UA47475C2 - Похідні заміщеного бензолсульфонаміду, спосіб їх одержання та фармацевтична композиція - Google Patents

Похідні заміщеного бензолсульфонаміду, спосіб їх одержання та фармацевтична композиція Download PDF

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Publication number
UA47475C2
UA47475C2 UA98115994A UA98115994A UA47475C2 UA 47475 C2 UA47475 C2 UA 47475C2 UA 98115994 A UA98115994 A UA 98115994A UA 98115994 A UA98115994 A UA 98115994A UA 47475 C2 UA47475 C2 UA 47475C2
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Ukraine
Prior art keywords
alkyl
phenyl
methyl
radicals
phenylisoxazol
Prior art date
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UA98115994A
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English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Джон Дж. Теллі
Джеймс В. Малєха
Стівен Бьортеншо
Месю Дж. Гренето
Джеффрі С. Картер
Джинглін Лі
Сринівазан Нагараян
Девід Л. Браун
Донелд Дж. мол. Роджер
Томес Д. Пєннінг
Іш К. Ханна
Сяндун Сю
Річард М. Вайер
Original Assignee
Дж.Д.Сьорль Енд Ко
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Application filed by Дж.Д.Сьорль Енд Ко filed Critical Дж.Д.Сьорль Енд Ко
Publication of UA47475C2 publication Critical patent/UA47475C2/uk

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/18—Sulfonamides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
UA98115994A 1996-04-12 1997-11-04 Похідні заміщеного бензолсульфонаміду, спосіб їх одержання та фармацевтична композиція UA47475C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63151496A 1996-04-12 1996-04-12
PCT/US1997/005497 WO1997038986A1 (en) 1996-04-12 1997-04-11 Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors

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