylation reaction may occur by formylating the o-cresol with paraformaldehyde, magnesium chloride (MgCl 2 ) and triethylamine (Et 3 N) in refluxing tetrahydrofuran (THF).
  • the reaction yields ortho-formylation of the o-cresol.
  • Another suitable formylation reaction is the Reimer-Tiemann reaction (i. e. , ortho-formylation of the o-cresol in chloroform/sodium hydroxide).
  • 3-methylcatechol is prepared directly from o-cresol.
  • the process includes oxidizing, under reaction conditions, o-cresol, and forming the 3- methylcatechol (Rx 4).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide.
  • the process further includes alkylating the 3-methylcathecol and forming the BMC as disclosed above.
  • reaction 4 A nonlimiting representation of reaction 4 is provided in pathway (III) below.
  • another process for producing BMC includes oxidizing 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde, under reaction conditions, and forming 5-tert-butyl-3-methylcatechol (Rx 5).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide.
  • the process includes synthesis of the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde.
  • the process includes formylating, under reaction conditions, 4-tert- butyl-2-methylphenol with paraformaldehyde and forming the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde (Rx 6).
  • Formylation may occur by way of any suitable formylation reaction as disclosed herein.
  • the process includes the synthesis of the 4-tert-butyl-2- methylphenol.
  • the process includes alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol to form 4-tert-butyl-2-methylphenol (Rx 7). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein.
  • the compound, o-cresol surprisingly has been found as an advantageous starting material for the production of BMC.
  • the compound o-cresol is inexpensive and provides a methyl group directly adjacent to an
  • the -OH group of o-cresol is a strong para-director for an electrophilic substitution reaction, enabling ready alkylation of o-cresol to 4-tert-butyl-2- methylphenol.
  • the 4-tert-butyl-2-methylphenol is subsequently formylated, under reaction conditions, to form the 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde.
  • the present disclosure provides another process for producing BMC.
  • a process is provided and includes oxidizing, under reaction conditions, 4-tert- butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 8). Oxidation may occur by way of addition of a peroxide to the 4-tert-butyl-2-methylcresol in a basic aqueous solution.
  • the process includes synthesis of the 4-tert-butyl-2- methylphenol.
  • the process includes alkylating, under reaction conditions, o-cresol with tert- butanol or isobutylene, and forming the 4-tert-butyl-2-methylphenol (Rx 9). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein.
  • the 4-tert-butyl-2- methylcresol is subsequently oxidized to form the BMC.
  • a process includes hydrolyzing, under reaction conditions, 2- halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 10).
  • hydrolyzing or “hydrolysis,” or “hydrolysis reaction” is a chemical reaction whereby water splits into H+ and OH- ions and the OH- ion replaces a functional group.
  • halo is a halogen atom — F, Cl, Br, I. In an embodiment, the halogen atom is bromine yielding 2-bromo-4-tert-butyl-6-methylphenol.
  • the halogen atom is chlorine yielding 2-chloro-4-tert-butyl-6-methylphenol.
  • the hydrolysis reaction is catalyzed by a base and/or a salt, such as such as copper (II) sulfate.
  • the process includes the synthesis of the 2-halo-4-tert-butyl-6- methylphenol.
  • the process includes halogenating, under reaction conditions, 4-tert-butyl-2- methylphenol, and forming the 2-halo-4-tert-butyl-6-methylphenol (Rx 11).
  • the term "halogenating,” or “halogenation,” or “halogenation reaction,” is the introduction of a halogen radical into an organic compound.
  • Halogenation occurs by reacting the 4-tert-butyl- 2-methylphenol with a halogenating agent, such as a brominating agent or a chlorinating agent.
  • a halogenating agent such as a brominating agent or a chlorinating agent.
  • suitable halogenating agents include N-bromosuccinamine (NBS), a brominating agent, and/or N-chlorosuccinamine (NCS), a chlorinating agent.
  • Halogenation may also occur by reacting the 4-tert-butyl-2-methylphenol with elemental halogen.
  • the term "X 2 " in pathway (VI) below denotes the reaction with elemental halogen.
  • the elemental halogen and may be Cl 2 or Br 2 .
  • the process includes synthesis of the 4-tert-butyl-2- methylphenol.
  • the 4-tert-butyl-2-methylphenol is formed by alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol as disclosed above (Rx 12).
  • the 4-tert-butyl-2-methylphenol is formed by alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol as disclosed above (Rx 12).
  • WHD/6867784 1 butyl-2-methylphenol is subsequently halogenated to form the 2-halo-4-tert-butyl-6- methylphenol.
  • a process includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3-aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol (Rx 13).
  • the term "hydrogenolyzing,” or “hydrogenolysis,” or “hydrogenolysis reaction” is a chemical reaction whereby a carbon-carbon or carbon-heteroatom single bond is cleaved by hydrogen.
  • suitable hydrogenolyzing agents include catalytic hydrogenolyzing agents (such as palladium catalysts) and borohydrides, such as sodium cyano-borohydride.
  • the process includes the synthesis of the 5-tert-butyl-3- aminomethylcateghol.
  • the process includes an aminoalkylating, under reaction conditions, 4-tert-butylcatechol, and forming the 5-tert-butyl-3-aminomethylcatechol (Rx 14).
  • the 5-tert- butyl-3-aminomethylcatechol is subsequently hydrogenolyzed to form the 5-tert-butyl-3- methylcatechol.
  • Aminoalkylation occurs by way of the Mannich reaction.
  • the "Mannich reaction” is an organic reaction which aminoalkylates an acidic proton located next to a carbonyl functional group with formaldehyde and ammonia or any primary or secondary amine.
  • a process for producing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate includes reacting BMC, under reaction conditions, with a member selected from an aromatic carboxylic acid and/or an aromatic carboxylic acid derivative, and subsequently forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
  • BMC is prepared by any of the synthesis pathways as previously disclosed herein.
  • an "aromatic carboxylic acid” is a compound containing at least one benzene ring with at least one carboxyl group directly bonded to the benzene ring. It is understood that the aromatic carboxylic acid may be a monocyclic structure or a polycyclic structure. The aromatic carboxylic acid may be a mono- or a poly-carboxylic acid. Nonlimiting examples of suitable aromatic carboxylic acids include benzoic acid, 1- naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and phenanthrene-3 -carboxylic acid.
  • a “derivative of an aromatic carboxylic acid” or “an aromatic carboxylic acid derivative,” as used herein, is an aromatic acyl halide, an aromatic anhydride, an aromatic carboxylate salt, or any combination thereof. It is understood that the derivative of the
  • aromatic carboxylic acid may be a monocyclic structure or a poly cyclic structure.
  • suitable aromatic acyl halides include halides of any of the aromatic carboxylic acids disclosed above (i.e., an acyl halide of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2- carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid).
  • aromatic acyl halides include benzoyl chloride, benzoyl fluoride, benzoyl bromide, and benzoyl iodide, naphthoyl chloride, naphthoyl fluoride, naphthoyl bromide, naphthoyl iodide, and any combination of the foregoing aromatic acyl halides.
  • Nonlimiting examples of suitable aromatic anhydrides include anhydride of the aromatic carboxylic acids disclosed above, (i.e., an anhydride of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 - carboxylic acid).
  • suitable aromatic anhydrides include benzoic anhydride and any combination of the foregoing aromatic anhydrides.
  • Nonlimiting examples of suitable aromatic carboxylate salts include potassium, sodium, or lithium salt of the aromatic carboxylic acids disclosed above (i.e., salts of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H- phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid).
  • suitable aromatic carboxylate salts include potassium benzoate, sodium benzoate, lithium benzoate, potassium 2-naphthoate, sodium 2-naphthoate, and any combination of the foregoing aromatic carboxylate salts.
  • the aromatic carboxylic acid, or derivative thereof may be substituted.
  • substituted aromatic carboxylic acid or derivative thereof is an aromatic carboxylic acid, or derivative thereof, whereby at least one of the benzene-ring substituents (other than the carboxyl group) is a substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof.
  • substituted aromatic carboxylic acid or derivative thereof includes substituted aromatic
  • WHD/6867784.1 carboxylic acid, substituted aromatic acyl halide, substituted aromatic anhydride, and/or substituted aromatic carboxylate salt.
  • hydrocarbyl and “hydrocarbon” refer to substituents containing only hydrogen and carbon atoms, including branched or unbranched, saturated or unsaturated, cyclic, polycyclic, fused, or acyclic species, and combinations thereof.
  • hydrocarbyl groups include alkyl-, cycloalkyl-, alkenyl-, alkadienyl-, cycloalkenyl-, cycloalkadienyl-, aryl-, aralkyl, alkylaryl, and alkynyl- groups.
  • substituted hydrocarbyl and “substituted hydrocarbon” refer to a hydrocarbyl group that is substituted with one or more nonhydrocarbyl substituent groups.
  • a nonlimiting example of a nonhydrocarbyl substituent group is a heteroatom.
  • a heteroatom refers to an atom other than carbon or hydrogen.
  • the heteroatom can be a non-carbon atom from Groups IV, V, VI, and VII of the Periodic Table.
  • Nonlimiting examples of heteroatoms include: halogens (F, Cl, Br, I), N, O, P, B, S, and Si.
  • a substituted hydrocarbyl group also includes a halohydrocarbyl group and/or a silicon-containing hydrocarbyl group.
  • halohydrocarbyl group refers to a hydrocarbyl group that is substituted with one or more halogen atoms.
  • sicon-containing hydrocarbyl group is a hydrocarbyl group that is substituted with one or more silicon atoms. The silicon atom(s) may or may not be in the carbon chain.
  • BMPD is formed by reacting BMC, under reaction conditions, with an aromatic carboxylic acid derivative, benzoyl chloride.
  • the process includes reacting BMC with benzoyl chloride in the presence of a base under reaction conditions, and forming BMPD (Rx 15).
  • base include pyridine, triethylamine, trimethylamine, and/or molecular sieves.
  • a nonlimiting representation of reaction 15 is provided in pathway (VIII) below.
  • BMPD 5 -tert-buty 1-3 -methyl- 1 ,2-phenylene dibenzoate
  • the reaction includes adding benzoyl chloride to a mixture of BMC, pyridine, and dichloromethane. Pyridine absorbs HCl, a by-product of the reaction.
  • the process includes forming the BMPD by adding the benzoyl chloride to a reaction mixture composed of the BMC, acetonitrile and triethylamine. Triethylamine absorbs HCl, a by-product of the reaction.
  • acetonitrile and triethylamine advantageously provides an environmentally safe, and low health risk (nontoxic) process for BMPD production, and large-scale (i.e., greater than 10 g, or greater than 1 kg) production of BMPD in particular.
  • the process includes adding water to the reaction mixture (containing BMPD, acetonitrile triethylamine, benzoyl chloride, and BMC); and precipitating the BMPD.
  • the solvent, acetonitrile is soluble in water. Bounded by no particular theory, addition of the water quenches the reaction and changes the solubility of the solvent to precipitate the BMPD from solution (the "BMPD-precipitate").
  • Provision of the acetonitrile solvent system advantageously provides a simple, cost-effective and effective procedure for BMPD production, suitable for commercial or industrial scale.
  • Figure 1 shows a nonlimiting flowchart for BMPD production.
  • the process includes purifying the BMPD, and forming a BMPD composition comprising greater than 98 wt %, or greater than 99 wt % BMPD.
  • WHD/6867784.1 purification of the BMPD includes performing one or more procedures on the BMPD- precipitate: recrystallization, extraction, concentration, washing, distillation, and any combination of the foregoing.
  • the purification includes dissolving the BMPD-precipitate in a non-aqueous solvent (such as ethyl a cetate), and extracting with water.
  • a non-aqueous solvent such as ethyl a cetate
  • water extraction removes ionic impurities and/or ionic byproducts from the non-aqueous phase thereby purifying the BMPD.
  • the non-aqueous phase is dried (over MgSO 4 ) and concentrated by way of roto-evaporation (the "concentrate") in conjunction with a hydrocarbon wash (heptane) to remove organic by-products/impurities. Recrystallization yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt %, BMPD.
  • the purification includes distilling the concentrate in conjunction with a hydrocarbon wash (heptane). Filtration and drying yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt % BMPD.
  • Figure 2 shows a nonlimiting flowchart for the purification of the BMPD-precipitate.
  • the BMPD is advantageously applied as an internal electron donor in procatalyst/catalyst compositions for the production of olefm-based polymers (propylene- based polymers in particular) as disclosed in U.S. provisional application no. 61/141,902 filed on December 31, 2008 and U.S. provisional application no. 61/141,959 filed on December 31, 2008, the entire content of each application incorporated by reference herein.
  • DEFINITIONS DEFINITIONS
  • compositions claimed herein through use of the term “comprising” may include any additional additive, adjuvant, or compound whether polymeric or otherwise, unless stated to the contrary.
  • any numerical range recited herein includes all values from the lower value to the upper value, in increments of one unit, provided that there is a separation of at least 2 units between any lower value and any higher value.
  • amount of a component, or a value of a compositional or a physical property such as, for example, amount of a blend component, softening temperature, melt index, etc.
  • amount of a blend component, softening temperature, melt index, etc. is between 1 and 100
  • all individual values, such as, 1, 2, 3, etc., and all subranges, such as, 1 to 20, 55 to 70, 197 to 100, etc., are expressly enumerated in this specification.
  • any numerical range recited herein includes any value or subrange within the stated range. Numerical ranges have been recited, as discussed herein, reference melt index, melt flow rate, and other properties.
  • blend or "polymer blend,” as used herein, is a blend of two or more polymers. Such a blend may or may not be miscible (not phase separated at molecular level). Such a blend may or may not be phase separated. Such a blend may or may not contain one or more domain configurations, as determined from transmission electron spectroscopy, light scattering, x-ray scattering, and other methods known in the art.
  • composition includes a mixture of materials which comprise the composition, as well as reaction products and decomposition products formed from the materials of the composition.
  • polymer is a macromolecular compound prepared by polymerizing monomers of the same or different type.
  • Polymer includes homopolymers, copolymers, terpolymers, interpolymers, and so on.
  • interpolymer means a polymer prepared by the polymerization of at least two types of monomers or comonomers.
  • copolymers which usually refers to polymers prepared from two different types of monomers or comonomers
  • terpolymers which usually refers to polymers prepared from three different types of monomers or comonomers
  • tetrapolymers which usually refers to polymers prepared from four different types of monomers or comonomers
  • olefin-based polymer is a polymer containing, in polymerized form, a majority weight percent of an olefin, for example ethylene or propylene, based on the total weight of the polymer.
  • olefin-based polymers include ethylene-based polymers and propylene-based polymers.
  • propylene-based polymer refers to a polymer that comprises a majority weight percent polymerized propylene monomer (based on the total amount of polymerizable monomers), and optionally may comprise at least one polymerized comonomer.
  • alkyl refers to a branched or unbranched, saturated or unsaturated acyclic hydrocarbon radical.
  • suitable alkyl radicals include, for example, methyl, ethyl, n-propyl, i-propyl, 2-propenyl (or allyl), vinyl, n-butyl, t- butyl, i-butyl (or 2-methylpropyl), etc.
  • the alkyls have 1 and 20 carbon atoms.
  • substituted alkyl refers to an alkyl as just described in which one or more hydrogen atom bound to any carbon of the alkyl is replaced by another group such as a halogen, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, halogen, haloalkyl, hydroxy, amino, phosphido, alkoxy, amino, thio, nitro, and combinations thereof.
  • Suitable substituted alkyls include, for example, benzyl, trifluoromethyl and the like.
  • aryl refers to an aromatic substituent which may be a single aromatic ring or multiple aromatic rings which are fused together, linked covalently,
  • WHD/6867784 1 or linked to a common group such as a methylene or ethylene moiety.
  • the aromatic ring(s) may include phenyl, naphthyl, anthracenyl, and biphenyl, among others.
  • the aryls have 1 and 20 carbon atoms.
  • substituted phenylene aromatic diester includes substituted 1,2- phenylene aromatic diester, substituted 1,3 -phenylene aromatic diester, and substituted 1,4-phenylene aromatic diester.
  • the substituted phenylene diester is a 1,2- phenylene aromatic diester with the structure (A) below:
  • R 1 -R 14 are the same or different.
  • Each of Ri-R 14 is selected from a hydrogen, substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof.
  • At least one of Ri-Ri 4 is not hydrogen
  • Example 1 Conversion of 3-methylcatechol to S-tert-butyl-S-methylcatechol
  • a 100-mL 3 -neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, dropping funnel is charged with 6.8 g of 2-hydroxy-3-methylaldehyde and 25 mL of 2N NaOH aqueous solution.
  • a diluted H 2 O 2 is added in portion of 10 mL to maintain internal temperature between 40 0 C to 50 0 C.
  • the temperature rises to 45 0 C and a dark solution results.
  • the temperature is allowed to fall to 4O 0 C before a second portion of hydrogen peroxide is added.
  • a 1-L 4-neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, nitrogen inlet and bubbler is charged with 20.64 mL of o-cresol and 14.0 g of paraformaldehyde.
  • THF is charged via syringe followed by addition of triethylamine via dropping funnel.
  • o-cresol is added slowly via syringe, resulting in an opaque, light pink mixture that is refluxed for 4 hours.
  • the reaction is cooled and diluted with 200 mL of ether, washed with 1 N HCl, water, and dried over Na 2 SO 4 .
  • a 500 mL three-neck round bottom flask with thermowell is fitted with an addition funnel/N 2 inlet, mechanical stirrer and a stopper. After the system is purged with N 2 the vessel is loaded with the 5-tert-butyl-3-methylcatechol (20.0 g, 0.11 mol) and CH 3 CN (100 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the vessel is added triethylamine (26.8 g, 0.27 mol) and the internal temperature of the reaction is taken to 1O 0 C using a dry ice/water bath. Benzoyl chloride (34.4 g, 0.24 mol) is added dropwise keeping the temperature at 10-20 0 C. The addition takes about 30 minutes. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature for 1 hour.
  • a 1 -liter three neck round bottom flask with thermowell is fitted with a N 2 inlet, mechanical stirrer and a stopper.
  • water 400 mL
  • the slurry from above is added in eight portions over about 20 min.
  • the resulting slurry is stirred at ambient temperature for 30 minutes and then the solid is collected via filtration.
  • the crude solid is dissolved in EtOAc (150 mL) and extracted with water (75 mL).
  • the aqueous phase is discarded and the EtOAc phase is dried over MgSO 4 .
  • the MgSO 4 is removed by filtration providing 175 g of light brown solution.
  • the solution is concentrated on a rotary evaporator (45-5O 0 C bath @ 150-200 mmHg) taking 96 g of solvent
  • a 5L three-neck round bottom flask with thermowell is fitted with an addition funnel/N 2 inlet, mechanical stirrer and a stopper. After the system is purged with N 2 the pot is loaded with the starting 5-tert-butyl-3-methylcatechol (314.3 g, 1.75 mol) and CH 3 CN (1570 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the pot is added triethylamine (423 g, 4.17 mol) and the internal temperature of the reaction is taken to 1O 0 C using a dry ice/water bath. Benzoyl chloride (543 g, 3.84 mol) is added dropwise keeping the temperature at 10-20 0 C. Initially only half of the benzoyl chloride is added into the additional funnel to prevent all of the material from being added at once. The entire addition takes about 2 hours. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature overnight.
  • a total of 1243.4 g is produced at 92% yield with a melting point 110-112 0 C.
  • the material has a purity greater than 99 wt %.

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BRPI0918707A BRPI0918707A2 (pt) 2008-12-31 2009-12-31 processo para produção de diésteres aromáticos de fenileno substituídos
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JP2011544626A JP5461583B2 (ja) 2008-12-31 2009-12-31 置換フェニレン芳香族ジエステルの製造
RU2011132141/04A RU2553475C2 (ru) 2008-12-31 2009-12-31 Получение замещенных фенилен ароматических сложных диэфиров
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US10358505B2 (en) 2010-12-21 2019-07-23 W. R. Grace & Co.-Conn. Process for production of high melt flow propylene-based polymer and product from same
US11254756B2 (en) 2010-12-21 2022-02-22 W.R. Grace & Co.-Conn. Process for production of high melt flow propylene-based polymer and product from same
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US20140012035A1 (en) * 2011-03-29 2014-01-09 Linfeng Chen Production of Substituted Phenylene Aromatic Diesters
CN103562172A (zh) * 2011-03-29 2014-02-05 陶氏环球技术有限责任公司 取代的亚苯基芳族二酯的制备
JP2014519477A (ja) * 2011-03-29 2014-08-14 ダウ グローバル テクノロジーズ エルエルシー 置換フェニレン芳香族ジエステルの製造
JP2014529624A (ja) * 2011-08-30 2014-11-13 ダウ グローバル テクノロジーズ エルエルシー 内部電子供与体として使用するための置換フェニレンジベンゾエートの生成およびポリマー調製のためのプロ触媒
US9133286B2 (en) 2011-08-30 2015-09-15 W. R. Grace & Co.-Conn Production of substituted phenylene dibenzoate internal electron donor and procatalyst with same
CN120483875A (zh) * 2025-07-10 2025-08-15 营口市向阳催化剂有限责任公司 取代亚苯基芳族二酯的制备方法及其在催化剂制备中的应用
CN120483875B (zh) * 2025-07-10 2025-10-21 营口市向阳催化剂有限责任公司 取代亚苯基芳族二酯的制备方法及其在催化剂制备中的应用

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