MX2010000803A - Formulaciones de analgesicos no opioides y opioides confinados. - Google Patents

Formulaciones de analgesicos no opioides y opioides confinados.

Info

Publication number
MX2010000803A
MX2010000803A MX2010000803A MX2010000803A MX2010000803A MX 2010000803 A MX2010000803 A MX 2010000803A MX 2010000803 A MX2010000803 A MX 2010000803A MX 2010000803 A MX2010000803 A MX 2010000803A MX 2010000803 A MX2010000803 A MX 2010000803A
Authority
MX
Mexico
Prior art keywords
abuse
drug
formulations
relevant
acetaminophen
Prior art date
Application number
MX2010000803A
Other languages
English (en)
Inventor
Gerd Woehrle
Joerg Rosenberg
Thomas Y Kessler
Joerg Breitenbach
Salih Durak
Friedrich W Richter
Sandeep Dutta
Wei Liu
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of MX2010000803A publication Critical patent/MX2010000803A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Abstract

Las modalidades preferidas ilustrativas en la presente solicitud proporcionan formulaciones y métodos para el suministro de fármacos, particularmente fármacos de abuso, que tienen un fármaco de abuso relevante substancialmente confinado en el núcleo y un fármaco de no abuso relevante en una región que no es el núcleo. Estas formulaciones tienen un potencial reducido de abuso. En la formulación, de preferencia el fármaco de abuso relevante es un opioide y el fármaco de no abuso relevante es acetaminofen o ibuprofeno. Muy preferiblemente, el opioide es hidrocodona, y el analgésico de no abuso relevante es acetaminofen. En ciertas modalidades preferidas, las formas de dosis se caracterizan por resistencia a la extracción de solvente; alteración, trituración o molienda. Ciertas modalidades de las invenciones proporcionan formas de dosis que proveen una ráfaga inicial de liberación de fármaco seguido por un periodo prolongado de liberación de fármaco controlable.
MX2010000803A 2007-07-20 2007-07-20 Formulaciones de analgesicos no opioides y opioides confinados. MX2010000803A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/073957 WO2009014534A1 (en) 2007-07-20 2007-07-20 Formulations of nonopioid and confined opioid analgesics

Publications (1)

Publication Number Publication Date
MX2010000803A true MX2010000803A (es) 2010-06-23

Family

ID=39338644

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010000803A MX2010000803A (es) 2007-07-20 2007-07-20 Formulaciones de analgesicos no opioides y opioides confinados.

Country Status (14)

Country Link
EP (1) EP2182928A1 (es)
JP (1) JP2010534204A (es)
KR (1) KR20100055431A (es)
CN (1) CN101917977B (es)
AU (1) AU2007356880A1 (es)
BR (1) BRPI0721940A2 (es)
CA (1) CA2690829A1 (es)
IL (1) IL202680A0 (es)
MX (1) MX2010000803A (es)
NZ (1) NZ581767A (es)
RU (1) RU2477995C2 (es)
TW (1) TW200904431A (es)
WO (1) WO2009014534A1 (es)
ZA (1) ZA200908900B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
MX2010012039A (es) 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
MX2012000317A (es) 2009-07-22 2012-02-08 Gruenenthal Gmbh Forma de dosificacion de liberacion controlada extruida por fusion en caliente.
RU2015138422A (ru) 2009-07-22 2018-12-25 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
KR101572336B1 (ko) * 2010-12-22 2015-11-26 퍼듀 퍼머 엘피 케이싱된 탬퍼 저항성 제어 방출 투여 형태
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
AU2012292418B2 (en) 2011-07-29 2017-02-16 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
FR2979242A1 (fr) * 2011-08-29 2013-03-01 Sanofi Sa Comprime contre l'usage abusif, a base de paracetamol et d'oxycodone
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
CN104394851B (zh) 2012-04-18 2017-12-01 格吕伦塔尔有限公司 抗篡改和抗剂量‑倾泻药物剂型
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096438A1 (es) * 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
US10195153B2 (en) 2013-08-12 2019-02-05 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
KR101881074B1 (ko) * 2013-11-13 2018-08-17 내셔널 디펜스 에듀케이션 앤드 리서치 파운데이션 간에 대한 부작용이 없는 신규의 아세트아미노펜 화합물 조성물
CN105934241B (zh) 2013-11-26 2020-06-05 格吕伦塔尔有限公司 通过低温研磨制备粉末状药物组合物
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
JP2017516789A (ja) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エタノール過量放出に対して防護されている多粒子
ES2809458T3 (es) 2014-07-17 2021-03-04 Pharmaceutical Manufacturing Res Services Inc Forma de dosificación llena de líquido, disuasoria del abuso y de liberación inmediata
JP2017531026A (ja) 2014-10-20 2017-10-19 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド 徐放性乱用抑止性液体充填剤形
EP3285745A1 (en) 2015-04-24 2018-02-28 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
US20180200190A1 (en) * 2015-07-10 2018-07-19 Sun Pharma Advanced Research Company Ltd. Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
SE541800C2 (en) 2018-04-20 2019-12-17 Scania Cv Ab A method of controlling a powertrain, a control arrangement, a vehicle, a computer program and a computer-readable medium
JP6858729B2 (ja) * 2018-05-25 2021-04-14 ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102716101A (zh) * 1999-10-29 2012-10-10 欧罗赛铁克股份有限公司 控释氢可酮制剂
US20030092724A1 (en) * 2001-09-18 2003-05-15 Huaihung Kao Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
CA2540056C (en) * 2003-09-26 2015-03-24 Alza Corporation Controlled release formulations of opioid and nonopioid analgesics
AU2004314693B2 (en) * 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
EA020867B1 (ru) * 2006-03-06 2015-02-27 Поузен Инк. Лекарственные формы для введения комбинаций лекарственных средств
US8765178B2 (en) * 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods

Also Published As

Publication number Publication date
AU2007356880A1 (en) 2009-01-29
CN101917977B (zh) 2013-05-29
CN101917977A (zh) 2010-12-15
RU2477995C2 (ru) 2013-03-27
JP2010534204A (ja) 2010-11-04
EP2182928A1 (en) 2010-05-12
RU2010106202A (ru) 2011-08-27
WO2009014534A1 (en) 2009-01-29
KR20100055431A (ko) 2010-05-26
IL202680A0 (en) 2010-06-30
ZA200908900B (en) 2014-05-28
CA2690829A1 (en) 2009-01-29
BRPI0721940A2 (pt) 2014-03-18
TW200904431A (en) 2009-02-01
NZ581767A (en) 2012-05-25

Similar Documents

Publication Publication Date Title
MX2010000803A (es) Formulaciones de analgesicos no opioides y opioides confinados.
SG169334A1 (en) Dosage form and method for the delivery of drugs of abuse
WO2008131056A3 (en) Sustained release monoeximic formulations of opioid and nonopioid analgesics
WO2010011439A3 (en) Gip-based mixed agonists for treatment of metabolic disorders and obesity
WO2007103293A3 (en) Ethanol-resistant sustained release formulations
WO2007143155A3 (en) Sustained release pharmaceutical dosage form containing phenylephrine
MX2009003771A (es) Formulaciones robustas de liberacion sostenida.
MX2009005339A (es) Suspensiones analgesicas de liberacion modificada.
WO2005034859A3 (en) Extended release formulations of opioids and method of use thereof
NZ629468A (en) Tamper resistant immediate release formulations
MX2011011480A (es) Composicines de tabletas que se desintegran oralmente que comprenden combinaciones de analgesicos no opioides y opioides.
MX2009013574A (es) Formas de dosificacion solidas o semisolidas de liberacion modificada.
WO2009091576A3 (en) Parenteral formulations of dopamine agonists
WO2007053698A3 (en) Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
WO2006089843A3 (fr) Forme medicamenteuse orale microparticulaire anti-mesusage
WO2011106416A3 (en) Abuse-resistant formulations
WO2009120889A3 (en) Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists
NZ596879A (en) Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug
WO2008034041A3 (en) Therapeutic combinations
IL177829A0 (en) Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
MX2010001789A (es) Regimen de dosificacion de ibuprofeno de liberacion inmediata y liberacion sostenida.
SI2056825T1 (sl) Uporaba formulacij opioida v brezigelnih razdeljevalnih napravah za zdravila
WO2008143906A3 (en) Hypercompressed particles for controlled release of ophthalmic medications
WO2010127100A8 (en) Compositions comprising an antihistamine, antitussive and decongestant in extended release formulations
AU2007225022A8 (en) Non-codeine opioid analgesic process and formulations

Legal Events

Date Code Title Description
FA Abandonment or withdrawal