WO1993006723A1 - Fungicide tablet - Google Patents

Fungicide tablet Download PDF

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Publication number
WO1993006723A1
WO1993006723A1 PCT/US1992/007804 US9207804W WO9306723A1 WO 1993006723 A1 WO1993006723 A1 WO 1993006723A1 US 9207804 W US9207804 W US 9207804W WO 9306723 A1 WO9306723 A1 WO 9306723A1
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Prior art keywords
tablet
characterized
chemical fungicide
composition
weight
Prior art date
Application number
PCT/US1992/007804
Other languages
French (fr)
Inventor
John M. Casberg
Cheryl B. French
Original Assignee
Olin Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US77171191A priority Critical
Priority to US771,711 priority
Application filed by Olin Corporation filed Critical Olin Corporation
Publication of WO1993006723A1 publication Critical patent/WO1993006723A1/en

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    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M177/00Special methods of preparation of lubricating compositions; Chemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M133/00Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
    • C10M133/02Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of less than 30 atoms
    • C10M133/24Nitriles
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    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M133/00Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
    • C10M133/02Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of less than 30 atoms
    • C10M133/30Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of less than 30 atoms containing a nitrogen-to-oxygen bond
    • C10M133/32Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of less than 30 atoms containing a nitrogen-to-oxygen bond containing a nitro group
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M135/00Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium
    • C10M135/32Heterocyclic sulfur, selenium or tellurium compounds
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M135/00Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium
    • C10M135/32Heterocyclic sulfur, selenium or tellurium compounds
    • C10M135/34Heterocyclic sulfur, selenium or tellurium compounds the ring containing sulfur and carbon only
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M135/00Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium
    • C10M135/32Heterocyclic sulfur, selenium or tellurium compounds
    • C10M135/36Heterocyclic sulfur, selenium or tellurium compounds the ring containing sulfur and carbon with nitrogen or oxygen
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M173/00Lubricating compositions containing more than 10% water
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    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2201/00Inorganic compounds or elements as ingredients in lubricant compositions
    • C10M2201/02Water
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2215/00Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
    • C10M2215/10Amides of carbonic or haloformic acids
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2215/00Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
    • C10M2215/16Nitriles
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2215/00Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
    • C10M2215/20Containing nitrogen-to-oxygen bonds
    • C10M2215/202Containing nitrogen-to-oxygen bonds containing nitro groups
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/09Heterocyclic compounds containing no sulfur, selenium or tellurium compounds in the ring
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/10Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/10Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
    • C10M2219/102Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon only in the ring
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/10Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
    • C10M2219/104Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/10Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
    • C10M2219/104Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
    • C10M2219/106Thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10MLUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2219/00Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
    • C10M2219/10Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
    • C10M2219/104Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
    • C10M2219/108Phenothiazine
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    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10NINDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2240/00Specified uses or applications of lubricating compositions
    • C10N2240/40Metal working
    • CCHEMISTRY; METALLURGY
    • C10PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10NINDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2250/00Form or state of lubricant compositions in which they are used
    • C10N2250/02Emulsions; Colloids; Micelles

Abstract

A chemical fungicide tablet is disclosed and a method of producing such a tablet and a method of fungicidal treatment of a fluid reservoir through use of the tablet.

Description

"FUNGICIDE TABLET"

This invention relates generally to chemical tablets and, more specifically, to a chemical fungicide tablet and, still more specifically to a sodium pyridine thione tablet, to the method of compressively forming the tablet and to the method of employing that tablet in a fluid reservoir for fungicidal purpose.

Chemical tablets for fluid reservoir bactericidal purpose are known. No chemical fungicide tablet is known for that purpose. One bactericidal tablet is a 28.4 gm, 2.0 inch diameter, 0.428 inch high, 1.29 gm/cc density tris(hydroxymethyl) ni romethane known as the "Angus SST Sump Saving Tablet" available commercially from Angus Chemical Company. Sodium pyridine thione ("NaPT") in liquid form is presently used in fluid reservoirs for fungicidal purpose. Solid sodium pyridine thione is not currently available for these applications. Sodium pyridine thione powder is a powerful sternutator (sneeze inducer) and therefore difficult to handle in powder form. While the liquid NaPT is completely water soluble and is highly effective in the proper dosage, measuring liquids for the proper dosing of small reservoirs (10-500 gallons) is difficult for those in charge of maintenance of the fluid reservoirs. The primary type of fluid reservoir involved is a small (10-500 gallon) fluid sump for etalworking equipment and the normal person in charge of the sump is the machinist. Machinists are normally not skilled in bacteriology or chemistry, so proper dosing with a liquid dosant can be problematic. Difficulties in measuring small quantities of liquids leads to overdosing and to greater incidence of dermal contact through spilling. These problems are solved in the tablet of the present invention and in the process of making the tablet and in the process of using the tablet by providing a chemical fungicide tablet which dissolves quickly. The dosing problem is solved in that the tablet can be made of a size and composition which achieves the proper dosage (or some specific portion of the dosage if multiple tablets doses are used) and which need not be handled by the machinist or other operator of the fluid reservoir. It is an object of the present invention to provide a fast dissolving fungicidal tablet.

It is a further object of the invention to provide a sodium pyrithione tablet.

It is another object of the present invention to provide a rapidly dissolving sodium pyrithione tablet. It is an object of the present invention to provide a process for making a chemical fungicide (preferably a sodium pyrithione) tablet that will rapidly dissolve. It is another object of the present invention to provide a method of fungicidal treatment of a fluid reservoir which method uses a rapidly dissolving chemical tablet.

It is a preferred feature of the present invention that the tablet has a moisture content of less than about 7.5% by weight and more preferably within the range of from about 0.25% to about 7.5%.

It is an advantage of the present invention that the tablet is capable of achieving an effective dosage within approximately 30 minutes with a tablet surface area of less than 5 square inches.

It is another advantage of the present invention that the tablet is relatively strong, preferably having a compressive yield strength of at least about 90 pounds.

These and other objects, features and advantages are obtained by the tablet and methods of the present invention. The tablet of the invention is preferably a sodium pyridine thione fungicidal chemical tablet.

Other fungicides useful in fabricating the tablet include zinc pyrithione; l,2-benzisothiazolin-3-one;

3-iodo-2-ρropynyl butyl carbamate; 2-bromo-2-nitropropan-l,3-diol;

1,2-dibromo-2,4-dicyanobutane;

2-(4-thiazolyl)-benzimidazole;

2,4,5, 6-Tetrachloroisophthalonitrile; l-imidazoyl-l-(4 -chlorophenoxy)-3,3-dimethylbutan-2- one; l-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)- pyridone and salts;

2-(thiocyanomethylthio)benzothiazole and combinations thereof. Preferably the tablet is a fungicidal tablet for fluid reservoir treatment, which tablet comprises compressed granules of sodium pyrithione.

The method of manufacturing the tablet is a method of forming a chemical fungicide tablet, which method comprises the steps of:

(a) introducing a quantity of granular solid chemical fungicide into a tabletting mold, the chemical fungicide granules having a moisture content of less than about 7.5% by weight and more preferably within the range of from about 0.25% to about 7.5%;

(b) compressing the introduced granules into a tablet with a density of at least 0.6 gm/cc and more preferably greater than 1.0 gm/cc; and

(c) ejecting the tablet from the die without breaking the tablet.

The method of treatment using the tablet is a method of fungicidal treatment of a fluid reservoir, which method comprises the steps of:

(a) introducing at least one chemical fungicide tablet into the fluid reservoir;

(b) dissolving the introduced tablet in the reservoir fluid at a rate of at least 0.5 grams per minute in order to obtain a fungicidally effective concentration of chemical fungicide in the reservoir.

The chemical fungicide employed in the present invention is sodium pyrithione.

The sodium pyrithione suitably employed in the process of the present invention is a well known commercial product and is commonly made by reacting 2-chloropyridine-N-oxide with NaSH and NaOH, as disclosed in U.S. Patent No. 3,159,640.

The process of making the tablet of the present invention includes the steps of: (a) introducing a quantity of granular chemical fungicide into a tabletting mold, the chemical fungicide granules having a moisture content of less than about 7.5% and preferably within the range of from about 0.25% up to about 7.5% by weight; (b) compressing the introduced granules into a tablet with a density of at least 0.6 gm/cc preferably greater than 1.0 gm/cc; and (c) ejecting the tablet from the die without breaking the tablet.

The method preferably further comprises the step of coating with a lubricating compound the portion of the tableting mold which is intended to contact the chemical fungicide granules. The lubricating compound is preferably tetrafluoroethylene although any other lubricating compound, such as a stearate compound, which is non-reactive with chemical fungicide and which does not adhere to chemical fungicide can be utilized.

The invention also provides the method of fungicidal treatment of a fluid reservoir, which method comprises the steps of: (a) introducing at least one chemical fungicide tablet into the fluid reservoir; (b) dissolving the introduced tablet in the reservoir fluid at a rate of at least 0.5 grams per minute to obtain a fungicidally effective concentration of chemical fungicide in the reservoir. Metalworking fluids are complex solutions or emulsions of agents designed but not limited to: minimize friction and remove heat; to protect against corrosion; to keep the solution stable; to lubricate and reduce surface tension; to provide extreme-pressure lubrication and to provide microbial protection. The typical ingredients found in metalworking fluid compositions consists of: water; mineral oil; sulfonates; non-ionic, anionic, and cationic surfactants; polyalkylene glycols; fatty acids; carboxylic acid esters; phosphate esters; chlorinated and sulfurized extreme pressure agents; ethanolamines; amine borates; biocides; fragrances; and dyes. The preferred fungicide is sodium pyrithione. A 15 gram tablet has been found to be a preferred size to serve as a single tablet dosage for small fluid reservoirs and a suitable size for larger reservoirs, as well, since for larger reservoirs the dosage can be applied by use of multiple tablets. The sodium pyrithione dissolves rapidly in the fluid, normally water, so that a fungicidally effective concentration of 60 ppm is reached within less than 30 minutes. In contrast, the bactericidal 28gm Angus SST tablets noted above must reach a concentration of 600 ppm to be effective as a bactericide. An advantage of sodium pyrithione in the fungicidal treatment of fluid reservoirs is the relatively low concentration that is fungicidally effective.

EXAMPLE 1

A 15 gram quantity of granulated sodium pyrithione of a particle size of the following distribution: Particle Size (microns)

>500 300-500 150-300 075-150 038-075

<Q38

Figure imgf000008_0001
Total 100.0

was placed in a one inch diameter tabletting mold cavity of cylindrical shape and compressed with a Carver Model B press at room temperature (about twenty-two degrees Centigrade) and a pressure of 12,700 psi for a duration of about 1-2 seconds. The particles had a water content of approximately 0.4% and the finished tablet had a water content of approximately 0.4%. The finished tablet had a compressive yield strength (crush strength) of about 105 pounds. The finished sodium pyrithione tablet was placed in a 5 gallon tank of water with one-half gallon per minute circulation in and out of the tank and was found to dissolve at a rate in excess of 15 gm/30 min. An effective fungicidal concentration of 790 ppm (well in excess of the fungicidally effective concentration of 60 ppm) was achieved in less than 30 minutes, indicating satisfactory dissolving rate.

EXAMPLE 2

A 15 gram quantity of granulated sodium pyrithione of a particle size of the following distribution:

Particle Size (microns) Percent >500 22.7 300-500 12.1

150-300 23.1

075-150 21.5

038-075 13.4

<038 7.2 Total 100.0

was placed in a one inch diameter tabletting mold cavity of cylindrical shape and compressed at room temperature (about 22 degrees Centigrade) and a pressure of 12,700 psi for a duration of about 1-2 seconds. The particles had a water content of approximately 3.8% and the finished tablet had a water content of approximately 3.8%. The finished tablet had a compressive yield strength (crush strength) of >350 pounds.

While the invention has been described above with references to specific embodiments thereof, it is apparent that many changes, modifications and variations in the materials, arrangements of parts and steps can be made without departing from the inventive concept disclosed herein. For example, in employing the tablet of the present invention, the tablet could have any desired shape and size. Accordingly, the spirit and broad scope of the appended claims is intended to embrace all such changes, modifications and variations that may occur to one of skill in the art upon a reading of the disclosure.

Claims

WHAT IS CLAIMED IS:
1. A metalworking fluid composition characterized by said composition comprising:
(a) a chemical fungicide tablet; and (b) an aqueous metalworking fluid.
2. The composition of Claim 1 characterized in that the fungicide is selected from the group consisting sodium pyrithione, zinc pyrithione; l,2-benzisothiazolin-3-one; 3-iodo-2-propynyl butyl carbamate; 2-bromo-2-nitropropan-l,3-diol;
1,2-dibromo-2,4-dicyanobutane;
2- (4-thiazolyl)-benzimidazole;
2,4,5,6-Tetrachloroisophthalonitrile; l-imidazoyl-l-(4 '-chlorophenoxy)-3,3-dimethylbutan-2- one; l-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(lH) pyridone and salts;
2-(thiocyanomethylthio)benzothiazole and combinations thereof.
3. The composition of Claim 1 characterized n that the tablet has a moisture content of less than about 7.5% by weight.
4. The composition of Claim 1 characterized in that the tablet has a moisture content within the range of from about 0.25% up to about 7.5% by weight.
5. The composition of Claim 1 characterized in that the tablet has a moisture content within the range of from about 1.00% up to about 5.0% by weight. 6. The composition of Claim 1 characterized in that the tablet has a moisture content within the range of from about 1.25% up to about 4.0% by weight.
7. A fungicidal tablet for fluid reservoir treatment characterized in that the tablet comprises compressed granules of chemical fungicide.
8. The tablet of Claim 7 characterized in that the fungicide is sodium pyrithione.
9. The tablet of Claim 7 characterized in that the tablet has interconnected granules and no connective binder other than the chemical fungicide granules themselves.
10. The tablet of Claim 7 characterized in that the tablet has a moisture content less than about 7.5% by weight.
11. The tablet of Claim 7 characterized in that the tablet has a moisture content within the range of from about 1.00% up to about 5.0% by weight.
12. The tablet of Claim 7 characterized in that the tablet has a moisture content within the range of from about 1.25% up to about 4.0% by weight. lS. A method of forming a chemical fungicide tablet characterized by the steps of:
(a) introducing a quantity of granular chemical fungicide into a tabletting mold, the chemical fungicide granules having a moisture content less than 7.5% by weight;
(b) compressing the introduced granules into a tablet with a density of at least 0.6 gm/cc; and
(c) ejecting the tablet from the die without breaking the tablet.
14. The method of Claim 13 characterized in that the chemical fungicide is sodium pyridine thione.
15. The method of Claim 13 characterized in that the tablet is compressed to a density greater than l.Ogm/cc.
16. The method of Claim 13 characterized by the further step of coating with a lubricating compound the portion of the tableting mold which is intended to contact the chemical fungicide granules.
17. The method of Claim 16 characterized in that the lubricating compound is tetrafluoroethylene.
18. The method of Claim 16 characterized in that the lubricating compound is a stearate compound. 19. A method of fungicidal treatment of a fluid reservoir characterized by the steps of:
(a) introducing at least one chemical fungicide tablet into the fluid reservoir; and (b) dissolving the introduced tablet in the reservoir fluid at a rate of at least 0.5 grams per minute in order to obtain a fungicidally effective concentration of chemical fungicide in the reservoir.
20. An industrial or commercial composition characterized by said composition comprising:
(a) a base fluid; and
(b) a chemical fungicide tablet.
PCT/US1992/007804 1991-10-04 1992-09-17 Fungicide tablet WO1993006723A1 (en)

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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017491A1 (en) * 1993-12-22 1995-06-29 Cincinnati Milacron Inc. Improved aqueous functional fluid
WO2001092444A3 (en) * 2000-05-26 2002-04-04 Avecia Ltd Method and compositions for inhibiting the growth of microorganisms in metal working fluids
GB2369624A (en) * 2000-08-07 2002-06-05 Clariant Uk Ltd Tablet compositions for use in tanning liquors
WO2006074882A1 (en) * 2005-01-15 2006-07-20 Clariant Produkte (Deutschland) Gmbh Aqueous fungicide preparations
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US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US10080721B2 (en) 2009-07-22 2018-09-25 Gruenenthal Gmbh Hot-melt extruded pharmaceutical dosage form
US10130591B2 (en) 2003-08-06 2018-11-20 Grünenthal GmbH Abuse-proofed dosage form
US10154966B2 (en) 2013-05-29 2018-12-18 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
US10201502B2 (en) 2011-07-29 2019-02-12 Gruenenthal Gmbh Tamper-resistant tablet providing immediate drug release
US10300141B2 (en) 2010-09-02 2019-05-28 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
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