|
PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
EP1065207A1
(en)
*
|
1999-07-02 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
|
|
WO2001025220A1
(en)
|
1999-10-07 |
2001-04-12 |
Amgen Inc. |
Triazine kinase inhibitors
|
|
DE19948417A1
(de)
*
|
1999-10-07 |
2001-04-19 |
Morphochem Ag |
Imidazol-Derivate und ihre Verwendung als Arzneimittel
|
|
ATE380031T1
(de)
|
1999-12-10 |
2007-12-15 |
Pfizer Prod Inc |
Pyrrolo 2,3-d pyrimidinderivate enthaltende zusammensetzungen
|
|
ES2452696T3
(es)
*
|
2000-01-24 |
2014-04-02 |
Genzyme Corporation |
Métodos para detectar inhibidores de JAK3
|
|
EP1875900A3
(en)
*
|
2000-01-24 |
2010-07-21 |
Genzyme Corporation |
JAK/STAT pathway inhibitors and the use thereof for the treatment of osteoarthritis
|
|
MY137020A
(en)
*
|
2000-04-27 |
2008-12-31 |
Abbott Lab |
Diazabicyclic central nervous system active agents
|
|
CA2412560C
(en)
|
2000-06-26 |
2008-12-30 |
Pfizer Products Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
|
|
US6864255B2
(en)
|
2001-04-11 |
2005-03-08 |
Amgen Inc. |
Substituted triazinyl amide derivatives and methods of use
|
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
|
US7301023B2
(en)
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
KR100875380B1
(ko)
*
|
2001-06-23 |
2008-12-23 |
아벤티스 파마슈티칼스 인크. |
단백질 키나제 억제제로서의 피롤로피리미딘
|
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
US7323469B2
(en)
|
2001-08-07 |
2008-01-29 |
Novartis Ag |
7H-pyrrolo[2,3-d]pyrimidine derivatives
|
|
GT200200234A
(es)
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
|
US6642381B2
(en)
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
|
ES2262996T3
(es)
|
2002-01-07 |
2006-12-01 |
Eisai Co., Ltd. |
Deazapurinas y sus usos.
|
|
GB0202679D0
(en)
*
|
2002-02-05 |
2002-03-20 |
Glaxo Group Ltd |
Novel compounds
|
|
EP1388541A1
(en)
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
|
CA2507392A1
(en)
|
2002-11-26 |
2004-06-10 |
Pfizer Products Inc. |
Method of treatment of transplant rejection
|
|
WO2004093812A2
(en)
*
|
2003-04-22 |
2004-11-04 |
Irm Llc |
Compounds that induce neuronal differentiation in embryonic stem cells
|
|
CA2543116A1
(en)
*
|
2003-10-27 |
2005-05-19 |
Genelabs Technologies, Inc. |
Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
|
|
US20050165029A1
(en)
*
|
2004-01-13 |
2005-07-28 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
|
GB0403606D0
(en)
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
|
CA2563699C
(en)
|
2004-04-23 |
2014-03-25 |
Exelixis, Inc. |
Kinase modulators and method of use
|
|
EP1768662A2
(en)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
CA2572314A1
(en)
|
2004-06-29 |
2006-01-12 |
Christopher N. Farthing |
Pyrrolo[2,3-d]pyrimidines that modulate ack1 and lck activity
|
|
TW200615268A
(en)
|
2004-08-02 |
2006-05-16 |
Osi Pharm Inc |
Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
|
FR2880626B1
(fr)
*
|
2005-01-13 |
2008-04-18 |
Aventis Pharma Sa |
Derives de la purine, compositions les contenant et utilisation
|
|
WO2006091450A1
(en)
*
|
2005-02-18 |
2006-08-31 |
Lexicon Genetics Incorporated |
4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
|
|
CN101175753B
(zh)
|
2005-05-13 |
2011-03-23 |
Irm责任有限公司 |
作为蛋白激酶抑制剂的化合物和组合物
|
|
CN102127078A
(zh)
|
2005-07-14 |
2011-07-20 |
安斯泰来制药株式会社 |
Janus激酶3的杂环类抑制剂
|
|
EP1910358A2
(en)
|
2005-07-14 |
2008-04-16 |
Astellas Pharma Inc. |
Heterocyclic janus kinase 3 inhibitors
|
|
EP2270014A1
(en)
|
2005-09-22 |
2011-01-05 |
Incyte Corporation |
Azepine inhibitors of janus kinases
|
|
EP1931674B1
(en)
|
2005-09-30 |
2012-12-12 |
Vertex Pharmaceuticals Incorporated |
Deazapurines useful as inhibitors of janus kinases
|
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
EP3838903B1
(en)
|
2005-12-13 |
2023-11-22 |
Incyte Holdings Corporation |
Pyrrolo[2,3-d]pyrimidine derivative as janus kinase inhibitor
|
|
KR20090007319A
(ko)
*
|
2006-03-11 |
2009-01-16 |
베르날리스 (알 앤드 디) 리미티드 |
Ｈｓｐ90 억제제로서 사용되는 피롤로피리미딘 유도체
|
|
SG170828A1
(en)
|
2006-04-05 |
2011-05-30 |
Vertex Pharmaceuticals Inc Us |
Deazapurines useful as inhibitors of janus kinases
|
|
GB0608176D0
(en)
*
|
2006-04-25 |
2006-06-07 |
Astex Therapeutics Ltd |
Pharmaceutical Compounds
|
|
EP3421471B1
(en)
|
2006-04-25 |
2021-05-26 |
Astex Therapeutics Limited |
Purine and deazapurine derivatives as pharmaceutical compounds
|
|
WO2008012635A2
(en)
*
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
US20080161320A1
(en)
*
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
SG174772A1
(en)
*
|
2006-09-11 |
2011-10-28 |
Curis Inc |
Multi-functional small molecules as anti-proliferative agents
|
|
WO2008075007A1
(en)
*
|
2006-12-21 |
2008-06-26 |
Cancer Research Technology Limited |
Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
|
|
AR064416A1
(es)
*
|
2006-12-21 |
2009-04-01 |
Cancer Rec Tech Ltd |
Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
|
|
US8513270B2
(en)
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
|
MX2009007426A
(es)
|
2007-01-12 |
2009-07-17 |
Astellas Pharma Inc |
Compuesto de piridina condensado.
|
|
PE20090996A1
(es)
*
|
2007-04-02 |
2009-07-15 |
Palau Pharma Sa |
Derivados de pirrolopirimidina como inhibidores de cinasa jak3
|
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
CN101932582B
(zh)
|
2007-06-13 |
2013-09-25 |
因塞特公司 |
詹纳斯激酶抑制剂(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的盐
|
|
GB0713602D0
(en)
*
|
2007-07-12 |
2007-08-22 |
Syngenta Participations Ag |
Chemical compounds
|
|
JP5536647B2
(ja)
*
|
2007-07-27 |
2014-07-02 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ピロロピリミジン
|
|
CN101772502A
(zh)
|
2007-08-08 |
2010-07-07 |
莱西肯医药有限公司 |
作为激酶抑制剂用于治疗癌和炎症的(7H-吡咯并[2,3-d]嘧啶-4-基)哌嗪类化合物
|
|
WO2009030871A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Vernalis R & D Ltd |
Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
|
|
ES2522365T3
(es)
|
2007-10-11 |
2014-11-14 |
Astrazeneca Ab |
Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B
|
|
KR101580482B1
(ko)
|
2007-11-16 |
2015-12-28 |
인사이트 홀딩스 코포레이션 |
야누스 키나제 억제제로서의 ４－피라졸릴－ｎ－아릴피리미딘－２－아민 및 ４－피라졸릴－ｎ－헤테로아릴피리미딘－２－아민
|
|
UA101493C2
(ru)
|
2008-03-11 |
2013-04-10 |
Инсайт Корпорейшн |
Производные азетидина и циклобутана как ингибиторы jak
|
|
EP2297153B1
(en)
|
2008-04-21 |
2015-05-27 |
Lexicon Pharmaceuticals, Inc. |
Limk2 inhibitors, compositions comprising them, and methods of their use
|
|
US8871753B2
(en)
|
2008-04-24 |
2014-10-28 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
DK2384326T3
(da)
|
2008-08-20 |
2014-05-05 |
Zoetis Llc |
Pyrrolo[2,3-d]pyrimidinforbindelser
|
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
|
JOP20190230A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
DE102009005193A1
(de)
*
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
|
|
WO2010085597A1
(en)
|
2009-01-23 |
2010-07-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
EP2396004A4
(en)
|
2009-02-11 |
2012-07-25 |
Reaction Biology Corp |
SELECTIVE KINASE HEMMER
|
|
EP3026052A1
(en)
|
2009-04-20 |
2016-06-01 |
Auspex Pharmaceuticals, Inc. |
Preparation of deuterated piperidine inhibitors of janus kinase 3
|
|
US8716303B2
(en)
*
|
2009-05-22 |
2014-05-06 |
Incyte Corporation |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
RS59632B1
(sr)
|
2009-05-22 |
2020-01-31 |
Incyte Holdings Corp |
3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori
|
|
BR112012000422A2
(pt)
*
|
2009-07-08 |
2017-05-09 |
Leo Pharma As |
composto, composição farmacêutica, uso de um composto, e, método para a prevenir tratar ou melhorar doenças do sistema imune
|
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
EP2473054B1
(en)
*
|
2009-09-04 |
2017-06-14 |
The Regents of the University of Michigan |
Compositions and methods for treatment of leukemia
|
|
PL2473049T3
(pl)
|
2009-09-04 |
2019-07-31 |
Biogen Ma Inc. |
Inhibitory kinazy tyrozynowej brutona
|
|
WO2011044481A1
(en)
|
2009-10-09 |
2011-04-14 |
Incyte Corporation |
Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
KR20120083452A
(ko)
|
2009-10-15 |
2012-07-25 |
화이자 인코포레이티드 |
피롤로［2,3-ｄ］피리미딘 화합물
|
|
US9074143B2
(en)
*
|
2009-12-11 |
2015-07-07 |
Uop Llc |
Process for producing hydrocarbon fuel
|
|
JP5739446B2
(ja)
|
2009-12-18 |
2015-06-24 |
ファイザー・インク |
ピロロ［２，３−ｄ］ピリミジン化合物
|
|
EP2531508A1
(en)
|
2010-02-05 |
2012-12-12 |
Pfizer Inc. |
Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors
|
|
MX2012009541A
(es)
*
|
2010-02-18 |
2012-10-01 |
Incyte Corp |
Derivados de ciclobutano y metilciclobutano como inhibidores de janus cinasa.
|
|
ME02386B
(me)
|
2010-03-10 |
2016-09-20 |
Incyte Holdings Corp |
Derivati piperidin-4-il azetidina kao inhibitori jak1
|
|
NZ603686A
(en)
|
2010-05-21 |
2014-11-28 |
Incyte Corp |
Topical formulation for a jak inhibitor
|
|
EP2590981B1
(en)
|
2010-07-09 |
2014-09-03 |
Leo Pharma A/S |
Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
|
|
KR101541086B1
(ko)
*
|
2010-08-20 |
2015-08-03 |
허치슨 메디파르마 리미티드 |
피롤로피리미딘 화합물 및 그 용도
|
|
CN102372717B
(zh)
*
|
2010-08-20 |
2014-06-18 |
和记黄埔医药（上海）有限公司 |
吡咯并嘧啶类化合物及其用途
|
|
WO2012022045A1
(en)
*
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
|
TWI401258B
(zh)
*
|
2010-09-08 |
2013-07-11 |
Hutchison Medipharma Ltd |
吡咯並嘧啶類化合物及其用途
|
|
TW201249845A
(en)
|
2010-11-19 |
2012-12-16 |
Incyte Corp |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
JP5917544B2
(ja)
|
2010-11-19 |
2016-05-18 |
インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン
|
|
ES2617339T3
(es)
|
2010-12-16 |
2017-06-16 |
Calchan Limited |
Derivados de pirrolopirimidina inhibidores de ASK1
|
|
WO2012088682A1
(en)
*
|
2010-12-29 |
2012-07-05 |
Shanghai Fochon Pharmaceutical Co Ltd. |
2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
|
|
EP2661436B1
(en)
|
2011-01-07 |
2016-04-13 |
Leo Pharma A/S |
Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
|
|
DE102011008352A1
(de)
*
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
|
|
EP2670244B1
(en)
|
2011-02-04 |
2018-04-11 |
Duquesne University of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
|
MX357939B
(es)
|
2011-02-18 |
2018-07-31 |
Novartis Pharma Ag |
Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak).
|
|
WO2012127506A1
(en)
|
2011-03-22 |
2012-09-27 |
Advinus Therapeutics Limited |
Substituted fused tricyclic compounds, compositions and medicinal applications thereof
|
|
US9402847B2
(en)
|
2011-04-01 |
2016-08-02 |
Astrazeneca Ab |
Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
|
|
KR20140040819A
(ko)
|
2011-06-20 |
2014-04-03 |
인사이트 코포레이션 |
Ｊａｋ 저해제로서의 아제티디닐 페닐, 피리딜 또는 피라지닐 카르복스아미드 유도체
|
|
RU2014102764A
(ru)
*
|
2011-06-29 |
2015-08-10 |
Мерк Шарп И Доум Корп. |
Способ получения хиральных ингибиторов дипептидилпептидазы iv
|
|
BR112014000314A2
(pt)
|
2011-07-08 |
2017-01-10 |
Novartis Ag |
derivados de pirrolo pirimidina
|
|
CA2844507A1
(en)
|
2011-08-10 |
2013-02-14 |
Novartis Pharma Ag |
Jak pi3k/mtor combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
ES3018133T3
(en)
|
2011-11-30 |
2025-05-14 |
Univ Emory |
Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
|
|
DK2785349T4
(da)
|
2011-11-30 |
2023-01-09 |
Astrazeneca Ab |
Kombinationsbehandling af cancer
|
|
US8993756B2
(en)
|
2011-12-06 |
2015-03-31 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
CN105732639A
(zh)
*
|
2012-06-29 |
2016-07-06 |
辉瑞大药厂 |
作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类
|
|
MX2015002887A
(es)
*
|
2012-09-06 |
2015-07-06 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
|
|
IN2015DN02008A
(cg-RX-API-DMAC10.html)
|
2012-09-21 |
2015-08-14 |
Advinus Therapeutics Ltd |
|
|
CA2881070A1
(en)
*
|
2012-10-26 |
2014-05-01 |
F. Hoffmann-La Roche Ag |
Inhibitors of bruton's tyrosine kinase
|
|
CN102936251A
(zh)
*
|
2012-11-05 |
2013-02-20 |
上海毕得医药科技有限公司 |
一种吡咯并[2,3-d]嘧啶衍生物的制备方法
|
|
US10166191B2
(en)
|
2012-11-15 |
2019-01-01 |
Incyte Corporation |
Sustained-release dosage forms of ruxolitinib
|
|
RS56503B1
(sr)
|
2013-02-22 |
2018-02-28 |
Pfizer |
Derivati pirolo [2,3-d] pirimidina kao inhibitori janus kinaza (jak)
|
|
DK2964650T3
(en)
|
2013-03-06 |
2019-02-11 |
Incyte Holdings Corp |
PROCEDURES AND INTERMEDIATES FOR THE MANUFACTURE OF A JAK INHIBITOR
|
|
EP2970119B1
(en)
*
|
2013-03-14 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
SI3030227T1
(sl)
|
2013-08-07 |
2020-08-31 |
Incyte Corporation |
Dozirne oblike s podaljšanim sproščanjem za inhibitor JAK1
|
|
HRP20171846T1
(hr)
|
2013-12-05 |
2018-01-12 |
Pfizer Inc. |
PIROLO[2,3-d]PIRIMIDINIL-, PIROLO[2,3-b]PIRAZINIL- I PIROLO[2,3-d]PIRIDINILAKRILAMIDI
|
|
US9695171B2
(en)
|
2013-12-17 |
2017-07-04 |
Pfizer Inc. |
3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
EP3180344B1
(en)
|
2014-08-12 |
2019-09-18 |
Pfizer Inc |
Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
|
|
US10246464B2
(en)
|
2014-09-09 |
2019-04-02 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
CN105524067A
(zh)
*
|
2014-09-28 |
2016-04-27 |
江苏柯菲平医药股份有限公司 |
4-取代吡咯并[2,3-d]嘧啶化合物及其用途
|
|
US10703756B2
(en)
|
2015-05-01 |
2020-07-07 |
Pfizer Inc. |
Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof
|
|
WO2016197027A1
(en)
|
2015-06-04 |
2016-12-08 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
TWI703150B
(zh)
|
2015-06-04 |
2020-09-01 |
美商庫拉腫瘤技術股份有限公司 |
用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
|
|
PL3330271T3
(pl)
|
2015-07-31 |
2022-12-19 |
Taiho Pharmaceutical Co., Ltd. |
Związek pirolo[2,3-d]pirymidyny lub jego sól
|
|
KR101771219B1
(ko)
*
|
2015-08-21 |
2017-09-05 |
양지화학 주식회사 |
야누스 키나제 1 선택적 억제제 및 그 의약 용도
|
|
AU2016322813B2
(en)
|
2015-09-14 |
2021-04-01 |
Pfizer Inc. |
Novel imidazo (4,5-c) quinoline and imidazo (4,5-c)(1,5) naphthyridine derivatives as LRRK2 inhibitors
|
|
CN108472298B
(zh)
|
2015-11-24 |
2021-04-20 |
深圳阿拉丁医疗科技有限公司 |
选择性激酶抑制剂
|
|
CN107098908B
(zh)
*
|
2016-02-23 |
2021-01-08 |
欣凯医药科技(上海)有限公司 |
一种吡咯并嘧啶类化合物的制备方法和应用
|
|
SMT202300273T1
(it)
|
2016-03-16 |
2023-09-06 |
Kura Oncology Inc |
Derivati di tieno[2,3–d]pirimidina sostituiti come inibitori di menina–mll e metodi d’uso
|
|
MA43823A
(fr)
|
2016-03-16 |
2018-11-28 |
Kura Oncology Inc |
Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation
|
|
CN107513069A
(zh)
*
|
2016-06-16 |
2017-12-26 |
正大天晴药业集团股份有限公司 |
手性吡咯并嘧啶化合物的制备方法
|
|
CN107513067A
(zh)
|
2016-06-16 |
2017-12-26 |
北京赛林泰医药技术有限公司 |
含有取代环戊基的吡咯并嘧啶化合物
|
|
WO2018017153A1
(en)
|
2016-07-21 |
2018-01-25 |
Biogen Ma Inc. |
Succinate forms and compositions of bruton's tyrosine kinase inhibitors
|
|
WO2018140648A1
(en)
|
2017-01-25 |
2018-08-02 |
Eric Jon Jacobsen |
Pyrrolopyrimidine itk inhibitors for treating inflammation and cancer
|
|
CN110248663A
(zh)
*
|
2017-02-03 |
2019-09-17 |
利奥制药有限公司 |
作为新型JAK激酶抑制剂的5-(7H-吡咯并[2,3-d]嘧啶-4-基)-5-氮杂螺[2.5]辛烷-8-甲酸衍生物
|
|
CN117298275A
(zh)
|
2017-03-24 |
2023-12-29 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
|
|
CN108794480A
(zh)
*
|
2017-04-28 |
2018-11-13 |
天津药物研究院有限公司 |
吡咯并嘧啶类化合物、其制备方法和用途
|
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
EP3684361A4
(en)
|
2017-09-20 |
2021-09-08 |
Kura Oncology, Inc. |
SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHOD OF USING
|
|
KR102821964B1
(ko)
|
2017-11-03 |
2025-06-19 |
어클라리스 쎄라퓨틱스, 인코포레이티드 |
치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법
|
|
WO2019090143A1
(en)
|
2017-11-03 |
2019-05-09 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrimidine-5-carboxylate analogs and methods of making the same
|
|
US10596161B2
(en)
|
2017-12-08 |
2020-03-24 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
LT3746429T
(lt)
|
2018-01-30 |
2022-05-10 |
Incyte Corporation |
(1-(3-fluor-2-(trifluormetil)izonikotinil)piperidin-4-ono) gamybos būdai
|
|
MY206999A
(en)
|
2018-03-30 |
2025-01-23 |
Incyte Corp |
Treatment of hidradenitis suppurativa using jak inhibitors
|
|
JP7591500B2
(ja)
|
2018-08-10 |
2024-11-28 |
アクラリス セラピューティクス，インコーポレイテッド |
ピロロピリミジンｉｔｋ阻害剤
|
|
GB201818750D0
(en)
*
|
2018-11-16 |
2019-01-02 |
Institute Of Cancer Res Royal Cancer Hospital |
Lox inhibitors
|
|
CN109394768B
(zh)
*
|
2018-12-10 |
2019-08-23 |
牡丹江医学院 |
一种治疗湿疹的药物及其制备方法
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
EP3946606B1
(en)
|
2019-03-27 |
2025-01-01 |
Insilico Medicine IP Limited |
Bicyclic jak inhibitors and uses thereof
|
|
PH12021552036A1
(en)
|
2019-05-02 |
2022-05-23 |
Aclaris Therapeutics Inc |
Substituted pyrrolopyridines as jak inhibitors
|
|
KR20230031981A
(ko)
|
2019-05-14 |
2023-03-07 |
프로벤션 바이오, 인코포레이티드 |
제1형 당뇨병을 예방하기 위한 방법 및 조성물
|
|
PE20230251A1
(es)
|
2019-11-22 |
2023-02-07 |
Incyte Corp |
Terapia de combinacion que comprende un inhibidor de alk2 y un inhibidor de jak2
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US12006366B2
(en)
|
2020-06-11 |
2024-06-11 |
Provention Bio, Inc. |
Methods and compositions for preventing type 1 diabetes
|
|
WO2023055731A1
(en)
*
|
2021-09-28 |
2023-04-06 |
Sanford Burnham Prebys Medical Discovery Institute |
Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof
|