TR201910320T4 - Karaciğer organoidi, kullanımları ve elde edilmesine yönelik kültür yöntemi. - Google Patents

Karaciğer organoidi, kullanımları ve elde edilmesine yönelik kültür yöntemi. Download PDF

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Publication number
TR201910320T4
TR201910320T4 TR2019/10320T TR201910320T TR201910320T4 TR 201910320 T4 TR201910320 T4 TR 201910320T4 TR 2019/10320 T TR2019/10320 T TR 2019/10320T TR 201910320 T TR201910320 T TR 201910320T TR 201910320 T4 TR201910320 T4 TR 201910320T4
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obtaining
culture method
liver organoid
organoid
liver
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TR2019/10320T
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Huch Ortega Meritxell
Carolus Clevers Johannes
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Koninklijke Nederlandse Akademie Van Wetenschappen
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Publication of TR201910320T4 publication Critical patent/TR201910320T4/tr

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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Abstract

Buluş, bir karaciğer organoidi, kullanımları ve elde edilmesine yönelik yöntemler ile ilgilidir.
TR2019/10320T 2010-07-29 2011-07-29 Karaciğer organoidi, kullanımları ve elde edilmesine yönelik kültür yöntemi. TR201910320T4 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36873610P 2010-07-29 2010-07-29
EP10171265A EP2412800A1 (en) 2010-07-29 2010-07-29 Liver organoid, uses thereof and culture method for obtaining them
US201161520569P 2011-06-10 2011-06-10

Publications (1)

Publication Number Publication Date
TR201910320T4 true TR201910320T4 (tr) 2019-08-21

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TR2019/10320T TR201910320T4 (tr) 2010-07-29 2011-07-29 Karaciğer organoidi, kullanımları ve elde edilmesine yönelik kültür yöntemi.

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US (3) US9765301B2 (tr)
EP (3) EP2412800A1 (tr)
JP (3) JP6110299B2 (tr)
KR (2) KR102034121B1 (tr)
CN (1) CN103237888B (tr)
AU (3) AU2011284445C1 (tr)
BR (1) BR112013002249A2 (tr)
CA (2) CA3064220A1 (tr)
DK (1) DK2598633T3 (tr)
ES (1) ES2735248T3 (tr)
HR (1) HRP20191087T1 (tr)
HU (1) HUE044255T2 (tr)
IL (1) IL224409A (tr)
MX (1) MX353579B (tr)
PL (1) PL2598633T3 (tr)
PT (1) PT2598633T (tr)
RU (1) RU2579995C2 (tr)
SG (3) SG187219A1 (tr)
TR (1) TR201910320T4 (tr)
WO (1) WO2012014076A2 (tr)

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