US20060193914A1 - Crush resistant delayed-release dosage forms - Google Patents

Crush resistant delayed-release dosage forms Download PDF

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Publication number
US20060193914A1
US20060193914A1 US11/348,295 US34829506A US2006193914A1 US 20060193914 A1 US20060193914 A1 US 20060193914A1 US 34829506 A US34829506 A US 34829506A US 2006193914 A1 US2006193914 A1 US 2006193914A1
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US
United States
Prior art keywords
dosage form
optionally
form according
active substance
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/348,295
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English (en)
Inventor
Judy Ashworth
Elisabeth Arkenau Maric
Johannes Bartholomaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36384542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20060193914(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Assigned to GRUNENTHAL GMBH reassignment GRUNENTHAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ASHWORTH, JUDY DR., ARKENAU-MARIC, ELISABETH DR., BARTHOLOMAUS, JOHANNES DR.
Priority to US11/462,216 priority Critical patent/US20070048228A1/en
Publication of US20060193914A1 publication Critical patent/US20060193914A1/en
Priority to US12/140,665 priority patent/US8192722B2/en
Priority to US12/140,568 priority patent/US20080311187A1/en
Assigned to GRUENENTHAL GMBH reassignment GRUENENTHAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARKENAU-MARIC, ELISABETH, DR., BARTHOLOMAEUS, JOHANNES, DR., ASHWORTH, JUDY, DR., KUGELMANN, HEINRICH
Priority to US12/640,915 priority patent/US20100151028A1/en
Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS (EXCLUSIVELY LICENSED PATENTS) Assignors: ENDO PHARMACEUTICALS INC.
Assigned to MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT reassignment MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS Assignors: ENDO PHARMACEUTICALS INC.
Assigned to ENDO PHARMACEUTICALS INC. reassignment ENDO PHARMACEUTICALS INC. RELEASE OF SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS RECORDED AT REEL/FRAME 25456/172 Assignors: JPMORGAN CHASE BANK N.A., AS ADMINISTRATIVE AGENT
Priority to US13/723,273 priority patent/US20130171075A1/en
Priority to US14/084,162 priority patent/US20140079780A1/en
Priority to US14/138,372 priority patent/US20140170079A1/en
Priority to US14/141,793 priority patent/US20140112984A1/en
Assigned to ENDO PHARMACEUTICALS SOLUTIONS INC. reassignment ENDO PHARMACEUTICALS SOLUTIONS INC. RELEASE OF PATENT SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS Assignors: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
Assigned to DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT reassignment DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT GRANT OF SECURITY INTEREST IN LICENSED PATENTS Assignors: ENDO PHARMACEUTICALS, INC.
Assigned to ENDO PHARMACEUTICALS INC. reassignment ENDO PHARMACEUTICALS INC. CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF RECEIVING PARTY IN RELEASE OF PATENT SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS PREVIOUSLY RECORDED ON REEL 032380 FRAME 0157. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS.. Assignors: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
Priority to US14/324,366 priority patent/US20140322311A1/en
Priority to US14/749,939 priority patent/US20150290138A1/en
Priority to US14/848,457 priority patent/US20150374630A1/en
Priority to US14/875,007 priority patent/US20160022587A1/en
Priority to US14/994,691 priority patent/US20160120810A1/en
Priority to US15/061,252 priority patent/US10675278B2/en
Priority to US15/132,325 priority patent/US9629807B2/en
Priority to US15/459,180 priority patent/US10058548B2/en
Assigned to ENDO PHARMACEUTICALS, INC., ENDO PHARMACEUTICALS SOLUTIONS, INC., ASTORA WOMEN'S HEALTH HOLDINGS, LLC reassignment ENDO PHARMACEUTICALS, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: DEUTSCHE BANK AG NEW YORK BRANCH
Priority to US15/649,880 priority patent/US20170312271A1/en
Priority to US16/016,924 priority patent/US20180369235A1/en
Priority to US16/032,467 priority patent/US20190008849A1/en
Priority to US16/455,813 priority patent/US20190321358A1/en
Priority to US16/797,055 priority patent/US20200215053A1/en
Abandoned legal-status Critical Current

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    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/14—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
    • B29C48/146—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration in the die
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/16—Articles comprising two or more components, e.g. co-extruded layers
    • B29C48/18—Articles comprising two or more components, e.g. co-extruded layers the components being layers
    • B29C48/21—Articles comprising two or more components, e.g. co-extruded layers the components being layers the layers being joined at their surfaces
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/435—Sub-screws
    • B29C48/44—Planetary screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2793/00—Shaping techniques involving a cutting or machining operation
    • B29C2793/009—Shaping techniques involving a cutting or machining operation after shaping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/0261—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using ultrasonic or sonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/22—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length
    • B29C43/24—Calendering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0001—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0044—Stabilisers, e.g. against oxydation, light or heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/25—Solid
    • B29K2105/251—Particles, powder or granules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/772—Articles characterised by their shape and not otherwise provided for

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US11/348,295 2003-08-06 2006-02-06 Crush resistant delayed-release dosage forms Abandoned US20060193914A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
US11/462,216 US20070048228A1 (en) 2003-08-06 2006-08-03 Abuse-proofed dosage form
US12/140,665 US8192722B2 (en) 2003-08-06 2008-06-17 Abuse-proof dosage form
US12/140,568 US20080311187A1 (en) 2005-02-04 2008-06-17 Crush resistan delayed-release dosage form
US12/640,915 US20100151028A1 (en) 2005-02-04 2009-12-17 Crush resistant delayed-release dosage forms
US13/723,273 US20130171075A1 (en) 2003-08-06 2012-12-21 Abuse-proofed dosage form
US14/084,162 US20140079780A1 (en) 2005-02-04 2013-11-19 Crush resistant delayed-release dosage forms
US14/138,372 US20140170079A1 (en) 2003-08-06 2013-12-23 Abuse-proofed dosage form
US14/141,793 US20140112984A1 (en) 2005-02-04 2013-12-27 Crush resistant delayed-release dosage forms
US14/324,366 US20140322311A1 (en) 2005-02-04 2014-07-07 Crush resistan delayed-release dosage form
US14/749,939 US20150290138A1 (en) 2005-02-04 2015-06-25 Crush resistant delayed-release dosage forms
US14/848,457 US20150374630A1 (en) 2005-02-04 2015-09-09 Crush resistant delayed-release dosage forms
US14/875,007 US20160022587A1 (en) 2003-08-06 2015-10-05 Abuse-proofed dosage form
US14/994,691 US20160120810A1 (en) 2005-02-04 2016-01-13 Crush resistant delayed-release dosage forms
US15/061,252 US10675278B2 (en) 2005-02-04 2016-03-04 Crush resistant delayed-release dosage forms
US15/132,325 US9629807B2 (en) 2003-08-06 2016-04-19 Abuse-proofed dosage form
US15/459,180 US10058548B2 (en) 2003-08-06 2017-03-15 Abuse-proofed dosage form
US15/649,880 US20170312271A1 (en) 2005-02-04 2017-07-14 Crush resistant delayed-release dosage forms
US16/016,924 US20180369235A1 (en) 2005-02-04 2018-06-25 Crush resistant delayed-release dosage forms
US16/032,467 US20190008849A1 (en) 2003-08-06 2018-07-11 Abuse-proofed dosage form
US16/455,813 US20190321358A1 (en) 2003-08-06 2019-06-28 Abuse-proofed dosage form
US16/797,055 US20200215053A1 (en) 2003-08-06 2020-02-21 Abuse-proofed dosage form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005005446A DE102005005446A1 (de) 2005-02-04 2005-02-04 Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102005005446.3 2005-02-04

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US10/718,112 Continuation-In-Part US8114383B2 (en) 2003-08-06 2003-11-20 Abuse-proofed dosage form
US10/718,112 Continuation US8114383B2 (en) 2003-08-06 2003-11-20 Abuse-proofed dosage form

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US11/349,544 Continuation-In-Part US8075872B2 (en) 2003-08-06 2006-02-06 Abuse-proofed dosage form
US11/349,544 Continuation US8075872B2 (en) 2003-08-06 2006-02-06 Abuse-proofed dosage form
US11/462,216 Continuation-In-Part US20070048228A1 (en) 2003-08-06 2006-08-03 Abuse-proofed dosage form
US12/140,568 Division US20080311187A1 (en) 2005-02-04 2008-06-17 Crush resistan delayed-release dosage form
US12/640,915 Division US20100151028A1 (en) 2005-02-04 2009-12-17 Crush resistant delayed-release dosage forms

Publications (1)

Publication Number Publication Date
US20060193914A1 true US20060193914A1 (en) 2006-08-31

Family

ID=36384542

Family Applications (16)

Application Number Title Priority Date Filing Date
US11/348,295 Abandoned US20060193914A1 (en) 2003-08-06 2006-02-06 Crush resistant delayed-release dosage forms
US12/140,568 Abandoned US20080311187A1 (en) 2005-02-04 2008-06-17 Crush resistan delayed-release dosage form
US12/640,915 Abandoned US20100151028A1 (en) 2005-02-04 2009-12-17 Crush resistant delayed-release dosage forms
US14/084,162 Abandoned US20140079780A1 (en) 2005-02-04 2013-11-19 Crush resistant delayed-release dosage forms
US14/141,793 Abandoned US20140112984A1 (en) 2005-02-04 2013-12-27 Crush resistant delayed-release dosage forms
US14/324,366 Abandoned US20140322311A1 (en) 2005-02-04 2014-07-07 Crush resistan delayed-release dosage form
US14/749,939 Abandoned US20150290138A1 (en) 2005-02-04 2015-06-25 Crush resistant delayed-release dosage forms
US14/848,457 Abandoned US20150374630A1 (en) 2005-02-04 2015-09-09 Crush resistant delayed-release dosage forms
US14/994,691 Abandoned US20160120810A1 (en) 2005-02-04 2016-01-13 Crush resistant delayed-release dosage forms
US15/061,252 Active US10675278B2 (en) 2005-02-04 2016-03-04 Crush resistant delayed-release dosage forms
US15/459,180 Expired - Lifetime US10058548B2 (en) 2003-08-06 2017-03-15 Abuse-proofed dosage form
US15/649,880 Abandoned US20170312271A1 (en) 2005-02-04 2017-07-14 Crush resistant delayed-release dosage forms
US16/016,924 Abandoned US20180369235A1 (en) 2005-02-04 2018-06-25 Crush resistant delayed-release dosage forms
US16/032,467 Abandoned US20190008849A1 (en) 2003-08-06 2018-07-11 Abuse-proofed dosage form
US16/455,813 Abandoned US20190321358A1 (en) 2003-08-06 2019-06-28 Abuse-proofed dosage form
US16/797,055 Abandoned US20200215053A1 (en) 2003-08-06 2020-02-21 Abuse-proofed dosage form

Family Applications After (15)

Application Number Title Priority Date Filing Date
US12/140,568 Abandoned US20080311187A1 (en) 2005-02-04 2008-06-17 Crush resistan delayed-release dosage form
US12/640,915 Abandoned US20100151028A1 (en) 2005-02-04 2009-12-17 Crush resistant delayed-release dosage forms
US14/084,162 Abandoned US20140079780A1 (en) 2005-02-04 2013-11-19 Crush resistant delayed-release dosage forms
US14/141,793 Abandoned US20140112984A1 (en) 2005-02-04 2013-12-27 Crush resistant delayed-release dosage forms
US14/324,366 Abandoned US20140322311A1 (en) 2005-02-04 2014-07-07 Crush resistan delayed-release dosage form
US14/749,939 Abandoned US20150290138A1 (en) 2005-02-04 2015-06-25 Crush resistant delayed-release dosage forms
US14/848,457 Abandoned US20150374630A1 (en) 2005-02-04 2015-09-09 Crush resistant delayed-release dosage forms
US14/994,691 Abandoned US20160120810A1 (en) 2005-02-04 2016-01-13 Crush resistant delayed-release dosage forms
US15/061,252 Active US10675278B2 (en) 2005-02-04 2016-03-04 Crush resistant delayed-release dosage forms
US15/459,180 Expired - Lifetime US10058548B2 (en) 2003-08-06 2017-03-15 Abuse-proofed dosage form
US15/649,880 Abandoned US20170312271A1 (en) 2005-02-04 2017-07-14 Crush resistant delayed-release dosage forms
US16/016,924 Abandoned US20180369235A1 (en) 2005-02-04 2018-06-25 Crush resistant delayed-release dosage forms
US16/032,467 Abandoned US20190008849A1 (en) 2003-08-06 2018-07-11 Abuse-proofed dosage form
US16/455,813 Abandoned US20190321358A1 (en) 2003-08-06 2019-06-28 Abuse-proofed dosage form
US16/797,055 Abandoned US20200215053A1 (en) 2003-08-06 2020-02-21 Abuse-proofed dosage form

Country Status (28)

Country Link
US (16) US20060193914A1 (ru)
EP (2) EP1845956B1 (ru)
JP (1) JP5202963B2 (ru)
KR (1) KR101299928B1 (ru)
CN (1) CN101175482B (ru)
AR (2) AR054328A1 (ru)
AU (1) AU2006210145B9 (ru)
BR (1) BRPI0606145C1 (ru)
CA (1) CA2595954C (ru)
CY (2) CY1118914T1 (ru)
DE (1) DE102005005446A1 (ru)
DK (2) DK2478896T3 (ru)
ES (2) ES2629303T3 (ru)
HR (2) HRP20170746T1 (ru)
HU (2) HUE035492T2 (ru)
IL (1) IL185018A (ru)
LT (2) LT1845956T (ru)
MX (1) MX2007009393A (ru)
NO (1) NO342922B1 (ru)
NZ (1) NZ560203A (ru)
PE (1) PE20061087A1 (ru)
PL (2) PL2478896T3 (ru)
PT (2) PT1845956T (ru)
RU (2) RU2399371C2 (ru)
SI (2) SI2478896T1 (ru)
TW (1) TWI381860B (ru)
WO (1) WO2006082099A1 (ru)
ZA (1) ZA200705836B (ru)

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US20080020032A1 (en) * 2006-07-21 2008-01-24 Michael Crowley Hydrophobic abuse deterrent delivery system for hydromorphone
WO2008033523A1 (en) 2006-09-15 2008-03-20 Cima Labs Inc. Abuse resistant drug formulation
US20080220079A1 (en) * 2007-03-02 2008-09-11 Farnam Companies, Inc. Sustained release compositions using wax-like materials
US20080280981A1 (en) * 2004-03-04 2008-11-13 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20090005408A1 (en) * 2003-12-24 2009-01-01 Grunenthal Gmbh Process for the production of an abuse-proofed dosage form
US20090017114A1 (en) * 2003-07-31 2009-01-15 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20090052818A1 (en) * 2007-07-10 2009-02-26 Jason Matthew Mitmesser Hybrid bearing
US20090081290A1 (en) * 2006-08-25 2009-03-26 Purdue Pharma L.P. Tamper resistant dosage forms
US20090209646A1 (en) * 2004-03-04 2009-08-20 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20100015223A1 (en) * 2006-03-01 2010-01-21 Ethypharm Sa Crush-Resistant Tablets Intended to Prevent Accidental Misuse and Unlawful Diversion
WO2010044842A1 (en) * 2008-10-16 2010-04-22 University Of Tennessee Research Foundation Tamper resistant oral dosage forms containing an embolizing agent
US20100209498A1 (en) * 2007-04-20 2010-08-19 Girish Kumar Jain Pharmaceutical compositions of duloxetine
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
US20110038930A1 (en) * 2009-07-22 2011-02-17 Grunenthal Gmbh Hot-melt extruded pharmaceutical dosage form
US20110099815A1 (en) * 2009-10-21 2011-05-05 Eveready Battery Company, Inc. Lubrication Box For A Wet Shaving Implement
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
US20110165248A1 (en) * 2008-09-18 2011-07-07 Meridith Lee Machonis Pharmaceutical dosage forms comprising poly(e-caprolactone)
US20110230559A1 (en) * 2004-03-04 2011-09-22 Ferring B.V. Tranexamic Acid Formulations
US20110237615A1 (en) * 2008-12-12 2011-09-29 Paladin Labs Inc. Narcotic Drug Formulations with Decreased Abuse Potential
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US8114384B2 (en) 2004-07-01 2012-02-14 Gruenenthal Gmbh Process for the production of an abuse-proofed solid dosage form
US8192722B2 (en) 2003-08-06 2012-06-05 Grunenthal Gmbh Abuse-proof dosage form
WO2012085657A2 (en) 2010-12-23 2012-06-28 Purdue Pharma L.P. Tamper resistant solid oral dosage forms
US20120202838A1 (en) * 2010-11-04 2012-08-09 Abbott Laboratories Drug formulations
US8273795B2 (en) 2004-03-04 2012-09-25 Ferring B.V. Tranexamic acid formulations
US8383152B2 (en) * 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
US8722086B2 (en) 2007-03-07 2014-05-13 Gruenenthal Gmbh Dosage form with impeded abuse
US8808745B2 (en) 2001-09-21 2014-08-19 Egalet Ltd. Morphine polymer release system
US8877241B2 (en) 2003-03-26 2014-11-04 Egalet Ltd. Morphine controlled release system
US20140356428A1 (en) * 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
US9005660B2 (en) 2009-02-06 2015-04-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
US9023394B2 (en) 2009-06-24 2015-05-05 Egalet Ltd. Formulations and methods for the controlled release of active drug substances
US9044402B2 (en) 2012-07-06 2015-06-02 Egalet Ltd. Abuse-deterrent pharmaceutical compositions for controlled release
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US20140079780A1 (en) 2014-03-20
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PT1845956T (pt) 2017-07-04
EP1845956B1 (de) 2017-03-22
RU2010119291A (ru) 2011-11-20
SI2478896T1 (sl) 2017-12-29
BRPI0606145B1 (pt) 2019-09-17
US20160184297A1 (en) 2016-06-30
US20150290138A1 (en) 2015-10-15
KR20070111510A (ko) 2007-11-21
US20140322311A1 (en) 2014-10-30
US20190321358A1 (en) 2019-10-24
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PL1845956T3 (pl) 2017-08-31
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PE20061087A1 (es) 2006-12-15
CA2595954A1 (en) 2006-08-10
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US20140112984A1 (en) 2014-04-24
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US20190008849A1 (en) 2019-01-10
US20200215053A1 (en) 2020-07-09
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US20100151028A1 (en) 2010-06-17
US20160120810A1 (en) 2016-05-05
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US20080311187A1 (en) 2008-12-18
IL185018A0 (en) 2007-12-03
PL2478896T3 (pl) 2018-02-28
SI1845956T1 (sl) 2017-07-31
CN101175482A (zh) 2008-05-07
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US10675278B2 (en) 2020-06-09
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