UA65538C2 - Ultrafine dry powder compositions of biological macromolecules, methods for their preparation and application - Google Patents
Ultrafine dry powder compositions of biological macromolecules, methods for their preparation and application Download PDFInfo
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- UA65538C2 UA65538C2 UA98126441A UA98126441A UA65538C2 UA 65538 C2 UA65538 C2 UA 65538C2 UA 98126441 A UA98126441 A UA 98126441A UA 98126441 A UA98126441 A UA 98126441A UA 65538 C2 UA65538 C2 UA 65538C2
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
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- General Health & Medical Sciences (AREA)
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- Otolaryngology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/644,681 US6051256A (en) | 1994-03-07 | 1996-05-08 | Dispersible macromolecule compositions and methods for their preparation and use |
PCT/US1997/007779 WO1997041833A1 (en) | 1996-05-08 | 1997-05-07 | Dispersible macromolecule compositions and methods for their preparation and use |
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Publication Number | Publication Date |
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UA65538C2 true UA65538C2 (en) | 2004-04-15 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UA98126441A UA65538C2 (en) | 1996-05-08 | 1997-07-05 | Ultrafine dry powder compositions of biological macromolecules, methods for their preparation and application |
Country Status (30)
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US (5) | US6051256A (de) |
EP (1) | EP0948317A4 (de) |
JP (2) | JP2000510471A (de) |
CN (1) | CN1138531C (de) |
AP (1) | AP987A (de) |
AU (1) | AU730059B2 (de) |
BG (1) | BG64113B1 (de) |
BR (1) | BR9709057A (de) |
CA (1) | CA2253393C (de) |
CZ (1) | CZ295644B6 (de) |
EA (1) | EA000956B1 (de) |
EE (1) | EE03591B1 (de) |
GE (1) | GEP20012345B (de) |
HK (1) | HK1020319A1 (de) |
IL (1) | IL126754A (de) |
IS (1) | IS4879A (de) |
LT (1) | LT4553B (de) |
LV (1) | LV12231B (de) |
NO (1) | NO985196L (de) |
NZ (1) | NZ332480A (de) |
OA (1) | OA10914A (de) |
PL (1) | PL190732B1 (de) |
RO (1) | RO118523B1 (de) |
SI (1) | SI9720031A (de) |
SK (1) | SK285400B6 (de) |
TR (1) | TR199802247T2 (de) |
TW (1) | TW550089B (de) |
UA (1) | UA65538C2 (de) |
WO (1) | WO1997041833A1 (de) |
YU (1) | YU49206B (de) |
Families Citing this family (360)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
NZ257212A (en) * | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US7448375B2 (en) * | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
US20010003739A1 (en) * | 1993-06-24 | 2001-06-14 | Astrazeneca Ab | Systemic administration of a therapeutic preparation |
TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
US6794357B1 (en) * | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
PL179443B1 (pl) * | 1994-03-07 | 2000-09-29 | Inhale Therapeutic Syst | Kompozycja insuliny, sposób wytwarzania kompozycji insuliny i sposób wytwarzania dawki insuliny w postaci aerozolu PL PL PL PL |
ES2245780T3 (es) * | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | Metodos y composiciones para la formulacion de interferones como un polvo seco. |
US6165976A (en) * | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
DE69530519T2 (de) | 1994-12-22 | 2004-03-04 | Astrazeneca Ab | Parathyroidhormon pth enthaltende therapeutische zubereitung zur inhalation |
US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
EE9700138A (et) | 1994-12-22 | 1997-12-15 | Astra Aktiebolag | Aerosoolravimvormid |
US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
US6165463A (en) * | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
US6019968A (en) * | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
US6315983B1 (en) | 1996-01-24 | 2001-11-13 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for the production of powdered pulmonary surfactant preparations |
US6503480B1 (en) * | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
TR200001021T2 (tr) | 1997-07-18 | 2000-09-21 | Infimed Inc. | Aktif maddelerin kontrollü salınması için biyo aşındırılabilir makromerler. |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
WO1999055310A1 (en) | 1998-04-27 | 1999-11-04 | Altus Biologics Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
US6284282B1 (en) | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
WO1999055362A1 (en) * | 1998-04-29 | 1999-11-04 | Genentech, Inc. | Spray dried formulations of igf-i |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
US6451349B1 (en) | 1998-08-19 | 2002-09-17 | Quadrant Healthcare (Uk) Limited | Spray-drying process for the preparation of microparticles |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
US20070212422A1 (en) * | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
CA2367131C (en) | 1999-04-05 | 2007-07-03 | Solomon S. Steiner | Methods for fine powder formation |
WO2000061178A1 (en) * | 1999-04-13 | 2000-10-19 | Inhale Therapeutics Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
JP2002541213A (ja) * | 1999-04-13 | 2002-12-03 | インヘール セラピューティック システムズ, インコーポレイテッド | 不妊症の処置のための乾燥粉末処方物の肺投与 |
CN1198593C (zh) | 1999-06-09 | 2005-04-27 | 罗伯特·E·希弗斯 | 超临界流体辅助的喷雾和鼓泡干燥 |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
PT1196430E (pt) * | 1999-06-29 | 2012-04-18 | Mannkind Corp | Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos |
JP4327394B2 (ja) * | 1999-06-30 | 2009-09-09 | ネクター セラピューティクス | 乾燥粉末を調製するための噴霧乾燥法 |
EP1074248A1 (de) * | 1999-07-08 | 2001-02-07 | Arnold Hilgers | Verabreichungssystem für biologisches Material |
ITMI991582A1 (it) * | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
US7252840B1 (en) | 1999-08-25 | 2007-08-07 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles |
WO2001013891A2 (en) * | 1999-08-25 | 2001-03-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
US20010036481A1 (en) * | 1999-08-25 | 2001-11-01 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
NZ518401A (en) | 1999-10-29 | 2004-01-30 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
US7507687B2 (en) * | 2000-03-22 | 2009-03-24 | Cabot Corporation | Electrocatalyst powders, methods for producing powder and devices fabricated from same |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
DK1280520T4 (en) * | 2000-05-10 | 2018-06-25 | Novartis Ag | Phospholipid based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US20030003057A1 (en) * | 2000-07-07 | 2003-01-02 | Jeffry Weers | Methods for administering leuprolide by inhalation |
US7575761B2 (en) * | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
AU2001277230A1 (en) * | 2000-08-01 | 2002-02-13 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution andparticles made thereby |
EP1309312A2 (de) * | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhalierbare sprühgetrocknete pulver aus proteinen die bündel aus 4 helices ausbilden mit minimierter aggregation |
AU2002224408B2 (en) * | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US7374782B2 (en) | 2000-10-27 | 2008-05-20 | Baxter International Inc. | Production of microspheres |
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
ES2281458T3 (es) * | 2000-12-21 | 2007-10-01 | Nektar Therapeutics | Composiciones de polvo estables en almacenamiento del receptor de interleucina 4. |
US20020141946A1 (en) * | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
US20050159376A1 (en) * | 2002-02-20 | 2005-07-21 | Slrna Therapeutics, Inc. | RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
US20050148530A1 (en) * | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US20050233344A1 (en) * | 2001-05-18 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA) |
US20050159382A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
US20050233997A1 (en) * | 2001-05-18 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
US20050159380A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA) |
US20050119212A1 (en) * | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA) |
US20050256068A1 (en) * | 2001-05-18 | 2005-11-17 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA) |
US20050267058A1 (en) * | 2001-05-18 | 2005-12-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA) |
US20060019913A1 (en) * | 2001-05-18 | 2006-01-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
US20070042983A1 (en) * | 2001-05-18 | 2007-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US20050182007A1 (en) * | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
US20050287128A1 (en) * | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
US20050176664A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA) |
US20050222066A1 (en) * | 2001-05-18 | 2005-10-06 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20050227935A1 (en) * | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA) |
US7517864B2 (en) * | 2001-05-18 | 2009-04-14 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20050164968A1 (en) * | 2001-05-18 | 2005-07-28 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA) |
US20070270579A1 (en) * | 2001-05-18 | 2007-11-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US20050176666A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA) |
US20050014172A1 (en) * | 2002-02-20 | 2005-01-20 | Ivan Richards | RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA) |
US20060241075A1 (en) * | 2001-05-18 | 2006-10-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA) |
US20050054596A1 (en) * | 2001-11-30 | 2005-03-10 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20050182009A1 (en) * | 2001-05-18 | 2005-08-18 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA) |
US20050187174A1 (en) * | 2001-05-18 | 2005-08-25 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
US20080161256A1 (en) * | 2001-05-18 | 2008-07-03 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US20050203040A1 (en) * | 2001-05-18 | 2005-09-15 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
US20050143333A1 (en) * | 2001-05-18 | 2005-06-30 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
US20040198682A1 (en) * | 2001-11-30 | 2004-10-07 | Mcswiggen James | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA) |
US20050282188A1 (en) * | 2001-05-18 | 2005-12-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US20050288242A1 (en) * | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA) |
EP1270012A1 (de) * | 2001-06-21 | 2003-01-02 | Pfizer Products Inc. | Verwendung pulmonär verabreichten Insulins zur Behandlung von Diabetes |
US20050123509A1 (en) * | 2001-10-19 | 2005-06-09 | Lehrman S. R. | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
US20050013867A1 (en) * | 2001-10-19 | 2005-01-20 | Lehrman S. Russ | Use of proton sequestering agents in drug formulations |
EP1446104B2 (de) * | 2001-11-01 | 2011-08-03 | Novartis AG | Sprühtrocknungsverfahren |
WO2003043585A2 (en) * | 2001-11-20 | 2003-05-30 | Advanced Inhalation Research, Inc. | Improved particulate compositions for pulmonary delivery |
US20030099601A1 (en) * | 2001-11-27 | 2003-05-29 | Gordon Marc S. | Inhalation lung surfactant therapy |
US20070203333A1 (en) * | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20050075304A1 (en) * | 2001-11-30 | 2005-04-07 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20040138163A1 (en) * | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
EP1458360B1 (de) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonale verabreichung von aminoglykosiden |
US20050042632A1 (en) * | 2002-02-13 | 2005-02-24 | Sirna Therapeutics, Inc. | Antibodies having specificity for nucleic acids |
US20050137153A1 (en) * | 2002-02-20 | 2005-06-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA) |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US20040014679A1 (en) * | 2002-02-20 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Inhalation powder containing the CGRP antagonist BIBN4096 and process for the preparation thereof |
CN101143221A (zh) * | 2002-03-15 | 2008-03-19 | 布赖汉姆妇女医院 | 适合治疗剂全身性递送的中央气道给药 |
US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
WO2003079993A2 (en) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | hGH (HUMAN GROWTH HORMONE) FORMULATIONS FOR PULMONARY ADMINISTRATION |
WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
KR20050011741A (ko) * | 2002-04-11 | 2005-01-29 | 메드이뮨 백신즈 인코포레이티드 | 분무 건조에 의한 생물학적 활성 물질의 보존 |
EP1551852A4 (de) * | 2002-04-25 | 2007-03-21 | Momenta Pharmaceuticals Inc | Verfahren und produkte zur verabreichung an die schleimhaut |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
DE10234165B4 (de) * | 2002-07-26 | 2008-01-03 | Advanced Micro Devices, Inc., Sunnyvale | Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material |
KR20100107083A (ko) * | 2002-12-17 | 2010-10-04 | 메디뮨 엘엘씨 | 생물활성 물질의 고압 분무 건조 |
EP2526996B1 (de) | 2002-12-20 | 2019-09-11 | Xeris Pharmaceuticals, Inc. | Formulierung für intrakutane Injektion |
KR20050088243A (ko) * | 2002-12-30 | 2005-09-02 | 넥타르 테라퓨틱스 | 프리필름화 분무기 |
WO2004060903A2 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy |
ES2589578T5 (es) * | 2002-12-31 | 2019-07-23 | Novartis Ag | Formulación farmacéutica con un agente activo insoluble para administración pulmonar |
KR100500675B1 (ko) * | 2003-02-10 | 2005-07-11 | 주식회사 에이앤피사이언스 | 고유량 입자 분무장치 |
GB0304540D0 (en) * | 2003-02-27 | 2003-04-02 | Elan Drug Delivery Ltd | Particle formulation and its preparation |
JP2007500234A (ja) * | 2003-05-28 | 2007-01-11 | ネクター セラピューティクス | 水に不溶な活性剤を含む医薬的成形 |
US20050014230A1 (en) * | 2003-07-16 | 2005-01-20 | Ccl Holding Co., Ltd. | Preparation of fully human antibodies |
DE602004000493T2 (de) * | 2003-07-28 | 2006-08-31 | Pioneer Hi-Bred International, Inc. | Vorrichtung und verfahren zur aufbringung von substanzen an geerntete futterpflanzen und getreide |
US20050043247A1 (en) * | 2003-08-18 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Spray-dried amorphous BIBN 4096, process for preparing and the use thereof as inhalative |
US20050042178A1 (en) * | 2003-08-18 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Microparticles containing the CGRP-antagonist 1-[N2-[3,5-dibrom-N-[[4-(3,4-dihydro-2(1H)-oxoquinazoline-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine, process for preparing and the use thereof as inhalation powder |
US20050042180A1 (en) * | 2003-08-18 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Powder formulation containing the CGRP antagonist 1 [N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2 (1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin, process for preparing and the use thereof as inhalation powder |
US20050042179A1 (en) * | 2003-08-18 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Inhalative powder formulations containing the CGRP-antagonist 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
CA2540699A1 (en) * | 2003-10-01 | 2005-04-14 | Momenta Pharmaceuticals, Inc. | Polysaccharides for pulmonary delivery of active agents |
US7338171B2 (en) * | 2003-10-27 | 2008-03-04 | Jen-Chuen Hsieh | Method and apparatus for visual drive control |
US20050214224A1 (en) * | 2003-11-04 | 2005-09-29 | Nektar Therapeutics | Lipid formulations for spontaneous drug encapsulation |
KR20050056799A (ko) * | 2003-12-10 | 2005-06-16 | 엘지.필립스 엘시디 주식회사 | 액정 표시패널의 실 패턴 구조 |
US7192919B2 (en) | 2004-01-07 | 2007-03-20 | Stelios Tzannis | Sustained release compositions for delivery of pharmaceutical proteins |
KR100985126B1 (ko) * | 2004-01-12 | 2010-10-05 | 맨카인드 코포레이션 | 제2형 당뇨병에서 혈청 프로인슐린 수치의 감소 방법 |
EP1713441A2 (de) * | 2004-02-12 | 2006-10-25 | Nektar Therapeutics | Interleukin-13-antagonist-pulver, sprühgetrocknete partikel und verfahren |
US20080090753A1 (en) * | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
AU2005222613B2 (en) * | 2004-03-12 | 2009-12-17 | Biodel, Inc. | Rapid acting drug delivery compositions |
MXPA06012240A (es) | 2004-04-23 | 2007-01-31 | Cydex Inc | Formulacion para inhalador de polvo seco que contiene eter sulfoalquilico-ciclodextrina. |
US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
DE102004022926A1 (de) * | 2004-05-10 | 2005-12-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete Pulver enthaltend zumindest ein 1,4 O-verknüpftes Saccharose-Derivat und Verfahren zu deren Herstellung |
US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
DE102004022928A1 (de) * | 2004-05-10 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
MXPA06015220A (es) * | 2004-06-21 | 2007-12-13 | Nektar Therapeutics | Composiciones comprendiendo anfotericina b, metodos y sistemas. |
US8513204B2 (en) * | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
UA103758C2 (ru) | 2004-07-19 | 2013-11-25 | Биокон Лимитед | Конъюгаты олигомеров инсулина, их композиции и применение |
US20060024272A1 (en) | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
DE602005024413D1 (de) | 2004-08-20 | 2010-12-09 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
ES2540886T3 (es) | 2004-08-23 | 2015-07-14 | Mannkind Corporation | Sales de dicetopiperazina para la administración de fármacos |
SE0402345L (sv) * | 2004-09-24 | 2006-03-25 | Mederio Ag | Uppmätt läkemedelsdos |
US9149433B2 (en) * | 2004-11-30 | 2015-10-06 | Basf Corporation | Method for formation of micro-prilled polymers |
EP1819639A4 (de) * | 2004-11-30 | 2012-05-02 | Univ Tulane | Zerstäubendes behandlungsverfahren |
US20060160871A1 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
US20090053314A1 (en) * | 2005-03-22 | 2009-02-26 | Regeron, Inc. | Submicronization of proteins using supercritical fluids |
CN101184522B (zh) | 2005-05-18 | 2011-12-21 | 尼克塔治疗公司 | 用于支气管内治疗的阀、设备和方法 |
WO2007019554A2 (en) * | 2005-08-08 | 2007-02-15 | Momenta Pharmaceuticals, Inc. | Polysaccharides for delivery of active agents |
KR101557502B1 (ko) | 2005-09-14 | 2015-10-06 | 맨카인드 코포레이션 | 결정질 미립자 표면에 대한 활성제의 친화력의 증가를기반으로 하는 약물 제제의 방법 |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US8084420B2 (en) * | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US20070086952A1 (en) * | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
ES2390286T3 (es) | 2005-12-16 | 2012-11-08 | Nektar Therapeutics | Conjugados poliméricos de GLP-1 |
WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
KR101787939B1 (ko) | 2006-01-24 | 2017-10-18 | 안선 바이오파르마, 아이엔씨. | 고분자 미소 구체들의 조제를 위한 기술 |
GB0602897D0 (en) * | 2006-02-13 | 2006-03-22 | Jagotec Ag | Improvements In Or Relating To Dry Powder Inhaler Devices |
AU2007216966C1 (en) | 2006-02-22 | 2014-03-20 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
CA2649109A1 (en) * | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
WO2008051570A1 (en) | 2006-10-23 | 2008-05-02 | Starkey Laboratories, Inc. | Entrainment avoidance with an auto regressive filter |
GB0622818D0 (en) * | 2006-11-15 | 2006-12-27 | Jagotec Ag | Improvements in or relating to organic compounds |
GB0625303D0 (en) * | 2006-12-19 | 2007-01-24 | Jagotec Ag | Improvements in and relating to metered dose inhalers |
US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
WO2008124522A2 (en) * | 2007-04-04 | 2008-10-16 | Biodel, Inc. | Amylin formulations |
WO2008137747A1 (en) | 2007-05-02 | 2008-11-13 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
EP2207890A4 (de) | 2007-10-05 | 2010-12-15 | Barofold Inc | Hochdruckbehandlung aggregierter interferone |
JP5649451B2 (ja) * | 2007-12-21 | 2015-01-07 | シーエヌジェイ ホールディングス,インコーポレイテッド | トレハロースを含む安定化第ix因子製剤 |
EP2077132A1 (de) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung |
AU2009204309B2 (en) * | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8834930B2 (en) | 2008-05-15 | 2014-09-16 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
PL2293833T3 (pl) | 2008-06-13 | 2016-08-31 | Mannkind Corp | Inhalator proszkowy i układ do dostarczania leku |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
EP2609954B1 (de) | 2008-06-20 | 2021-12-29 | MannKind Corporation | Interaktives Gerät für die Echtzeit-Profilierung von Inhalationsversuchen |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
CA2737461A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
EP2341942A1 (de) | 2008-09-19 | 2011-07-13 | Nektar Therapeutics | Polymerkonjugate aus therapeutischen peptiden |
US8962026B2 (en) * | 2008-09-26 | 2015-02-24 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
US8062875B2 (en) | 2008-10-03 | 2011-11-22 | E. I. du Pont de Nemous & Company | Perhydrolases for enzymatic peracid generation |
WO2010057197A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
WO2010078373A1 (en) | 2008-12-29 | 2010-07-08 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
EP2401587A2 (de) | 2009-02-27 | 2012-01-04 | Tandem Diabetes Care, Inc. | Verfahren und vorrichtungen zur bestimmung des flussreservoirvolumens |
US9250106B2 (en) | 2009-02-27 | 2016-02-02 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
EP2405963B1 (de) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Gerät, system und verfahren zur messung von widerstand in einem inhaliergerät |
WO2010107964A1 (en) | 2009-03-18 | 2010-09-23 | Pleiades Cardio-Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
CA2755773A1 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of btb and cnc homology 1, basic leucine zipper transcription factor 1 (bach 1) gene expression using short interfering nucleic acid (sina) |
WO2010107957A2 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP2408458A1 (de) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | Rna-schnittstellen-vermittelte unterdrückung der signal transducer and activator of transcription 6 (stat6) genexpression mit short interfering nucleic acid (sina) |
EP2408916A2 (de) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der genexpression von ctgf (connective tissue growth factor) unter verwendung von sina (short interfering nucleic acid) |
EP2411520A2 (de) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der genexpression von tslp (thymic stromal lymphopoietin) unter verwendung von sina (short interfering nucleic acid) |
SG174581A1 (en) | 2009-03-27 | 2011-10-28 | Merck Sharp & Dohme | RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
JP2012521762A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いた神経成長因子β鎖(NGFβ)遺伝子発現のRNA干渉媒介性阻害 |
WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP2411019A2 (de) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der signal transducer and activator of transcription 1 (stat1) gen-expression mittels sina (short interfering nucleic acid) |
JP5670421B2 (ja) | 2009-03-31 | 2015-02-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | コンポーネント表面のコーティング方法 |
CA2757500A1 (en) | 2009-04-01 | 2010-10-07 | Promedior, Inc. | Pulmonary and nasal delivery of serum amyloid p |
EP2432531B1 (de) | 2009-05-18 | 2019-03-06 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
CA2764759A1 (en) | 2009-06-09 | 2010-12-16 | Defyrus, Inc. | Administration of interferon for prophylaxis against or treatment of pathogenic infection |
KR20180079458A (ko) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
EP3284494A1 (de) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Tragbares infusionspumpensystem |
US8222012B2 (en) | 2009-10-01 | 2012-07-17 | E. I. Du Pont De Nemours And Company | Perhydrolase for enzymatic peracid production |
US20130131192A1 (en) | 2009-11-03 | 2013-05-23 | Grifols Therapeutics Inc. | Composition, method, and kit for alpha-1 proteinase inhibitor |
US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
CA2781792C (en) | 2009-11-25 | 2019-04-02 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
EP2330094B1 (de) * | 2009-12-03 | 2017-02-08 | PURAC Biochem BV | Alkalimetallcinnamatpulver und Herstellungsverfahren dafür |
CN102741410B (zh) | 2009-12-09 | 2016-11-16 | 日东电工株式会社 | Hsp47表达的调节 |
CN101816913B (zh) * | 2010-05-20 | 2015-10-21 | 吴传斌 | 一种微球制造方法及制造设备 |
CA2801936C (en) | 2010-06-21 | 2021-06-01 | Mannkind Corporation | Dry powder drug delivery system and methods |
WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US20120046225A1 (en) | 2010-07-19 | 2012-02-23 | The Regents Of The University Of Colorado, A Body Corporate | Stable glucagon formulations for the treatment of hypoglycemia |
ES2639888T3 (es) | 2010-09-24 | 2017-10-30 | University Of Florida Research Foundation, Inc. | Materiales y procedimientos para mejorar la función gastrointestinal |
EP3766975A1 (de) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna-interferenz-vermittelte inhibition von genexpression unter verwendung kurzer interferierender nukleinsäure (sina) |
CA2823628A1 (en) | 2011-01-05 | 2012-07-12 | Hospira, Inc. | Spray drying vancomycin |
MX344465B (es) * | 2011-02-10 | 2016-12-14 | Crucell Holland Bv | Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica. |
CA2767773C (en) | 2011-02-11 | 2015-11-24 | Grain Processing Corporation | Composition comprising a salt and a crystallization interrupter |
US8708159B2 (en) * | 2011-02-16 | 2014-04-29 | Oakwood Laboratories, Llc | Manufacture of microspheres using a hydrocyclone |
WO2012114230A1 (en) | 2011-02-25 | 2012-08-30 | Koninklijke Philips Electronics N.V. | An aerosol generating device for nebulizing a liquid and a method of temperature control of a liquid to be nebulized |
AU2012223365B2 (en) | 2011-03-03 | 2016-11-10 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating lung disease and injury |
SG193389A1 (en) | 2011-03-10 | 2013-10-30 | Xeris Pharmaceuticals Inc | Stable formulations for parenteral injection of peptide drugs |
EP3225235B1 (de) | 2011-03-10 | 2020-12-16 | Xeris Pharmaceuticals, Inc. | Stabile peptid-formulierungen zur parenteralen injektion |
EP2694402B1 (de) | 2011-04-01 | 2017-03-22 | MannKind Corporation | Blisterverpackung für pharmakartuschen |
EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
AU2012254999B2 (en) * | 2011-05-19 | 2016-02-11 | Savara, Inc. | Dry powder vancomycin compositions and associated methods |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
EP2998289B1 (de) | 2011-06-08 | 2019-08-07 | Nitto Denko Corporation | Verbindungen für die gezielte wirkstofffreisetzung und verbesserung der sirna-wirkung |
TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Hsp47表現調控強化用類視色素脂質體 |
US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
EP2776053A1 (de) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Verfahren und zusammensetzungen zur schmerzbehandlung |
CN104023743B (zh) | 2011-10-25 | 2017-05-03 | 普罗西纳治疗有限公司 | 抗体制剂和方法 |
CN103930096B (zh) | 2011-10-31 | 2017-05-31 | Xeris药物公司 | 用于治疗糖尿病的制剂 |
US9643996B2 (en) * | 2011-11-04 | 2017-05-09 | Battelle Memorial Institute | Processes for producing protein microparticles |
EP2601941A1 (de) | 2011-12-06 | 2013-06-12 | Ludwig-Maximilians-Universität München | Verbindungen auf beta-O/S/N-Fettsäurebasis als Antibakterium- und Antiprotozoenmittel |
MX2014007277A (es) | 2011-12-16 | 2014-07-28 | Novartis Ag | Aparato de aerosolizacion para administracion de farmaco independiente del perfil de inhalacion. |
US20150010527A1 (en) | 2012-02-01 | 2015-01-08 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
ES2691083T3 (es) | 2012-04-05 | 2018-11-23 | University Of Florida Research Foundation, Inc. | Composición para el tratamiento de fibrosis quística y la inducción de secreción de iones |
US8753643B1 (en) | 2012-04-11 | 2014-06-17 | Life-Science Innovations, Llc | Spray dried compositions and methods of use |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
RU2666963C2 (ru) | 2012-04-13 | 2018-09-13 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Агрегированные частицы |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
WO2014005103A2 (en) | 2012-06-28 | 2014-01-03 | Ansun Biopharma, Inc. | Microparticle formulations for delivery to the lower and central respiratory tract and methods of manufacture |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
EP2911690A1 (de) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalierbare influenza-impfstoffzusammensetzungen und verfahren |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
WO2014124096A1 (en) | 2013-02-06 | 2014-08-14 | Perosphere Inc. | Stable glucagon formulations |
US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
EP3427730B1 (de) | 2013-03-11 | 2024-07-10 | University of Florida Research Foundation, Inc. | Materialien und methoden zur verbesserung der lungenfunktion |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
KR102499439B1 (ko) | 2013-03-15 | 2023-02-13 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
JP2016518388A (ja) | 2013-04-30 | 2016-06-23 | オティトピック インク. | 乾燥粉末配合および使用方法 |
WO2014207213A1 (en) | 2013-06-28 | 2014-12-31 | Medizinische Universität Innsbruck | Novel inhibitors of protein kinase c epsilon signaling |
MX2020009878A (es) | 2013-07-18 | 2022-07-27 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos. |
JP2016530930A (ja) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | 通気装置及び方法 |
EP3030298B1 (de) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Vernebler |
PL2835146T3 (pl) | 2013-08-09 | 2021-04-06 | Boehringer Ingelheim International Gmbh | Nebulizator |
US9993488B2 (en) | 2014-02-20 | 2018-06-12 | Otitopic Inc. | Dry powder formulations for inhalation |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
ES2913297T3 (es) | 2014-05-07 | 2022-06-01 | Boehringer Ingelheim Int | Nebulizador |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
EP2947460A1 (de) | 2014-05-22 | 2015-11-25 | Medizinische Universität Wien | Personalisierte Therapie von Entzündungen um Zusammenhang mit Krebs mithilfe von Verfahren zur Bestimmung der Empfänglichkeit auf die Behandlung mit EGFR-Hemmern/-Antagonisten |
WO2016007682A1 (en) | 2014-07-08 | 2016-01-14 | Amphastar Pharmaceuticals Inc. | Micronized insulin, micronized insulin analogues, and methods of manufacturing the same |
CA2957399C (en) | 2014-08-06 | 2023-09-26 | Xeris Pharmaceuticals, Inc. | Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes |
US10575417B2 (en) | 2014-09-08 | 2020-02-25 | The Stanley Works Israel Ltd. | Jobsite communications center |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US20170304459A1 (en) | 2014-10-10 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
EP3204039B1 (de) | 2014-10-10 | 2022-06-08 | The Regents Of The University Of Michigan | Nanoemulsionszusammensetzungen zur prävention, unterdrückung oder eliminierung von allergischen und entzündlichen erkrankungen |
EP3212212B1 (de) | 2014-10-31 | 2020-09-23 | Monash University | Puderzubereitung |
EP3616689A1 (de) | 2014-11-24 | 2020-03-04 | Entrinsic Health Solutions, Inc. | Aminosäurezusammensetzungen zur behandlung der symptome einer krankheit |
RU2017125957A (ru) | 2015-01-04 | 2019-02-04 | Проталикс Лтд. | Модифицированная днказа и ее применения |
WO2016135139A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 2,3-dihydrocyclopenta[b]quinoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135137A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Substituted 4-(phenylamino)quinoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135138A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135140A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 4-aminoquinazoline derivatives as mth1 inhibitors for the therapy of cancer |
US10864190B2 (en) | 2015-04-22 | 2020-12-15 | CeMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH | Combination of an antiandrogen with a vitamin K antagonist or with a gamma-glutamyl carboxylase inhibitor for the therapy of androgen receptor positive cancer |
CN108704204A (zh) * | 2015-05-16 | 2018-10-26 | 苏州汉方医药有限公司 | 由手动悬浮微颗粒发生器和鱼腥草或鱼腥草素组成的药盒 |
WO2016196976A1 (en) | 2015-06-04 | 2016-12-08 | Xeris Pharmaceuticals, Inc. | Glucagon delivery apparatuses and related methods |
US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
EP3307295A1 (de) | 2015-06-10 | 2018-04-18 | Xeris Pharmaceuticals, Inc. | Verwendung von niedrigdosiertem glucagon |
US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
HUE056897T2 (hu) | 2015-12-09 | 2022-03-28 | Univ Wien Med | Monomaleimid-funkcionalizált platinavegyületek rákterápiához |
CN106968984B (zh) * | 2015-12-11 | 2020-10-23 | 松下知识产权经营株式会社 | 涡轮机 |
US10322168B2 (en) | 2016-01-07 | 2019-06-18 | Amphastar Pharmaceuticals, Inc. | High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same |
EP3402788A1 (de) | 2016-01-15 | 2018-11-21 | Universität Hamburg | Verbindungen vom flavonoidtyp mit einem o-rhamnosyl-rückstand |
US11833118B2 (en) | 2016-01-20 | 2023-12-05 | Flurry Powders, Llc | Encapsulation of lipophilic ingredients in dispersible spray dried powders suitable for inhalation |
EP3405175A4 (de) | 2016-01-20 | 2019-09-25 | Flurry Powders, LLC | Verkapselung von lipophilen inhaltsstoffen in dispergierbaren sprühgetrockneten inhalierbaren pulvern |
CN114847965A (zh) | 2016-02-01 | 2022-08-05 | 英凯达治疗公司 | 电子监测联合吸入药理学疗法管理心律失常 |
CA3013988A1 (en) | 2016-02-15 | 2017-08-24 | Cemm-Forschungszentrum Fur Molekulare Medizin Gmbh | Taf1 inhibitors for the therapy of cancer |
US20190111069A1 (en) | 2016-04-15 | 2019-04-18 | Oxford University Innovation Limited | Adenosine Receptor Modulators for the Treatment of Circadian Rhythm Disorders |
US10704425B2 (en) * | 2016-07-14 | 2020-07-07 | General Electric Company | Assembly for a gas turbine engine |
MX2019003821A (es) | 2016-10-04 | 2019-12-18 | Univ Florida | Composiciones de aminoacidos y usos de las mismas. |
KR20190103154A (ko) | 2016-11-14 | 2019-09-04 | 체엠엠 - 포르슝스첸트룸 퓨어 몰레쿨라레 메디친 게엠베하 | 암의 치료법을 위한 brd4 억제제 및 항폴레이트의 조합 |
WO2018209107A1 (en) | 2017-05-10 | 2018-11-15 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
JP7210476B2 (ja) | 2017-05-22 | 2023-01-23 | インスメッド インコーポレイテッド | リポ‐グリコペプチド可切断性誘導体及びその使用 |
WO2018222922A1 (en) | 2017-06-02 | 2018-12-06 | Xeris Pharmaceuticals, Inc. | Precipitation resistant small molecule drug formulations |
WO2019016240A1 (en) | 2017-07-19 | 2019-01-24 | Leadiant Biosciences Ltd | ADENOSINE DEAMINASE FOR TREATING OR IMPROVING SCLERRODERMIS ASSOCIATED VASCULOPATHY |
US20210179591A1 (en) | 2017-12-05 | 2021-06-17 | Eth Zurich | New compounds for use as a therapeutically active substance and in particular for use in the treatment of tumors |
US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
AU2019247641A1 (en) | 2018-04-06 | 2020-11-12 | Zilentin AG | Bumetanide derivatives for the therapy of hyperhidrosis |
US20210163406A1 (en) | 2018-04-06 | 2021-06-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bumetanide Derivatives for the Therapy of Stroke and Other Neurological Diseases/Disorders Involving NKCCs |
FI3599243T3 (fi) | 2018-07-26 | 2023-06-22 | Cvie Therapeutics Ltd | 17beeta-heterosyklyylidigitaliksen kaltaisia yhdisteitä sydämen vajaatoiminnan hoitoon |
AU2019407650B2 (en) | 2018-12-17 | 2022-10-27 | Tolremo Therapeutics Ag | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of cancer |
JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
RU193395U1 (ru) * | 2019-06-17 | 2019-10-28 | Евгений Викторович Крейдин | Генератор сухого солевого аэрозоля |
US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
KR20220079597A (ko) | 2019-10-02 | 2022-06-13 | 톨레모 테라퓨틱스 아게 | 헤테로사이클릭 유도체, 약학 조성물 및 암의 치료 또는 개선에서 그들의 용도 |
WO2021064141A1 (en) | 2019-10-02 | 2021-04-08 | Tolremo Therapeutics Ag | Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b |
ES2970792T3 (es) | 2019-10-09 | 2024-05-30 | Windtree Therapeutics Inc | Derivados de androstano con actividad como estimuladores puros o predominantemente puros de SERCA2A para el tratamiento de la insuficiencia cardíaca |
US20230124700A1 (en) | 2019-10-16 | 2023-04-20 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof |
WO2021074418A1 (en) | 2019-10-16 | 2021-04-22 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Carbazole-type cullin ring ubiquitin ligase compounds and uses thereof |
US20230158125A1 (en) | 2020-04-20 | 2023-05-25 | Sorrento Therapeutics, Inc. | Pulmonary Administration of ACE2 Polypeptides |
AU2021295432A1 (en) | 2020-06-25 | 2023-02-23 | Tolremo Therapeutics Ag | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease |
US12084419B2 (en) | 2020-06-27 | 2024-09-10 | Crescenta Biosciences | Cell metabolism modulating compounds and uses thereof |
EP3939578A1 (de) | 2020-07-13 | 2022-01-19 | Novaremed Ltd. | Verbindungen zur behandlung oder vorbeugung einer infektion, die aus einer coronavirus- und/oder einer coronavirusinduzierten erkrankung resultiert |
EP3964497A1 (de) | 2020-09-04 | 2022-03-09 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Substituierte vicinale diaminverbindungen und deren verwendung zur behandlung, linderung oder vorbeugung von schmerzen |
WO2022074656A1 (en) | 2020-10-07 | 2022-04-14 | Protalix Ltd. | Long-acting dnase |
CN116568671A (zh) | 2020-10-16 | 2023-08-08 | 分子医学研究中心责任有限公司 | 杂环Cullin-RING泛素连接酶化合物及其用途 |
CA3212085A1 (en) | 2021-04-07 | 2022-10-13 | Charles-Henry Fabritius | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer |
WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
WO2023203174A1 (en) | 2022-04-20 | 2023-10-26 | Proxygen Gmbh | Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof |
Family Cites Families (193)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE421211A (de) | 1936-05-02 | |||
GB621785A (en) | 1943-07-27 | 1949-04-20 | Teco Sa | Apparatus for the pulverisation of liquids in the form of aerosols |
US2598525A (en) * | 1950-04-08 | 1952-05-27 | E & J Mfg Co | Automatic positive pressure breathing machine |
US3362405A (en) * | 1964-04-06 | 1968-01-09 | Hamilton O. Hazel | Method and apparatus for admixing gas with solid particles |
US3674901A (en) * | 1966-07-26 | 1972-07-04 | Nat Patent Dev Corp | Surgical sutures |
US3425600A (en) * | 1966-08-11 | 1969-02-04 | Abplanalp Robert H | Pressurized powder dispensing device |
DE2121066C3 (de) | 1971-04-29 | 1974-05-30 | Knapsack Ag, 5033 Huerth-Knapsack | Zerstäubungsdüse für einen Zerstäubungstrockner |
US4052255A (en) | 1971-10-07 | 1977-10-04 | J. M. Huber Corporation | Spray dryer discharge system |
US3790079A (en) * | 1972-06-05 | 1974-02-05 | Rnb Ass Inc | Method and apparatus for generating monodisperse aerosol |
US3825188A (en) * | 1973-03-23 | 1974-07-23 | Par Wey Mfg Co | Liquid spray head |
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
GB1479283A (en) * | 1973-07-23 | 1977-07-13 | Bespak Industries Ltd | Inhaler for powdered medicament |
FR2257351A1 (en) | 1974-01-11 | 1975-08-08 | Obert Jean Claude | Aerosol device for solid vaccines - feed and breaker screws deliver material sideways into blower chamber |
IT1016489B (it) * | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
US4005711A (en) * | 1975-01-13 | 1977-02-01 | Syntex Puerto Rico, Inc. | Inhalation device |
US3964483A (en) * | 1975-01-13 | 1976-06-22 | Syntex Puerto Rico, Inc. | Inhalation device |
FR2299011A1 (fr) * | 1975-01-29 | 1976-08-27 | Obert Jean Claude | Generateur d'aerosols de part |
US3991304A (en) * | 1975-05-19 | 1976-11-09 | Hillsman Dean | Respiratory biofeedback and performance evaluation system |
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
US4035317A (en) * | 1975-06-30 | 1977-07-12 | American Cyanamid Company | Rapidly dissolving, water-soluble polymers and spray drying method for their production |
GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
US3994421A (en) * | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
JPS5254709A (en) * | 1975-10-31 | 1977-05-04 | Lion Corp | Multi-stage spray drying method |
DK150716C (da) | 1976-12-01 | 1987-10-26 | Niro Atomizer As | Fremgangsmaade ved behandling af et pulver- eller partikelformet produkt og apparat til brug ved udoevelse af fremgangsmaaden |
FI54093C (fi) | 1976-12-20 | 1978-10-10 | Outokumpu Oy | Saett att framstaella pulverformigt selen fraon raoselen |
US4211769A (en) * | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
NL7712041A (en) | 1977-11-01 | 1979-05-03 | Handelmaatschappij Voorheen Be | Suction equipment for powdery material - incorporates ejector type suction pump and cyclone type separator |
JPS5829150B2 (ja) | 1977-12-03 | 1983-06-21 | ナカヤ産業株式会社 | 噴霧装置 |
US4268460A (en) * | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
DE2960616D1 (en) * | 1978-05-03 | 1981-11-12 | Fisons Plc | Inhalation device |
US4253468A (en) * | 1978-08-14 | 1981-03-03 | Steven Lehmbeck | Nebulizer attachment |
US4503035B1 (en) * | 1978-11-24 | 1996-03-19 | Hoffmann La Roche | Protein purification process and product |
SU1003926A1 (ru) | 1979-01-24 | 1983-03-15 | Всесоюзный Научно-Исследовательский И Конструкторский Институт Автогенного Машиностроения | Порошковый питатель |
DE3013839A1 (de) | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
IT1116047B (it) * | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
JPS6034925B2 (ja) * | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
IE50472B1 (en) * | 1979-10-30 | 1986-04-30 | Riker Laboratories Inc | Breath actuated devices for administering powdered medicaments |
US4294624A (en) * | 1980-03-14 | 1981-10-13 | Veltman Preston Leonard | Drying co-mingled carbohydrate solution and recycled product by dielectric heating |
US4452239A (en) * | 1980-03-25 | 1984-06-05 | Hilal Malem | Medical nebulizing apparatus |
US4484577A (en) * | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
GB2105189B (en) | 1981-07-24 | 1985-03-20 | Fisons Plc | Inhalation drugs |
US5260306A (en) * | 1981-07-24 | 1993-11-09 | Fisons Plc | Inhalation pharmaceuticals |
EP0072046B1 (de) * | 1981-07-24 | 1986-01-15 | FISONS plc | Inhalierbare Arzneimittel, Verfahren zu deren Herstellung und pharmazeutische Formulierungen diese enthaltend |
KR890000664B1 (ko) | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
CH656077A5 (de) | 1982-01-29 | 1986-06-13 | Glatt Maschinen & Apparatebau | Verfahren zum ueberziehen von teilchen, insbesondere arzneimittel-teilchen, und vorrichtung zur durchfuehrung des verfahrens. |
US4823784A (en) * | 1982-04-30 | 1989-04-25 | Cadema Medical Products, Inc. | Aerosol inhalation apparatus |
US4659696A (en) * | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
CH662277A5 (de) * | 1982-10-08 | 1987-09-30 | Glaxo Group Ltd | Medikamentenverabreichungsgeraet. |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
CA1200416A (en) * | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
US4486435A (en) | 1983-05-16 | 1984-12-04 | Basf Wyandotte Corporation | Spray-dried vitamin powders using hydrophobic silica |
US5038769A (en) | 1983-06-29 | 1991-08-13 | Krauser Robert S | Method and apparatus for treating ailments |
US4649911A (en) * | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
DE3345722A1 (de) * | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Inhalator |
US4534343A (en) * | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
US4721709A (en) * | 1984-07-26 | 1988-01-26 | Pyare Seth | Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions |
US4624251A (en) * | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
NZ209900A (en) * | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
FR2575678B1 (fr) * | 1985-01-04 | 1988-06-03 | Saint Gobain Vitrage | Ejecteur pneumatique de poudre |
US4942544A (en) * | 1985-02-19 | 1990-07-17 | Kenneth B. McIntosh | Medication clock |
US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
PH26882A (en) * | 1985-07-30 | 1992-11-16 | Glaxo Group Ltd | Devices for administering medicaments to patients |
US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
SE453566B (sv) * | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
US5017372A (en) * | 1986-04-14 | 1991-05-21 | Medicis Corporation | Method of producing antibody-fortified dry whey |
US4739754A (en) * | 1986-05-06 | 1988-04-26 | Shaner William T | Suction resistant inhalator |
US4790305A (en) * | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
US4926852B1 (en) * | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
US5042975A (en) * | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
ES2053549T3 (es) * | 1986-08-11 | 1994-08-01 | Innovata Biomed Ltd | Un proceso para la preparacion de una formulacion farmaceutica apropiada para inhalacion. |
US4871489A (en) | 1986-10-07 | 1989-10-03 | Corning Incorporated | Spherical particles having narrow size distribution made by ultrasonic vibration |
US4760093A (en) * | 1986-10-21 | 1988-07-26 | American Home Products Corporation (Del.) | Spray dried acetaminophen |
DE3636669C2 (de) * | 1986-10-28 | 2001-08-16 | Siemens Ag | Anordnung zur Zufuhr von Aerosol zu den Luftwegen und/oder Lungen eines Patienten |
US5049388A (en) * | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
DE3642106A1 (de) | 1986-12-10 | 1988-06-16 | Bayer Ag | Verfahren zur herstellung von polymerisatpulvern durch zerstaeubungstrocknung |
US5093316A (en) * | 1986-12-24 | 1992-03-03 | John Lezdey | Treatment of inflammation |
US4784878A (en) | 1987-04-06 | 1988-11-15 | Damrow Company, Inc. | Spray drying method and apparatus for concurrent particle coating |
GB8710290D0 (en) * | 1987-04-30 | 1987-06-03 | Unilever Plc | Preparation of granular detergent composition |
US4835187A (en) * | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
US5139016A (en) * | 1987-08-07 | 1992-08-18 | Sorin Biomedica S.P.A. | Process and device for aerosol generation for pulmonary ventilation scintigraphy |
IT1222509B (it) * | 1987-08-17 | 1990-09-05 | Miat Spa | Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli |
CH672048A5 (de) * | 1987-09-16 | 1989-10-31 | Nestle Sa | |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
US5081228A (en) * | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
US4968607A (en) * | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
JP2524379B2 (ja) | 1988-01-29 | 1996-08-14 | 大川原化工機株式会社 | ノズル装置とそれを組込んでなるスプレ―ドライヤ―装置 |
ATE98094T1 (de) | 1988-06-03 | 1993-12-15 | Niro Sterner Inc | Spruehtrocknungsverfahren und vorrichtung zum gleichzeitigen beschichten von teilchen. |
IT1217890B (it) * | 1988-06-22 | 1990-03-30 | Chiesi Farma Spa | Dispositivo per l'inalazione di aerosol dosati |
US5066522A (en) | 1988-07-14 | 1991-11-19 | Union Carbide Chemicals And Plastics Technology Corporation | Supercritical fluids as diluents in liquid spray applications of adhesives |
EP0360340A1 (de) * | 1988-09-19 | 1990-03-28 | Akzo N.V. | Peptidenthaltende Zubereitung zur intranasalen Verabreichung |
DE68914932T2 (de) * | 1988-10-04 | 1994-08-11 | Univ Johns Hopkins | Inhalationsgerät für Aerosolen. |
US4984158A (en) * | 1988-10-14 | 1991-01-08 | Hillsman Dean | Metered dose inhaler biofeedback training and evaluation system |
US5011678A (en) * | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
GB8903593D0 (en) * | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
IT1228459B (it) * | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
SE466684B (sv) * | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
US5009367A (en) * | 1989-03-22 | 1991-04-23 | Union Carbide Chemicals And Plastics Technology Corporation | Methods and apparatus for obtaining wider sprays when spraying liquids by airless techniques |
US5206306A (en) * | 1989-03-31 | 1993-04-27 | The B. F. Goodrich Company | Process for making a polymer for an optical substrate by hydrogenating a cycloolefin copolymer |
IT1230313B (it) * | 1989-07-07 | 1991-10-18 | Somova Spa | Inalatore per medicamenti in capsule. |
US5232707A (en) | 1989-07-10 | 1993-08-03 | Syntex (U.S.A.) Inc. | Solvent extraction process |
US5238920A (en) * | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
IT1237118B (it) * | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
GB9001635D0 (en) * | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
DE4004904A1 (de) * | 1990-02-16 | 1990-09-13 | Gerhard Brendel | Trommel-applikator |
WO1991016882A1 (en) * | 1990-05-08 | 1991-11-14 | Liposome Technology, Inc. | Direct spray-dried drug/lipid powder composition |
US5000888A (en) * | 1990-05-23 | 1991-03-19 | Basf Corporation | Process for spray drying riboflavin to produce a granulate product having low binder content |
ES2078447T3 (es) | 1990-06-15 | 1995-12-16 | Merck & Co Inc | Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales. |
IT1243344B (it) * | 1990-07-16 | 1994-06-10 | Promo Pack Sa | Inalatore plurimonodose per medicamenti in polvere |
US5037912A (en) * | 1990-07-26 | 1991-08-06 | The Goodyear Tire & Rubber Company | Polymerization of 1,3-butadiene to trans-1,4-polybutadiene with organolithium and alkali metal alkoxide |
GB9017155D0 (en) * | 1990-08-03 | 1990-09-19 | Ici Plc | Spray drying |
US5235969A (en) * | 1990-08-20 | 1993-08-17 | Intersurgical (Guernsey) Limited | Nebulizer having combined structure for removing particles over two microns |
US5230884A (en) * | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
US5200399A (en) * | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
US5217004A (en) * | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
EP0563120B1 (de) * | 1990-12-17 | 1997-10-01 | Minnesota Mining And Manufacturing Company | Inhalationsgerät |
US5099833A (en) * | 1991-02-19 | 1992-03-31 | Baxter International Inc. | High efficiency nebulizer having a flexible reservoir |
WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
US5186164A (en) * | 1991-03-15 | 1993-02-16 | Puthalath Raghuprasad | Mist inhaler |
DE59107894D1 (de) * | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
GB9106648D0 (en) * | 1991-03-28 | 1991-05-15 | Rhone Poulenc Rorer Ltd | New inhaler |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
DE4193534T1 (de) * | 1991-04-15 | 1997-07-24 | Leiras Oy | Vorrichtung zum Abmessen einer Dosis pulverförmigen Arzneimittels für die Inhalation |
DE4117751A1 (de) * | 1991-05-30 | 1992-12-03 | Bayer Ag | Verfahren zur isolierung von polycarbonaten |
ES2141108T3 (es) * | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5269980A (en) | 1991-08-05 | 1993-12-14 | Northeastern University | Production of polymer particles in powder form using an atomization technique |
US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
DE69220317T2 (de) | 1991-10-01 | 1997-10-16 | Takeda Chemical Industries Ltd | Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe |
US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
US5320094A (en) * | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
DE69306755T2 (de) * | 1992-01-21 | 1997-04-10 | Stanford Res Inst Int | Verbessertes verfahren zur herstellung von mikronisierter polypeptidarzneimitteln |
US5639441A (en) | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
WO1993025198A1 (en) | 1992-06-12 | 1993-12-23 | Teijin Limited | Ultrafine powder for inhalation and production thereof |
US5376359A (en) * | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
AU4198793A (en) * | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
NZ257212A (en) | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
ES2127835T3 (es) * | 1992-10-26 | 1999-05-01 | Sanol Arznei Schwarz Gmbh | Procedimiento para la preparacion de microcapsulas. |
GB9226474D0 (en) * | 1992-12-18 | 1993-02-10 | Ici Plc | Production of particulate materials |
US5364838A (en) * | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
US5354934A (en) * | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
IL105658A (en) * | 1993-05-11 | 1995-10-31 | Ultrasonic Dryer Ltd | Spray drying system |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
TW402506B (en) * | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
US5595761A (en) | 1994-01-27 | 1997-01-21 | The Board Of Regents Of The University Of Oklahoma | Particulate support matrix for making a rapidly dissolving tablet |
US5635210A (en) | 1994-02-03 | 1997-06-03 | The Board Of Regents Of The University Of Oklahoma | Method of making a rapidly dissolving tablet |
ATE268605T1 (de) | 1994-03-04 | 2004-06-15 | Genentech Inc | Pharmazeutische akzeptabel dnase zusammensetzung |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
PL179443B1 (pl) | 1994-03-07 | 2000-09-29 | Inhale Therapeutic Syst | Kompozycja insuliny, sposób wytwarzania kompozycji insuliny i sposób wytwarzania dawki insuliny w postaci aerozolu PL PL PL PL |
ES2245780T3 (es) * | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | Metodos y composiciones para la formulacion de interferones como un polvo seco. |
US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
AU701440B2 (en) * | 1994-09-29 | 1999-01-28 | Quadrant Drug Delivery Limited | Spray-dried microparticles as therapeutic vehicles |
US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
WO1996028205A1 (en) | 1995-03-14 | 1996-09-19 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
US5922253A (en) | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
US5667806A (en) * | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
US5687905A (en) | 1995-09-05 | 1997-11-18 | Tsai; Shirley Cheng | Ultrasound-modulated two-fluid atomization |
DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
DE19617487A1 (de) | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
US6503480B1 (en) * | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
TW305239U (en) | 1996-06-28 | 1997-05-11 | Ind Tech Res Inst | Generating apparatus of gaseous glue capable of distributing particles with narrow diameters |
JP3585654B2 (ja) | 1996-07-11 | 2004-11-04 | 株式会社パウダリングジャパン | 2段乾燥式スプレードライヤー装置 |
US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
EP0952821A4 (de) | 1996-12-31 | 2006-07-26 | Nektar Therapeutics | Verfahren zur sprühtrocknung wässriger suspensionen von hydrophoben arzneistoffen und hydrophilen hilfsstoffen sowie mittels eines solchen verfahrens hergestellte zusammensetzungen |
US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
US6383810B2 (en) * | 1997-02-14 | 2002-05-07 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
US6051257A (en) * | 1997-02-24 | 2000-04-18 | Superior Micropowders, Llc | Powder batch of pharmaceutically-active particles and methods for making same |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
GB9727102D0 (en) | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
GB9825883D0 (en) | 1998-11-27 | 1999-01-20 | Aea Technology Plc | Formation of monodisperse particles |
US6223455B1 (en) | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
US20020081266A1 (en) * | 1999-08-20 | 2002-06-27 | Norton Healthcare Ltd. | Spray dried powders for pulmonary or nasal administration |
NL1013893C2 (nl) | 1999-12-20 | 2001-06-21 | Stork Friesland Bv | Inrichting voor het verstuiven van een vloeibaar product, een daarvan voorziene sproeidroog- en conditionerings-inrichting alsmede een werkwijze voor het conditioneren van een vloeibaar product. |
US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
US6455028B1 (en) | 2001-04-23 | 2002-09-24 | Pharmascience | Ipratropium formulation for pulmonary inhalation |
EP1446104B2 (de) | 2001-11-01 | 2011-08-03 | Novartis AG | Sprühtrocknungsverfahren |
-
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